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CiteWeb id: 19960000064

CiteWeb score: 5983

DOI: 10.1126/science.272.5259.263

A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human primary macrophages. Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.

The publication "In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 1000. Additionally, the publicaiton "In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector" is placed in the Top 100 among other scientific works published in 1996.
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