Autors:

CiteWeb id: 19930000029

CiteWeb score: 8444

DOI: 10.1016/0092-8674(93)90529-Y

Summary h-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. /in-4 acts by negatively regulating the level of LIN-14 protein, creating a temporal decrease in LIN-14 protein starting in the first larval stage (Ll). We have cloned the C. elegans lin-4 locus by chromosomal walking and transformation rescue. We used the C. elegans clone to isolate the gene from three other Caenorhabditis species; all four Caenorhabditis clones functionally rescue the h-4 null allele of C. elegans. Comparison of the /in-4 genomic sequence from these four species and site-directed mutagenesis of potential open reading frames indicated that /in-d does not encode a protein. Two small /in-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3’untranslated region (UTR) of lin-74 mRNA, suggesting that /in-4 regulates h-74 translation via an antisense RNA-RNA interaction.

The publication "The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to lin-14" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 1000. Additionally, the publicaiton "The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to lin-14" is placed in the Top 100 among other scientific works published in 1993.
Links to full text of the publication: