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CiteWeb id: 19930000027

CiteWeb score: 8555

DOI: 10.1126/science.8346443

The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.

The publication "Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families." is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 1000. Additionally, the publicaiton "Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families." is placed in the Top 100 among other scientific works published in 1993.
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