# Publications in 2014

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The advent of proteomics has brought with it the hope of discovering novel biomarkers that can be used to diagnose diseases, predict susceptibility and monitor progression. Much of this effort has focused upon the mass spectral identification of the thousands...

Wan-Jian Yin, Tingting Shi, Yanfa Yan

Jeff Hearn, D.H.J. Morgan

.Objective: The indications for the use of thrombolytic agents in massive pulmonary embolism (MPE) remain controversial and it has been suggested that transthoracic echocardiographic (TTE) examination, which is able to detect an associated right ventricular...

SummaryFor economic development to succeed in Africa in the next 50 years, African agriculture will have to change beyond recognition. Production will have to have increased massively, but also labor productivity, requiring a vast reduction in the proportion...

: The Unified Modeling Language UML is a language for specifying visualizing and documenting object oriented systems UML combines the concepts of OOA OODOMT and OOSE and is intended as a standard in the domain of object oriented analysis and design Due...

BACKGROUND:Elevated lipoprotein-associated phospholipase A2 activity promotes the development of vulnerable atherosclerotic plaques, and elevated plasma levels of this enzyme are associated with an ...

An Introduction to Nonlinear Analysis: Theory is an overview of some basic, important aspects of Nonlinear Analysis, with an emphasis on those not included in the classical treatment of the field. Today Nonlinear Analysis is a very prolific part of modern...

Intelligence led policing is now a term in common usage within Australian law enforcement. This paper considers the origins, definition and aims of intelligence led policing, as well as a model of how it should work, through interpretation of the criminal...

Patient AccessPatients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply.

3D: three-dimensionalAAA: abdominal aortic aneurysmAAS: acute aortic syndromeACC: American College of CardiologyACE: angiotensin-converting enzymeAD: Aortic dissectionADAM: Aneurysm Detection and ManagementAHA: American Heart AssociationAJAX:...

Direct digital acquisition of intra-oral radiographs has been possible only in the last decade. Several studies have shown that, theoretically, there are a number of advantages of direct digital radiography compared with conventional film. Laboratory...

Sheila Dark Videbeck, Cathy J. Miller

The role of epistasis in the genetic architecture of quantitative traits is controversial, despite the biological plausibility that nonlinear molecular interactions underpin the genotype-phenotype map. This controversy arises because most genetic variation...

Glen A. Satten, Laurence M. Grummer-Strawn

Electron Kebebew, Orlo H. Clark

: A measurement of the energy dependence of antineutrino disappearance at the Daya Bay Reactor Neutrino Experiment is reported. Electron antineutrinos ($\overline{\nu}_{e}$) from six $2.9$ GW$_{\rm th}$ reactors were detected with six detectors deployed...

Over the last 40 years, transition metal catalysis has enabled bond formation between aryl and olefinic (sp2) carbons in a selective and predictable manner with high functional group tolerance. Couplings involving alkyl (sp3) carbons have proven more...

This review is intended to update the most recent developments of asymmetric aziridination in numerous reaction types, such as nitrene transfer to alkenes, carbene transfer to imines, cyclisation reactions, aza-Darzens reactions, ylide-mediated aziridinations...

The temperature of cities continues to increase because of the heat island phenomenon and the undeniable climatic change. The observed high ambient temperatures intensify the energy problem of cities, deteriorates comfort conditions, put in danger the...

M Cohnen, Kemper J, Möbes O, Pawelzik J, Mödder U

We report the repeating occurrence of short- and long-term slow slip events (SSE) which are accompanied by deep tremor activity around the Bungo channel region, southwest Japan. Both of these activities are detected by NIED Hi-net, which is composed of...

Probiotic supplements induce immunological responses in the host, and dietary fructooligosaccharides (FOS) stimulate the growth of selected intestinal microflora. In this study we investigated the immunological influences of orally administrated FOS....

This review considers evidence that acute and chronic kidney diseases are not distinct entities but rather are closely interconnected. The implications of this insight are discussed in terms of the approach to patients with kidney disease.

Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is used for recycling cytoplasm to generate macromolecular building blocks and energy under stress conditions, to remove superfluous and damaged organelles to adapt...

After evaluating a safety signal regarding pancreatitis and pancreatic cancer in patients using incretin-based drugs, the Food and Drug Administration and the European Medicines Agency conclude that assertions of a causal association are inconsistent...

There is an apparent paradox in our under- standing of molecular evolution. Current biochemically based models predict that evolutionary trees should not be recoverable for divergences beyond a few hundred million years. In practice, however, trees often...

As technology expands and health care resources become more limited, there is increasing pressure on surgeons to evaluate surgical procedures and technology to ensure they are effective. No longer is evidence from case series acceptable, and treatments...

Background Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non–small-cell lung cancers (NSCLCs) that may be susceptible to therapeutic ROS1 kinase inhibition....

Bernd J. Pichler, Guido Boening, Magdalena Rafecas, W. Pimpl, Eckart Lorenz, N. Schmitz

Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary...

SummaryWe performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discovered putative tumor suppressor genes by determining...

Objective: Sensory gating deficits found in schizophrenia can be assessed by using a paired auditory stimulus paradigm to measure auditory evoked response. The ratio of the P50 response amplitude of the second or test stimulus to that of the first or...

Peter Reimer, Ernst J. Rummeny, Heike E. Daldrup, Thomas Hesse, Thomas Balzer, Bernd Tombach, P. E. Peters

Radiologists and radiotherapists were one of the earliest occupational groups to be exposed to ionizing radiation. Their patterns of mortality provide information on the long-term effects of fractionated external radiation exposure. British radiologists...

hazard ratio, 1.27; 95% confidence intercal, 1.07– 1.51; P=0.007). Corresponding rates at 12 months were 1.9% versus 1.3% (hazard ratio, 1.46; 95% confidence interval, 1.15– 1.88; P=0.002), with no significant difference...

type="main"> We present a model of sovereign debt in which, contrary to conventional wisdom, government defaults are costly because they destroy the balance sheets of domestic banks. In our model, better financial institutions allow banks to be more leveraged,...

: The techniques and analysis presented in this paper provide new methods to solve optimization problems posed on Riemannian manifolds. A new point of view is offered for the solution of constrained optimization problems. Some classical optimization techniques...

Antifungal activities were examined and compared for some 40 kinds of aliphatic and aromatic aldehydes, alcohols, phenolic compounds, ether compounds and hydrocarbons from essential oils and for some related compounds, using seven fungi.PDFRelated articlesView...

This work considers a computationally and statistically efficient parameter estimation method for a wide class of latent variable models--including Gaussian mixture models, hidden Markov models, and latent Dirichlet allocation--which exploits a certain...

Graphene and other two-dimensional materials, such as transition metal dichalcogenides, have rapidly established themselves as intriguing building blocks for optoelectronic applications, with a strong focus on various photodetection platforms. The versatility...

Ele Ferrannini, Elza Muscelli, Silvia Frascerra, Simona Baldi, Andrea Mari, T. Heise, Uli C. Broedl, Hans-Juergen Woerle

Patient AccessPatients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply.

Vinay Chaudhry, Guido Cavaletti

EPSRC (UK) [EP/K04074X/1]; DARPA (US) MESO project [N66001-11-1-4105]; Department of Energy, Office of Basic Energy Science [DE-AC02-76SF00515, DE-AC02-05CH11231]; NSF of China; National Basic Research Program of China; International Science and Technology...

Paul McGale, C J Taylor, C Correa, D Cutter, F. Duane, M Ewertz, Richard Gray, Gurdeep Singh Mannu, Richard Peto, Yixin Wang, Zhaoming Wang, Sarah C. Darby

.The goal of this experiment was to examine contraction-mediated activation of superoxide dismutase (SOD) gene expression in rat superficial vastus lateralis (SVL, type IIb) and deep vastus lateralis (DVL, type IIa) muscles. Female Sprague-Dawley rats...

The human epidermal growth factor receptor (EGFR) family consists of four members that belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated extracellular domain, a single hydrophobic transmembrane segment, and...

Measuring the magnetic configuration at complex buried layers and interfaces is an important task, which requires especially a non-destructive probing technique. X-ray resonant magnetic reflectometry (XRMR) combines the non-destructive depth profiling...

Diets link environmental and human health. Rising incomes and urbanization are driving a global dietary transition in which traditional diets are replaced by diets higher in refined sugars, refined fats, oils and meats. By 2050 these dietary trends, if...

Jillian J. Jordan, Alexander Peysakhovich, David G. Rand

Javier Tamames, Georg Casari, Christos Ouzounis, Alfonso Valencia

In recent years, we have witnessed the rapid proliferation and widespread adoption of a new class of information technologies, commonly known as social media. Researchers often rely on social network analysis (SNA) when attempting to understand these...

Xiang Li, Joseph B. Rayman, Eric R. Kandel, Irina L. Derkatch

Based on first-principle calculations, we show that a family of nonmagnetic materials including TaAs, TaP, NbAs, and NbP are Weyl semimetals (WSM) without inversion centers. We find twelve pairs of Weyl points in the whole Brillouin zone (BZ) for each...

Juan Márquez, Scott Bb, Laurence Flint, Hubert van Hoogstraten, Annie C. Chen, H. Zheng, Silvio Danese, P. Rutgeerts

Jan Budczies, Berit M. Pfitzner, Klaus-Jürgen Winzer, Cornelia Radke, Manfred Dietel, Oliver Fiehn, Carsten Denkert

Tomohiko Ichikawa, Hiroki Haradome, Junichi Hachiya, Toshiaki Nitatori, Takuto Araki

Purpose To evaluate panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevavcizumab plus mFOLFOX6 in patients with previously untreated wild-type (WT) KRAS exon 2 (codons 12 and 13) metastatic colorectal cancer (mCRC). A...

Bioinspired computation methods, such as evolutionary algorithms and ant colony optimization, are being applied successfully to complex engineering and combinatorial optimization problems, and it is very important that we understand the computational...

Lisa W. Coyne, Kirstin B. Birtwell, Louise McHugh, Kelly G. Wilson

The presence of cyanide ions in surface water is not only caused by industrial waste but also by biological processes. Owing to the extreme toxicity of cyanide in physiological systems and its widespread presence in the environment, considerable attention...

Despite being sessile organisms constantly exposed to potential pathogens and pests, plants are surprisingly resilient to infections. Plants can detect invaders via the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition...

Patient AccessPatients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply.

There is a well-reported tendency for canopy height to be underestimated in small-footprint airborne laser scanning (ALS) data of coniferous woodland. This is commonly explained by a failure to record treetops because of insufficient ALS sampling density....

Internet of Things (IoT) is going to create a world where physical objects are seamlessly integrated into information networks in order to provide advanced and intelligent services for human-beings. Trust management plays an important role in IoT for...

Common bean (Phaseolus vulgaris L.) is the most important grain legume for human consumption and has a role in sustainable agriculture owing to its ability to fix atmospheric nitrogen. We assembled 473 Mb of the 587-Mb genome and genetically anchored...

useful in analysis, and is related to the left centralizer concept which J. G. Wendel used to investigate group algebras. The commutative version of this idea was first introduced by S. Helgason under the name of the algebra of multipliers (see (4)),...

This guideline is the result of a systematic literature review using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is...

The canonical framework used to price risky debt implies that the payoff structure of levered equity resembles the payoff of a call option, while the bondholders face a payoff structure that is equivalent to that of an investor writing a put option. As...

We marry ideas from deep neural networks and approximate Bayesian inference to derive a generalised class of deep, directed generative models, endowed with a new algorithm for scalable inference and learning. Our algorithm introduces a recognition model...

G. R. Rogers, Analisa Villarreal, Dorothy Kammerer-Doak, Clifford Qualls

An international panel of experts prepared an evidenced-based guideline for vaccination of immunocompromised adults and children. These guidelines are intended for use by primary care and subspecialty providers who care for immunocompromised patients....

The design and characterization of metal–organic complexes for optoelectronic applications is an active area of research. The metal–organic complex offers unique optical and electronic properties arising from the interplay between the inorganic metal...

Zhonghan Li, Tariq M. Rana

In this multicenter, parallel-group trial, we randomly assigned patients in the intensive care unit (ICU) who had septic shock and a hemoglobin concentration of 9 g per deciliter or less to receive 1 unit of leukoreduced red cells when the hemoglobin...

This paper reviews recent research studies on the application of the nonlocal continuum theory in modeling of carbon nanotubes and graphene sheets. A variety of nonlocal continuum models in modeling of the two materials under static and dynamic loadings...

Bacteria have traditionally been regarded as individual organisms growing in homogeneous planktonic populations. However, bacteria in natural environments usually form communities of surface-adherent organisms embedded in an extracellular matrix, called...

In the regression‐discontinuity (RD) design, units are assigned to treatment based on whether their value of an observed covariate exceeds a known cutoff. In this design, local polynomial estimators are now routinely employed to construct confidence...

Methods We searched Web of Science, Embase, and the Cochrane Database, from inception to July 8, 2012, for trials assessing the effects of vitamin D (D3 or D2, but not vitamin D metabolites) on bone mineral density. We included all randomised trials comparing...

A review of 384 studies of psychologically oriented alcoholism treatment showed that differences in treatment methods did not significantly affect long-term outcome. Mean abstinence rates did not differ between treated and untreated alcoholics, but more...

Motivation: The recently released Infinium HumanMethylation450 array (the ‘450k’ array) provides a high-throughput assay to quantify DNA methylation at approximately 450,000 loci across a range of genomic features. Although less comprehensive than...

The sterilizing effect of supercritical carbon dioxide (SC-C02) is described as compared with gaseous C02(G-C02) and liquid C02(L-C02). Baker’s yeast, Escherichia coli, Staphylococcus aureus and conidia of Aspergillus niger were sterilized by treating...

Ofelia García, Li Wei

Numerous studies have shown that repetitive transcranial magnetic stimulation (rTMS) produced significant clinical effects in patients with various neurological and psychiatric disorders.

Excavations of a complex of caves in the Sierra de Atapuerca in northern Spain have unearthed hominin fossils that range in age from the early Pleistocene to the Holocene1. One of these sites, the ‘Sima de los Huesos’ (‘pit of bones’), has yielded...

Background and Purpose—Stroke mortality has been declining since the early 20th century. The reasons for this are not completely understood, although the decline is welcome. As a result of recent striking and more accelerated decreases in stroke mortality,...

This article discusses alternatives to single-step mixture modeling. A 3-step method for latent class predictor variables is studied in several different settings, including latent class analysis, latent transition analysis, and growth mixture modeling....

Protein secondary structure carries information about local structural arrangements. Significant majority of successful methods for predicting the secondary structure is based on multiple sequence alignment. However, the multiple alignment fails to achieve...

. Cenozoic magmatic activity in northern Chile led to the formation of two contrasting porphyry copper belts: (1) a Paleocene–Early Eocene belt comprising small porphyry copper deposits (e.g., Lomas Bayas) of normal calc-alkaline affinity; and (2) a...

Though only a decade has elapsed since the default network (DN) was first defined as a large-scale brain system, recent years have brought great insight into the network’s adaptive functions. A growing theme highlights the DN as playing a key role in...

The rapid collection of brain images from healthy and diseased subjects has stimulated the development of pow- erful mathematical algorithms to compare, pool and average brain data across whole populations. Brain structure is so complex and variable that...

Rafael S. Sanchez, González-Pedro, Jung Woo Lee, Park Ng, Yong Soo Kang, Iván Mora-Seró, Juan Bisquert

The area of teachers' continuing professional development (CPD) is of growing interest internationally. However, while an increasing range of literature focuses on particular aspects of CPD, there is a paucity of literature addressing the spectrum of...

The immunostimulants 3-O-desacyl-4’-monophosphoryl lipid A (MPL) and the saponin QS-21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate immune response to orchestrate the quality and intensity of the adaptive immune...

The mammalian intestines contain an enormous number of microorganisms within the lumen. Given the constant exposure to these microbes, the intestinal immune system has the difficult task of maintaining tolerance to commensal bacteria while remaining responsive...

Extracellular vesicles, including exosomes, are small membrane vesicles derived from multivesicular bodies or from the plasma membrane. Most, if not all, cell types release extracellular vesicles, which then enter the bodily fluids. These vesicles contain...

Frances E. Allen, Michael G. Burke, Philippe Charles, Ron Cytron, Jeanne Ferrante

B. R. Hergenhahn

Ida Pernicova, Márta Korbonits

Jeffrey Diller, Charles Favre

Highly efficient p–i–n perovskite solar cells employing a flat and thick CH3NH3PbI3 film and a thin PCBM film are fabricated by the solution-process at low temperature. Through attainment of optimized PCBM thickness and insertion of the LiF interlayer,...

This is the novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profiles in the gastrointestinal tract is to...

Rebecca Siegel, Carol DeSantis, Ahmedin Jemal

Dawn M. Holman, Vicki B. Benard, Katherine B. Roland, Meg Watson, Nicole Liddon, Shannon Stokley

R. Oliver, H. G. Hewitt

High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific immunity, which enhances tumor control both locally and distantly. Unfortunately, local relapses often occur following IR treatment, indicating that IR-induced...

I develop a highly tractable general equilibrium model in which heterogeneous producers face collateral constraints, and study the effect of financial frictions on capital misallocation and aggregate productivity. My economy is isomorphic to a Solow model...

Printing technologies have undergone signficant development because they are an enabler in science and engineering research; they also have significant practical applications in manufacturing. Micro- and nano-printing techniques have found a number of...

Graduate School of Arts and Sciences Thesis and Dissertation Guidelines Thesis Dissertation

The Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) here presents its updated recommendations for the treatment of documented fungal infections. Invasive fungal infections are a main cause of morbidity...

Andrew J. Powell, Taylor Chung, Tal Geva

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