CiteWeb

WorldWeb citation database

Publications in 2012

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BODIPY dyes in photodynamic therapy

BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby...

RobiNA: a user-friendly, integrated software solution for RNA-Seq-based transcriptomics

Recent rapid advances in next generation RNA sequencing (RNA-Seq)-based provide researchers with unprecedentedly large data sets and open new perspectives in transcriptomics. Furthermore, RNA-Seq-based transcript profiling can be applied to non-model...

Femoroacetabular Impingement: Radiographic Diagnosis—What the Radiologist Should Know

OBJECTIVE. The purpose of this article is to show the important radiographic criteria that indicate the two types of femoroacetabular impingement: pincer and cam impingement. In addition, potential pitfalls in pelvic imaging concerning femoroacetabular...

Maximum Likelihood Fitting of ARMA Models to Time Series With Missing Observations

The method of calculating the exact likelihood function of a stationary autoregressive moving average (ARMA) time series based on Akaike's Markovian representation and using Kalman recursive estimation is reviewed. This state space approach involves matrices...

The Attributable Morbidity and Mortality of Ventilator-Associated Pneumonia in the Critically Ill Patient

To evaluate the attributable morbidity and mortality of ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients, we conducted a prospective, matched cohort study. Patients expected to be ventilated for > 48 h were prospectively followed...

Statistical models for longitudinal zero‐inflated count data with applications to the substance abuse field

This study fills in the current knowledge gaps in statistical analysis of longitudinal zero-inflated count data by providing a comprehensive review and comparison of the hurdle and zero-inflated Poisson models in terms of the conceptual framework, computational...

Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB

Description: Although approximately 85 million units of red blood cells (RBCs) are transfused annually worldwide, transfusion practices vary widely. The AABB (formerly, the American Association of Blood Banks) developed this guideline to provide clinical...

Efficacy and Safety of Inhaled Corticosteroids in Asthma

Inhaled glucocorticosteroids have now become first-line therapy for the treatment of chronic asthma in many countries. They are the most effective asthma therapy currently available, and numerous studies have documented their long-term efficacy in asthma...

Science and Statistics

Aspects of scientific method are discussed: In particular, its representation as a motivated iteration in which, in succession, practice confronts theory, and theory, practice. Rapid progress requires sufficient flexibility to profit from such confrontations,...

Diagnostic Criteria for Mild Cognitive Impairment in Parkinson’s Disease: Movement Disorder Society Task Force Guidelines

Irene Litvan, Jennifer G. Goldman, Alexander I. Tröster, Ben Schmand, Daniel Weintraub, Ronald C. Petersen, Brit Mollenhauer, Charles H. Adler, Karen Marder, Caroline H. Williams-Gray, Maria C. Rodriguez-Oroz, Murat Emre

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria.

Giedrius Gasiunas, Rodolphe Barrangou, Philippe Horvath, Virginijus Siksnys

The variable nature of cognitive control: a dual mechanisms framework.

A core component of cognitive control – the ability to regulate thoughts and actions in accordance with internally represented behavioral goals – might be its intrinsic variability. In this article, I describe the dual mechanisms of control (DMC)...

Psychological therapies for the management of chronic pain (excluding headache) in adults

BackgroundPsychological treatments are designed to treat pain, distress and disability, and are in common practice. No comprehensive systematic review has been published since 1999.Objectives To evaluate the effectiveness of psychological therapies on...

Estimates of Income for Small Places: An Application of James-Stein Procedures to Census Data

An adaptation of the James-Stein estimator is applied to sample estimates of income for small places (i.e., population less than 1,000) from the 1970 Census of Population and Housing. The adaptation incorporates linear regression in the context of unequal...

On Some Invariant Criteria for Grouping Data

This paper deals with methods of “cluster analysis”. In particular we attack the problem of exploring the structure of multivariate data in search of “clusters”. The approach taken is to use a computer procedure to obtain the “best” partition...

Principal Components Regression in Exploratory Statistical Research

Regression upon principal components of the percentage points of the income and education distributions for 1950 census tracts in the city of Chicago led to the estimation of “beta coefficient profiles” for television receiver and refrigerator ownership,...

The Growth of Low Skill Service Jobs and the Polarization of the U.S. Labor Market

We offer an integrated explanation and empirical analysis of the polarization of U.S. employment and wages between 1980 and 2005, and the concurrent growth of low skill service occupations. We attribute polarization to the interaction between consumer...

Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease

Thierry Troosters, Richard Casaburi, Marc Decramer

Estimation of Parameters for a Mixture of Normal Distributions

n observations are taken from a mixture of K normal subpopulations, where the value of K is known. It is assumed that these n observations are given as N frequencies from equally spaced intervals. Initial guesses of the K means, K variances, and K −...

Families of Multivariate Distributions

For many years there has been an interest in families of bivariate distributions with marginals as parameters. Genest and MacKay (1986a,b) showed that several such families that appear in the literature can be derived by a unified method. A similar conclusion...

Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up

Results Approximately 92% of the study participants were followed to 10 years and 57% to 13 years. At 13 years, 4250 participants had been diagnosed with prostate cancer in the intervention arm compared with 3815 in the control arm. Cumulative incidence...

Hydrogenated TiO2 nanotube arrays for supercapacitors.

We report a new and general strategy for improving the capacitive properties of TiO2 materials for supercapacitors, involving the synthesis of hydrogenated TiO2 nanotube arrays (NTAs). The hydrogenated TiO2 (denoted as H–TiO2) were obtained by calcination...

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Pract

Stephan D. Fihn, Julius M. Gardin, Jonathan Abrams, Kathleen Berra, James C. Blankenship, Apostolos P. Dallas, Pamela S. Douglas, JoAnne M. Foody, Thomas C. Gerber, Spencer B. King, Paul Kligfield, Harlan M. Krumholz, Raymond Y. Kwong, Michael J. Lim, Jane A. Linderbaum, Michael J. Mack, Mark A. Munger, Richard L. Prager, Joseph F. Sabik, Leslee J. Shaw, Joanna D. Sikkema, Craig R. Smith, Sidney C. Smith, John A. Spertus

In vivo genome editing using a high-efficiency TALEN system

Victoria M. Bedell, Ying Wang, Jarryd M. Campbell, Tanya L. Poshusta, Colby G. Starker, Randall G. Krug, Wenfang Tan, Sumedha G. Penheiter, Alvin C.H. Ma, Anskar Y. H. Leung, Scott C. Fahrenkrug, Daniel F. Carlson, Daniel F. Voytas, Karl J. Clark, Jeffrey J. Essner, Stephen C. Ekker

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

Kazuko Haga, Andrew C. Kruse, Hidetsugu Asada, Takami Yurugi-Kobayashi, Mitsunori Shiroishi, Cheng Zhang, William I. Weis, Tetsuji Okada, Brian K. Kobilka, Takuya Kobayashi

Crystal structure of the [micro]-opioid receptor bound to a morphinan antagonist

Aashish Manglik, Andrew C. Kruse, Tong Sun Kobilka, Foon Sun Thian, Jesper Mosolff Mathiesen, Roger K. Sunahara, Leonardo Pardo, Brian K. Kobilka, Sébastien Granier

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 : The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the...

Nonparametric Estimation of Nonstationary Spatial Covariance Structure

Estimation of the covariance structure of spatial processes is a fundamental prerequisite for problems of spatial interpolation and the design of monitoring networks. We introduce a nonparametric approach to global estimation of the spatial covariance...

Estimating Mixture of Dirichlet Process Models

Current Gibbs sampling schemes in mixture of Dirichlet process (MDP) models are restricted to using “conjugate” base measures that allow analytic evaluation of the transition probabilities when resampling configurations, or alternatively need to rely...

Displacement, diaspora, and geographies of identity

Displacement, Diaspora, and Geographies of Identity challenges conventional understandings of identity based on notions of nation and culture as bounded or discrete. Through careful examinations of various transnational, hybrid, border, and diasporic...

Search for squarks and gluinos using final states with jets and missing transverse momentum with the ATLAS detector in √s = 7 TeV proton-proton collisions

A search for squarks and gluinos in final states containing jets, missing transverse momentum and no electrons or muons is presented. The data were recorded by the ATLAS experiment in √s=7TeV proton–proton collisions at the Large Hadron Collider....

Photoredox functionalization of C–H bonds adjacent to a nitrogen atom

The functionalization of C–H bonds and the visible light photoredox catalysis represent two prominent challenges in organic chemistry. In this regard, the combination of visible-light catalysis and C–H bond functionalization adjacent to a tertiary...

RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

Background Cutaneous squamous-cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF inhibitors. Methods We performed a molecular analysis to identify oncogenic mutations (HRAS, KRAS, NRAS, CDKN2A, and TP53) in the lesions...

Cyclic X-Ray Responses in Mammalian Cells in Vitro1

Various radiation responses in mammalian cells depend on the position of the cell within its generation cycle (that is, its age) at the time of irradiation. Studies have most often been made by irradiating synchronized populations of cells in vitro. Results...

Bayesian Prediction of Deterministic Functions, with Applications to the Design and Analysis of Computer Experiments

This article is concerned with prediction of a function y(t) over a (multidimensional) domain T, given the function values at a set of “sites” {t (1), t (2), …, t (n)} in T, and with the design, that is, with the selection of those sites. The motivating...

Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease.

Changes in lung hyperinflation, dyspnea, and exercise endurance are important outcomes in assessing therapeutic responses in chronic obstructive pulmonary disease (COPD). Therefore, we studied the reproducibility of Borg dyspnea ratings, inspiratory capacity...

On the Use of Cause-Specific Failure and Conditional Failure Probabilities: Examples from Clinical Oncology Data

Nonparametric maximum likelihood estimation of the probability of failing from a particular cause by time t in the presence of other acting causes (i.e., the cause-specific failure probability) is discussed. A commonly used incorrect approach is to take...

From Bulk to Monolayer MoS2: Evolution of Raman Scattering

Hong Li, Qing Zhang, Chin Chong Ray Yap, Teo Hang Tong Edwin, Aurelien Olivier, Dominique Baillargeat

Pre-School Children's Knowledge of English Phonology.

The author suggests that some preschool children have an unconscious knowledge of aspects of the sound system of English; that these children tacitly organize phonetic segments into categories defined by articulatory features; and that these children...

Probability Inequalities for the Sum of Independent Random Variables

This paper proves a number of inequalities which improve on existing upper limits to the probability distribution of the sum of independent random variables. The inequalities presented require knowledge only of the variance of the sum and the means and...

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

The past decade has seen an explosion of research on roles of neuronastrocyte interactions in the control of brain function. We highlight recent studies performed on the tripartite synapse, the structure consisting of pre- and postsynaptic elements of...

A modified Artificial Bee Colony algorithm for real-parameter optimization

Swarm intelligence is a research field that models the collective intelligence in swarms of insects or animals. Many algorithms that simulates these models have been proposed in order to solve a wide range of problems. The Artificial Bee Colony algorithm...

A systematic review of the global prevalence of low back pain

Damian Hoy, Chris Bain, Gail M. Williams, Lyn March, Peter Brooks, Fiona M. Blyth, Anthony D. Woolf, Theo Vos, Rachelle Buchbinder

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi, Li-Ying Han, Kalindi Bakshi, Andres Stucky, Robert L. Fuino, Krista R. Kawaguchi, Andrew J. Samoyedny, Robert S. Wilson, Zoe Arvanitakis, Julie A. Schneider, Bryan A. Wolf, David A. Bennett, John Q. Trojanowski, Steven E. Arnold

A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology

Accurate quantification in PET and SPECT requires correction for a number of physical factors, such as photon attenuation, Compton scattering and random coincidences (in PET). Another factor affecting quantification is the limited spatial resolution....

Maintaining a Consistent Big Picture: Meaningful Use of a Web‐based POC EHR System

Gail M. Keenan, Elizabeth Yakel, Yingwei Yao, Dianhui Xu, Laura A. Szalacha, Dana Tschannen, Yvonne Ford, Yu-Chung Chen, Andrew Johnson, Karen Dunn Lopez, Diana J. Wilkie

Non‐Basic High‐Performance Molecules for Solution‐Processed Organic Solar Cells

Thomas S. van der Poll, John A. Love, Thuc-Quyen Nguyen, Guillermo C. Bazan

The other

In this issue of DATA BASE four Deans discuss the current state and the future of information systems within their Business Schools. They reflect on the malaise affecting academic information systems. This article examines the field in terms of its history,...

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

SUMMARY Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many proteins within these bodies contain KH or RRM RNA-binding domains as well as low complexity (LC) sequences of unknown function. We discovered that exposure of...

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Chao Lu, Patrick S. Ward, Gurpreet S. Kapoor, Daniel Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher R. Edwards, Raya Khanin, Maria E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O’Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff, Craig B. Thompson

A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health.

a b s t r a c t The intimate connection between the brain and the heart was enunciated by Claude Bernard over 150 years ago. In our neurovisceral integration model we have tried to build on this pioneering work. In the present paper we further elaborate...

Measurement and detection of radiation

This article reviews Measurement and Detection of Radiation. by Nicholas Tsoulfanidis, Sheldon Landsberger 3rd ed., , Taylor & Francis Group, Boca Raton, FL, 2011. Hardcover, 518 pp. Price: $129.95. ISBN: 978-1-42009-185-4.

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

The 1000 Genomes Project and disease-specific sequencing efforts are producing large collections of haplotypes that can be used as reference panels for genotype imputation in genome-wide association studies (GWAS). However, imputing from large reference...

Dynamic Generalized Linear Models and Bayesian Forecasting

Dynamic Bayesian models are developed for application in nonlinear, non-normal time series and regression problems, providing dynamic extensions of standard generalized linear models. A key feature of the analysis is the use of conjugate prior and posterior...

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

We report the results of whole-genome and transcriptome sequencing of tumor and adjacent normal tissue samples from 17 patients with non-small cell lung carcinoma (NSCLC). We identified 3,726 point mutations and more than 90 indels in the coding sequence,...

Theory and applications of hazard plotting for censored failure data

This paper presents theory and applications of a simple graphical method, called hazard plotting, for the analysis of multiply censored life data consisting of failure times of failed units intermixed with running times on unfailed units. Applications...

Health Effects of Toxin-Producing Cyanobacteria: “The CyanoHABs”

Increasingly, harmful algal blooms (HABs) are being reported worldwide due to several factors, primarily eutrophication, climate change and more scientific monitoring. All but cyanobacteria toxin poisonings (CTPs) are mainly a marine occurrence. CTPs...

The pandemic of physical inactivity: global action for public health

SummaryPhysical inactivity is the fourth leading cause of death worldwide. We summarise present global efforts to counteract this problem and point the way forward to address the pandemic of physical inactivity. Although evidence for the benefits of physical...

Nanoparticle Delivery of Cancer Drugs

Nanomedicine, the application of nanotechnology to medicine, enabled the development of nanoparticle therapeutic carriers. These drug carriers are passively targeted to tumors through the enhanced permeability and retention effect, so they are ideally...

Evaluation of Strength Reduction Factors for Earthquake‐Resistant Design

Strength reduction factors which permit estimation of inelastic strength demands from elastic strength demands are evaluated. Results from various investigations of strength reduction factors carried out over the last 30 years are reviewed, and their...

Burden of Gastrointestinal Disease in the United States: 2012 Update

Anne F. Peery, Evan S. Dellon, Jennifer L. Lund, Seth D. Crockett, Christopher E. McGowan, William J. Bulsiewicz, Lisa M. Gangarosa, Michelle Thiny, Karyn Stizenberg, Douglas R. Morgan, Yehuda Ringel, Hannah P. Kim, Marco daCosta DiBonaventura, Charlotte F. Carroll, Jeffery K. Allen, Suzanne F. Cook, Robert S. Sandler, Michael Kappelman, Nicholas J. Shaheen

Testing for Unit Roots in Seasonal Time Series

Regression estimators of coefficients in seasonal autoregressive models are described. The percentiles of the distributions for time series that have unit roots at the seasonal lag are computed by Monte Carlo integration for finite samples and by analytic...

Randomized Placebo-controlled Crossover Trial of Continuous Positive Airway Pressure for Mild Sleep Apnea/Hypopnea Syndrome

The minimal disease severity at which patients with the sleep apnea/hypopnea syndrome (SAHS) gain benefit from treatment is not well characterized, although a pilot study of continuous positive airway pressure (CPAP) therapy showed daytime improvements...

Mechanisms and Responses of a Dielectric Barrier Plasma Actuator: Geometric Effects

C. Lon Enloe, Thomas McLaughlin, Robert Van Dyken, Kimberlee Kachner, Eric J. Jumper, Thomas C. Corke, M. Post, O. Haddad

From cloud computing to cloud manufacturing

Cloud computing is changing the way industries and enterprises do their businesses in that dynamically scalable and virtualized resources are provided as a service over the Internet. This model creates a brand new opportunity for enterprises. In this...

Congenital Diaphragmatic Hernia

Rationale: Endothelin-1 (ET1) is dysregulated in pulmonary hypertension (PH). It may be important in the pathobiology of congenital diaphragmatic hernia (CDH). Objectives: We hypothesized that ET1 levels in the first month would be higher in infants with...

Reciprocal interactions of the intestinal microbiota and immune system

Craig L. Maynard, Charles O. Elson, Robin D. Hatton, Casey T. Weaver

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Andrew C. Kruse, Jianxin Hu, Albert C. Pan, Daniel H. Arlow, Daniel M. Rosenbaum, Erica Rosemond, Hillary F. Green, Tong Liu, Pil Seok Chae, Ron O. Dror, David E. Shaw, William I. Weis, Jürgen Wess, Brian K. Kobilka

Global Prevalence of Autism and Other Pervasive Developmental Disorders

We provide a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide. A secondary aim was to consider the possible impact of geographic, cultural/ethnic, and socioeconomic factors on prevalence...

A Common Pesticide Decreases Foraging Success and Survival in Honey Bees

Nonlethal exposure of honey bees to thiamethoxam (neonicotinoid systemic pesticide) causes high mortality due to homing failure at levels that could put a colony at risk of collapse. Simulated exposure events on free-ranging foragers labeled with an RFID...

Disclosure in the Corporate Annual Reports of Swedish Companies

Sweden is of interest because of the rapid growth in the Stockholm stock exchange and because of the country's disproportionate number of multinational enterprises. This paper reports on the extent of disclosure in the corporate annual reports of Swedish...

Computational and Inferential Difficulties with Mixture Posterior Distributions

This article deals with both exploration and interpretation problems related to posterior distributions for mixture models. The specification of mixture posterior distributions means that the presence of k! modes is known immediately. Standard Markov...

Percentage Points for a Generalized ESD Many-Outlier Procedure

A generalized (extreme Studentized deviate) ESD many-outlier procedure is given for detecting from 1 to k outliers in a data set. This procedure has an advantage over the original ESD many-outlier procedure (Rosner 1975) in that it controls the type I...

Chronic Kidney Disease after Acute Kidney Injury: A Systematic Review and Meta-analysis

Acute kidney injury may increase the risk for chronic kidney disease and end-stage renal disease. In an attempt to summarize the literature and provide more compelling evidence, we conducted a systematic review comparing the risk for CKD, ESRD, and death...

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

Background Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A...

Reality: The Search for Objectivity or the Quest for a Compelling Argument

It is said that we human beings are rational animals. On account of this, we devalue emotions and exalt rationality so much that, whenever we see some complex behaviour in a non-human animal, we want to ascribe rational thinking to it. In this process,...

An NGA Model for the Average Horizontal Component of Peak Ground Motion and Response Spectra

We present a model for estimating horizontal ground motion amplitudes caused by shallow crustal earthquakes occurring in active tectonic environments. The model provides predictive relationships for the orientation-independent average horizontal component...

Electric Vehicle Technology Explained

James Larminie, John Lowry

Using Sample Survey Weights in Multiple Regression Analyses of Stratified Samples

The rationale for the use of sample survey weights in a least squares regression analysis is examined with respect to four increasingly general specifications of the population regression model. The appropriateness of the weighted regression estimate...

Bacterial infection in chronic obstructive pulmonary disease. A study of stable and exacerbated outpatients using the protected specimen brush.

The lower airways of asymptomatic chronic obstructive pulmonary disease (COPD) patients can be colonized by bacteria, mainly Haemophilus influenza, Streptococcus pneumoniae, and Moraxella catarrhalis. However, the role of lower airway bacteria in stable...

Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Funding/Support: The Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines received support from the National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer...

Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome.

Rationale: Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may...

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Recent years have witnessed the rise of the gut microbiota as a major topic of research interest in biology. Studies are revealing how variations and changes in the composition of the gut microbiota influence normal physiology and contribute to diseases...

Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial

[GMR], 0.91; 95% CI, 0.86 to 0.97; P 0.005). Fewer participants receiving bevacizumab had an arteriothrombotic event or heart failure (odds ratio [OR], 0.23; 95% CI,...

Improved Outcome Based on Fluid Management in Critically III Patients Requiring Pulmonary Artery Catheterization

We performed a randomized, prospective trial to evaluate whether fluid management that emphasized diuresis and fluid restriction in patients with pulmonary edema could affect the development or resolution of extravascular lung water (EVLW), as well as...

Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial.

Summary Background D2 gastrectomy is recommended in US and European guidelines, and is preferred in east Asia, for patients with resectable gastric cancer. Adjuvant chemo therapy improves patient outcomes after surgery , but the benefi ts after a D2 resection...

Interventions for providers to promote a patient‐centred approach in clinical consultations

Patient AccessPatients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply.

High-efficiency dye-sensitized solar cell with a novel co-adsorbent

A new record efficiency (11.4%) of dye-sensitized solar cell was obtained by design and syntheses of donor–acceptor type co-adsorbents which effectively overcome the competitive light absorption by I−/I3−, avoid dye aggregation, and reduce the charge...

Severe Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease

Rationale: Severe pulmonary hypertension occurs occasionally in patients with chronic obstructive pulmonary disease (COPD), but no detailed description of these patients is available. Objectives: To identifyandcharacterizepatientswithCOPDandseverepulmonary...

Fabrication of biodegradable polymer scaffolds to engineer trabecular bone

We present a novel method for manufacturing three-dimensional, biodegradable poly(DLlactic-co-glycolic acid) (PLGA) foam scaffolds for use in bone regeneration. The technique involves the formation of a composite material consisting of gelatin microspheres...

Effect of organic matter application on methane emission from some Japanese paddy fields

Emission rates of CH4 from four Japanese paddy fields were measured throughout the cultivation period in 1988 by using the closed chamber method. Large seasonal variations of the CH4 flux were observed. The emission was closely related to the decrease...

Bright Coherent Ultrahigh Harmonics in the keV X-ray Regime from Mid-Infrared Femtosecond Lasers

When you play a string instrument, you raise the frequency, or pitch, of the note by shortening the vibrating portion of the string: Drop the length in half, and you hear a harmonic at double the frequency. It is possible to do essentially the same thing...

Airway Smooth Muscle Cell Proliferation Is Increased in Asthma

This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work...

Stochastic thermodynamics, fluctuation theorems and molecular machines

Stochastic thermodynamics as reviewed here systematically provides a framework for extending the notions of classical thermodynamics such as work, heat and entropy production to the level of individual trajectories of well-defined non-equilibrium ensembles....

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Sandra Misale, Rona Yaeger, Sebastijan Hobor, Elisa Scala, Manickam Janakiraman, David Liska, Emanuele Valtorta, Roberta Schiavo, Michela Buscarino, Giulia Siravegna, K. Bencardino, Andrea Cercek, Chin-Tung Chen, Silvio Veronese, Carlo Zanon, Andrea Sartore-Bianchi, Marcello Gambacorta, Margherita Gallicchio, Efsevia Vakiani, Valentina Boscaro, Enzo Medico, Martin R. Weiser, Salvatore Siena, Federica Di Nicolantonio, David B. Solit, Alberto Bardelli

3D Macroporous Graphene Frameworks for Supercapacitors with High Energy and Power Densities

Bong Gill Choi, MinHo Yang, Won Hi Hong, Jang Wook Choi, Yun Suk Huh

Size-Dependent Fracture of Silicon Nanoparticles During Lithiation

X H Liu, Li Zhong, Shan Huang, Scott X. Mao, Ting Zhu, Jianyu Huang

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

Chromosomes are the physical realization of genetic information and thus form the basis for its readout and propagation. Here we present a high-resolution chromosomal contact map derived from a modified genome-wide chromosome conformation capture approach...

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

Identifying genes that give rise to diseases is one of the major goals of sequencing human genomes. However, putative loss-of-function genes, which are often some of the first identified targets of genome and exome sequencing, have often turned out to...

Effects of Continuous Positive Airway Pressure on Early Signs of Atherosclerosis in Obstructive Sleep Apnea

Rationale: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes, including myocardial infarction and stroke. Atherosclerosis is a key mechanism for these cardiovascular events. Recent cross-sectional studies showed the presence...

Survival Curve for Cancer Patients Following Treatment

On the basis of experience with calculated survivorships of patients following treatment for cancer, a simple function, in terms of two physically meaningful parameters, has been evolved, which fits such survivorship data very well. These two parameters...

Increased 8-Isoprostane, a Marker of Oxidative Stress, in Exhaled Condensate of Asthma Patients

Oxidative stress has an important role in the pathogenesis of asthma. 8-Isoprostane is a prostaglandin (PG)-F2–like compound belonging to the F2 isoprostane class that is produced in vivo by the free radical-catalyzed peroxidation of arachidonic acid....

Flexible triboelectric generator

Charges induced in triboelectric process are usually referred as a negative effect either in scientific research or technological applications, and they are wasted energy in many cases. Here, we demonstrate a simple, low cost and effective approach of...

Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology

Background Approximately 15 to 30% of thyroid nodules evaluated by means of fine-needle aspiration are not clearly benign or malignant. Patients with cytologically indeterminate nodules are often referred for diagnostic surgery, though most of these nodules...

Epigenetic Regulation by Long Noncoding RNAs

The past 5 years have uncovered thousands of long (>100 nucleotides) noncoding RNAs (lncRNAs) outpacing our understanding of their functions and mechanisms in regulating the genome. Lee (p. [1435][1]) reviews the known and suspected means by which these...

Effects of Maternal Smoking during Pregnancy and Environmental Tobacco Smoke on Asthma and Wheezing in Children

The effects of maternal smoking during pregnancy and childhood environmental tobacco smoke (ETS) exposure on asthma and wheezing were investigated in 5,762 school-aged children residing in 12 Southern California communities. Responses to a selfadministered...

Conversion of Wastes into Bioelectricity and Chemicals by Using Microbial Electrochemical Technologies

Waste biomass is a cheap and relatively abundant source of electrons for microbes capable of producing electrical current outside the cell. Rapidly developing microbial electrochemical technologies, such as microbial fuel cells, are part of a diverse...

Near-infrared hyperspectral imaging for predicting colour, pH and tenderness of fresh beef

Hyperspectral imaging system operated in the near infrared (NIR) region (900–1700 nm) was developed for non-contact measurement of surface colour, pH and tenderness of fresh beef. Hyperspectral images were acquired for beef samples and their spectral...

Methods for Handling Missing Data

John W. Graham, Patricio Cumsille, Allison E. Shevock

The global diversity of birds in space and time

Current global patterns of biodiversity result from processes thatoperate over both space and time and thus require an integratedmacroecological and macroevolutionary perspective. Moleculartime trees have advanced our understanding of the tempo andmode...

Beyond the “Village” Rhetoric: Creating Healthy Communities for Children and Adolescents

The role ofcommuitity in childandado1e.scentder~elopnrent is emerging as a significant area of theoretical inquiry. research, and application. Thi.s article describes the developn~ent and utilizafior~ of a comprehensive community c hange effort desigrted...

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