CiteWeb

WorldWeb citation database

Publications in 2012

Page 7
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.

David M. Brown, Victor Chong, Korobelnik Jf, Peter K. Kaiser, Quan Dong Nguyen, Bernd Kirchhof, Allen C. Ho, Yuichiro Ogura, George D. Yancopoulos, Neil Stahl, Robert Vitti, Alyson J. Berliner, Yuhwen Soo, Majid Anderesi, Georg Groetzbach, Bernd Sommerauer, Rupert Sandbrink, Christian Simader, Ursula Schmidt-Erfurth

The Arctic’s rapidly shrinking sea ice cover: a research synthesis

The sequence of extreme September sea ice extent minima over the past decade suggests acceleration in the response of the Arctic sea ice cover to external forcing, hastening the ongoing transition towards a seasonally open Arctic Ocean. This reflects...

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified...

International Variation in Prostate Cancer Incidence and Mortality Rates

Wide variation exists internationally for prostate cancer (PCa) rates due to differences in detection practices, treatment, and lifestyle and genetic factors.

Methodological issues ‐ Reflections on quantification in corporate social reporting content analysis

A key assumption underlying many corporate social reporting content analysis studies is that volume of disclosure signifies the relative importance of disclosures. Most of these studies have only quantified disclosures in annual reports, and there is...

Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)

In order to describe the outcomes of patients hospitalized with an acute exacerbation of severe chronic obstructive pulmonary disease (COPD) and determine the relationship between patient characteristics and length of survival, we studied a prospective...

Early skin‐to‐skin contact for mothers and their healthy newborn infants

Elizabeth Moore, Gene Cranston Anderson, Therese Dowswell

The toxic A[beta] oligomer and Alzheimer's disease: an emperor in need of clothes

The 'toxic Aβ oligomer' hypothesis has attracted considerable attention among Alzheimer's disease researchers as a way of resolving the lack of correlation between deposited amyloid-β (Aβ) in amyloid plaques-in terms of both amount and location-and...

Bacterial Decolorization and Degradation of Azo Dyes

Azo compounds constitute the largest and the most diverse group of synthetic dyes and are widely used in a number of industries such as textile, food, cosmetics and paper printing. They are generally recalcitrant to biodegradation due to their xenobiotic...

Epigenetic protein families: a new frontier for drug discovery

Epigenetic regulation of gene expression is a dynamic and reversible process that establishes normal cellular phenotypes but also contributes to human diseases. At the molecular level, epigenetic regulation involves hierarchical covalent modification...

Architecture of the human regulatory network derived from ENCODE data

Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes; the ensemble of these binding events forms a regulatory network, constituting the wiring diagram for a cell. To examine the principles of the human transcriptional...

Using Multivariate Matched Sampling and Regression Adjustment to Control Bias in Observational Studies

Monte Carlo methods are used to study the efficacy of multivariate matched sampling and regression adjustment for controlling bias due to specific matching variables X when dependent variables are moderately nonlinear in X. The general conclusion is that...

Higgs mass and vacuum stability in the Standard Model at NNLO

We present the rst complete next-to-next-to-leading order analysis of the Standard Model Higgs potential. We computed the two-loop QCD and Yukawa corrections to the relation between the Higgs quartic coupling ( ) and the Higgs mass (Mh), reducing the...

A systematic literature review of empirical evidence on computer games and serious games

This paper examines the literature on computer games and serious games in regard to the potential positive impacts of gaming on users aged 14 years or above, especially with respect to learning, skill enhancement and engagement. Search terms identified...

Penalized Regressions: The Bridge versus the Lasso

Bridge regression, a special family of penalized regressions of a penalty function Σ|βj|γ with γ ≤ 1, considered. A general approach to solve for the bridge estimator is developed. A new algorithm for the lasso (γ = 1) is obtained by studying the...

Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations

Rationale: Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial.Objectives: We investigated whether...

Spin-Torque Switching with the Giant Spin Hall Effect of Tantalum

One of the primary challenges in the field of spin-electronics, which exploits the electron's spin rather than its charge, is to create strong currents of electrons with polarized spins. One way to do this is to use a ferromagnet as a polarizer, a principle...

Systemic Banking Crises Database; An Update

We update the widely used banking crises database by Laeven and Valencia (2008, 2010) with new information on recent and ongoing crises, including updated information on policy responses and outcomes (i.e. fiscal costs, output losses, and increases in...

Reactive Oxygen Species, Oxidative Damage, and Antioxidative Defense Mechanism in Plants under Stressful Conditions

Reactive oxygen species (ROS) are produced as a normal product of plant cellular metabolism. Various environmental stresses lead to excessive production of ROS causing progressive oxidative damage and ultimately cell death. Despite their destructive activity,...

Diagnosis of Ventilator-associated Pneumonia by Bacteriologic Analysis of Bronchoscopic and Nonbronchoscopic “Blind” Bronchoalveolar Lavage Fluid

Substantial efforts have been devoted to improving the means for early and accurate diagnosis of ventilator-associated (VA) pneumonia in intensive care unit (ICU) patients because of its high incidence and mortality. A good diagnostic yield has been reported...

SINA: Accurate high-throughput multiple sequence alignment of ribosomal RNA genes

Motivation: In the analysis of homologous sequences, computation of multiple sequence alignments (MSAs) has become a bottleneck. This is especially troublesome for marker genes like the ribosomal RNA (rRNA) where already millions of sequences are publicly...

Self Modeling Curve Resolution

This paper presents a method for determining the shapes of two overlapping functionsfi(x) andf2(x) from an observed set of additive mixtures, {aifi(x) + lif2(x); i = 1, ... , n}, of the two functions. This type of problem arises in the fields of spectrophotometry,...

Risk of Post-traumatic Stress Symptoms in Family Members of Intensive Care Unit Patients

Rationale: Intensive care unit (ICU) admission of a relative is a stressful event that may cause symptoms of post-traumatic stress disorder (PTSD). Objectives: Factors associated with these symptoms need to be identified. Methods: For patients admitted...

Censored Data and the Bootstrap

This article concerns setting standard errors and confidence intervals for the parameters of an unknown distribution when the data is subject to right censoring. The bootstrap, which is an elaboration of the jackknife, provides a general method for answering...

The epidemiology of interstitial lung diseases.

Little epidemiologic data are available on the occurrence of interstitial lung diseases (ILDs) in the general population. To describe the prevalence and incidence of ILDs a population-based registry of patients with ILDs was established in Bernalillo...

Simplified calculation of eigenvector derivatives

A simplified procedure is presented for the determination of the derivatives of eigenvectors of nth order algebraic eigensystems. The method is applicable to symmetric or nonsymmetric systems, and requires knowledge of only one eigenvalue and its associated...

Real-time compressive tracking

It is a challenging task to develop effective and efficient appearance models for robust object tracking due to factors such as pose variation, illumination change, occlusion, and motion blur. Existing online tracking algorithms often update models with...

Advanced Asymmetric Supercapacitors Based on Ni(OH)2/Graphene and Porous Graphene Electrodes with High Energy Density

Jun Yan, Zhuangjun Fan, Wei Sun, Guoqing Ning, Tong Wei, Qiang Zhang, Rufan Zhang, Linjie Zhi, Fei Wei

Signal Transduction by Vascular Endothelial Growth Factor Receptors

Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this familyof...

Digital Image Restoration

The field of digital image restoration is concerned with the reconstruction or estimation of uncorrupted images from noisy, blurred ones. This blurring may be caused by optical distortions, object motion during imaging, or atmospheric turbulence. There...

American Society of Clinical Oncology Provisional Clinical Opinion: The Integration of Palliative Care Into Standard Oncology Care

Purpose American Society of Clinical Oncology (ASCO) provisional clinical opinion (PCO) offers timely clinical direction to ASCO’s membership following publication or presentation of potentially practice-changing data from major studies. This PCO addresses...

Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions

Exposure to even very low levels of lead, cadmium, and mercury ions is known to cause neurological, reproductive, cardiovascular, and developmental disorders, which are more serious problems for children particularly. Accordingly, great efforts have been...

Dissociation between Airway Inflammation and Airway Hyperresponsiveness in Allergic Asthma

In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do...

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

ALK fusion genes occur in a subset of non-small-cell lung cancers (NSCLCs). We assessed the tolerability and activity of crizotinib in patients with NSCLC who were prospectively identified to have an ALK fusion within the first-in-man phase 1 crizotinib...

Annotation of functional variation in personal genomes using RegulomeDB

Alan P. Boyle, Eurie L. Hong, Manoj Hariharan, Yong Cheng, Marc A. Schaub, Maya Kasowski, Konrad J Karczewski, Julie Park, Benjamin C. Hitz, Shuai Weng, J. Michael Cherry, Michael Snyder

The Generalized Dynamic Factor Model

This article proposes a new forecasting method that makes use of information from a large panel of time series. Like earlier methods, our method is based on a dynamic factor model. We argue that our method improves on a standard principal component predictor...

Graphene/metal oxide composite electrode materials for energy storage

Recent progress on graphene/metal oxide composites as advanced electrode materials in lithium ion batteries (LIBs) and electrochemical capacitors (ECs) is described, highlighting the importance of synergistic effects between graphene and metal oxides...

Analysis of the bread wheat genome using whole-genome shotgun sequencing.

Bread wheat (Triticum aestivum) is a globally important crop, accounting for 20 per cent of the calories consumed by humans. Major efforts are underway worldwide to increase wheat production by extending genetic diversity and analysing key traits, and...

Logistic Regression, Survival Analysis, and the Kaplan-Meier Curve

We discuss the use of standard logistic regression techniques to estimate hazard rates and survival curves from censored data. These techniques allow the statistician to use parametric regression modeling on censored data in a flexible way that provides...

Clinical Control and Histopathologic Outcome of Asthma when Using Airway Hyperresponsiveness as an Additional Guide to Long-Term Treatment

According to international guidelines, the level and adjustment of antiinflammatory treatment for asthma are based solely on symptoms and lung function. We investigated whether a treatment strategy aimed at reducing airway hyperresponsiveness (AHR strategy)...

Dark energy cosmology: the equivalent description via different theoretical models and cosmography tests

Kazuharu Bamba, Salvatore Capozziello, Shin'ichi Nojiri, Sergei D. Odintsov

High-efficiency inverted dithienogermole|[ndash]|thienopyrrolodione-based polymer solar cells

Cephas E. Small, Jegadesan Subbiah, Chad M. Amb, Tzung-Han Lai, John R. Reynolds, Franky So

The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

Neuronal activity in the brain gives rise to transmembrane currents that can be measured in the extracellular medium. Although the major contributor of the extracellular signal is the synaptic transmembrane current, other sources — including Na+ and...

Multi-column deep neural networks for image classification

Traditional methods of computer vision and machine learning cannot match human performance on tasks such as the recognition of handwritten digits or traffic signs. Our biologically plausible, wide and deep artificial neural network architectures can....

Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

Purpose There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling, has...

OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Supported by Genentech.Processed as a Rapid Communication manuscript. Listen to the podcast by Dr Konstantinopoulos at www.jco.org/podcastsPresented in part at the 47th Annual Meeting of the American Society of Clinical Oncology, June 3-7, 2011, Chicago,...

SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler

There is a rapidly increasing amount of de novo genome assembly using next-generation sequencing (NGS) short reads; however, several big challenges remain to be overcome in order for this to be efficient and accurate. SOAPdenovo has been successfully...

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010

Theo Vos, Abraham D. Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, Majid Ezzati, Kenji Shibuya, Joshua A. Salomon, Safa Abdalla, Victor Aboyans, Jerry Abraham, Ilana N Ackerman, Rakesh Aggarwal, Stephanie Y Ahn, Mohammed K. Ali, Miriam Alvarado, H. Ross Anderson, Laurie Anderson, Kathryn Andrews, Charles Atkinson, Larry M. Baddour, Adil N Bahalim, Suzanne Barker-Collo, Lope H. Barrero, David H Bartels, Amanda Baxter, Michelle L. Bell, Emelia J. Benjamin, Eduardo Bernabé, Kavi Bhalla, Bishal Bhandari, Boris Bikbov, Aref Bin Abdulhak, Gretchen L. Birbeck, James Black, Hannah Blencowe, Jed D Blore, Ian Bolliger, Audrey Bonaventure, Soufiane Boufous, Rupert Bourne, Michel Boussinesq, Tasanee Braithwaite, Carol Brayne, Lisa Bridgett, Simon Brooker, Peter Brooks, Traolach S. Brugha, Claire Bryan-Hancock, Chiara Bucello

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers

Representative histologic appearances of ROS1-rearranged tumors, stained with hematoxylin and eosin, with (A and B) two tumors harboring adenocarcinoma with highly atypical cytologic features including malignant giant cells (A is a high-magnification...

The brain basis of emotion: A meta-analytic review

Researchers have wondered how the brain creates emotions since the early days of psychological science. With a surge of studies in affective neuroscience in recent decades, scientists are poised to answer this question. In this target article, we present...

The biology of heterostyly

Heterostyly is a genetically controlled floral polymorphism that is known to occur in 24 families of flowering plants. The floral morphs differ reciprocally in stamen and style lengths. They often differ in pollen grain size and production, and may differ...

Applied Physiology of Soccer

Applied Physiology of Soccer

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension.

Rationale: Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently...

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here,...

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.

The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S had only been known for its toxicity and environmental hazard. Physiological...

Acoustic Modeling Using Deep Belief Networks

Gaussian mixture models are currently the dominant technique for modeling the emission distribution of hidden Markov models for speech recognition. We show that better phone recognition on the TIMIT dataset can be achieved by replacing Gaussian mixture...

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

SummaryNeurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic and association cortices as Alzheimer's disease evolves. However, the mechanism involved in this hierarchical pattern of disease progression is unknown....

Testing Density Forecasts, with Applications to Risk Management

The forecast evaluation literature has traditionally focused on methods of assessing point forecasts. However, in the context of many models of financial risk, interest centers on more than just a single point of the forecast distribution. For example,...

MESSENGER and Mariner 10 Flyby Observations of Magnetotail Structure and Dynamics at Mercury

increasing antisunward distance ∣X∣, B � ∣X∣ G , with G varying from � 5.4 for northward to � 1.6 for southward IMF. Low-latitude boundary layers (LLBLs) containing strong northward magnetic field were detected at the tail flanks during...

Mechanisms of Gamma Oscillations

Gamma rhythms are commonly observed in many brain regions during both waking and sleep states, yet their functions and mechanisms remain a matter of debate. Here we review the cellular and synaptic mechanisms underlying gamma oscillations and outline...

FLASH assembly of TALENs for high-throughput genome editing

Deepak Reyon, Shengdar Q Tsai, Cyd Khayter, Jennifer A Foden, Jeffry D. Sander, J. Keith Joung

The development and evaluation of the Earth Gravitational Model 2008 (EGM2008)

Nikolaos K. Pavlis, Simon Holmes, Steve Kenyon, John Factor

The Fitting of Power Series, Meaning Polynomials, Illustrated on Band-Spectroscopic Data

The prototype of fitting polynomials to equally-spaced data—in which the equalspacing is theoretically precise and the data is accurate to many decimal places—arises in the analysis of band spectra. A hard look at such examples forces us to reexamine...

A Monte Carlo Approach to Nonnormal and Nonlinear State-Space Modeling

A solution to multivariate state-space modeling, forecasting, and smoothing is discussed. We allow for the possibilities of nonnormal errors and nonlinear functionals in the state equation, the observational equation, or both. An adaptive Monte Carlo...

The Analysis of Categorical Data from Complex Sample Surveys: Chi-Squared Tests for Goodness of Fit and Independence in Two-Way Tables

The effect of stratification and clustering on the asymptotic distributions of standard Pearson chi-squared test statistics for goodness of fit (simple hypothesis) and independence in a two-way contingency table, denoted as X 2 and XI 2, respectively,...

Relationship marketing: strategic and tactical implications

Discusses the logic of the re‐emerging relationship approach to marketing and presents key strategic as well as tactical implications for a firm attempting to apply a relationship marketing strategy. Notes that major changes in the business philosophy...

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Cécile Guichard, Giuliana Amaddeo, Sandrine Imbeaud, Yannick Ladeiro, Laura Pelletier, Ichrafe Ben Maad, Julien Calderaro, Paulette Bioulac-Sage, Mélanie Letexier, F. Degos, B. Clement, Charles Balabaud, Eric Chevet, Alexis Laurent, Gabrielle Couchy, Eric Letouzé, Fabien Calvo, Jessica Zucman-Rossi

The Effect of Multiple Small Doses of X Rays on Skin Reactions in the Mouse and a Basic Interpretation

Multiple-fraction experiments have been carried out to determine the response to repeated small doses of 240 kV X rays down to 45 rad per fraction, using the mouse skin reaction system. A method of irradiating without anesthetic was developed so that...

Distributed GraphLab: a framework for machine learning and data mining in the cloud

While high-level data parallel frameworks, like MapReduce, simplify the design and implementation of large-scale data processing systems, they do not naturally or efficiently support many important data mining and machine learning algorithms and can lead...

The public disclosure of environmental performance information—a dual test of media agenda setting theory and legitimacy theory

This paper documents the results of an empirical study undertaken within Australia of the relationship between the print media coverage given to various industries' environmental effects, and the levels of annual report environmental disclosures made...

Terabit free-space data transmission employing orbital angular momentum multiplexing

Jian Wang, Jeng-Yuan Yang, Irfan Fazal, Nisar Ahmed, Yan Yan, Hao Huang, Yongxiong Ren, Yang Yue, Samuel Dolinar, Alan E. Willner

The Elasticity of Taxable Income with Respect to Marginal Tax Rates: A Critical Review

This paper critically surveys the large and growing literature estimating the elasticity of taxable income with respect to marginal tax rates using tax return data. First, we provide a theoretical framework showing under what assumptions this elasticity...

Ordered Hypotheses for Multiple Treatments: A Significance Test for Linear Ranks

In many experiments the background evidence, theories, or conditions suggest an expected ordering among the treatment effects, yet in the analysis of variance such implicit hypotheses are typically neglected. A ranking statistic L is presented as test...

ZINC: a free tool to discover chemistry for biology.

ZINC is a free public resource for ligand discovery. The database contains over twenty million commercially available molecules in biologically relevant representations that may be downloaded in popular ready-to-dock formats and subsets. The Web site...

Photoisomerization in different classes of azobenzene

Azobenzene undergoes trans → cisisomerization when irradiated with light tuned to an appropriate wavelength. The reverse cis →transisomerization can be driven by light or occurs thermally in the dark. Azobenzene's photochromatic properties make it...

Conditions under Which Mean Square Ratios in Repeated Measurements Designs Have Exact F-Distributions

Investigation is made of the character of the covariance matrix which will result in exact F-distributions for the treatments and interaction variance ratios in repeated measurements designs. It is shown, assuming multivariate normality, that the matrix...

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

SummaryElevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The effect of high levels of c-Myc on global gene regulation is poorly understood but is...

The Decomposition of Time-Varying Hazard into Phases, Each Incorporating a Separate Stream of Concomitant Information

The hazard function of time-related events, such as death or reoperation following heart valve replacement, often is time-varying in a structured fashion, as is the influence of risk factors associated with the events. A completely parametric system is...

Endothelial Function in Obstructive Sleep Apnea and Response to Treatment

Impaired endothelium-dependent vascular relaxation is a prognostic marker of atherosclerosis and cardiovascular disease. We evaluated endothelium-dependent flow-mediated dilation (FMD) and endothelium-independent nitroglycerin (NTG)–induced dilation...

The renaissance of dye-sensitized solar cells

Dye-sensitized solar cells (DSCs) are attractive because they are made from cheap materials that do not need to be highly purified and can be printed at low cost 1 . DSCs are unique compared with almost all other kinds of solar cells in that electron...

Progress Toward In Vivo Use of siRNAs-II

RNA interference (RNAi) has been extensively employed for in vivo research since its use was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it is now routinely possible to obtain reagents that suppress expression of...

Bayesian Estimation and Prediction Using Asymmetric Loss Functions

Estimators and predictors that are optimal relative to Varian's asymmetric LINEX loss function are derived for a number of well-known models. Their risk functions and Bayes risks are derived and compared with those of usual estimators and predictors....

Effect of Three Decades of Screening Mammography on Breast-Cancer Incidence

Background To reduce mortality, screening must detect life-threatening disease at an earlier, more curable stage. Effective cancer-screening programs therefore both increase the incidence of cancer detected at an early stage and decrease the incidence...

Consensus statement on the pathology of IgG4-related disease

Vikram Deshpande, Yoh Zen, John K. C. Chan, Eunhee E Yi, Yasuharu Sato, Tadashi Yoshino, Günter Klöppel, J. Godfrey Heathcote, Arezou Khosroshahi, Judith A. Ferry, Rob C. Aalberse, Donald B. Bloch, William R. Brugge, Adrian C Bateman, Mollie N. Carruthers, Suresh T. Chari, Wah Cheuk, Lynn D. Cornell, Carlos Fernández-del Castillo, David G. Forcione, Daniel L. Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Gregory Y. Lauwers, Yasufumi Masaki, Yasuni Nakanuma, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant V. Sahani, Thomas C. Smyrk, James R. Stone, Masayuki Takahira, George Webster, Motohisa Yamamoto, Giuseppe Zamboni, Hisanori Umehara, John H. Stone

The Epidemiology of Severe Sepsis in Children in the United States

Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United...

Biomolecular coronas provide the biological identity of nanosized materials

Marco P. Monopoli, Christoffer Åberg, Anna Salvati, Kenneth A. Dawson

The Nature and Organization of Individual Differences in Executive Functions Four General Conclusions

Executive functions (EFs)—a set of general-purpose control processes that regulate one’s thoughts and behaviors—have become a popular research topic lately and have been studied in many subdisciplines of psychological science. This article summarizes...

Modeling Multiple Time Series with Applications

An approach to the modeling and analysis of multiple time series is proposed. Properties of a class of vector autoregressive moving average models are discussed. Modeling procedures consisting of tentative specification, estimation, and diagnostic checking...

Randomized Study of Adding Inhaled Iloprost to Existing Bosentan in Pulmonary Arterial Hypertension

Rationale: Small, open-label studies suggest that combinations of existing therapiesmay be effective for pulmonaryarterial hypertension (PAH). Objective: To evaluate the safety and efficacy of adding inhaled iloprost, a prostacyclin analog, to the endothelin...

A distinct lineage of influenza A virus from bats

Suxiang Tong, Yan Li, Pierre Rivailler, Christina Conrardy, Danilo A. Alvarez Castillo, Li-Mei Chen, Sergio Recuenco, James A. Ellison, Charles T. Davis, Ian A. York, Amy S. Turmelle, David Moran, Shannon Rogers, Mang Shi, Ying Tao, Michael Ryan Weil, Kevin Tang, Lori A. Rowe, Scott Sammons, Xiyan Xu, Michael Frace, Kim A. Lindblade, Nancy J. Cox, Larry J. Anderson, Charles E. Rupprecht, Ruben O. Donis

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

Nanomaterials hold promise as multifunctional diagnostic and therapeutic agents. However, the effective application of nanomaterials is hampered by limited understanding and control over their interactions with complex biological systems. When a nanomaterial...

De Novo Gene Disruptions in Children on the Autistic Spectrum

Exome sequencing of 343 families, each with a single child on the autism spectrum and at least one unaffected sibling, reveal de novo small indels and point substitutions, which come mostly from the paternal line in an age-dependent manner. We do not...

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling molecules, and at high levels, they damage organelles, particularly the mitochondria. Oxidative damage...

MicroRNA profiling: approaches and considerations

MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of thousands of genes in a broad range of organisms in both normal physiological contexts and in disease contexts. miRNA expression profiling is gaining popularity because...

Determining the Order of Differencing in Autoregressive Processes

One way of handling nonstationarity in time series is to compute first differences and fit a model to the differenced series unless the differenced series also looks nonstationary. In that case, second- or higher-order differencing is done. To decide...

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute...

Cellular and molecular mechanisms of metformin: an overview

Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now recommended as the first-line oral therapy for T2D (Type 2 diabetes). The main...

Controlled Trial of Continuous Positive Airway Pressure in Obstructive Sleep Apnea and Heart Failure

Obstructive sleep apnea (OSA) is highly prevalent among patients with congestive heart failure (CHF) and may contribute to progression of cardiac dysfunction via hypoxia, elevated sympathetic nervous system activity, and systemic hypertension. Our aim...

International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values

Atsunori Kashiwagi, Masato Kasuga, Eiichi Araki, Yoshitomo Oka, Toshiaki Hanafusa, Hiroshi Ito, Makoto Tominaga, Shinichi Oikawa, Mitsuhiko Noda, Takahiko Kawamura, Tokio Sanke, Mitsuyoshi Namba, Mitsuru Hashiramoto, Takayuki Sasahara, Yoshihiko Nishio, Katsuhiko Kuwa, Kohjiro Ueki, Izumi Takei, Masao Umemoto, Masami Murakami, Minoru Yamakado, Yutaka Yatomi, Hatsumi Ohashi

Ordinal Measures of Association

Ordinally invariant, i.e., rank, measures of association for bivariate populations are discussed, with emphasis on the probabilistic and operational interpretations of their population values. The three measures considered at length are the quadrant measure,...

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