CiteWeb

WorldWeb citation database

Publications in 2012

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Characteristics of Physical Activities in Daily Life in Chronic Obstructive Pulmonary Disease

Quantification of physical activities in daily life in patients with chronic obstructive pulmonary disease has increasing clinical interest.However,detailedcomparisonwithhealthysubjectsisnotavailable.Furthermore,itisunknownwhethertimespentactivelyduring...

The Efficiency of Cox's Likelihood Function for Censored Data

D.R. Cox has suggested a simple method for the regression analysis of censored data. We carry out an information calculation which shows that Cox's method has full asymptotic efficiency under conditions which are likely to be satisfied in many realistic...

A Method for Obtaining and Analyzing Sensitivity Data

The standard method of dealing with sensitivity of dosage-mortality data is the probit technique developed by Bliss and Fisher. This paper provides an alternative technique based on a special system for obtaining such data. It has some advantages when...

Smart Grid — The New and Improved Power Grid: A Survey

The Smart Grid, regarded as the next generation power grid, uses two-way flows of electricity and information to create a widely distributed automated energy delivery network. In this article, we survey the literature till 2011 on the enabling technologies...

Sleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men

Sleep-disordered breathing is a prevalent condition associated with impairment of daytime function and may predispose individuals to metabolic abnormalities independent of obesity. The primary objective of this study was to determine the metabolic consequences...

Problems in the Analysis of Survey Data, and a Proposal

Most of the problems of analyzing survey data have been reasonably well handled, except those revolving around the existence of interaction effects. Indeed, increased efficiency in handling multivariate analyses even with non-numerical variables, has...

Development of ozone reactivity scales for volatile organic compounds

This paper discusses methods for ranking photochemical ozone formation reactivities of volatile organic compounds (VOCs). Photochemical mechanisms for the atmospheric reactions of 118 VOCs were used to calculate their effects on ozone formation under...

Combined results of searches for the standard model Higgs boson in pp collisions at sqrt(s) = 7 TeV

This article is published Open Access, is distributed under the terms of the Creative Commons Attribution License 3.0.-- et al.

RETHINKING THE EFFECT OF IMMIGRATION ON WAGES

This paper asks the following important question: what was the effect of surging immigration on average and individual wages of U.S.-born workers during the period 1990-2004? Building on section VI I of Borjas (2003) we emphasize the need for a general...

A Study of the Environmental Disclosure Practices of Australian Corporations

This paper analyses the environmental disclosure practices of Australian corporate entities. The paper documents three separate but related investigations. First, in a review of a sample of annual reports for the 1991 financial year, it is apparent that...

Cross-Validation of Regression Models

A methodolgy for assessment of the predictive ability of regression models is presented. Attention is given to models obtained via subset selection procedures, which are extremely difficult to evaluate by standard techniques. Cross-validatory assessments...

The artificial leaf.

To convert the energy of sunlight into chemical energy, the leaf splits water via the photosynthetic process to produce molecular oxygen and hydrogen, which is in a form of separated protons and electrons. The primary steps of natural photosynthesis involve...

Rational Design of High Performance Conjugated Polymers for Organic Solar Cells

The research on the polymer-based solar cells (PSCs) has attracted an increasing amount of attention in recent years because PSCs pose potential advantages over mainstream inorganic-based solar cells, such as significantly reduced material/fabrication...

A physical, genetic and functional sequence assembly of the barley genome

Klaus F.X. Mayer, Robbie Waugh, Peter Langridge, Timothy J. Close, Roger P. Wise, Andreas Graner, Takashi Matsumoto, Kazuhiro Sato, Alan H. Schulman, Ruvini Ariyadasa, Daniela Schulte, Naser Poursarebani, Ruonan Zhou, Burkhard Steuernagel, Martin Mascher, Uwe Scholz, Bu-Jun Shi, Kavitha Madishetty, Jan T. Svensson, Prasanna R. Bhat, Matthew J. Moscou, Josh Resnik, Gary J. Muehlbauer, Peter E. Hedley, Hui Liu, Jenny Morris, Zeev Frenkel, Avraham Korol, Hélène Bergès, Stefan Taudien, Marius Felder, Marco Groth, Matthias Platzer, Axel Himmelbach, Stefano Lonardi, Denisa Duma, Matthew Alpert, Francesa Cordero, Marco Beccuti, Gianfranco Ciardo, Yaqin Ma, Steve Wanamaker, Federica Cattonaro, Vera Vendramin, Simone Scalabrin, Slobodanka Radovic, Rod A. Wing, Michele Morgante, Thomas Nussbaumer, Heidrun Gundlach

Estimation of Limited Dependent Variable Models With Dummy Endogenous Regressors

Applied economists have long struggled with the question of how to accommodate binary endogenous regressors in models with binary and nonnegative outcomes. I argue here that much of the difculty with limited dependent variables comes from a focus on structural...

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation

PMID: 22687263 [PubMed - indexed for MEDLINE] Free full text Funding for this study was provided by the Health Technology Assessment Programme of the National Institute for Health Research.

The IntAct molecular interaction database in 2012

IntAct is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. Two levels of curation are now available within the database, with both IMEx-level annotation and...

Inflammasomes in health and disease

Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which...

Expert Systems and Probabilistic Network Models

Artificial intelligence and expert systems have seen a great deal of research in recent years, much of which has been devoted to methods for incorporating uncertainty into models. This book is devoted to providing a thorough and up-to-date survey of this...

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

Many genome-wide association studies (GWAS) have identified loci and variants associated with disease, but the ability to predict disease on the basis of these genetic variants remains small. Maurano et al. (p. [1190][1]; see the Perspective by [Schadt...

Ventilator-associated pneumonia caused by potentially drug-resistant bacteria

To determine risk factors for ventilator-associated pneumonia (VAP) caused by potentially drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and/or Stenotrophomonas maltophilia,...

ESUR prostate MR guidelines 2012

The aim was to develop clinical guidelines for multi-parametric MRI of the prostate by a group of prostate MRI experts from the European Society of Urogenital Radiology (ESUR), based on literature evidence and consensus expert opinion. True evidence-based...

E‐service quality: a model of virtual service quality dimensions

Service quality is increasingly recognised as an important aspect of electronic commerce (e‐commerce). Because the online comparison of the technical features of products is essentially costless, feasible, and easier than comparisons of products through...

The Influence of Head Motion on Intrinsic Functional Connectivity MRI

Functional connectivity MRI (fcMRI) has been widely applied to explore group and individual differences. A confounding factor is head motion. Children move more than adults, older adults more than younger adults, and patients more than controls. Head...

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Sohrab P. Shah, Andrew Roth, Rodrigo Goya, Arusha Oloumi, Gavin Ha, Yongjun Zhao, Gulisa Turashvili, Jiarui Ding, Kane Tse, Gholamreza Haffari, Ali Bashashati, Leah M Prentice, Jaswinder Khattra, Angela Burleigh, Damian Yap, Virginie Bernard, Andrew McPherson, Karey Shumansky, Anamaria Crisan, Ryan Giuliany, Alireza Heravi Moussavi, Jamie Rosner, Daniel Lai, Inanc Birol, Richard Varhol, Angela Tam, Noreen Dhalla, Thomas Zeng, Kevin Ma, Simon K. Chan, Malachi Griffith, Annie Moradian, S.-W. Grace Cheng, Gregg B. Morin, Peter H. Watson, Karen Gelmon, Stephen Chia, Suet-Feung Chin, Christina Curtis, Oscar M. Rueda, Paul D.P. Pharoah, Sambasivarao Damaraju, John R. Mackey, Kelly Hoon, Timothy Harkins, Vasisht R. Tadigotla, Mahvash Sigaroudinia, Philippe Gascard, Thea D. Tlsty, Joseph F. Costello

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted

Guy De Backer, Ian Graham, Željko Reiner, W. M. Monique Verschuren, Christian Albus, Pascale Benlian, Gudrun Boysen, Renata Cifkova, Christi Deaton, Shah Ebrahim, Miles Fisher, Giuseppe Germano, Richard Hobbs, Arno W. Hoes, Sehnaz Karadeniz, Eva Prescott, Lars Rydén, Martin Scherer, Mikko Syvänne, Wilma Scholte op Reimer, Christiaan J. Vrints, David Wood, José Zamorano, Faiez Zannad

The Concept of Equality of Educational Opportunity

Although there is wide agreement in the United States that our society accepts and supports the fundamental value of equal opportunity, when it comes to areas of specific application there is considerable disagreement over its meaning. In this article,...

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis

Methods We considered infectious agents classifi ed as carcinogenic to humans by the International Agency for Research on C ancer. We calculated their population attributable fraction worldwide and in eight geographical regions, using statistics on estimated...

Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial

Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel...

Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome.

The impact of a new therapy that includes pressure-controlled inverse ratio ventilation followed by extracorporeal CO2 removal on the survival of patients with severe ARDS was evaluated in a randomized controlled clinical trial. Computerized protocols...

Student Social Class and Teacher Expectations: The Self-Fulfilling Prophecy in Ghetto Education

Many studies have shown that academic achievement is highly correlated with social class. Few, however, have attempted to explain exactly how the school helps to reinforce the class structure of the society. In this article Dr. Rist reports the results...

Validation of Regression Models: Methods and Examples

Methods to determine the validity of regression models include comparison of model predictions and coefficients with theory, collection of new data to check model predictions. comparison of results with theoretical model calculations, and data splitting...

Global nutrition transition and the pandemic of obesity in developing countries

Decades ago, discussion of an impending global pandemic of obesity was thought of as heresy. But in the 1970s, diets began to shift towards increased reliance upon processed foods, increased away-from-home food intake, and increased use of edible oils...

Numerical Computation of Multivariate Normal Probabilities

The numerical computation of a multivariate normal probability is often a difficult problem. This article describes a transformation that simplifies the problem and places it into a form that allows efficient calculation using standard numerical multiple...

Testing and Modeling Threshold Autoregressive Processes

The threshold autoregressive model is one of the nonlinear time series models available in the literature. It was first proposed by Tong (1978) and discussed in detail by Tong and Lim (1980) and Tong (1983). The major features of this class of models...

A Regression Method for Real Estate Price Index Construction

Quality differences make estimation of price indexes for real properties difficult, but these can be largely avoided by basing an index on sales prices of the same property at different times. The problem of combining price relatives of repeat sales of...

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe, Heidi M. Ott, Gopinath Ganji, Susan Korenchuk, Christine Thompson, Glenn S. Van Aller, Yan Liu, Alan P. Graves, Anthony Della Pietra, Elsie Diaz, Louis V. LaFrance, Mark Mellinger, Celine Duquenne, Xinrong Tian, Ryan G. Kruger, Charles F. McHugh, Martin Brandt, William H. Miller, Dashyant Dhanak, Sharad K. Verma, Peter J. Tummino, Caretha L. Creasy

Dissecting Android Malware: Characterization and Evolution

The popularity and adoption of smart phones has greatly stimulated the spread of mobile malware, especially on the popular platforms such as Android. In light of their rapid growth, there is a pressing need to develop effective solutions. However, our...

The Case Against Statistical Significance Testing

In recent years the use of traditional statistical methods in educational research has increasingly come under attack. In this article, Ronald P. Carver exposes the fantasies often entertained by researchers about the meaning of statistical significance....

Biocomposites reinforced with natural fibers: 2000-2010

a b s t r a c t Due to environment and sustainability issues, this century has witnessed remarkable achievements in green technology in the field of materials science through the devel- opment of biocomposites. The development of high-performance materials...

Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease

The preferred initial treatment for patients with stable coronary artery disease is the best available medical therapy. We hypothesized that in patients with functionally significant stenoses, as determined by measurement of fractional flow reserve (FFR),...

The Intrinsic Bayes Factor for Model Selection and Prediction

In the Bayesian approach to model selection or hypothesis testing with models or hypotheses of differing dimensions, it is typically not possible to utilize standard noninformative (or default) prior distributions. This has led Bayesians to use conventional...

Internet of things: Vision, applications and research challenges

The term “Internet-of-Things” is used as an umbrella keyword for covering various aspects related to the extension of the Internet and the Web into the physical realm, by means of the widespread deployment of spatially distributed devices with embedded...

A Comparative Study of Various Tests for Normality

Results are given of an empirical sampling study of the sensitivities of nine statistical procedures for evaluating the normality of a complete sample. The nine statistics are W (Shapiro and Wilk, 1965), (standard third moment), b 2 (standard fourth moment),...

Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C

Background Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease. Cystatin C is an alternative filtration marker...

Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates

Magneticresonance imaging(MRI)has showna greatreduction inmedialtemporallobeandhippocampal volumeof patients withAlzheimer's disease ascomparedtocontrols. Quantitative volumetric measurements arenotyetavailable for routineclinical use.We investigated...

CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells.

A major limitation in the study of vectorial ion transport, secretion, and differentiated function in the human airway epithelium has been the lack of suitable cell culture systems. Progress in this direction has been made through the transformation of...

What is Sociology

This publication of Norbert Elias' broadest statement of the fundamentals of sociology is in important respects very different from the discipline as it is institutionalised today. In his vision, sociology is concerned with the whole course of the development...

The state of working America

Lawrence Mishel, Josh Bivens, Elise Gould, Heidi Shierholz

The Lifelong Effects of Early Childhood Adversity and Toxic Stress

in fields of inquiry as diverse as neuroscience, molecular biology, genomics, developmental psychology, epidemiology, sociology, and economics are catalyzing an important paradigm shift in our un- derstanding of health and disease across the lifespan....

Materials Science and Engineering A

a b s t r a c t The isothermal oxidation of the ZrB2–SiC–ZrC ceramic was carried out at a constant temperature of 1000 ± 2 ◦ C, 1200 ± 5 ◦ C and 1400 ± 5 ◦ C, respectively, for different times in static air. The surface oxidation was favorable...

Linking Crystallographic Model and Data Quality

Protein crystallography has revolutionized our understanding of a whole variety of biological processes (see the Perspective by [Evans][1] ). In crystallography, the measure of agreement between the data and the calculated model is not on the same scale...

The Estimation of the Parameters of a Linear Regression System Obeying Two Separate Regimes

In attempting to estimate the parameters of a linear regression system obeying two separate regimes, it is necessary first to estimate the position of the point in time at which the switch from one regime to the other occurred. The suggested maximum likelihood...

SPECTRAL SIGNATURES OF PARTICULATE MINERALS IN THE VISIBLE AND NEAR INFRARED

The utility of multispectral remote sensing techniques for discriminating among materials is based on the differences that exist among their spectral properties. As distinct from spectral variations that occur as a consequence of target condition and...

2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease‐modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis

Daniel E. Furst, Aseem Bharat, Jeffrey R. Curtis, Arthur Kavanaugh, James R. O'Dell, Kevin L. Winthrop, Timothy Beukelman, S. Louis Bridges, Maria E. Suarez-Almazor, Claire Bombardier, Maxime Dougados, Dinesh Khanna, Charles King, Amye Leong, Eric L. Matteson, John T. Schousboe, Eileen Moynihan, Karen S. Kolba, Archana Jain, Elizabeth R. Volkmann, Harsh Agrawal, Sangmee Bae, Amy S. Mudano, Nivedita M. Patkar, Kenneth G. Saag

RPL: IPv6 Routing Protocol for Low power and Lossy Networks

Today, Low Power and Lossy Networks (LLNs) represent one of the most interesting research areas. They include Wireless Personal Area Networks (WPANs), low-power Power Line Communication (PLC) networks and Wireless Sensor Networks (WSNs). Such networks...

Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure.

Recent studies suggest that noninvasive positive pressure ventilation (NPPV) administered by nasal or oronasal mask avoids the need for endotracheal intubation, rapidly improves vital signs, gas exchange, and sense of dyspnea, and may reduce mortality...

Echocardiographic Assessment of Pulmonary Hypertension in Patients with Advanced Lung Disease

Doppler echocardiography is commonly used to estimate systolic pulmonary artery pressure and to diagnose pulmonary hypertension, but data relating to its utility in patients with advanced lung disease are limited. In a cohort study of 374 lung transplant...

Functional abilities after stroke: measurement, natural history and prognosis.

living. There is still no better measure; specifically, the Barthel ADL Index is not inferior to the widely used Functional Independence Measure which was originally derived from it. We also introduced five categories, and although we stated explicitly...

An Effective Bandwidth Selector for Local Least Squares Regression

Local least squares kernel regression provides an appealing solution to the nonparametric regression, or “scatterplot smoothing,” problem, as demonstrated by Fan, for example. The practical implementation of any scatterplot smoother is greatly enhanced...

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Li Ding, Timothy J. Ley, David E. Larson, Christopher A. Miller, Daniel C. Koboldt, John S. Welch, Julie K. Ritchey, Margaret A. Young, Tamara L. Lamprecht, Michael D. McLellan, Joshua F. McMichael, John W. Wallis, Charles Lu, Dong Shen, Christopher C. Harris, David J. Dooling, Robert S. Fulton, Lucinda Fulton, Ken Chen, Heather Schmidt, Joelle Kalicki-Veizer, Vincent Magrini, Lisa L. Cook, Sean D. McGrath, Tammi L. Vickery, Michael C. Wendl, Sharon Heath, Mark A. Watson, Daniel C. Link, Michael H. Tomasson, William D. Shannon, Jacqueline E. Payton, Shashikant Kulkarni, Peter Westervelt, Matthew J. Walter, Timothy A. Graubert, Elaine R. Mardis, Richard K. Wilson, John F. DiPersio

Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration: Two-Year Results

Daniel F. Martin, Maureen G. Maguire, Stuart L. Fine, Gui-Shuang Ying, Glenn J. Jaffe, Juan E. Grunwald, Cynthia A. Toth, Maryann Redford, Frederick L. Ferris

Time as a Trade Barrier

International trade occurs in physical space and moving goods requires time. This paper examines the importance of time as a trade barrier, estimates the magnitude of time costs, and relates these to patterns of trade and the international organization...

Work Groups and Teams in Organizations

Steve W. J. Kozlowski, Bradford S. Bell

Modeling and Forecasting U.S. Mortality

Time series methods are used to make long-run forecasts, with confidence intervals, of age-specific mortality in the United States from 1990 to 2065. First, the logs of the age-specific death rates are modeled as a linear function of an unobserved period-specific...

Antithrombotic Therapy for Atrial Fibrillation Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Funding/Support: The Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines received support from the National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer...

Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease

Though exercise training is part of most pulmonary rehabilitation programs, whether there is a physiologic basis for increased exercise tolerance is unclear. We sought to determine whether patients with chronic obstructive pulmonary disease (COPD) are...

Transcatheter Aortic-Valve Replacement for Inoperable Severe Aortic Stenosis

Background Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known. Methods We randomly assigned...

Global estimates of visual impairment: 2010

Donatella Pascolini, Silvio P. Mariotti

Approximations to the Log-Likelihood Function in the Nonlinear Mixed-Effects Model

Nonlinear mixed-effects models have received a great deal of attention in the statistical literature in recent years because of the flexibility they offer in handling the unbalanced repeated-measures data that arise in different areas of investigation,...

Alveolar Fluid Clearance Is Impaired in the Majority of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome

Because experimental studies have shown that intact alveolar epithelial fluid transport function is critical for resolution of pulmonary edema and acute lung injury, we measured net alveolar fluid clearance in 79 patients with acute lung injury or the...

Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

Background Preexposure prophylaxis with antiretroviral agents has been shown to reduce the transmission of human immunodeficiency virus (HIV) among men who have sex with men; however, the efficacy among heterosexuals is uncertain. Methods We randomly...

Elastic optical networking: a new dawn for the optical layer?

Optical networks are undergoing significant changes, fueled by the exponential growth of traffic due to multimedia services and by the increased uncertainty in predicting the sources of this traffic due to the ever changing models of content providers...

Transaction Cost Economics

Steven Tadelis, Oliver E. Williamson

Estimating the Number of Classes via Sample Coverage

Assume that a random sample is drawn from a population with unknown number of classes and possibly unequal class probabilities. A nonparametric estimation technique is proposed to estimate the number of classes using the idea of sample coverage, which...

The gifts of Athena : historical origins of the knowledge economy

In The Gifts of Athena, Joel Mokyr constructs an original framework to analyze scientific and technical progress appeared in the modern West in the past two centuries. The progress was driven not just by the appearance of new technological ideas but also...

The landscape of cancer genes and mutational processes in breast cancer

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder are passenger mutations. The driver mutations and...

Breast patterns as an index of risk for developing breast cancer

The radiographic appearance of the breast parenchyma provides a method of predicting who will develop a breast cancer. This paper describes a restrospective study of 7,214 patients. On the basis of the radiographic appearance of the breast parenchyma,...

Evaluating Online Labor Markets for Experimental Research: Amazon.com's Mechanical Turk

We examine the trade-offs associated with using Amazon.com’s Mechanical Turk (MTurk) interface for subject recruitment. We first describe MTurk and its promise as a vehicle for performing low-cost and easy-to-field experiments. We then assess the internal...

Experimental design

Maximizing data information requires careful selection, termed design, of the points at which data are observed. Experimental design is reviewed here for broad classes of data collection and analysis problems, including: fractioning techniques based on...

Extracellular-matrix tethering regulates stem-cell fate

To investigate how substrate properties influence stem-cell fate, we cultured single human epidermal stem cells on polydimethylsiloxane (PDMS) and polyacrylamide (PAAm) hydrogel surfaces, 0.1 kPa-2.3 MPa in stiffness, with a covalently...

Plasma surface modification of polymers for improved adhesion: a critical review

Since the earliest systematic research during the 1960s, the field of materials surface modification by 'cold', low-pressure plasma treatment has undergone an enormous expansion. Much of this expansion has taken place in recent years, particularly in...

Endothelial and perivascular cells maintain haematopoietic stem cells

Several cell types have been proposed to create niches for haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have not been systematically studied and no such factor has been conditionally deleted from any candidate...

Targeting MET in cancer: rationale and progress

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of cancer. Genetic and biochemical data have demonstrated that the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the...

The genomic basis of adaptive evolution in threespine sticklebacks

Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop...

Building high-level features using large scale unsupervised learning

Marc'Aurelio Ranzato, Rajat Monga, Matthieu Devin, Kai Chen, Greg Corrado, Jeffrey Dean, Q. Le, Andrew Y. Ng

Antibody therapy of cancer

Andrew Scott, Jedd D. Wolchok, Lloyd J. Old

InterPro in 2011: new developments in the family and domain prediction database

InterPro (http://www.ebi.ac.uk/interpro/) is a database that integrates diverse information about protein families, domains and functional sites, and makes it freely available to the public via Web-based interfaces and services. Central to the database...

Nitric oxide synthases: regulation and function

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as substrates and require the cofactors reduced nicotinamide-adenine-dinucleotide...

Efficient Estimation of a System of Regression Equations when Disturbances are Both Serially and Contemporaneously Correlated

This paper considers the problem of obtaining efficient estimates for the parameters of a system of M regression equations. The disturbance terms of this system are assumed to be related by both serial and contemporaneous correlation. Under the further...

Neutrophilic Inflammation in Severe Persistent Asthma

Airway inflammation in severe asthma is not well characterized but may involve neutrophils. We have compared induced sputum profiles in patients with asthma of varying severity and normal control subjects. We have also measured exhaled nitric oxide (NO)...

CD8+ T-Lymphocytes in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease

To investigate whether the inflammatory process in peripheral airways is different in smokers who develop symptoms of chronic bronchitis and chronic airflow limitation and in asymptomatic smokers who do not develop chronic airflow limitation, we examined...

Clinical Risks for Development of the Acute Respiratory Distress Syndrome

Tofurther understanding of the epidemiology of acute respiratory distress syndrome (ARDS), we prospec­ tively identified 695 patients admitted to our intensive care units from 1983 through 1985 meeting criteria for seven clinical risks, and followed...

International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas

The international consensus guidelines for management of intraductal papillary mucinous neoplasm and mucinous cystic neoplasm of the pancreas established in 2006 have increased awareness and improved the management of these entities. During the subsequent...

Optimal Properties of Exponentially Weighted Forecasts

The exponentially weighted average can be interpreted as the expected value of a time series made up of two kinds of random components: one lasting a single time period (transitory) and the other lasting through all subsequent periods (permanent). Such...

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

Recent debates have focused on the degree of genetic variation and its impact upon health at the genomic level in humans (see the Perspective by [ Casals and Bertranpetit ][1]). Tennessen et al. (p. [64][2], published online 17 May), looking at all of...

Systematic identification of genomic markers of drug sensitivity in cancer cells

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer...

Fractional Calculus: Some Basic Problems in Continuum and Statistical Mechanics

: We review some applications of fractional calculus developed by the author (partly in collaboration with others) to treat some basic problems in continuum and statistical mechanics. The problems in continuum mechanics concern mathematical modelling...

Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial

The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary mechanisms of action and synergistic antitumour activity in models of HER2-overexpressing breast cancer. We argue that the two anti-HER2 agents...

Peripheral Muscle Weakness in Patients with Chronic Obstructive Pulmonary Disease

Peripheral muscle weakness is commonly found in patients with chronic obstructive pulmonary disease (COPD) and may play a role in reducing exercise capacity. The purposes of this study were to evaluate, in patients with COPD: (1) the relationship between...

Growth of Large-Area and Highly Crystalline MoS2 Thin Layers on Insulating Substrates

The two-dimensional layer of molybdenum disulfide (MoS2) has recently attracted much interest due to its direct-gap property and potential applications in optoelec- tronics and energy harvesting. However, the synthetic approach to obtain high-quality...

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

Background Ruxolitinib, a selective inhibitor of Janus kinase (JAK) 1 and 2, has clinically significant activity in myelofibrosis. Methods In this double-blind trial, we randomly assigned patients with intermediate-2 or high-risk myelofibrosis to twice-daily...

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib) is highly effective in the treatment of melanoma 1 . However, colon cancer patients harbouring the same BRAF(V600E) oncogenic lesion have poor prognosis and show...

Gadodiamide-Associated Nephrogenic Systemic Fibrosis: Why Radiologists Should Be Concerned

OBJECTIVE. Nephrogenic systemic fibrosis (NSF) is a rare multisystemic fibrosing disorder that principally affects the skin but may affect other organs of patients with renal insufficiency. The purpose of our study was to identify any common risk factors...

Perioperative Management of Antithrombotic Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Funding/Support: The Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines received support from the National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer...

2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis

WHO recommends routine use of rotavirus vaccines in all countries, particularly in those with high mortality attributable to diarrhoeal diseases. To establish the burden of life-threatening rotavirus disease before the introduction of a rotavirus vaccine,...

Literacy and Language: Relationships during the Preschool Years

Drawing upon recent research findings and upon a case study of a child learning to talk and to read, Catherine Snow outlines the important similarities in the development of both language and literacy. The characteristics of parent-child interaction which...

Latent Space Approaches to Social Network Analysis

Network models are widely used to represent relational information among interacting units. In studies of social networks, recent emphasis has been placed on random graph models where the nodes usually represent individual social actors and the edges...

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