CiteWeb

WorldWeb citation database

Publications in 2012

Page 4
The accessible chromatin landscape of the human genome.

Robert E. Thurman, Eric Rynes, Richard Humbert, Jeff Vierstra, Matthew T. Maurano, Eric Haugen, Nathan C. Sheffield, Andrew B. Stergachis, Hao Wang, Benjamin Vernot, Kavita S. Garg, Sam John, Richard Sandstrom, Daniel Bates, Lisa Boatman, Theresa K. Canfield, Morgan Diegel, Douglas Dunn, Ak Ebersol, Tristan Frum, Erika Giste, Audra K. Johnson, Ericka M. Johnson, Tanya Kutyavin, Bryan R. Lajoie, Bum-Kyu Lee, Kristen Lee, Darin London, Dimitra M. Lotakis, Shane Neph, Fidencio Neri, Eric Nguyen, Hongzhu Qu, Alex Reynolds, Vaughn Roach, Alexias Safi, Minerva Sanchez, Amartya Sanyal, Anthony Shafer, Jeremy M. Simon, Lingyun Song, Shinny Vong, Molly Weaver, Yongqi Yan, Zhancheng Zhang, Zhuzhu Zhang, Boris Lenhard, Muneesh Tewari, Michael O. Dorschner, R. Scott Hansen

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.

Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.

Improving neural networks by preventing co-adaptation of feature detectors

: When a large feedforward neural network is trained on a small training set, it typically performs poorly on held-out test data. This "overfitting" is greatly reduced by randomly omitting half of the feature detectors on each training case. This prevents...

Conversion of biomass to selected chemical products

This critical review provides a survey illustrated by recent references of different strategies to achieve a sustainable conversion of biomass to bioproducts. Because of the huge number of chemical products that can be potentially manufactured, a selection...

Solution-processed small-molecule solar cells with 6.7% efficiency

Yanming Sun, Wei Lin Leong, Christopher J. Takacs, Guillermo C. Bazan

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

Stephan J. Sanders, Michael T. Murtha, Abha R. Gupta, John D. Murdoch, Melanie J. Raubeson, A. Jeremy Willsey, A. Gulhan Ercan-Sencicek, Nicholas M. DiLullo, Neelroop Parikshak, Jason L. Stein, Michael F. Walker, Gordon T. Ober, Nicole A. Teran, Youeun Song, Paul El-Fishawy, Ryan C. Murtha, Murim Choi, John D. Overton, Robert D. Bjornson, Nicholas Carriero, Kyle A. Meyer, Kaya Bilguvar, Shrikant Mane, Nenad Šestan, Richard P. Lifton, Murat Gunel, Kathryn Roeder, Daniel H. Geschwind, Bernie Devlin, Matthew W. State

Nicotine receptor partial agonists for smoking cessation

From the information we found (27 trials, 12,625 people), varenicline at standard dose more than doubled the chances of quitting compared with placebo. Low-dose varenicline (four trials, 1266 people) roughly doubled the chances of quitting, and reduced...

A Test of Goodness of Fit

Some (large sample) significance points are tabulated for a distribution-free test of goodness of fit which was introduced earlier by the authors. The test, which uses the actual observations without grouping, is sensitive to discrepancies at the tails...

Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7

We previously reported an increased risk for bronchial obstructive disease and allergic sensitization up to age 3 in 47 children hospitalized with a respiratory syncytial virus (RSV) bronchiolitis in infancy compared with 93 matched control subjects recruited...

Local literacies : reading and writing in one community

Local Literacies is a unique detailed study of the role of reading and writing in people’s everyday lives. By concentrating on a selection of people in a particular community in Lancaster, England, the authors analyse how they use literacy in their...

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

Summary: The two main functions of bioinformatics are the organization and analysis of biological data using computational resources. Geneious Basic has been designed to be an easyto-use and flexible desktop software application framework for the organization...

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: baryon acoustic oscillations in the Data Release 9 spectroscopic galaxy sample

We present measurements of galaxy clustering from the Baryon Oscillation Spectroscopic Survey (BOSS), which is part of the Sloan Digital Sky Survey III (SDSS-III). These use the Data Release 9 (DR9) CMASS sample, which contains 264 283 massive galaxies...

Context-Dependent Pre-Trained Deep Neural Networks for Large-Vocabulary Speech Recognition

We propose a novel context-dependent (CD) model for large-vocabulary speech recognition (LVSR) that leverages recent advances in using deep belief networks for phone recognition. We describe a pre-trained deep neural network hidden Markov model (DNN-HMM)...

Candida and candidiasis.

Richard A. Calderone, Cornelius J. Clancy

Energy Transfer Mechanisms and the Molecular Exciton Model for Molecular Aggregates1, 2

Energytransferphenomenacontinuetofascinatethebiologist, chemist, and physicist, and the literature contains numerous experiments designed to demonstrate the presence of excitation energy transfer. At the present stage of development of the theoryofsuchprocesses,...

Energy-aware resource allocation heuristics for efficient management of data centers for Cloud computing

Cloud computing offers utility-oriented IT services to users worldwide. Based on a pay-as-you-go model, it enables hosting of pervasive applications from consumer, scientific, and business domains. However, data centers hosting Cloud applications consume...

Five years of GWAS discovery.

Peter M. Visscher, Matthew A. Brown, Mark I. McCarthy, Jian Yang

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3.

Pablo Cingolani, Adrian E. Platts, Le Lily Wang, Melissa Coon, Tung Nguyen, Luan Wang, Susan Land, Xiangyi Lu, Douglas M. Ruden

Resilient distributed datasets: a fault-tolerant abstraction for in-memory cluster computing

We present Resilient Distributed Datasets (RDDs), a distributed memory abstraction that lets programmers perform in-memory computations on large clusters in a fault-tolerant manner. RDDs are motivated by two types of applications that current computing...

Testing a Point Null Hypothesis: The Irreconcilability of P Values and Evidence

The problem of testing a point null hypothesis (or a “small interval” null hypothesis) is considered. Of interest is the relationship between the P value (or observed significance level) and conditional and Bayesian measures of evidence against the...

A Clinical Index to Define Risk of Asthma in Young Children with Recurrent Wheezing

Because most cases of asthma begin during the first years of life, identification of young children at high risk of developing the disease is an important public health priority. We used data from the Tucson Children’s Respiratory Study to develop two...

The reduction of graphene oxide

Graphene has attracted great interest for its excellent mechanical, electrical, thermal and optical properties. It can be produced by micro-mechanical exfoliation of highly ordered pyrolytic graphite, epitaxial growth, chemical vapor deposition, and the...

Registry of transcatheter aortic-valve implantation in high-risk patients

Background Transcatheter aortic-valve implantation (TAVI) is an emerging intervention for the treatment of high-risk patients with severe aortic stenosis and coexisting illnesses. We report the results of a prospective multicenter study of the French...

Objective Measurement of Patterns of Nasal CPAP Use by Patients with Obstructive Sleep Apnea

Obstruction of the upper airway during sleep (OSAS) is widely treated by having patients self-administer nasal continuous positive airway pressure (CPAP). To obtain objective evidence of the patterns of CPAP use, information was gathered from two urban...

Semiparametric Estimates of the Relation between Weather and Electricity Sales

A nonlinear relationship between electricity sales and temperature is estimated using a semiparametric regression procedure that easily allows linear transformations of the data. This accommodates introduction of covariates, timing adjustments due to...

Strategies for multivessel revascularization in patients with diabetes

In some randomized trials comparing revascularization strategies for patients with diabetes, coronary-artery bypass grafting (CABG) has had a better outcome than percutaneous coronary intervention (PCI). We sought to discover whether aggressive medical...

Tracking-Learning-Detection

This paper investigates long-term tracking of unknown objects in a video stream. The object is defined by its location and extent in a single frame. In every frame that follows, the task is to determine the object's location and extent or indicate that...

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

Background Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations. Methods We conducted a randomized trial of oral antiretroviral therapy for use...

Functional Supramolecular Polymers

While polymers are constructed from chemically bonded units, supramolecular polymers arise through reversible linkages, such as hydrogen bonding and electrostatic interactions. Recent advances in the field of supramolecular polymer science have moved...

Indication of Reactor ν̅ e Disappearance in the Double Chooz Experiment

Y. Abe, T. Akiri, J. C. dos Anjos, F. Ardellier, A.F. Barbosa, A. Baxter, A. Bernstein, T. J. C. Bezerra, L. Bezrukhov, E. Blucher, N. S. Bowden, C. Buck, J. Busenitz, A. Cabrera, L. Camilleri, R. Carr, María L. Cerrada, P.-J. Chang, P. Chimenti, A. P. Collin, E. Conover, J. Conrad, S. Cormon, J. I. Crespo-Anadón, M. Cribier, K. Crum, A. Cucoanes, E. Damon, J. V. Dawson, S. Dazeley, M. Dierckxsens, D. Dietrich, Z. Djurcic, M. Dracos, V. Durand, Y. Efremenko, M. Elnimr, Y. Endo, A. Etenko, E. Falk, M. Fallot, M. Fechner, F. von Feilitzsch, S. M. Fernandes, D. Franco, A. J. Franke, M. Franke, H. Furuta, I. Gil-Botella, M. Goeger-Neff

Rhodium catalyzed chelation-assisted C-H bond functionalization reactions.

Denise A. Colby, Andy S. Tsai, Robert G. Bergman, Jonathan A. Ellman

Guidelines for the use and interpretationof assays for monitoring autophagy

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continuedto accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have...

The Epidemiology of Adult Obstructive Sleep Apnea

Obstructive sleep apnea is a chronic condition characterized by frequent episodes of upper airway collapse during sleep. Its effect on nocturnal sleep quality and ensuing daytime fatigue and sleepiness are widely acknowledged. Increasingly, obstructive...

Regression with Missing X's: A Review

The literature of regression analysis with missing values of the independent variables is reviewed. Six classes of procedures are distinguished: complete case analysis, available case methods, least squares on imputed data, maximum likelihood, Bayesian...

An assessment of the use of partial least squares structural equation modeling in marketing research

Most methodological fields undertake regular critical reflections to ensure rigorous research and publica- tion practices, and, consequently, acceptance in their domain. Interestingly, relatively little attention has been paid to assessing the use of...

National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications

Summary Background Preterm birth is the second largest direct cause of child deaths in children younger than 5 years. Yet, data regarding preterm birth (<37 completed weeks of gestation) are not routinely collected by UN agencies, and no systematic country...

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Macrophages provide protection against a wide variety of infections and critically shape the inflammatory environment in many tissues. These cells come in many flavors, as determined by differences in gene expression, cell surface phenotype and specific...

The Art of Multiprocessor Programming, Revised Reprint

Revised and updated with improvements conceived in parallel programming courses, The Art of Multiprocessor Programming is an authoritative guide to multicore programming. It introduces a higher level set of software development skills than that needed...

Complex seismic trace analysis

The conventional seismic trace can be viewed as the real component of a complex trace which can be uniquely calculated under usual conditions. The complex trace permits the unique separation of envelope amplitude and phase information and the calculation...

Control of valley polarization in monolayer MoS2 by optical helicity

: Electronic and spintronic devices rely on the fact that free charge carriers in solids carry electric charge and spin, respectively. There are, however, other properties of charge carriers that might be exploited in new families of devices. In particular,...

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

No published meta-analyses have assessed efficacy and effectiveness of licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to confirm influenza.

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

An understanding of the interactions between nanoparticles and biological systems is of significant interest. Studies aimed at correlating the properties of nanomaterials such as size, shape, chemical functionality, surface charge, and composition with...

The mystery of missing heritability: Genetic interactions create phantom heritability.

justified, because models with interactions are also consistent with observable data; and (iii) under such models, the total heritability may be much smaller and thus the proportion of heritability explained much larger. For example, 80% of the currently...

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.

Rationale: The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma.Objectives: To identify...

Rivaroxaban in Patients with a Recent Acute Coronary Syndrome

Rivaroxaban significantly reduced the primary efficacy end point, as compared with placebo, with respective rates of 8.9% and 10.7% (hazard ratio in the rivaroxaban group, 0.84; 95% confidence interval [CI], 0.74 to 0.96;...

Sequential Imputations and Bayesian Missing Data Problems

For missing data problems, Tanner and Wong have described a data augmentation procedure that approximates the actual posterior distribution of the parameter vector by a mixture of complete data posteriors. Their method of constructing the complete data...

Practical Reliability Engineering

With emphasis on practical aspects of engineering, this bestseller has gained worldwide recognition through progressive editions as the essential reliability textbook. This fifth edition retains the unique balanced mixture of reliability theory and applications,...

Prevalence of asthma and atopy in two areas of West and East Germany.

The German reunification offers a unique opportunity to study the impact of environmental factors on the development of childhood respiratory and allergic disorders in ethnically similar populations. We inves­ tigated the prevalence of asthma, hay fever,...

A framework for human microbiome research

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established...

Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.

Subclinical Atrial Fibrillation and the Risk of Stroke

One quarter of strokes are of unknown cause, and subclinical atrial fibrillation may be a common etiologic factor. Pacemakers can detect subclinical episodes of rapid atrial rate, which correlate with electrocardiographically documented atrial fibrillation....

Pedestrian Detection: An Evaluation of the State of the Art

Pedestrian detection is a key problem in computer vision, with several applications that have the potential to positively impact quality of life. In recent years, the number of approaches to detecting pedestrians in monocular images has grown steadily....

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

Choosing appropriate primers is probably the single most important factor affecting the polymerase chain reaction (PCR). Specific amplification of the intended target requires that primers do not have matches to other targets in certain orientations and...

3D Graphene–Cobalt Oxide Electrode for High-Performance Supercapacitor and Enzymeless Glucose Detection

Using a simple hydrothermal procedure, cobalt oxide (Co3O4) nanowires were in situ synthesized on three-dimensional (3D) graphene foam grown by chemical vapor deposition. The structure and morphology of the resulting 3D graphene/Co3O4 composites were...

Studies of the Mortality of Atomic Bomb Survivors.Report 12, Part I. Cancer: 1950–1990

This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986–1990, and analysis includes an additional...

Valley polarization in MoS2 monolayers by optical pumping

: We report experimental evidences on selective occupation of the degenerate valleys in MoS2 monolayers by circularly polarized optical pumping. Over 30% valley polarization has been observed at K and K' valley via the polarization resolved luminescence...

The Abuse of Power

It is well known that statistical power calculations can be valuable in planning an experiment. There is also a large literature advocating that power calculations be made whenever one performs a statistical test of a hypothesis and one obtains a statistically...

Self-assembly of block copolymers

Block copolymer (BCP) self-assembly has attracted considerable attention for many decades because it can yield ordered structures in a wide range of morphologies, including spheres, cylinders, bicontinuous structures, lamellae, vesicles, and many other...

Cognitive Dysfunction in Multiple Sclerosis

In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest...

Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism

A fixed-dose regimen of rivaroxaban, an oral factor Xa inhibitor, has been shown to be as effective as standard anticoagulant therapy for the treatment of deep-vein thrombosis, without the need for laboratory monitoring. This approach may also simplify...

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

Methods In the prospective, randomised CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction (CADUCEUS) trial, we enrolled patients 2–4 weeks after myocardial infarction (with left ventricular ejection fraction of 25–45%) at...

Clinical pharmacokinetics of mycophenolate mofetil

Roy Bullingham, Andrew J. Nicholls, Barbara Kamm

What the Student Does: Teaching for Enhanced Learning.

Many teachers see major difficulties in maintaining academic standards in today's larger and more diversified classes. The problem becomes more tractable if learning outcomes are seen as more a function of students’ activities than of their fixed characteristics....

Remodeling in Asthma and Chronic Obstructive Lung Disease

Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural “remodeling” inappropriate to the maintenance of normal lung function. The clinically observed distinctions between asthma and...

The Genomes OnLine Database (GOLD) v.4: status of genomic and metagenomic projects and their associated metadata

The Genomes On Line Database (GOLD) is a comprehensive resource that provides information on genome and metagenome projects worldwide. Complete and ongoing projects and their associated metadata can be accessed in GOLD through precomputed lists and a...

Dynamic analysis of structural systems using component modes

A method is developed for analyzing complex structural systems that can be divided into interconnected components. Displacements of the separate components are expressed in generalized coordinates that are defined by displacement modes. These are generated...

Efflux-mediated drug resistance in bacteria.

Drug resistance in bacteria, and especially resistance to multiple antibacterials, has attracted much attention in recent years. In addition to the well known mechanisms, such as inactivation of drugs and alteration of targets, active efflux is now known...

Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.

understood. Objectives: To define the relationship between specific viral illnesses and early childhood asthma development. Methods: A total of 259 children were followed prospectively from birth to 6 years of age. The etiology and timing of specific...

Looking for evidence of mixing in the solar wind from 0.31 to 0.98 AU

[1] To determine the efficacy of turbulence in the solar wind, the amount of mixing of the solar wind plasma is quantified. If magnetohydrodynamic turbulence in the solar wind acts as does Navier-Stokes turbulence, the chunk mixture of scalar quantities...

A Reference Bayesian Test for Nested Hypotheses and its Relationship to the Schwarz Criterion

To compute a Bayes factor for testing H 0: ψ = ψ0 in the presence of a nuisance parameter β, priors under the null and alternative hypotheses must be chosen. As in Bayesian estimation, an important problem has been to define automatic,...

Exploratory Projection Pursuit

A new projection pursuit algorithm for exploring multivariate data is presented that has both statistical and computational advantages over previous methods. A number of practical issues concerning its application are addressed. A connection to multivariate...

Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a generally fatal disorder with a reported median survival of 3 to 6 yr. This has been based on relatively few studies with diagnoses inconsistently confirmed by adequate lung biopsy. Retrospective analysis of 104...

Embryonic stem cell trials for macular degeneration: a preliminary report

Methods We started two prospective clinical studies to establish the safety and tolerability of subretinal transplantation of hESC-derived retinal pigment epithelium (RPE) in patients with Stargardt’s macular dystrophy and dry age-related macular degeneration—the...

A Method for Simulating Stable Random Variables

A new algorithm is presented for simulating stable random variables on a digital computer for arbitrary characteristic exponent α(0 < α ≤ 2) and skewness parameter β(-1 ≤ β ≤ 1). The algorithm involves a nonlinear transformation...

GENCODE: The reference human genome annotation for The ENCODE Project

The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation data set, few new protein-coding...

A Network Algorithm for Performing Fisher's Exact Test in r × c Contingency Tables

An exact test of significance of the hypothesis that the row and column effects are independent in an r x c contingency table can be executed in principle by generalizing Fisher's exact treatment of the 2 x 2 contingency table. Each table in a conditional...

Financial Cryptography and Data Security

Radu Sion, Reza Curtmola, Sven Dietrich, Aggelos Kiayias, Josep M. Miret, Kazue Sako, Francesc Sebé

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative stress refers to the imbalance due to excess ROS or oxidants over the capability...

Regulated Rewriting in Formal Language Theory

It is well-known that context-free grammars cannot cover all aspects of natural languages, progamming languages and other related fields. Therefore a lot of mechanisms have been introduced which control the application of context-free rules. This book...

EULDPH: A new technique for making computer‐assisted depth estimates from magnetic data

A method for rapidly making depth estimates from large amounts of magnetic data is described. The technique is based upon Euler’s homogeneity relationship (hence, the acronym EULDPH) and differs from similar techniques which are currently available...

IMF Working Paper

These are documents released under a Freedom of Information request seeking documents relating to the IMF Working Paper ‘A Modern History of Fiscal Prudence and Prolificacy’, release on 9 January 2013

Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

The role of dynamic hyperinflation (DH) in exercise limitation in chronic obstructive pulmonary disease (COPD) remains to be defined. We examined DH during exercise in 105 patients with COPD (FEV1 = 37 ± 13% predicted; mean ± SD) and studied the relationships...

Exploring the reliability of social and environmental disclosures content analysis

This paper reports the results of an exploratory study of inter‐coder reliability of annual report social and environmental disclosures content analysis. Using the sentence‐based coding instruments and decision rules from Hackston and Milne (1996),...

Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

using the same contrast. (iii) By exciting different molecules at different optical wavelengths, PAT reveals rich optical contrasts according to chem- ical composition. (iv) PAT images optical ab- sorption with 100% sensitivity (5), two orders of magnitude...

Atom Transfer Radical Polymerization (ATRP): Current Status and Future Perspectives

Current status and future perspectives in atom transfer radical polymerization (ATRP) are presented. Special emphasis is placed on mechanistic understanding of ATRP, recent synthetic and process development, and new controlled polymer architectures enabled...

The Definition of Generalized Helicoidal Parameters and of Axis Curvature for Irregular Nucleic Acids

An algorithm is presented which solves the problem of obtaining a rigorous helicoidal description of an irregular nucleic acid segment. Central to this approach is the definition of a function describing simultaneously the curvature of the nucleic acid...

Addressing cloud computing security issues

The recent emergence of cloud computing has drastically altered everyone's perception of infrastructure architectures, software delivery and development models. Projecting as an evolutionary step, following the transition from mainframe computers to client/server...

Are we ready for autonomous driving? The KITTI vision benchmark suite

Today, visual recognition systems are still rarely employed in robotics applications. Perhaps one of the main reasons for this is the lack of demanding benchmarks that mimic such scenarios. In this paper, we take advantage of our autonomous driving platform...

Measuring quality of life in asthma.

The aim of this study was to evaluate the measurement properties of an Asthma Quality of Life Questionnaire. The study design was an 8-wk unblinded single cohort with assessments at 0, 4, and 8 wk. Thirtynine adults with symptomatic asthma...

Accuracy and resolution of Kinect depth data for indoor mapping applications.

Consumer-grade range cameras such as the Kinect sensor have the potential to be used in mapping applications where accuracy requirements are less strict. To realize this potential insight into the geometric quality of the data acquired by the sensor is...

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.

Molecular replacement with MOLREP

A.A. Vagin, Alexei Teplyakov

Prostate-cancer mortality at 11 years of follow-up

Background Several trials evaluating the effect of testing of prostate-specific antigen (PSA) on prostate-cancer mortality have shown conflicting results. We updated prostatecancer mortality in the European Randomized Study of Screening for Prostate Cancer...

Engineering the third wave of biocatalysis

Uwe T. Bornscheuer, R. J. Kazlauskas, S. Lutz, J. C. Moore, K. Robins

Direct Clustering of a Data Matrix

Clustering algorithms are now in widespread use for sorting heterogeneous data into homogeneous blocks. If the data consist of a number of variables taking values over a number of cases, these algorithms may be used either to construct clusters of variables...

Tricuspid Annular Displacement Predicts Survival in Pulmonary Hypertension

Rationale: Right ventricular (RV) function is an important determinant of prognosis in pulmonary hypertension. However, noninvasive assessment of the RV function is often limited by complex geometry and poor endocardial definition.Objectives: To test...

Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial

The Solitaire Flow Restoration Device is a novel, self-expanding stent retriever designed to yield rapid flow restoration in acute cerebral ischaemia. We compared the efficacy and safety of Solitaire with the standard, predicate mechanical thrombectomy...

Combinatorial Optimization: Theory and Algorithms

This comprehensive textbook on combinatorial optimization places specialemphasis on theoretical results and algorithms with provably goodperformance, in contrast to heuristics. It is based on numerous courses on combinatorial optimization and specialized...

Sitaxsentan Therapy for Pulmonary Arterial Hypertension

Sitaxsentan may benefit patients with pulmonary arterial hypertension by blocking the vasoconstrictor effects of endothelin-A while maintaining the vasodilator/clearance functions of endothelin-B receptors. Patients with pulmonary arterial hypertension...

Putatively psychosis-prone subjects 10 years later

The predictive validities of several indicators of psychosis proneness were evaluated in a 10-yr longitudinal study (N = 508). As hypothesized, high scorers on the Perceptual Aberration Scale, Magical Ideation Scale, or both (n = 182), especially those...

Nine-Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Final Maps and Results

We present the final nine-year maps and basic results from the Wilkinson Microwave Anisotropy Probe (WMAP) mission. The full nine-year analysis of the time-ordered data provides updated characterizations and calibrations of the experiment. We also provide...

A Nonparametric “Trim and Fill” Method of Accounting for Publication Bias in Meta-Analysis

Meta-analysis collects and synthesizes results from individual studies to estimate an overall effect size. If published studies are chosen, say through a literature review, then an inherent selection bias may arise, because, for example, studies may tend...

Clonal evolution in cancer

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal...

Combined results of searches for the standard model Higgs boson in pp collisions at sqrt(s) = 7 TeV

Combined results are reported from searches for the standard model Higgs boson in proton–proton collisions at 1.5 σ ( 2.1 σ ) . More data are required to ascertain the origin of the observed excess.

A Note on the Delta Method

The delta method is an intuitive technique for approximating the moments of functions of random variables. This note reviews the delta method and conditions under which delta-method approximate moments are accurate.

A simplification of the Zoeppritz equations

The compressional wave reflection coefficient R(θ) given by the Zoeppritz equations is simplified to the following: R(θ)=R0+[A0R0+Δσ(1-σ)2]sin2θ+1/2ΔVpVp(tan2θ-sin2θ). The first term gives the amplitude at normal incidence (θ = 0),...

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