CiteWeb

WorldWeb citation database

Publications in 2012

Page 13
Severe Periodontitis and Risk for Poor Glycemic Control in Patients with Non-Insulin-Dependent Diabetes Mellitus

This study tested the hypothesis that severe periodontitis in persons with non-insulin-dependent diabetes mellitus (NIDDM) increases the risk of poor glycemic control. Data from the longitudinal study of residents of the Gila River Indian Community were...

How Does Capital Affect Bank Performance During Financial Crises

This paper empirically examines how capital affects a bank’s performance (survival and market share) and how this effect varies across banking crises, market crises, and normal times that occurred in the US over the past quarter century. We have two...

Regression testing minimization, selection and prioritization: a survey

Regression testing is a testing activity that is performed to provide confidence that changes do not harm the existing behaviour of the software. Test suites tend to grow in size as software evolves, often making it too costly to execute entire test suites....

Fractional calculus: models and numerical methods

Kai Diethelm, Enrico Scalas, Juan J. Trujillo

Sub-nanometre sized metal clusters: from synthetic challenges to the unique property discoveries

Sub-nanometre sized metal clusters, with dimensions between metal atoms and nanoparticles, have attracted more and more attention due to their unique electronic structures and the subsequent unusual physical and chemical properties. However, the tiny...

Inferences on the Parameters of the Weibull Distribution

The problems of estimation and testing hypotheses regarding the parameters in the Weibull distribution are considered in this paper. The following results are given: 1. Exact confidence intervals for the parameters based upon maximum likelihood estimators...

Severe Community- Acquired Pneumonia

The purpose of the study was to validate the criteria used in the guidelines of the American Thoracic Society (ATS) for severe community-acquired pneumonia (CAP). Severe pneumonia was defined as admission to the intensive care unit (ICU). Overall 331...

The Analysis of Panel Data under a Markov Assumption

Methods for the analysis of panel data under a continuous-time Markov model are proposed. We present procedures for obtaining maximum likelihood estimates and associated asymptotic covariance matrices for transition intensity parameters in time homogeneous...

Examples of Adaptive MCMC

We investigate the use of adaptive MCMC algorithms to automatically tune the Markov chain parameters during a run. Examples include the Adaptive Metropolis (AM) multivariate algorithm of Haario, Saksman, and Tamminen (2001), Metropolis-within-Gibbs algorithms...

Three things everyone should know to improve object retrieval

The objective of this work is object retrieval in large scale image datasets, where the object is specified by an image query and retrieval should be immediate at run time in the manner of Video Google [28]. We make the following three contributions:...

A Bayes Rule for the Symmetric Multiple Comparisons Problem

A simple LSD (least significant difference) rule is presented for simultaneously testing the differences between n treatments considered in all possible pairs. This rule is a simpler, fully completed, version of the Bayes rule presented for special cases...

pH in Expired Breath Condensate of Patients with Inflammatory Airway Diseases

Endogenous airway acidification, as assessed by pH in expired breath condensate, has been implicated in asthma pathophysiology. We measured pH in breath condensate of patients with inflammatory airway diseases in stable condition and examined its relationship...

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

randomization on completion of chemotherapy; hazard ratio for progression or death, 0.35; 95% confidence interval [CI], 0.25 to 0.49; P<0.001). Subgroup analyses of progression-free survival...

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

In patients with relapsing-remitting multiple sclerosis, BG-12 (at both doses) and glatiramer acetate significantly reduced relapse rates and improved neuroradiologic outcomes relative to placebo. (Funded by Biogen Idec; CONFIRM ClinicalTrials.gov number,...

Efficient TALEN-mediated gene knockout in livestock

Daniel F. Carlson, Wenfang Tan, Simon Lillico, Dana Stverakova, Chris Proudfoot, Michelle Christian, Daniel F. Voytas, Charles R. Long, C. Bruce A. Whitelaw, Scott C. Fahrenkrug

Oscillatory Blowing: A Tool to Delay Boundary-Layer Separation

Avi Seifert, Tzach Bachar, Dagmar Koss, Misha Shepshelovich, I. Wygnanskil

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

Inflammation is a well-established driver of tumorigenesis. For example, patients with inflammatory bowel disease have an elevated risk of developing colorectal cancer (CRC). Whether the gut microbiota also contributes to the development of CRC is less...

Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique.

Hydrophilic interaction liquid chromatography (HILIC) provides an alternative approach to effectively separate small polar compounds on polar stationary phases. The purpose of this work was to review the options for the characterization of HILIC stationary...

Connective Tissue Disease–associated Pulmonary Arterial Hypertension in the Modern Treatment Era

Rationale: Pulmonary arterial hypertension in association with connective tissue disease (CTD-PAH) has historically had a poor prognosis, with a 1-year survival rate among patients with systemic sclerosis–associated pulmonary arterial hypertension (SSc-PAH)...

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

The programmed necrosis induced by TNF-α requires the activities of the receptor-interacting serine-threonine kinases RIP1 and RIP3 and their interaction with the mixed lineage kinase domain-like protein MLKL. We report the identification of RIP1- and...

Disorders of the Respiratory Muscles

The act of breathing depends on coordinated activity of the respiratory muscles to generate subatmospheric pressure. This action is compromised by disease states affecting anatomical sites ranging from the cerebral cortex to the alveolar sac. Weakness...

A Linear Mixed-Effects Model with Heterogeneity in the Random-Effects Population

This article investigates the impact of the normality assumption for random effects on their estimates in the linear mixed-effects model. It shows that if the distribution of random effects is a finite mixture of normal distributions, then the random...

Global burden of human papillomavirus and related diseases

The worldwide prevalence of infection with human papillomavirus (HPV) in women without cervical abnormalities is 11–12% with higher rates in sub-Saharan Africa (24%), Eastern Europe (21%) and Latin America (16%). The two most prevalent types are HPV16...

Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro

This work investigates the cytocompatibility of several photoinitiating systems for potential cell encapsulation applications. Both UV and visible light initiating schemes were examined. The UV photoinitiators included 2,2-dimethoxy-2-phenylacetophenone...

Non-specific low back pain

SummaryNon-specific low back pain has become a major public health problem worldwide. The lifetime prevalence of low back pain is reported to be as high as 84%, and the prevalence of chronic low back pain is about 23%, with 11–12% of the population...

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

Purpose BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel BH3 mimetic navitoclax (ABT-263) specifically inhibits BCL2 and related proteins BCL-xL and BCL-w, potently inducing apoptosis of CLL cells in vitro. A phase I...

An examination of social and environmental reporting strategies

The purpose of this study is to examine three electric utilities, two publicly owned and one privately owned. The basis of this examination is legitimacy theory employing a small sample case‐type approach. In particular we are interested in social and...

Free Radical Biology and Medicine

The Sestrin2 (Sesn2) gene encodes a conserved antioxidant protein that is induced on oxidative stress and protects cells against reactive oxygen species. NF-E2-related factor-2 (Nrf2) is an essential transcription factor that regulates expression of a...

Heterogeneous cellular networks: From theory to practice

The proliferation of internet-connected mobile devices will continue to drive growth in data traffic in an exponential fashion, forcing network operators to dramatically increase the capacity of their networks. To do this cost-effectively, a paradigm...

A Reconciled Estimate of Ice-Sheet Mass Balance

We combined an ensemble of satellite altimetry, interferometry, and gravimetry data sets using common geographical regions, time intervals, and models of surface mass balance and glacial isostatic adjustment to estimate the mass balance of Earth’s polar...

Complete optical absorption in periodically patterned graphene.

This work has been supported by the Spanish MICINN (MAT2010-14885 and Consolider NanoLight.es), Fundacio Cellex Barcelona, and the European Commission (FP7-ICT-2009-4-248909-LIMA and FP7-ICT-2009-4-248855-N4E).

Synthesis of nitrogen-doped porous carbon nanofibers as an efficient electrode material for supercapacitors.

Supercapacitors (also known as ultracapacitors) are considered to be the most promising approach to meet the pressing requirements of energy storage. Supercapacitive electrode materials, which are closely related to the high-efficiency storage of energy,...

Model-Based Direct Adjustment

Direct adjustment or standardization applies population weights to subclass means in an effort to estimate population quantities from a sample that is not representative of the population. Direct adjustment has several attractive features, but when there...

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Michael Krauthammer, Yong Kong, Byung Hak Ha, Perry Evans, Antonella Bacchiocchi, James P. McCusker, Elaine Cheng, Matthew J. Davis, Gerald Goh, Murim Choi, Stephan Ariyan, Deepak Narayan, Ken Dutton-Regester, Ana Capatana, Edna C. Holman, Marcus Bosenberg, Mario Sznol, Harriet M. Kluger, Douglas E. Brash, David F. Stern, Miguel A. Materin, Roger S. Lo, Shrikant Mane, Shuangge Ma, Kenneth K. Kidd, Nicholas K. Hayward, Richard P. Lifton, Joseph Schlessinger, Titus J. Boggon, Ruth Halaban

Storm Impact Scale for Barrier Islands

A new scale is proposed that categorizes impacts to natural barrier islands resulting from tropical and extra-tropical storms. The proposed scale is fundamentally different than existing storm-related scales in that the coupling between forcing processes...

Hypoglycemia and risk of death in critically ill patients

Nice-Sugar Study Investigators, Simon Finfer, Bette Liu, Dean R. Chittock, Robyn Norton, Myburgh Ja, Colin McArthur, Imogen Mitchell, Denise Foster, Dhingra, William R. Henderson, Ronco Jj, Bellomo R, D Cook, Ellen McDonald, Peter Dodek, Paul C. Hébert, Daren K. Heyland, Bruce G. Robinson

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Jinghe Huang, Gilad Ofek, Leo Laub, Mark K. Louder, Nicole A. Doria-Rose, Nancy S. Longo, Hiromi Imamichi, Robert T. Bailer, Bimal K. Chakrabarti, Shailendra Kumar Sharma, S. Munir Alam, Tao Wang, Yongping Yang, Baoshan Zhang, Stephen A. Migueles, Richard Wyatt, Barton F. Haynes, Peter D. Kwong, John R. Mascola, Mark Connors

Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea

Increased carotid intima-media thickness (IMT) and increased serum levels of inflammatory markers, such as C-reactive protein (CRP), interleukin (IL)-6, and IL-18, are associated with an increased risk of cardiovascular and cerebrovascular diseases. The...

How Far are Automatically Chosen Regression Smoothing Parameters from their Optimum

We address the problem of smoothing parameter selection for nonparametric curve estimators in the specific context of kernel regression estimation. Call the “optimal bandwidth” the minimizer of the average squared error. We consider several automatically...

Simulation of Transition with a Two-Equation Turbulence Model

This paper demonstrates how well the A>co turbulence model describes the nonlinear growth of flow instabilities from laminar flow into the turbulent flow regime. Viscous modifications are proposed for the A>co model that yield close agreement with measurements...

Networks formed from interdependent networks

Jianxi Gao, Sergey V. Buldyrev, H. Eugene Stanley, Shlomo Havlin

Measures of Conditional Linear Dependence and Feedback between Time Series

Measures of linear dependence and feedback for two multiple time series conditional on a third are defined. The measure of conditional linear dependence is the sum of linear feedback from the first to the second conditional on the third, linear feedback...

Violin Plots: A Box Plot-Density Trace Synergism

Many modifications build on Tukey's original box plot. A proposed further adaptation, the violin plot, pools the best statistical features of alternative graphical representations of batches of data. It adds the information available from local density...

Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials

Objective To determine whether treatment with agonists of glucagon-like peptide-1 receptor (GLP-1R) result in weight loss in overweight or obese patients with or without type 2 diabetes mellitus.Design Systematic review with meta-analyses.Data sources...

Cancer treatment and survivorship statistics, 2012†‡§

Although there has been considerable progress in reducing cancer incidence in the United States, the number of cancer survivors continues to increase due to the aging and growth of the population and improvements in survival rates. As a result, it is...

Pathogenesis of Obstructive and Central Sleep Apnea

Considerable progress has been made over the last several decades in our understanding of the pathophysiology of both central and obstructive sleep apnea. Central sleep apnea, in its various forms, is generally the product of an unstable ventilatory control...

Randomized Phase II Trial of Everolimus in Combination With Tamoxifen in Patients With Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer With Prior Exposure to Aromatase Inhibitors: A GINECO Stu

Purpose Cross-talk between signal transduction pathways likely contributes to hormone resistance in metastatic breast cancer (mBC). Everolimus, an oral inhibitor of the mammalian target of rapamycin, has restored sensitivity in endocrine-resistance models...

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Structures of G protein–coupled receptors (GPCRs) determined in the past few years, have provided insight into the function of this important family of membrane proteins. Liu et al. (p. [232][1]) used a protein-engineering strategy to produce a stabilized...

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

article i nfo Background: Cells continuously secrete a large number of microvesicles, macromolecular complexes, and small molecules into the extracellular space. Of the secreted microvesicles, the nanoparticles called exosomes are currently undergoing...

A Probability Distribution and its Uses in Fitting Data

A four-parameter probability distribution, which includes a wide variety of curve shapes, is presented. Because of the flexibility, generality, and simplicity of the distribution, it is useful in the representation of data when the underlying model is...

Variation and Commonality in Phenomenographic Research Methods.

This paper focuses on the data analysis stage of phenomenographic research, elucidating what is involved in terms of both commonality and variation in accepted practice. The analysis stage of phenomenographic research is often not well understood. This...

2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infections

Foot infections are a common and serious problem in persons with diabetes. Diabetic foot infections (DFIs) typically begin in a wound, most often a neuropathic ulceration. While all wounds are colonized with microorganisms, the presence of infection is...

International Principles For Social Impact Assessment

The “International Principles for Social Impact Assessment” is a statement of the core values of the SIA community together with a set of principles to guide SIA practice and the consideration of ‘the social’ in environmental impact assessment...

Routing Protocols in Wireless Sensor Networks: A Survey

Extensive usage of wireless sensor network (WSN) is the reason of development of many routing protocols. Recent advances in WSN now witness the increased interest in the potential use in applications like Military, Environmental, Health (Scanning), Space...

Environmental Transformations of Silver Nanoparticles: Impact on Stability and Toxicity

Silver nanoparticles (Ag-NPs) readily transform in the environment, which modifies their properties and alters their transport, fate, and toxicity. It is essential to consider such transformations when assessing the potential environmental impact of Ag-NPs....

The revised classification of eukaryotes.

This revision of the classification of eukaryotes, which updates that of Adl et al. [J. Eukaryot. Microbiol. 52 (2005) 399], retains an emphasis on the protists and incorporates changes since 2005 that have resolved nodes and branches in phylogenetic...

MCMC Analysis of Diffusion Models with Application to Finance

This article proposes a new method for estimation of parameters in diffusion processes from discrete observations. The method is based on Markov-chain Monte Carlo methodology and applies to a wide class of models including systems with unobservable state...

Treatment of HER2-positive breast cancer: current status and future perspectives

Carlos L. Arteaga, Mark X. Sliwkowski, C. Kent Osborne, Edith A. Perez, Fabio Puglisi, Luca Gianni

Rejection of Outliers

If one reading is a long way from the rest in a series of replicate determinations, or if in a least-squares analysis one reading is found to have a much greater residual than the others, there is temptation to reject it as spurious. Numerous criteria...

Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management.

#HASH##HASH##HASH# 5.1 GeneralWhen deciding the appropriate treatment strategy for active ulcerative colitis one should consider the activity, distribution (proctitis, left-sided, extensive1), and pattern of disease. The disease pattern includes relapse...

Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin: A tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial

Two hundred years ago, Henri Braconnot described a polysaccharide containing a substantial percent of nitrogen, later to be called chitin: that discovery stemmed from investigations on the composition of edible mushrooms and their nutritional value. The...

Fundamentals, processes and applications of high-permittivity polymer–matrix composites

There is an increasing need for high-permittivity (high- k ) materials due to rapid development of electrical/electronic industry. It is well-known that single composition materials cannot meet the high- k need. The combination of dissimilar materials...

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate...

A decade of weather extremes

Dim Coumou, Stefan Rahmstorf

Functional imaging studies of emotion regulation: a synthetic review and evolving model of the cognitive control of emotion

This paper reviews and synthesizes functional imaging research that over the past decade has begun to offer new insights into the brain mechanisms underlying emotion regulation. Toward that end, the first section of the paper outlines a model of the processes...

CT Angiography for Safe Discharge of Patients with Possible Acute Coronary Syndromes

Background Admission rates among patients presenting to emergency departments with possible acute coronary syndromes are high, although for most of these patients, the symptoms are ultimately found not to have a cardiac cause. Coronary computed tomographic...

Extremely efficient flexible organic light-emitting diodes with modified graphene anode

Tae-Hee Han, M. J. Choi, Seonghoon Woo, Sang‐Hoon Bae, Byung Hee Hong, J. Ahn, Tae-Woo Lee

3D carbon based nanostructures for advanced supercapacitors

Supercapacitors have attracted intense attention due to their great potential to meet the demand of both high energy density and power density in many advanced technologies. Various carbon-based nanocomposites are currently pursued as supercapacitor electrodes...

Advances in Biochemical Engineering Biotechnology

P. Zeng, Thomas Scheper, S. Hu, Cornelia Kasper

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Marica Bordicchia, Dianxin Liu, Ez-Zoubir Amri, Gérard Ailhaud, Paolo Dessì-Fulgheri, Chaoying Zhang, Nobuyuki Takahashi, Riccardo Sarzani, Sheila Collins

Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality.

Chronic obstructive pulmonary disease and other disorders, associated with reduced lung function, are strong risk factors for cardiovascular events, independent of smoking. Overall, when the lowest quintile of lung function, as measured by FEV1, is compared...

A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details

IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a...

Third universal definition of myocardial infarction

ACCF: American College of Cardiology FoundationACS: acute coronary syndromeAHA: American Heart AssociationCAD: coronary artery diseaseCABG: coronary artery bypass graftingCKMB: creatine kinase MB isoformcTn: cardiac troponinCT: computed...

Maximum Likelihood Estimation in the Weibull Distribution Based On Complete and On Censored Samples

This paper is concerned with the two-parameter Weibull distribution which is widely employed as a model in life testing. Maximum likelihood equations are derived for estimating the distribution parameters from (i) complete samples, (ii) singly censored...

Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity

SummaryBackgroundThe international (International Obesity Task Force; IOTF) body mass index (BMI) cut-offs are widely used to assess the prevalence of child overweight, obesity and thinness. Based on data from six countries fitted by the LMS method, they...

The Economic Way of Looking at Life

The economic approach My research uses economic approach to analyze social issues that range beyond those usually considered by economists. This lecture will describe the approach, and illustrate it with examples drawn from past and current work.

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

During cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identification of reprogramming...

A Critical Comparison of Three Strategies of Collecting Data from Households

Returns and findings from three strategies of data collection are compared. Each strategy contains personal interviews, telephone interviews, and mail questionnaires in different combinations—one mainly personal, one mainly telephone, and one mainly...

Lifetime Risks of Cardiovascular Disease

Background The lifetime risks of cardiovascular disease have not been reported across the age spectrum in black adults and white adults. Methods We conducted a meta-analysis at the individual level using data from 18 cohort studies involving a total of...

Why do people use Facebook

The social networking site, Facebook, has gained an enormous amount of popularity. In this article, we review the literature on the factors contributing to Facebook use. We propose a model suggesting that Facebook use is motivated by two primary needs:...

The economic cost of brain disorders in Europe

Background and purpose: In 2005, we presented for the first time overall estimates of annual costs for brain disorders (mental and neurologic disorders) in Europe. This new report presents updated, more accurate, and comprehensive 2010 estimates for 30...

Binomial Confidence Intervals

For X with Binomial (n, p) distribution, Section 1 gives a one-page table of .95 and .99 confidence intervals for p, for n = 1, 2, …, 30. This interval is equivariant under X → n − X and p → 1 − p, has approximately equal probability tails,...

The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change

Cyanobacteria are the most ancient phytoplankton on the planet and form harmful algal blooms in freshwater, estuarine, and marine ecosystems. Recent research suggests that eutrophication and climate change are two processes that may promote the proliferation...

Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks

Resting state functional connectivity reveals intrinsic, spontaneous networks that elucidate the functional architecture of the human brain. However, valid statistical analysis used to identify such networks must address sources of noise in order to avoid...

Obesity and Asthma

Asthma and obesity are prevalent disorders, each with a significant public health impact, and a large and growing body of literature suggests an association between the two. The systemic inflammatory milieu in obesity leads to metabolic and cardiovascular...

The 2012 Hormone Therapy Position Statement of The North American Menopause Society

Objective—This position statement aimed to update the evidence-based position statement published by The North American Menopause Society (NAMS) in 2010 regarding recommendations for hormone therapy (HT) for postmenopausal women. This updated position...

Health-related Quality of Life and Mortality in Male Patients with Chronic Obstructive Pulmonary Disease

To assess whether generic and specific health-related quality of sures were associated with the survival of patients with COPD life (HRQL) are independently associated with total and specific in two clinical trials (5, 6). These associations were indepenmortality...

Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)

These guidelines update previous guidance published in 2005. They have been revised by a group who are members of the UK and Ireland Neuroendocrine Tumour Society with endorsement from the clinical committees of the British Society of Gastroenterology,...

Toward almost closed genomes with GapFiller

De novo assembly is a commonly used application of next-generation sequencing experiments. The ultimate goal is to puzzle millions of reads into one complete genome, although draft assemblies usually result in a number of gapped scaffold sequences. In...

Top-down modulation: bridging selective attention and working memory

Selective attention, the ability to focus our cognitive resources on information relevant to our goals, influences working memory (WM) performance. Indeed, attention and working memory are increasingly viewed as overlapping constructs. Here, we review...

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

A balance between pro- and anti-inflammatory mechanisms at mucosal interfaces, which are sites of constitutive exposure to microbes and non-microbial foreign substances, allows for efficient protection against pathogens yet prevents adverse inflammatory...

Kynurenines in the mammalian brain: when physiology meets pathology

Robert Schwarcz, John P. Bruno, Paul J. Muchowski, Hui-Qiu Wu

Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome.

Rationale: The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an efficient maneuver to minimize it.Objectives: To test if a bedside recruitment strategy,...

Diketopyrrolopyrrole (DPP)-based materials for organic photovoltaics

Diketopyrrolopyrrole (DPP) pigments have been widely used in inks, paints, and plastics since it was first developed back in the early 1970s. The DPP-based materials were gradually exploited by optical and electrical applications for the excellent fluorescent...

An Analysis of Transformations Revisited

Following Box and Cox (1964), we assume that a transform Z i = h(Yi , λ) of our original data {Yi } satisfies a linear model. Consistency properties of the Box-Cox estimates (MLE's) of λ and the parameters in the linear model, as well as the asymptotic...

Broadband Light Bending with Plasmonic Nanoantennas

The precise manipulation of a propagating wave using phase control is a fundamental building block of optical systems. The wavefront of a light beam propagating across an interface can be modified arbitrarily by introducing abrupt phase changes. We experimentally...

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie Warholic, Christopher J. Sneeringer, Christina J. Allain, Christine Klaus, Joelle D Sacks, Alejandra Raimondi, Christina R. Majer, Jeffrey Song, Margaret Porter Scott, Jin L, Jesse J. Smith, Edward J. Olhava, Richard Chesworth, Mikel P. Moyer, Victoria M. Richon, Robert A. Copeland, Heike Keilhack, Roy M. Pollock

Biological studies of post-traumatic stress disorder

Roger K. Pitman, Ann M. Rasmusson, Karestan C. Koenen, Lisa M. Shin, Scott P. Orr, Mark W. Gilbertson, Mohammed R. Milad, Israel Liberzon

Covariance Analysis of Heart Transplant Survival Data

This paper presents a number of analyses to assess the effects of various covariates on the survival of patients in the Stanford Heart Transplantation Program. The data have been updated from pre- viously published versions and include some additional...

Designing antimicrobial peptides: form follows function

Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are becoming increasingly ineffective as a result of resistance, and it is imperative to find new antibacterial strategies. Natural antimicrobials, known as host...

Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Bernard Escudier, Tim Eisen, Camillo Porta, Jean Jacques Patard, V. Khoo, Ferran Algaba, Peter Mulders

Whole Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition

Matthew J. Ellis, Li Ding, Dong Shen, Jingqin Luo, Vera J. Suman, John W. Wallis, Brian A. Van Tine, Jeremy Hoog, Reece J. Goiffon, Ted Goldstein, Sam Ng, Li Lin, Robert Crowder, Jacqueline Snider, Karla Ballman, Jason Weber, Ken Chen, Daniel C. Koboldt, Cyriac Kandoth, William Schierding, Joshua F. McMichael, Christopher A. Miller, Charles Lu, Christopher C. Harris, Michael D. McLellan, Michael C. Wendl, Katherine DeSchryver, D. Craig Allred, Laura J. Esserman, Gary Unzeitig, Julie A. Margenthaler, Gildy V. Babiera, P. Kelly Marcom, J.M. Guenther, Marilyn Leitch, Kelly Hunt, John Olson, Yu Tao, Christopher A. Maher, Lucinda Fulton, Robert S. Fulton, Michelle Harrison, Ben Oberkfell, Feiyu Du, Ryan Demeter, Tammi L. Vickery, Adnan Elhammali, Helen Piwnica-Worms, Sandra A. McDonald, Mark A. Watson

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of a method to map it at single-base resolution on a genome-wide scale. Affinity purification-based methods cannot precisely locate 5hmC nor accurately determine its relative...

Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe

Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate. Although their hydrolysis spectrum may vary, they hydrolyse most β-lactams, including...

Equilibrium Beach Profiles: Characteristics and Applications

An understanding of equilibrium beach profiles can be useful in a number of types of coastal engineering projects. Empirical correlations between a scale parameter and the sediment size or fall velocity allow computation of equilibrium beach profiles....

What is Sustainable Development? Goals, Indicators, Values, and Practice

Kates W. Robert, Thomas M. Parris, Anthony Leiserowitz

Rating the methodological quality in systematic reviews of studies on measurement properties: a scoring system for the COSMIN checklist

Background The COSMIN checklist is a standardized tool for assessing the methodological quality of studies on measurement properties. It contains 9 boxes, each dealing with one measurement property, with 5–18 items per box about design aspects and statistical...

WHAT'S NEWS IN BUSINESS CYCLES

In this paper, we perform a structural Bayesian estimation of the contribution of anticipated shocks to business cycles in the postwar United States. Our theoretical framework is a real-business-cycle model augmented with four real rigidities: investment...

A Leavening Strategy to Prepare Reduced Graphene Oxide Foams

Zhiqiang Niu, Jun Chen, Huey Hoon Hng, Ma J, Xiaodong Chen

Exercise Capacity and Ventilatory, Circulatory, and Symptom Limitation in Patients with Chronic Airflow Limitation

Dyspnea, leg effort (Borg 0 to 10 scale), ventilation, and heart rate (emax/ecap; HRmax/HRcap expressed as a percentage of capacity) were measured at maximal exercise (cycle ergometer) in 97 patients with chronic airflow limitation (CAL)...

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