CiteWeb

WorldWeb citation database

Publications in 2012

Page 10
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale...

The Linear Programming Approach to Approximate Dynamic Programming

Daniela Pucci de Farias, Jennie Si, Andrew G. Barto, Warren B. Powell

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

MicroRNAs (miRNAs) are small, noncoding RNA genes that are found in the genomes of most eukaryotes, where they play an important role in the regulation of gene expression. Although whether gene activity is repressed by blocking translation of messenger...

Making Sense of MOOCs: Musings in a Maze of Myth, Paradox and Possibility

MOOCs (Massive Open Online Courses) are the educational buzzword of 2012. Media frenzy surrounds them and commercial interests have moved in. Sober analysis is overwhelmed by apocalyptic predictions that ignore the history of earlier educational technology...

ROS and redox signalling in the response of plants to abiotic stress

Nobuhiro Suzuki, Shai Koussevitzky, Ron Mittler, Gad Miller

A comparison study of basic data-driven fault diagnosis and process monitoring methods on the benchmark Tennessee Eastman process

This paper provides a comparison study on the basic data-driven methods for process monitoring and fault diagnosis (PM–FD). Based on the review of these methods and their recent developments, the original ideas, implementation conditions, off-line design...

Measuring the Benefits of Homeowning: Effects on Children Redux

We find that children of homeowners have better outcomes than children of renters whether their parents make a large or small initial investment in their home, as long as they make a minimal down payment when they buy their homes. Children with parents...

A Model of Airway Narrowing in Asthma and in Chronic Obstructive Pulmonary Disease

We have examined the effect of airway wall thickening, loss of lung recoil, and airway smooth muscle shortening on the increase in airway resistance using a model of the human tracheobronchial tree. The values for airway wall thickening were determined...

Nonparametric Statistical Data Modeling.

This article attempts to describe an approach to statistical data analysis which is simultaneously parametric and nonparametric. Given a random sample X 1, …, X n of a random variable X, one would like (1) to test the parametric goodness-of-fit hypothesis...

Bioethanol production from agricultural wastes: An overview

Due to rapid growth in population and industrialization, worldwide ethanol demand is increasing continuously. Conventional crops such as corn and sugarcane are unable to meet the global demand of bioethanol production due to their primary value of food...

The Life History of 21 Breast Cancers

Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic...

Neonicotinoid Pesticide Reduces Bumble Bee Colony Growth and Queen Production

Neonicotinoid insecticides were introduced in the early 1990s and have become one of the most widely used crop pesticides in the world. These compounds act on the insect central nervous system, and they have been shown to be persistent in the environment...

Benefits and Harms of CT Screening for Lung Cancer: A Systematic Review

Context Lung cancer is the leading cause of cancer death. Most patients are diagnosed with advanced disease, resulting in a very low 5-year survival. Screening may reduce the risk of death from lung cancer.Objective To conduct a systematic review of the...

Mixtures of g Priors for Bayesian Variable Selection

Zellner's g prior remains a popular conventional prior for use in Bayesian variable selection, despite several undesirable consistency issues. In this article we study mixtures of g priors as an alternative to default g priors that resolve many of the...

The Credit Ratings Game

The collapse of so many AAA-rated structured finance products in 2007-2008 has brought renewed attention to the causes of ratings failures and the conflicts of interest in the Credit Ratings Industry. We provide a model of competition among Credit Ratings...

Highly π‐Extended Copolymers with Diketopyrrolopyrrole Moieties for High‐Performance Field‐Effect Transistors

Huajie Chen, Yunlong Guo, Gui Yu, Yan Zhao, Ji Zhang, Dong Gao, Hongtao Liu, Yunqi Liu

Challenges and Opportunities for Measuring Physical Activity in Sedentary Adults

Increasing the physical activity of typically sedentary adult populations is at the forefront of the public health agenda. This review addresses the challenges in defining and measuring physical activity in this target group, for a number of purposes,...

Epitaxial Growth of a Silicene Sheet

Using atomic resolved scanning tunneling microscopy, we present here the experimental evidence of a silicene sheet (graphenelike structure) epitaxially grown on a close-packed silversurface [Ag(111)]. This has been achieved via direct condensation of...

Data Collection in a Flat World: Strengths and Weaknesses of Mechanical Turk Samples

Mechanical Turk (MTurk), an online labor system run by Amazon.com, provides quick, easy, and inexpensive access to online research participants. As use of MTurk has grown, so have questions from behavioral researchers about its participants, reliability,...

Smaller sulfur molecules promise better lithium-sulfur batteries.

The lithium–sulfur battery holds a high theoretical energy density, 4–5 times that of today’s lithium-ion batteries, yet its applications have been hindered by poor electronic conductivity of the sulfur cathode and, most importantly, the rapid fading...

Estimating Normal Means with a Dirichlet Process Prior

In this article, the Dirichlet process prior is used to provide a nonparametric Bayesian estimate of a vector of normal means. In the past there have been computational difficulties with this model. This article solves the computational difficulties by...

Linear Models for the Analysis of Longitudinal Studies

Longitudinal investigations play an increasingly prominent role in biomedical research. Much of the literature on specifying and fitting linear models for serial measurements uses methods based on the standard multivariate linear model. This article proposes...

The Efficiency of Logistic Regression Compared to Normal Discriminant Analysis

A random vector x arises from one of two multivariate normal distributions differing in mean but not covariance. A training set x 1, x 2, ··· x n of previous cases, along with their correct assignments, is known. These can be used to estimate Fisher's...

Multiple Imputation for Interval Estimation from Simple Random Samples with Ignorable Nonresponse

Several multiple imputation techniques are described for simple random samples with ignorable nonresponse on a scalar outcome variable. The methods are compared using both analytic and Monte Carlo results concerning coverages of the resulting intervals...

ABGD, Automatic Barcode Gap Discovery for primary species delimitation

Nicolas Puillandre, Alain Lambert, Sophie Brouillet, Guillaume Achaz

Parameter Estimates for Symmetric Stable Distributions

Building on results of an earlier article [6], estimators are suggested for the scale parameter and characteristic exponent of symmetric stable distributions, and Monte Carlo studies of these estimators are reported. The powers of various goodness-of-fit...

An Introduction to Kernel and Nearest-Neighbor Nonparametric Regression

Nonparametric regression is a set of techniques for estimating a regression curve without making strong assumptions about the shape of the true regression function. These techniques are therefore useful for building and checking parametric models, as...

Two Perspectives: On Self, Relationships, and Morality

Nona Plessner Lyons offers interview data from female and male children, adolescents, and adults in support of the assertions of Carol Gilligan (HER, 1977) that there are two distinct modes of describing the self in relation to others—separate/objective...

Towards an integrated crowdsourcing definition

'Crowdsourcing' is a relatively recent concept that encompasses many practices. This diversity leads to the blurring of the limits of crowdsourcing that may be identified virtually with any type of internet-based collaborative activity, such as co-creation...

The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy,...

Mechanical Ventilation Affects Local and Systemic Cytokines in an Animal Model of Acute Respiratory Distress Syndrome

We examined the hypothesis that injurious ventilatory strategies (large tidal volume [Vt] and/or low positive end-expiratory pressure [PEEP]) would increase release of inflammatory mediators into the lung and into the systemic circulation in a lung injury...

Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial

Summary Background Afatinib, an irreversible ErbB-family blocker, has shown preclinical activity when tested in EGFR mutant models with mutations that confer resistance to EGFR tyrosine-kinase inhibitors. We aimed to assess its effi cacy in patients with...

The European Sovereign Debt Crisis

The origin and propagation of the European sovereign debt crisis can be attributed to the flawed original design of the euro. In particular, there was an incomplete understanding of the fragility of a monetary union under crisis conditions, especially...

An Evaluation of Ten Pairwise Multiple Comparison Procedures by Monte Carlo Methods

Computer simulation techniques were used to study the Type I and Type III error rates and the correct decision rates for ten pairwise multiple comparison procedures. Results indicated that Scheffe's test, Tukey's test, and the Student-Newman-Keuls test...

n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.

BACKGROUND: The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown. METHODS: In this double-blind...

Findings of the 2012 workshop on statistical machine translation

This paper presents the results of the WMT12 shared tasks, which included a translation task, a task for machine translation evaluation metrics, and a task for run-time estimation of machine translation quality. We conducted a large-scale manual evaluation...

Random search for hyper-parameter optimization

Grid search and manual search are the most widely used strategies for hyper-parameter optimization. This paper shows empirically and theoretically that randomly chosen trials are more efficient for hyper-parameter optimization than trials on a grid. Empirical...

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Timothy R. Wilson, Jane Fridlyand, Yibing Yan, Elicia Penuel, Luciana Burton, Emily Chan, Jing Peng, Eva Lin, Yulei Wang, Jeffrey A. Sosman, Antoni Ribas, Jiang Li, John Moffat, Daniel P. Sutherlin, Hartmut Koeppen, Mark Merchant, Richard M. Neve, Jeffrey Settleman

Selecting the Number of Knots for Penalized Splines

Penalized splines, or P-splines, are regression splines fit by least-squares with a roughness penalty.P-splines have much in common with smoothing splines, but the type of penalty used with a P-spline is somewhat more general than for a smoothing spline....

Accounting for intermediates: Production sharing and trade in value added

We combine input–output and bilateral trade data to compute the value added content of bilateral trade. The ratio of value added to gross exports (VAX ratio) is a measure of the intensity of production sharing. Across countries, export composition drives...

Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease.

Treatment of chronic obstructive pulmonary disease (COPD) exacerbations improves outcomes; however, responses to treatment are variable, and patients with COPD often delay presentation or fail to seek therapy. The impact on exacerbation outcomes, hospitalization,...

Gene expression profiles and transcriptional regulatory pathways underlying mouse tissue macrophage identity and diversity

Emmanuel L. Gautier, Tal Shay, Jennifer Miller, Melanie Greter, Claudia Jakubzick, Stoyan Ivanov, Julie Helft, Andrew Chow, Kutlu G. Elpek, Simon Gordonov, Amin R. Mazloom, Avi Ma’ayan, Wei-Jen Chua, Ted H. Hansen, Shannon J. Turley, Miriam Merad, Gwendalyn J. Randolph

Application of Least Squares Regression to Relationships Containing Auto-Correlated Error Terms

We point out that autocorrelated error terms require modification of the usual methods of estimation and prediction; and we present evidence showing that the error terms involved in most current formulations of economic relations are highly positively...

A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention

Background The results of meta-analyses examining the relationship between vitamin D supplementation and fracture reduction have been inconsistent. Methods We pooled participant-level data from 11 double-blind, randomized, controlled trials of oral vitamin...

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Exposure to microbes during early childhood is associated with protection from immune-mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show that, in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate...

A travel guide to Cytoscape plugins

Rintaro Saito, Michael Smoot, Keiichiro Ono, Johannes Ruscheinski, Peng-Liang Wang, Samad Lotia, Alexander R. Pico, Gary D. Bader, Trey Ideker

Global political economy

The fourth edition of this popular text is a sophisticated and authoritative introduction to the field of global political economy that combines history and theoretical approaches with contemporary issues and debates. International experts have updated...

Cognitive reserve in ageing and Alzheimer's disease

The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others...

Direct Velocity Feedback Control of Large Space Structures

which relates the displacements u(x,t) of the equilibrium position of a flexible structure ft (a bounded open connected set with smooth boundary dfi in /7-dimensiona l space R") to the applied force distribution F(x,t). The mass density m(x) is a positive...

Council of Australian Governments

jurisdiction=Western Australia (Wa), contact=Tel: (+61 8) 9264 4111, Fax: (+61 8) 9264 5005, Web: http:, address=151 Royal Street, East Perth, Wa 6004

Mental health of displaced and refugee children resettled in high-income countries: risk and protective factors.

We undertook a systematic search and review of individual, family, community, and societal risk and protective factors for mental health in children and adolescents who are forcibly displaced to high-income countries. Exposure to violence has been shown...

Nanostructured metal oxide-based materials as advanced anodes for lithium-ion batteries.

The search for new electrode materials for lithium-ion batteries (LIBs) has been an important way to satisfy the ever-growing demands for better performance with higher energy/power densities, improved safety and longer cycle life. Nanostructured metal...

Comparison of the Coding Efficiency of Video Coding Standards—Including High Efficiency Video Coding (HEVC)

The compression capability of several generations of video coding standards is compared by means of peak signal-to-noise ratio (PSNR) and subjective testing results. A unified approach is applied to the analysis of designs, including H.262/MPEG-2 Video,...

Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

Background The prevalence of patent foramen ovale among patients with cryptogenic stroke is higher than that in the general population. Closure with a percutaneous device is often recommended in such patients, but it is not known whether this intervention...

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

Michael Remmert, Andreas Biegert, Andreas Hauser, Johannes Söding

Butterfly genome reveals promiscuous exchange of mimicry adaptations among species

The evolutionary importance of hybridization and introgression has long been debated1. Hybrids are usually rare and unfit, but even infrequent hybridization can aid adaptation by transferring beneficial traits between species. Here we use genomic tools...

Structure of the δ-opioid receptor bound to naltrindole

Sébastien Granier, Aashish Manglik, Andrew C. Kruse, Tong Sun Kobilka, Foon Sun Thian, William I. Weis, Brian K. Kobilka

Effectiveness of Long-Acting Reversible Contraception

METHODS We designed a large prospective cohort study to promote the use of long-acting reversible contraceptive methods as a means of reducing unintended pregnancies in our region. Participants were provided with reversible contraception of their choice...

A Survey of Monte Carlo Tree Search Methods

Monte Carlo tree search (MCTS) is a recently proposed search method that combines the precision of tree search with the generality of random sampling. It has received considerable interest due to its spectacular success in the difficult problem of computer...

The relationship between frequency of Facebook use, participation in Facebook activities, and student engagement

Educators and others are interested in the effects of social media on college students, with a specific focus on the most popular social media website-Facebook. Two previous studies have examined the relationship between Facebook use and student engagement,...

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

shuttle miRNAs and DC functions can be regulated by exogenous miRNAs, suggest that DC-to-DC interactions could be mediated through exosome-shuttle miRNAs, a hypothesis that remains to be tested. Importantly, the mechanism of transfer of exosome-shuttle...

Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non–Small-Cell Lung Cancer: Results From a Randomized, Double-Blind, Multicenter Phase II Study

Purpose Ipilimumab, which is an anti– cytotoxic T-cell lymphocyte-4 monoclonal antibody, showed a survival benefit in melanoma with adverse events (AEs) managed by protocol-defined guidelines. A phase II study in lung cancer assessed the activity of...

Asymptotic Theory of Least Absolute Error Regression

In the general linear model with independent and identically distributed errors and distribution function F, the estimator which minimizes the sum of absolute residuals is demonstrated to be consistent and asymptotically Gaussian with covariance matrix...

Local Likelihood Estimation

A scatterplot smoother is applied to data of the form {(x 1, y 1), (x 2, y 2, …, (xn, yn )} and uses local fitting to estimate the dependence of Y on X. A simple example is the running lines smoother, which fits a least squares line to the y values...

Approach and Avoidance Motivation

In this article, we introduce this special issue by establishing a conceptual foundation for the distinction between approach and avoidance motivation. We do so primarily by explicating several reasons why the approach‐avoidance distinction should be...

International evidence-based recommendations for point-of-care lung ultrasound

Mahmoud Elbarbary, Michael Blaivas, Daniel A. Lichtenstein, Lawrence A. Melniker, Luna Gargani, Vicki E. Noble, Gabriele Via, Anthony J. Dean, James W. Tsung, Roberto Copetti, Bélaïd Bouhemad, Angelika Reissig, Eustachio Agricola, Jean-Jacques Rouby, Charlotte Arbelot, Andrew S. Liteplo, Ashot E. Sargsyan, Fernando R. Silva, Richard Hoppmann, Raoul Breitkreutz, Luca Neri, Enrico Storti, Tomislav Petrovic

Instantaneous spectral analysis: Detection of low-frequency shadows associated with hydrocarbons

Instantaneous spectral analysis (ISA) is a continuous time-frequency analysis technique that provides a frequency spectrum for each time sample of a seismic trace. ISA achieves both excellent time and frequency localization utilizing wavelet transforms...

Prevalence of Oral HPV Infection in the United States, 2009-2010

Context Human papillomavirus (HPV) infection is the principal cause of a distinct form of oropharyngeal squamous cell carcinoma that is increasing in incidence among men in the United States. However, little is known about the epidemiology of oral HPV...

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Christopher E. Barbieri, Sylvan C. Baca, Michael S. Lawrence, Francesca Demichelis, Mirjam Blattner, Jean-Philippe Theurillat, Thomas A. White, Petar Stojanov, Eliezer M. Van Allen, Nicolas Stransky, Elizabeth Nickerson, Sung-Suk Chae, Gunther Boysen, Daniel Auclair, Robert Onofrio, Kyung Park, Naoki Kitabayashi, Theresa Y. MacDonald, Karen Sheikh, Terry Vuong, Candace Guiducci, Kristian Cibulskis, Andrey Sivachenko, Scott L. Carter, Gordon Saksena, Douglas Voet, Wasay M Hussain, Alex H. Ramos, Wendy Winckler, Michelle C Redman, Kristin Ardlie, Ashutosh Tewari, Juan Miguel Mosquera, Niels J. Rupp, Peter Wild, Holger Moch, Colm Morrissey, Peter S. Nelson, Philip W. Kantoff, Stacey Gabriel, Todd R. Golub, Matthew Meyerson, Eric S. Lander, Gad Getz, Mark A. Rubin, Levi A. Garraway

Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States

Ronald C. Kessler, Maria Petukhova, Nancy A. Sampson, Alan M. Zaslavsky, Hans-Ullrich Wittchen

Radiofrequency ablation of renal cell carcinoma: part 1, Indications, results, and role in patient management over a 6-year period and ablation of 100 tumors.

OBJECTIVE. The objectives of our article are to review our experience with radiofrequency ablation of renal cell carcinoma and to assess size and location as predictors of the ability to achieve complete necrosis by imaging criteria.MATERIALS AND METHODS....

Bayesian Variable Selection in Linear Regression

This article is concerned with the selection of subsets of predictor variables in a linear regression model for the prediction of a dependent variable. It is based on a Bayesian approach, intended to be as objective as possible. A probability distribution...

TOPOLOGICAL ORDERS IN RIGID STATES

We study a new kind of ordering — topological order — in rigid states (the states with no local gapless excitations). We concentrate on characterization of the different topological orders. As an example we discuss in detail chiral spin states of...

Errors of Measurement in Statistics

In this review of some of the recent work in the study of errora of measurement, attention is centered on the type of mathematical model used to represent errom of measurement, on the extent to which standard techniques of analysis become erroneous and...

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

Recombinant tissue plasminogen activator (rt-PA, alteplase) improved functional outcome in patients treated soon after acute ischaemic stroke in randomised trials, but licensing is restrictive and use varies widely. The IST-3 trial adds substantial new...

Wisdom of crowds for robust gene network inference

aureus, Saccharomyces cerevisiae and in silico microarray data. We characterize the performance, data requirements and inherent biases of different inference approaches, and we provide guidelines for algorithm application and development. We observed...

A Bivariate Extension of the Exponential Distribution

A bivariate extension of the exponential distribution is proposed as a model for certain problems in life testing. It applies, in particular, to two-component systems, which can function even if one of the components has failed. Various statistical properties...

Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica

Rationale: Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood.Objectives:...

Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants

► Small RNAs are important regulators of gene expression in plants and animals. ► Plant small RNAs play a role in biotic and abiotic stress responses. ► The expression of many miRNAs is responsive to various stresses. ► Stress-responsive small...

Trimmed Least Squares Estimation in the Linear Model

We consider two methods of defining a regression analog to a trimmed mean. The first was suggested by Koenker and Bassett and uses their concept of regression quantiles. Its asymptotic behavior is completely analogous to that of a trimmed mean. The second...

Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study.

patients who had a PSA response (235 [29·5%] of 797 patients vs 22 [5·5%] of 398; p<0·0001) were all improved in the abiraterone group compared with the placebo group. The most common grade 3–4 adverse events were fatigue (72 [9%]...

Development as the Aim of Education

The authors offer an explanation of the psychological and philosophical positions underlying aspects of educational progressivism. They contrast tenets of progressivism, most clearly identified with the work of John Dewey, with two other educational ideologies,...

Roll-to-roll fabrication of polymer solar cells

As the performance in terms of power conversion efficiency and operational stability for polymer and organic solar cells is rapidly approaching the key 10-10 targets (10 % efficiency and 10 years of stability) the quest for efficient, scalable, and rational...

The global CMT project 2004–2010: Centroid-moment tensors for 13,017 earthquakes

Earthquake moment tensors reflecting seven years of global seismic activity (2004–2010) are presented. The results are the product of the global centroid-moment-tensor (GCMT) project, which maintains and extends a catalog of global seismic moment tensors...

Measuring the Value of Housing Quality

Based on an extensive sample of individual dwelling units, this article estimates the market value, or the implicit prices, of specific aspects of the bundles of residential services consumed by urban households. Quantitative estimates were obtained by...

The acute respiratory distress syndrome.

The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure that is often associated with multiple organ failure. Several clinical disorders can precipitate ARDS, including pneumonia, sepsis, aspiration of gastric...

Large-Scale Bayesian Logistic Regression for Text Categorization

[This abstract is based on the authors’ abstract.] Logistic regression analysis of high-dimension data, such as natural language texts, poses computational and statistical challenges not readily met by maximum likelihood estimation. A simple Bayesian...

The JAK-STAT pathway at twenty.

George R. Stark, James E. Darnell

Executive functions and self-regulation

Self-regulation is a core aspect of adaptive human behavior that has been studied, largely in parallel, through the lenses of social and personality psychology as well as cognitive psychology. Here, we argue for more communication between these disciplines...

Large Scale Distributed Deep Networks

Recent work in unsupervised feature learning and deep learning has shown that being able to train large models can dramatically improve performance. In this paper, we consider the problem of training a deep network with billions of parameters using tens...

Mining actionlet ensemble for action recognition with depth cameras

Human action recognition is an important yet challenging task. The recently developed commodity depth sensors open up new possibilities of dealing with this problem but also present some unique challenges. The depth maps captured by the depth cameras...

Changes in Clinical and Physiologic Variables Predict Survival in Idiopathic Pulmonary Fibrosis

There is significant heterogeneity in survival time among patients with idiopathic pulmonary fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive...

Skeletal Muscle Adaptation to Endurance Training in Patients with Chronic Obstructive Pulmonary Disease

The purpose of this study was to evaluate the physiologic responses to endurance training in patients with moderate to severe airflow obstruction by specifically looking at changes in skeletal muscle enzy­ matic activities. Eleven patients (age = 65...

Metal–Oxide RRAM

In this paper, recent progress of binary metal-oxide resistive switching random access memory (RRAM) is reviewed. The physical mechanism, material properties, and electrical characteristics of a variety of binary metal-oxide RRAM are discussed, with a...

Large-Pore Apertures in a Series of Metal-Organic Frameworks

We report a strategy to expand the pore aperture of metal-organic frameworks (MOFs) into a previously unattained size regime (>32 angstroms). Specifically, the systematic expansion of a well-kno ...

Review of biodiesel composition, properties, and specifications

Biodiesel is a renewable transportation fuel consisting of fatty acid methyl esters (FAME), generally produced by transesterification of vegetable oils and animal fats. In this review, the fatty acid (FA) profiles of 12 common biodiesel feedstocks were...

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

animals used (i.e., species/strain, sex, and age/weight). Most of the papers surveyed did not report using randomisation (87%) or blinding (86%) to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical...

Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes.

All episodes of ventilator-associated pneumonia (VAP) caused by Staphylococcus aureus were prospec­ tively analyzed for a 30-mo period. Methicillin-sensitive S. aureus (MSSA) was isolated in 38 episodes and methicillin-resistant S. aureus (MRSA) in 11...

A global synthesis reveals biodiversity loss as a major driver of ecosystem change

Evidence is mounting that extinctions are altering key processes important to the productivity and sustainability of Earth’s ecosystems 1–4 . Further species loss will accelerate change in ecosystem processes 5–8 , but it is unclear how these effects...

Vorapaxar in the Secondary Prevention of Atherothrombotic Events

Morrow, David A Braunwald, Eugene Bonaca, Marc P Ameriso, Sebastian F Dalby, Anthony J Fish, Mary Polly Fox, Keith A A Lipka, Leslie J Liu, Xuan Nicolau, Jose Carlos Ophuis, A J Oude Paolasso, Ernesto Scirica, Benjamin M Spinar, Jindrich Theroux, Pierre...

Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study.

Aims/hypothesis The Di@bet.es Study is the first national study in Spain to examine the prevalence of diabetes and impaired glucose regulation. Methods A population-based, cross-sectional, cluster sampling study was carried out, with target population...

The Sleep Hypopnea Syndrome

We have observed patients who clinically have the obstructive sleep apnea syndrome but have no apneas, instead having recurrent nocturnal hypoventilation. There is disagreement about the definition and significance of such sleep-related hypopneas. We...

The ethical, social and environmental reporting‐performance portrayal gap

The purpose of this article is twofold. First, it assesses in detail the extent to which corporate reporting on ethical, social and environmental issues reflects corporate performance in case study company Alpha. This “reporting‐performance” portrayal...

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3.3 in one-third of pediatric...

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.

The pathogenesis of asthma remains unclear. An in vivo murine model of antigen-induced airway hyperreactivity and inflammation was developed to investigate the possibility, suggested by a wealth of descriptive human data, that alterations in immunoregulation...

Racial differences in sleep-disordered breathing in African-Americans and Caucasians.

In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members...

High-mobility and low-power thin-film transistors based on multilayer MoS2 crystals

Sunkook Kim, Aniruddha Konar, Wan Sik Hwang, Jong Hak Lee, Jiyoul Lee, Jaehyun Yang, Changhoon Jung, Hyoung-Sub Kim, Ji-Beom Yoo, Yong Wan Jin, Sang Yoon Lee, Debdeep Jena, Woong Choi, Kinam Kim

Marketing research : an applied approach

Naresh K. Malhotra, David F. Birks, Peter Wills

Drought, salt, and temperature stress-induced metabolic rearrangements and regulatory networks

Plants regularly face adverse growth conditions, such as drought, salinity, chilling, freezing, and high temperatures. These stresses can delay growth and development, reduce productivity, and, in extreme cases, cause plant death. Plant stress responses...

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