CiteWeb

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Publications in 2012

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Nonparametric Estimation from Incomplete Observations

In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss)....

Distribution of the Estimators for Autoregressive Time Series with a Unit Root

Let n observations Y 1, Y 2, ···, Y n be generated by the model Y t = pY t−1 + e t , where Y 0 is a fixed constant and {e t } t-1 n is a sequence of independent normal random variables with mean 0 and variance σ2....

Hierarchical Grouping to Optimize an Objective Function

A procedure for forming hierarchical groups of mutually exclusive subsets, each of which has members that are maximally similar with respect to specified characteristics, is suggested for use in large-scale (n > 100) studies when a precise optimal solution...

Response surface methodology : process and product optimization using designed experiments

Raymond H. Myers, Douglas C. Montgomery, Christine M. Anderson-Cook

Cancer statistics, 2012†‡

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the...

Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC

This article is published Open Access at sciencedirect.com. It is distributed under the terms of the Creative Commons AttributionLicense 3.0.-- Chatrchyan, S. et al.

R: A Language for Data Analysis and Graphics

languages-Becker, Chambers, and Wilks' S (1985) and Steel and Sussman's Scheme (1975). We felt that there were strong points in each of these languages and that it would be interesting to see if the strengths could be combined. The resulting language...

Structural equation modeling with Mplus: Basic concepts, applications, and programming

Psychology is a science that advances by leaps and bounds. The impulse of new mathematical models along with the incorporation of computers to research has drawn a new reality with many methodological progresses that only a few people could imagine not...

Robust Locally Weighted Regression and Smoothing Scatterplots

The visual information on a scatterplot can be greatly enhanced, with little additional cost, by computing and plotting smoothed points. Robust locally weighted regression is a method for smoothing a scatterplot, (x i , y i ), i = 1, …, n, in which...

Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC

Articulo escrito por muchos autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboracion y los autores que firman como pertenecientes a la UAM

NIH Image to ImageJ: 25 years of image analysis

Caroline Schneider, Wayne Rasband, Kevin W. Eliceiri

An integrated encyclopedia of DNA elements in the human genome

The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor...

The Colonial Origins of Comparative Development: An Empirical Investigation: Reply

In Acemoglu, Johnson, and Robinson, henceforth AJR, (2001), we advanced the hypothesis that the mortality rates faced by Europeans in different parts of the world after 1500 affected their willingness to establish settlements and choice of colonization...

Sampling-Based Approaches to Calculating Marginal Densities

Stochastic substitution, the Gibbs sampler, and the sampling-importance-resampling algorithm can be viewed as three alternative sampling- (or Monte Carlo-) based approaches to the calculation of numerical estimates of marginal probability distributions....

The American-European Consensus Conference on ARDS : definitions, mechanisms, relevant outcomes, and clinical trial coordination

The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the...

Introduction to linear regression analysis

Douglas C. Montgomery, Elizabeth Peck, G. Geoffrey Vining

Use of Ranks in One-Criterion Variance Analysis

Given C samples, with n i observations in the ith sample, a test of the hypothesis that the samples are from the same population may be made by ranking the observations from from 1 to Σn i (giving each observation in a group of ties the mean of the ranks...

Probability Inequalities for Sums of Bounded Random Variables

Upper bounds are derived for the probability that the sum S of n independent random variables exceeds its mean ES by a positive number nt. It is assumed that the range of each summand of S is bounded or bounded above. The bounds for Pr {S – ES ≥ nt}...

The Acute Respiratory Distress Syndrome

The acute respiratory distress syndrome is a common, devastating clinical syndrome of acute lung injury that affects both medical and surgical patients. Since the last review of this syndrome appeared in the Journal, 1 more uniform definitions have been...

The R Book

The high-level language of R is recognized as one of the most powerful and flexible statistical software environments, and is rapidly becoming the standard setting for quantitative analysis, statistics and graphics. R provides free access to unrivalled...

A proportional hazards model for the subdistribution of a competing risk

With explanatory covariates, the standard analysis for competing risks data involves modeling the cause-specific hazard functions via a proportional hazards assumption. Unfortunately, the cause-specific hazard function does not have a direct interpretation...

An integrated map of genetic variation from 1,092 human genomes

By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14...

Fractals Everywhere

Focusing on how fractal geometry can be used to model real objects in the physical world, this up-to-date edition featurestwo 16-page full-color inserts, problems and tools emphasizing fractal applications, and an answers section. A bonus CD of an IFS...

Software Architecture in Practice

The award-winning and highly influential Software Architecture in Practice, Third Edition, has been substantially revised to reflect the latest developments in the field. In a real-world setting, the book once again introduces the concepts and best practices...

An Efficient Method of Estimating Seemingly Unrelated Regressions and Tests for Aggregation Bias

In this paper a method of estimating the parameters of a set of regression equations is reported which involves application of Aitken's generalized least-squares [11 to the whole system of equations. Under conditions generally encountered in practice,...

Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association

Véronique L. Roger, Alan S. Go, Donald M. Lloyd-Jones, Emelia J. Benjamin, Jarett D. Berry, William B. Borden, Dawn M. Bravata, Shifan Dai, Earl S. Ford, Caroline S. Fox, Heather J. Fullerton, Cathleen Gillespie, Susan M. Hailpern, John A. Heit, Virginia J. Howard, Brett Kissela, Steven J. Kittner, Daniel T. Lackland, Judith H. Lichtman, Lynda D. Lisabeth, Diane M. Makuc, Gregory M. Marcus, Ariane J. Marelli, David B. Matchar, Claudia S. Moy, Dariush Mozaffarian, Michael E. Mussolino, Graham Nichol, Nina P. Paynter, Elsayed Z. Soliman, Paul D. Sorlie, Nona Sotoodehnia, Tanya N. Turan, Salim S. Virani, Nathan D. Wong, Daniel Woo, Melanie B. Turner

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Background Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We assessed the antitumor activity and safety of BMS-936558, an antibody that specifically blocks PD-1. Methods We enrolled...

Adapting to Unknown Smoothness via Wavelet Shrinkage

We attempt to recover a function of unknown smoothness from noisy sampled data. We introduce a procedure, SureShrink, that suppresses noise by thresholding the empirical wavelet coefficients. The thresholding is adaptive: A threshold level is assigned...

ImageNet Classification with Deep Convolutional Neural Networks

We trained a large, deep convolutional neural network to classify the 1.3 million high-resolution images in the LSVRC-2010 ImageNet training set into the 1000 different classes. On the test data, we achieved top-1 and top-5 error rates of 39.7\% and 18.9\%...

Families and family therapy

Sylvia Clavan, Salvador Minuchin

An Overview of CMIP5 and the Experiment Design

The fifth phase of the Coupled Model Intercomparison Project (CMIP5) will produce a state-of-the- art multimodel dataset designed to advance our knowledge of climate variability and climate change. Researchers worldwide are analyzing the model output...

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 : The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the...

An Integrated Encyclopedia of DNA Elements in the Human Genome

Bradley E. Bernstein, Ewan Birney, Ian Dunham, Eric D. Green, Chris Gunter, Michael Snyder, Tim Hubbard

Approximate Inference in Generalized Linear Mixed Models

Statistical approaches to overdispersion, correlated errors, shrinkage estimation, and smoothing of regression relationships may be encompassed within the framework of the generalized linear mixed model (GLMM). Given an unobserved vector of random effects,...

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate...

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. Methods To examine intratumor heterogeneity, we performed exome sequencing,...

Structural Equation Modeling

Jodie B. Ullman, Peter M. Bentler

Comprehensive molecular portraits of human breast tumours.

Daniel C. Koboldt, Robert S. Fulton, Michael D. McLellan, Heather Schmidt, Joelle Kalicki-Veizer, Joshua F. McMichael, Lucinda Fulton, David J. Dooling, Li Ding, Elaine R. Mardis, Richard K. Wilson, Adrian Ally, Miruna Balasundaram, Yaron S. N. Butterfield, Rebecca Carlsen, Candace D. Carter, Andy Chu, Eric Chuah, Hye-Jung E. Chun, Robin Coope, Noreen Dhalla, Ranabir Guin, Carrie Hirst, Martin Hirst, Robert A. Holt, Darlene Lee, Haiyan I. Li, Michael Mayo, Richard Moore, Andrew J. Mungall, Erin Pleasance, A. Gordon Robertson, Jacqueline E. Schein, Arash Shafiei, Payal Sipahimalani, Jared R. Slobodan, Dominik Stoll, Angela Tam, Nina Thiessen, Richard Varhol, Natasja Wye, Thomas Zeng, Yongjun Zhao, Inanc Birol, Steven J. M. Jones, Marco A. Marra, Andrew D. Cherniack, Gordon Saksena, Robert C. Onofrio, Nam H. Pho

European Review of Social Psychology

Wolfgang Stroebe, Miles Hewstone, A.S.R. Manstead

Analog Integrated Circuit Design

Tony Chan Carusone, D.A. Johns, Kenneth W. (Kenneth William) Martin

Locally Weighted Regression: An Approach to Regression Analysis by Local Fitting

Locally weighted regression, or loess, is a way of estimating a regression surface through a multivariate smoothing procedure, fitting a function of the independent variables locally and in a moving fashion analogous to how a moving average is computed...

Problems with Instrumental Variables Estimation when the Correlation between the Instruments and the Endogenous Explanatory Variable is Weak

We draw attention to two problems associated with the use of instrumental variables (IV), the importance of which for empirical work has not been fully appreciated. First, the use of instruments that explain little of the variation in the endogenous explanatory...

The Calculation of Posterior Distributions by Data Augmentation

The idea of data augmentation arises naturally in missing value problems, as exemplified by the standard ways of filling in missing cells in balanced two-way tables. Thus data augmentation refers to a scheme of augmenting the observed data so as to make...

Principal Component Analysis

Jian Guo Liu, Philippa J. Mason

Fast gapped-read alignment with Bowtie 2

Ben Langmead, Steven L. Salzberg

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors...

Experimentation in Software Engineering

Like other sciences and engineering disciplines, software engineering requires a cycle of model building, experimentation, and learning. Experiments are valuable tools for all software engineers who are involved in evaluating and choosing between different...

Objective Criteria for the Evaluation of Clustering Methods

Many intuitively appealing methods have been suggested for clustering data, however, interpretation of their results has been hindered by the lack of objective criteria. This article proposes several criteria which isolate specific aspects of the performance...

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012

The originally published version of this paper was incorrect. In the table on page 1816, the Class of recommendation and Level of evidence for ‘The patient is pacemaker dependent as a result of AV …

Guidelines for the use and interpretation of assays for monitoring autophagy

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies...

Antiretroviral Treatment of Adult HIV Infection 2012 Recommendations of the International Antiviral Society-USA Panel

Melanie Thompson, Judith A. Aberg, Jennifer Hoy, Amalio Telenti, Constance A. Benson, Pedro Cahn, Joseph J. Eron, Huldrych F. Günthard, Scott M. Hammer, Peter Reiss, Douglas D. Richman, G. Rizzardini, David L. Thomas, Donna M. Jacobsen, Paul A. Volberding

The Monte Carlo Method

We shall present here the motivation and a general description of a method dealing with a class of problems in mathematical physics. The method is, essentially, a statistical approach to the study of differential equations, or more generally, of integro-differential...

Understanding the Metropolis-Hastings Algorithm

We provide a detailed, introductory exposition of the Metropolis-Hastings algorithm, a powerful Markov chain method to simulate multivariate distributions. A simple, intuitive derivation of this method is given along with guidance on implementation. Also...

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin W. Eliceiri, Pavel Tomancak, Albert Cardona

MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice across a Large Model Space

Since its introduction in 2001, MrBayes has grown in popularity as a software package for Bayesian phylogenetic inference using Markov chain Monte Carlo (MCMC) methods. With this note, we announce the release of version 3.2, a major upgrade to the latest...

Rank Transformations as a Bridge between Parametric and Nonparametric Statistics

Many of the more useful and powerful nonparametric procedures may be presented in a unified manner by treating them as rank transformation procedures. Rank transformation procedures are ones in which the usual parametric procedure is applied to the ranks...

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

Background Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play a pivotal role in the ability of tumor cells to evade the host's immune system. Blockade of interactions between PD-1 and PD-L1 enhances...

Statistics and Causal Inference

Problems involving causal inference have dogged at the heels of statistics since its earliest days. Correlation does not imply causation, and yet causal conclusions drawn from a carefully designed experiment are often valid. What can a statistical model...

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

Results In 2009-2010 the age-adjusted mean BMI was 28.7 (95% CI, 28.3-29.1) for men and also 28.7 (95% CI, 28.4-29.0) for women. Median BMI was 27.8 (interquartile range [IQR], 24.7-31.7) for men and 27.3 (IQR, 23.3-32.7) for women. The...

mTOR Signaling in Growth Control and Disease

Mathieu Laplante, David M. Sabatini

Structure, function and diversity of the healthy human microbiome

Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics...

jModelTest 2: more models, new heuristics and parallel computing

Diego Darriba, Guillermo L. Taboada, Ramón Doallo, David Posada

2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation--developed with the special contribution of the European Heart Rhythm Association.

2012 focused update of the ESC Guidelines for the management of atrial fibrillation : an update of the 2010 ESC Guidelines for the management of atrial fibrillation: developed with the special contribution of the European Heart Rhythm Association

Bayesian Phylogenetics with BEAUti and the BEAST 1.7

Computational evolutionary biology, statistical phylogenetics, and coalescent-based population genetics are becoming increasingly central to the analysis and understanding of molecular sequence data. We present the Bayesian Evolutionary Analysis by Sampling...

Prevalence of lifetime DSM-IV affective disorders among older African Americans, Black Caribbeans, Latinos, Asians and Non-Hispanic White people

Amanda Toler Woodward, Robert Joseph Taylor, Kai McKeever Bullard, María P. Aranda, Karen D. Lincoln, Linda M. Chatters

Li-O2 and Li-S batteries with high energy storage

Peter G. Bruce, Stefan A. Freunberger, Laurence J. Hardwick, Jean‐Marie Tarascon

A Leisurely Look at the Bootstrap, the Jackknife, and Cross-Validation

This is an invited expository article for The American Statistician. It reviews the nonparametric estimation of statistical error, mainly the bias and standard error of an estimator, or the error rate of a prediction rule. The presentation is written...

Least Median of Squares Regression

Classical least squares regression consists of minimizing the sum of the squared residuals. Many authors have produced more robust versions of this estimator by replacing the square by something else, such as the absolute value. In this article a different...

GenAlEx 6.5: Genetic analysis in Excel. Population genetic software for teaching and research – an update.

Summary: GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and DNA sequences. Both frequency-based...

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs)...

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic...

Reducing Bias in Observational Studies Using Subclassification on the Propensity Score

The propensity score is the conditional probability of assignment to a particular treatment given a vector of observed covariates. Previous theoretical arguments have shown that subclassification on the propensity score will balance all observed covariates....

Observed Gender Differences in African American Mother-Child Relationships and Child Behavior

Jelani Mandara, Carolyn B. Murray, James Telesford, Fatima Varner, Scott Richman

On the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown

The standard tables used for the Kolmogorov-Smirnov test are valid when testing whether a set of observations are from a completely-specified continuous distribution. If one or more parameters must be estimated from the sample then the tables are no longer...

Third Universal Definition of Myocardial Infarction

Kristian Thygesen, Joseph S. Alpert, Allan S. Jaffe, Maarten L. Simoons, Bernard R. Chaitman, Harvey D. White

General Methods for Monitoring Convergence of Iterative Simulations

We generalize the method proposed by Gelman and Rubin (1992a) for monitoring the convergence of iterative simulations by comparing between and within variances of multiple chains, in order to obtain a family of tests for convergence. We review methods...

The concept of law

H. L. A. (Herbert Lionel Adolphus) Hart

2012 focused update of the ESC Guidelines for the management of atrial fibrillation

Atrial fibrillation; European Society of Cardiology; Guidelines; Anticoagulation; Novel oral anticoagulants; Left atrial appendage occlusion; Rate control; Cardioversion; Rhythm control; Antiarrhythmic drugs; Upstream therapy; Pulmonary vein isolation;...

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)

Examines Cardiovascular disease:  Prevention  Risk assessment  Risk management  Smoking  Nutrition  Physical activity  Psychosocial factors

The Truly Disadvantaged

Renowned American sociologist William Julius Wilson takes a look at the social transformation of inner city ghettos, offering a sharp evaluation of the convergence of race and poverty. Rejecting both conservative and liberal interpretations of life in...

Information Visualization: Perception for Design

Most designers know that yellow text presented against a blue background reads clearly and easily, but how many can explain why, and what really are the best ways to help others and ourselves clearly see key patterns in a bunch of data? When we use software,...

The adaptive lasso and its oracle properties

The lasso is a popular technique for simultaneous estimation and variable selection. Lasso variable selection has been shown to be consistent under certain conditions. In this work we derive a necessary condition for the lasso variable selection to be...

Ventilator-Associated Pneumonia

Ventilator-associated pneumonia (VAP) continues to complicate the course of 8 to 28% of patients receiving mechanical ventilation (MV). In contrast to infections of more frequently involved organs (e.g., urinary tract and skin), for which mortality is...

KEGG for integration and interpretation of large-scale molecular data sets

Minoru Kanehisa, Susumu Goto, Yoko Sato, Miho Furumichi, Mao Tanabe

Estimates of the Regression Coefficient Based on Kendall's Tau

The least squares estimator of a regression coefficient β is vulnerable to gross errors and the associated confidence interval is, in addition, sensitive to non-normality of the parent distribution. In this paper, a simple and robust (point as well as...

Spirometric Reference Values from a Sample of the General U.S. Population

Spirometric reference values for Caucasians, African-Americans, and Mexican-Americans 8 to 80 yr of age were developed from 7,429 asymptomatic, lifelong nonsmoking participants in the third National Health and Nutrition Examination Survey (NHANES III)....

Intellectual capital: an exploratory study that develops measures and models

This paper details an empirical pilot study that explores the development of several conceptual measures and models regarding intellectual capital and its impact on business performance. The objective of this pilot study is to explore the development...

A taxonomy and evaluation for developing 802.11-based wireless mesh network testbeds

The definition of wireless mesh networks (WMNs) has been used in the literature to connote and epitomize the ideal, ubiquitous, pervasive, and autonomic networking technology. An increasing interest has been emerging on the development of 802.11-based...

ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation

Ph. Gabriel Steg, Dan Atar, Carina Blomstrom Lundqvist, Michael A. Borger, Carlo Di Mario, Francisco Fernández-Avilés, Pantaleo Giannuzzi, Sigrun Halvorsen, Kurt Huber, Peter Jüni, Adnan Kastrati, Juhani Knuuti, Mattie J. Lenzen, Kenneth W. Mahaffey, Marco Valgimigli, Arnoud W.J. van't Hof, Doron Zahger, Jeroen J. Bax, Helmut Baumgartner, Claudio Ceconi, Veronica Dean, Christi Deaton, Robert Fagard, Christian Funck-Brentano, David Hasdai, Arno W. Hoes, Paulus Kirchhof, Philippe Kolh, Theresa McDonagh, Cyril Moulin, Bogdan A. Popescu, Željko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Adam Torbicki, Alec Vahanian, Stephan Windecker, Document Reviewers, Felicity Astin, Karin Åström-Olsson, Andrzej Budaj, Peter Clemmensen, Jean-Philippe Collet, Keith Fox, Ahmet Fuat, Olivija Gustiene, Christian W. Hamm, Petr Kala, Patrizio Lancellotti

Explaining the Gibbs Sampler

Computer-intensive algorithms, such as the Gibbs sampler, have become increasingly popular statistical tools, both in applied and theoretical work. The properties of such algorithms, however, may sometimes not be obvious. Here we give a simple explanation...

INTRODUCING EZTAXON-E: A PROKARYOTIC 16S RRNA GENE SEQUENCE DATABASE WITH PHYLOTYPES THAT REPRESENT UNCULTURED SPECIES

Despite recent advances in commercially optimized identification systems, bacterial identification remains a challenging task in many routine microbiological laboratories, especially in situations where taxonomically novel isolates are involved. The 16S...

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

This review is an updated and expanded version of the three prior reviews that were published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic agents, the time frame has been extended to cover the 30 years from January...

CMOS analog circuit design

P. E. (Phillip E.) Allen, Douglas R. Holberg

Testing for Common Trends

Cointegrated multiple time series share at least one common trend. Two tests are developed for the number of common stochastic trends (i.e., for the order of cointegration) in a multiple time series with and without drift. Both tests involve the roots...

Some New Three Level Designs for the Study of Quantitative Variables

A class of incomplete three level factorial designs useful for estimating the coefficients in a second degree graduating polynomial are described. The designs either meet, or approximately meet, the criterion of rotatability and for the most part can...

Measures of association for cross classifications

When populations are cross-classified with respect to two or more classifications or polytomies, questions often arise about the degree of association existing between the several polytomies. Most of the traditional measures or indices of association...

The Price of Inequality How Today's Divided Society Endangers Our Future

In this timely book, Stiglitz argues that inequality is both the cause and consequence of the failure of political systems and can lead to the failure of economic systems. He identifies three major themes: how markets don't work the way they are supposed...

Estimated Risks of Radiation-Induced Fatal Cancer from Pediatric CT

OBJECTIVE. In light of the rapidly increasing frequency of pediatric CT examinations, the purpose of our study was to assess the lifetime cancer mortality risks attributable to radiation from pediatric CT.MATERIALS AND METHODS. Organ doses as a function...

NINE-YEAR WILKINSON MICROWAVE ANISOTROPY PROBE (WMAP) OBSERVATIONS: COSMOLOGICAL PARAMETER RESULTS

We present cosmological parameter constraints based on the nal nine-year WMAP data, in conjunction with a number of additional cosmological data sets. The WMAP data alone, and in combination, continue to be remarkably well t by a six-parameter CDM model....

Metal-Organic Frameworks for Separations

Jian-Rong Li, Julian P. Sculley, Hong-Cai Zhou

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks.

Cole Trapnell, Adam C. Roberts, Loyal A. Goff, Geo Pertea, Daehwan Kim, David H. Kelley, Harold Pimentel, Steven L. Salzberg, John L. Rinn, Lior Pachter

Better Bootstrap Confidence Intervals

We consider the problem of setting approximate confidence intervals for a single parameter θ in a multiparameter family. The standard approximate intervals based on maximum likelihood theory, , can be quite misleading. In practice, tricks based on transformations,...

Enhanced power-conversion efficiency in polymer solar cells using an inverted device structure

typically based on n-type metal oxides, our device is solutionprocessed at room temperature, enabling easy processibility over a large area. Accordingly, the approach is fully amenable to highthroughput roll-to-roll manufacturing techniques, may be used...

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society,...

Probable Inference, the Law of Succession, and Statistical Inference

Probable Inference, the Law of Succession, and Statistical Inference

A Semantic Web Primer

The development of the Semantic Web, with machine-readable content, has the potential to revolutionize the World Wide Web and its uses. A Semantic Web Primer provides an introduction and guide to this continuously evolving field, describing its key ideas,...

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