CiteWeb

WorldWeb citation database

Publications in 2009

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Learning from Imbalanced Data

With the continuous expansion of data availability in many large-scale, complex, and networked systems, such as surveillance, security, Internet, and finance, it becomes critical to advance the fundamental understanding of knowledge discovery and analysis...

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

background Mild cognitive impairment is a transitional state between the cognitive changes of normal aging and very early Alzheimer’s disease. methods In a double-blind study, we evaluated subjects with the amnestic subtype of mild cognitive impairment....

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications. It includes AuNP synthesis, assembly and conjugation with...

Postmenopausal Estrogen and Progestin Use and the Risk of Cardiovascular Disease

Background Estrogen therapy in postmenopausal women has been associated with a decreased risk of heart disease. There is little information, however, about the effect of combined estrogen and progestin therapy on the risk of cardiovascular disease. Methods...

Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

Summary Background Long-term complications of critical illness include intensive care unit (ICU)-acquired weakness and neuropsychiatric disease. Immobilisation secondary to sedation might potentiate these problems. We assessed the effi cacy of combining...

Interpretative phenomenological analysis : theory, method and research

Interpretative phenomenological analysis (IPA) is an increasingly popular approach to qualitative inquiry. This handy text covers its theoretical foundations and provides a detailed guide to conducting IPA research.Extended worked examples from the authors'...

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies.

Objectives To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment.Design Meta-analysis.Data source Medline (1966-2007).Study...

Inferring weak population structure with the assistance of sample group information.

Genetic clustering algorithms require a certain amount of data to produce informative results. In the common situation that individuals are sampled at several locations, we show how sample group information can be used to achieve better results when the...

Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.

background Rimonabant, a selective cannabinoid-1 receptor (CB 1 ) blocker, has been shown to reduce body weight and improve cardiovascular risk factors in obese patients. The Rimonabant in Obesity–Lipids (RIO-Lipids) study examined the effects of rimonabant...

EGFR Antagonists in Cancer Treatment

Functional activation of growth factors and receptors of the epidermal growth factor receptor (EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer treatment. This article discusses the mechanisms of action of EGFR inhibitors,...

Crypt stem cells as the cells-of-origin of intestinal cancer

Intestinal cancer is initiated by Wnt- pathway- activating mutations in genes such as adenomatous polyposis coli ( APC). As in most cancers, the cell of origin has remained elusive. In a previously established Lgr5 ( leucine- rich- repeat containing G-...

Combination of isosorbide dinitrate and hydralazine in blacks with heart failure

background We examined whether a fixed dose of both isosorbide dinitrate and hydralazine provides additional benefit in blacks with advanced heart failure, a subgroup previously noted to have a favorable response to this therapy. methods A total of 1050...

Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial

Severe acute respiratory failure in adults causes high mortality despite improvements in ventilation techniques and other treatments (eg, steroids, prone positioning, bronchoscopy, and inhaled nitric oxide). We aimed to delineate the safety, clinical...

Propranolol for Severe Hemangiomas of Infancy

Despite their self-limited course, infantile capillary hemangiomas can impair vital or sensory functions or cause disfigurement. These authors have observed in 11 children that propranolol can inhibit the growth of these hemangiomas.

Memantine in Moderate-to-Severe Alzheimer's Disease

Background Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is implicated in neurodegenerative disorders. Accordingly, we investigated memantine, an NMDA antagonist, for the treatment of Alzheimer's disease. Methods Patients with...

Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma

Background The role of long-acting, inhaled β2-agonists in treating asthma is uncertain. In a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and higher doses of the inhaled glucocorticoid budesonide. Methods After...

Psychological Sequelae of the September 11 Terrorist Attacks in New York City

Background The scope of the terrorist attacks of September 11, 2001, was unprecedented in the United States. We assessed the prevalence and correlates of acute post-traumatic stress disorder (PTSD) and depression among residents of Manhattan five to eight...

Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus

Background Controversy exists about the best surgical treatment for esophageal carcinoma. Methods We randomly assigned 220 patients with adenocarcinoma of the mid-to-distal esophagus or adenocarcinoma of the gastric cardia involving the distal esophagus...

Decontamination and disinfection of water by solar photocatalysis: Recent overview and trends

In recent years, there has been a tremendous amount of research and development in the area of photocatalysis (heterogeneous and homogeneous), a process included in a special class of oxidation techniques defined as Advanced Oxidation Processes (AOPs),...

Radiation Dose Associated With Common Computed Tomography Examinations and the Associated Lifetime Attributable Risk of Cancer

Rebecca Smith-Bindman, Jafi A. Lipson, Ralph Marcus, Kwang-Pyo Kim, Mahadevappa Mahesh, R. Gould, Amy Berrington de Gonzalez, Diana L. Miglioretti

Ti based biomaterials, the ultimate choice for orthopaedic implants – A review

The field of biomaterials has become a vital area, as these materials can enhance the quality and longevity of human life and the science and technology associated with this field has now led to multi-million dollar business. The paper focuses its attention...

The Use of Fluorescein Diacetate and Phenosafranine for Determining Viability of Cultured Plant Cells

Various stains were tested with suspension cell cultures of Nicotiana tabacum (tobacco), Oryza sativa (rice), Glycine max (soybean), Daucus carota (carrot) and Lycopersicon esculentum (tomato). A drop of the culture medium containing each dye was mixed...

The Barthel ADL Index: a reliability study*

The Barthel Index is a valid measure of disability. In this study we investigated the reliability of four different methods of obtaining the score in 25 patients: self-report, asking a trained nurse who had worked with the patient for at least one shift,...

A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong

background There has been an outbreak of the severe acute respiratory syndrome (SARS) worldwide. We report the clinical, laboratory, and radiologic features of 138 cases of suspected SARS during a hospital outbreak in Hong Kong. methods From March 11...

Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for Breast Cancer

Background We compared docetaxel with vinorelbine for the adjuvant treatment of early breast cancer. Women with tumors that overexpressed HER2/neu were also assigned to receive concomitant treatment with trastuzumab or no such treatment. Methods We randomly...

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men

Many studies have shown cross-sectional (and two small studies, longitudinal) declines in total and/or free testosterone (T) levels, with age, in men. The extent to which decline in T is the result of the aging process per se, as opposed to chronic illness,...

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients

Our previous individual patient data (IPD) meta-analysis showed that chemotherapy improved survival in patients curatively treated for non-metastatic head and neck squamous cell carcinoma (HNSCC), with a higher benefit with concomitant chemotherapy. However...

The Identification, Conservation, and Management of Estuarine and Marine Nurseries for Fish and Invertebrates

Michael W. Beck, Kenneth L. Heck, Jr., Kenneth W. Able, Daniel L. Childers, David B. Eggleston, Bronwyn M. Gillanders, Benjamin Halpern, Cynthia G. Hays, Kaho Hoshino, Thomas J. Minello, Robert J. Orth, Peter F. Sheridan and Michael P. Weinstein

Induction of intestinal Th17 cells by segmented filamentous bacteria

The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We...

Markov Random Field Modeling in Image Analysis

Markov random field (MRF) theory provides a basis for modeling contextual constraints in visual processing and interpretation. It enables systematic development of optimal vision algorithms when used with optimization principles. This detailed and thoroughly...

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Stuart M. Chambers, Christopher A. Fasano, Eirini P. Papapetrou, Mark J. Tomishima, Michel Sadelain, Lorenz Studer

Antigenic and Genetic Characteristics of the Early Isolates of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Rebecca Garten, C. Todd Davis, Colin A. Russell, Bo Shu, Stephen Lindstrom, Amanda Balish, Wendy Sessions, Xiyan Xu, Eugene Skepner, Varough Deyde, Margaret Okomo-Adhiambo, Larisa Gubareva, John Barnes, Catherine B. Smith, Shannon L. Emery, Michael J. Hillman, Pierre Rivailler, James A. Smagala, Miranda de Graaf, David F. Burke, Ron A. M. Fouchier, Claudia Pappas, Celia Alpuche-Aranda, Hugo López-Gatell, Hiram Olivera, Irma López, Christopher A. Myers, Faix D, Patrick J. Blair, Cindy L. Yu, Kimberly M. Keene, P. David Dotson, David J. Boxrud, Anthony R. Sambol, Syed H. Abid, Kirsten St. George, Tammy Bannerman, Amanda L. Moore, David J. Stringer, Patricia Blevins, Gail J. Demmler-Harrison, Michele Ginsberg, Paula Kriner, SteveWaterman, Sandra Smole, Hugo F. Guevara, Edward A. Belongia, Patricia Clark, Sara T. Beatrice, Ruben O. Donis

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

Reprogramming of somatic cells to pluripotency, thereby creating induced pluripotent stem (iPS) cells, promises to transform regenerative medicine. Most instances of direct reprogramming have been achieved by forced expression of defined factors using...

Survival of Patients with Stage I Lung Cancer Detected on CT Screening

Claudia I. Henschke, David F. Yankelevitz, Daniel M. Libby, Mark Pasmantier, James P. Smith, Olli S. Miettinen

Low-temperature oxidation of CO catalysed by Co3O4 nanorods

[Xie, Xiaowei; Li, Yong; Shen, Wenjie] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China. [Liu, Zhi-Quan] Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China. [Haruta,...

Globalization in question

Matthew Paterson, Paul Hirst, Grahame Thompson

Small silencing RNAs: an expanding universe.

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their...

Frequency-tuned salient region detection

Detection of visually salient image regions is useful for applications like object segmentation, adaptive compression, and object recognition. In this paper, we introduce a method for salient region detection that outputs full resolution saliency maps...

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

Background Impaired endothelium-mediated relaxation contributes to vasospasm and myocardial ischemia in patients with coronary artery disease. We hypothesized that cholesterol-lowering therapy with the 3-hydroxy-3-methylglutaryl–coenzyme A reductase...

Knocking down barriers: advances in siRNA delivery

Kathryn A. Whitehead, Robert Langer, Daniel G. Anderson

Self-Regulation Failure: An Overview

The major patterns of self-regulatory failure are reviewed. Underregulation occurs because of deficient standards, inadequate monitoring, or inadequate strength. Misregulation occurs because offalse assumptions or misdirected efforts, especially an unwarranted...

Treatment of Traumatic Brain Injury with Moderate Hypothermia

Background Traumatic brain injury initiates several metabolic processes that can exacerbate the injury. There is evidence that hypothermia may limit some of these deleterious metabolic responses. Methods In a randomized, controlled trial, we compared...

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions...

Greenhouse-gas emission targets for limiting global warming to 2°C.

Malte Meinshausen, Nicolai Meinshausen, William Hare, S. C. B. Raper, K. Frieler, Reto Knutti, David J. Frame, Myles R. Allen

Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder Cancer

Background Despite aggressive local therapy, patients with locally advanced bladder cancer are at significant risk for metastases. We evaluated the ability of neoadjuvant chemotherapy to improve the outcome in patients with locally advanced bladder cancer...

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation

Background and Methods Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double-blind, placebo-controlled trial of a sustained-release form of bupropion for smoking cessation. We excluded smokers with current...

Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery

Background Perioperative myocardial ischemia is the single most important potentially reversible risk factor for mortality and cardiovascular complications after noncardiac surgery. Although more than 1 million patients have such complications annually,...

RING Domain E3 Ubiquitin Ligases

E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitinconjugating enzyme to substrate. The activity of most E3s is specified by a RING domain, which binds to an E2∼ubiquitin...

The coxibs, selective inhibitors of cyclooxygenase-2.

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual pain, and headache. Although they are effective, their long-term use is limited by gastrointestinal effects such as dyspepsia and abdominal pain and, less often,...

A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

Object. The extent of tumor resection that should be undertaken in patients with glioblastoma multiforme (GBM) remains controversial. The purpose of this study was to identify significant independent predictors of survival in these patients and to determine...

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Stephen G. Aller, Jun Yu, Andrew B. Ward, Yue Weng, Srinivas Chittaboina, Rupeng Zhuo, Pm Harrell, Qisheng Zhang, Ina L. Urbatsch

A comparison of suture repair with mesh repair for incisional hernia.

Background Incisional hernia is an important complication of abdominal surgery. Procedures for the repair of these hernias with sutures and with mesh have been reported, but there is no consensus about which type of procedure is best. Methods Between...

Chemoradiotherapy Followed by Surgery Compared with Surgery Alone in Squamous-Cell Cancer of the Esophagus

Background We conducted a multicenter, randomized trial to compare preoperative chemoradiotherapy followed by surgery with surgery alone in patients with stage I and II squamous-cell cancer of the esophagus. Methods The preoperative combined therapy consisted...

Socioeconomic Inequalities in Health in 22 European Countries

We observed variation across Europe in the magnitude of inequalities in health associated with socioeconomic status. These inequalities might be reduced by improving educational opportunities, inco ...

Calcium plus Vitamin D Supplementation and the Risk of Fractures

Background The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal. Methods We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled...

Melatonin in Humans

Three centuries ago, the French philosopher Rene Descartes described the pineal gland as “the seat of the soul,” but it was not until the late 1950s that melatonin, the principal substance secreted by the pineal gland, was identified.1 There is now...

A comparative study of Artificial Bee Colony algorithm

Artificial Bee Colony (ABC) algorithm is one of the most recently introduced swarm-based algorithms. ABC simulates the intelligent foraging behaviour of a honeybee swarm. In this work, ABC is used for optimizing a large set of numerical test functions...

A survey of collaborative filtering techniques

As one of the most successful approaches to building recommender systems, collaborative filtering (CF) uses the known preferences of a group of users to make recommendations or predictions of the unknown preferences for other users. In this paper, we...

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction

Background Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction. Methods The trial included...

Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion

Ghrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food intake and GH secretion. We determined plasma ghrelin concentrations in patients with simple obesity, anorexia nervosa, and type 2 diabetes mellitus by RIA. We...

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

One of the top priorities for an HIV vaccine is the ability to elicit a broadly neutralizing antibody response, which should provide the best protection against infection. In the 25 years since the discovery of HIV, very few broadly neutralizing antibodies...

Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial.

Use of cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), has the potential to increase survival in patients with advanced non-small-cell lung cancer. We therefore compared chemotherapy plus cetuximab with chemotherapy...

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Knut Woltjen, Iacovos P. Michael, Paria Mohseni, Ridham Desai, Maria Mileikovsky, Riikka H. Hämäläinen, Rebecca Cowling, Wei Wang, Pentao Liu, Marina Gertsenstein, Keisuke Kaji, Hoon-Ki Sung, Andras Nagy

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

Overweight and obese persons are at risk of a number of medical conditions which can lead to further morbidity and mortality. The primary objective of this study is to provide an estimate of the incidence of each co-morbidity related to obesity and overweight...

Staging of Non–Small-Cell Lung Cancer with Integrated Positron-Emission Tomography and Computed Tomography

Background We compared the diagnostic accuracy of integrated positron-emission tomography (PET) and computed tomography (CT) with that of CT alone, that of PET alone, and that of conventional visual correlation of PET and CT in determining the stage of...

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

Background Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein α gene (CEPBA), the myeloid–lymphoid...

Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death

background The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established....

The Extracellular Matrix: Not Just Pretty Fibrils

The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has many effects beyond providing structural support. ECM proteins typically include...

Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects1

A radioimmunoassay for angiotensin I and its application to the determination of renin activity is described. The assay employs antibodies raised to copolymers of angiotensin I and succinylated poly-l-lysine. Angiotensin labeled with 125I and purified...

Hypovitaminosis D in Medical Inpatients

Background Vitamin D deficiency is a major risk factor for bone loss and fracture. Although hypovitaminosis D has been detected frequently in elderly and housebound people, the prevalence of vitamin D deficiency among patients hospitalized on a general...

Papillary and follicular thyroid carcinoma

Papillary and follicular (differentiated) thyroid carcinomas are among the most curable cancers. However, some patients are at high risk for recurrent disease or even death. Most of these patients can be identified at the time of diagnosis by using well-established...

Research methods in health: investigating health and health services

This new edition of Ann Bowling's well-known and highly respected text has been thoroughly revised and updated to reflect key methodological developments in health research. It is a comprehensive, easy to read, guide to the range of methods used to study...

Valvular heart disease associated with fenfluramine-phentermine.

Background Fenfluramine and phentermine have been individually approved as anorectic agents by the Food and Drug Administration (FDA). When used in combination the drugs may be just as effective as either drug alone, with the added advantages of the need...

Complexity: A Guided Tour

What enables individually simple insects like ants to act with such precision and purpose as a group? How do trillions of individual neurons produce something as extraordinarily complex as consciousness? What is it that guides self-organizing structures...

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

Bone is remodeled continuously during adulthood through the resorption of old bone by osteoclasts and the subsequent formation of new bone by osteoblasts. These two closely coupled events are responsible for renewing the skeleton while maintaining its...

Induced pluripotent stem cells from a spinal muscular atrophy patient

Allison D. Ebert, Junying Yu, Ferrill F. Rose, Virginia B. Mattis, Christian L. Lorson, James A. Thomson, Clive N. Svendsen

Plant-Growth-Promoting Rhizobacteria

Several microbes promote plant growth, and many microbial products that stimulate plant growth have been marketed. In this review we restrict ourselves to bacteria that are derived from and exert this effect on the root. Such bacteria are generally designated...

Plasmon lasers at deep subwavelength scale

Rupert F. Oulton, Volker J. Sorger, Thomas Zentgraf, Ren-Min Ma, Christopher Gladden, Lun Dai, Guy Bartal, Xiang Zhang

Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children

Background A nationwide hepatitis B vaccination program was implemented in Taiwan in July 1984. To assess the effect of the program on the development of hepatocellular carcinoma, we studied the incidence of this cancer in children in Taiwan from 1981...

LACK OF EFFECT OF INDUCTION OF HYPOTHERMIA AFTER ACUTE BRAIN INJURY

Background Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparing the effects of hypothermia...

Neurologic and developmental disability at six years of age after extremely preterm birth

Background Birth before 26 weeks of gestation is associated with a high prevalence of neurologic and developmental disabilities in the infant during the first two years of life. Methods We studied at the time of early school age children who had been...

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Background Myeloma cells may secrete factors that affect the function of osteoblasts, osteoclasts, or both. Methods We subjected purified plasma cells from the bone marrow of patients with newly diagnosed multiple myeloma and control subjects to oligonucleotide...

Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications

Raphael Barbey, Laurent Lavanant, Dusko Paripovic, Nicolas Schüwer, Caroline Sugnaux, Stefano Tugulu, Harm-Anton Klok

The Stigma of Obesity: A Review and Update

Rebecca M. Puhl, Chelsea A. Heuer

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic.

This article is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence (http://creativecommons.org/licenses/by-nc-sa/3.0/), which permits distribution, and reproduction in any medium, provided...

Putting the fear back into fear appeals: The extended parallel process model

The fear appeal literature is diverse and inconsistent. Existing fear appeal theories explain the positive linear results occurring in many studies, but are unable to explain the boomerang or curvilinear results occurring in other studies. The present...

Platelet Glycoprotein IIb/IIIa Inhibition with Coronary Stenting for Acute Myocardial Infarction

Background When administered in conjunction with primary coronary stenting for the treatment of acute myocardial infarction, a platelet glycoprotein IIb/IIIa inhibitor may provide additional clinical benefit, but data on this combination therapy are limited....

National Standards for Diabetes Self- Management Education

Diabetes self-management education (DSME) is a critical element of care for all people with diabetes and is necessary in order to improve patient outcomes. The National Standards for DSME are designed to define quality diabetes self-management education...

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

Jan M. Ruijter, C. Ramakers, Willem M.H. Hoogaars, Y. Karlen, Onno Bakker, M.J.B. van den Hoff, A. F. M. Moorman

Ethics and Clinical Research

HUMAN experimentation since World War II has created some difficult problems with the increasing employment of patients as experimental subjects when it must be apparent that they would not have been available if they had been truly aware of the uses...

Breaking Spectrum Gridlock With Cognitive Radios: An Information Theoretic Perspective

Cognitive radios hold tremendous promise for increasing spectral efficiency in wireless systems. This paper surveys the fundamental capacity limits and associated transmission techniques for different wireless network design paradigms based on this promising...

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

Dohoon Kim, Chun-Hyung Kim, Jung-Il Moon, Young-Gie Chung, Mi-Yoon Chang, Baek-Soo Han, Sanghyeok Ko, Eungi Yang, Kwang Yul Cha, Robert Lanza, Kwang-Soo Kim

Parton distributions for the LHC

We present updated leading-order, next-to-leading order and next-to-next-to-leading order parton distribution functions (“MSTW 2008”) determined from global analysis of hard-scattering data within the standard framework of leading-twist fixed-order...

Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction ☆

Background As compared with thrombolytic therapy, primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction reduces the rates of death, reinfarction, and stroke, but recurrent ischemia, restenosis, and reocclusion of...

Report by the commission on the measurement of economic performance and social progress

As GDP is a measure of market capacity and not economic well-being, this report has been commissioned to more accurately understand the social progress indicators of any given state. Gross domestic product (GDP) is the most widely used measure of economic...

Long-Term Outcomes with Drug-Eluting Stents versus Bare-Metal Stents in Sweden

Background Recent reports have indicated that there may be an increased risk of late stent thrombosis with the use of drug-eluting stents, as compared with bare-metal stents. Methods We evaluated 6033 patients treated with drug-eluting stents and 13,738...

Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening

background Film mammography has limited sensitivity for the detection of breast cancer in women with radiographically dense breasts. We assessed whether the use of digital mammography would avoid some of these limitations. methods A total of 49,528 asymptomatic...

Prognostically useful gene-expression profiles in acute myeloid leukemia.

background In patients with acute myeloid leukemia (AML) a combination of methods must be used to classify the disease, make therapeutic decisions, and determine the prognosis. However, this combined approach provides correct therapeutic and prognostic...

Communication Systems

This best-selling, easy to read book offers the most complete discussion on the theories and principles behind today's most advanced communications systems. Throughout, Haykin emphasizes the statistical underpinnings of communication theory in a complete...

Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women

The human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine was immunogenic, generally well tolerated, and effective against HPV-16 or HPV-18 infections, and associated precancerous lesions in an event-triggered interim analysis of the phase III randomised,...

Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis

Background Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis. Methods We conducted a multicenter, randomized, noninferiority trial to compare stenting with...

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

Purpose To improve on current standards for breast cancer prognosis and prediction of chemotherapy benefit by developing a risk model that incorporates the gene expression‐based “intrinsic” subtypes luminal A, luminal B, HER2-enriched, and basal-like....

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico

Background In late March 2009, an outbreak of a respiratory illness later proved to be caused by novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in Mexico. We describe the clinical and epidemiologic characteristics of persons hospitalized...

DBpedia - A crystallization point for the Web of Data

The DBpedia project is a community effort to extract structured information from Wikipedia and to make this information accessible on the Web. The resulting DBpedia knowledge base currently describes over 2.6 million entities. For each of these entities,...

The Length of the Cervix and the Risk of Spontaneous Premature Delivery

Background The role of the cervix in the pathogenesis of premature delivery is controversial. In a prospective, multicenter study of pregnant women, we used vaginal ultrasonography to measure the length of the cervix; we also documented the incidence...

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

Silver nanoparticles (Ag-np) are being used increasingly in wound dressings, catheters, and various household products due to their antimicrobial activity. The toxicity of starch-coated silver nanoparticles was studied using normal human lung fibroblast...

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Ahmad M. Khalil, Mitchell Guttman, Maite Huarte, Manuel Garber, Arjun Raj, Dianali Rivea Morales, Kelly Thomas, Aviva Presser, Bradley E. Bernstein, Alexander van Oudenaarden, Aviv Regev, Eric S. Lander, John L. Rinn

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