CiteWeb

WorldWeb citation database

Publications in 2009

Page 5
The Risk of Transfusion-Transmitted Viral Infections

Background Accurate estimates of the risk of transfusion-transmitted infectious disease are essential for monitoring the safety of the blood supply and evaluating the potential effect of new screening tests. We estimated the risk of transmitting the human...

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide. Most (70-80%) HCV infections persist and about 30% of...

Software Cost Estimation with COCOMO II

Follow-on book to Dr. Barry Boehm's classic Software Cost Estimation, this book will show professional developers how to use the COCOMO (Cost Comparison Model) II model developed by Dr. Boehm at USC to generate end-to-end cost analysis figures for software...

Perioperative Normothermia to Reduce the Incidence of Surgical-Wound Infection and Shorten Hospitalization

Background Mild perioperative hypothermia, which is common during major surgery, may promote surgical-wound infection by triggering thermoregulatory vasoconstriction, which decreases subcutaneous oxygen tension. Reduced levels of oxygen in tissue impair...

Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study

background The Randomized Aldactone Evaluation Study (RALES) demonstrated that spironolactone significantly improves outcomes in patients with severe heart failure. Use of angiotensin-converting–enzyme (ACE) inhibitors is also indicated in these patients....

ACOG PRACTICE BULLETIN

Critical care in pregnancy is a field that remains unevenly researched. Although there is a body of evidence to guide many recommendations in critical care, limited research specifically addresses obstetric critical care. The purpose of this document...

Chemotherapy with Preoperative Radiotherapy in Rectal Cancer

Background Preoperative radiotherapy is recommended for selected patients with rectal cancer. We evaluated the addition of chemotherapy to preoperative radiotherapy and the use of postoperative chemotherapy in the treatment of rectal cancer. Methods We...

FIVE-YEAR WILKINSON MICROWAVE ANISOTROPY PROBE WMAP is the result of a partnership between Princeton University and NASA's Goddard Space Flight Center. Scientific guidance is provided by the WMAP Science Team. OBSERVATIONS: DATA PROCESSING, SKY MAPS,

G. Hinshaw, J. L. Weiland, R. S. Hill, N. Odegard, D. Larson, C. L. Bennett, J. Dunkley, B. Gold, M. R. Greason, N. Jarosik, Eiichiro Komatsu, M. R. Nolta, L. Page, David N. Spergel, Edward J. Wollack, M. Halpern, A. Kogut, M. Limon, S. S. Meyer, G. S. Tucker, Edward L. Wright

The Antiphospholipid Syndrome

The antiphospholipid syndrome is an autoimmune disorder of hypercoagulability characterized by the presence of autoantibodies to various phospholipids or phospholipid-binding proteins. The autoantibodies include anticardiolipin antibodies, lupus anticoagulant...

Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

Background The optimal combination drug therapy for hypertension is not established, although current U.S. guidelines recommend inclusion of a diuretic. We hypothesized that treatment with the combination of an angiotensin-converting–enzyme (ACE) inhibitor...

Measuring balance in the elderly: preliminary development of an instrument

The goal for this study was to develop a measure of balance appropriate for elderly individuals. In total, 38 patients, ranging in age from 60 to 93 years, and 32 professionals, including nurses, physicians, and physical and occupational therapists were...

Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease

Background A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol is not known. We examined the effect of DNA-sequence...

Factors Predicting the Subjective Well-Being of Nations

Ed Diener, Marissa L. Diener, Carol Diener

Mechanisms of Endocytosis

Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins...

Genre as social action

This essay proposes a conception of genre based on conventionalized social motives which are found in recurrent situation‐types. The thesis is that genre must be conceived in terms of rhetorical action rather than substance or form.

Interaction Analysis: Foundations and Practice

Brigitte Jordan, Austin Henderson

Hypertension and Associated Metabolic Abnormalities — The Role of Insulin Resistance and the Sympathoadrenal System

Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system

Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Background. In patients with acute exacer- bations of chronic obstructive pulmonary disease, nonin- vasive ventilation may be used in an attempt to avoid en- dotracheal intubation and complications associated with mechanical ventilation. Methods. We conducted...

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

background Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor...

Towards wafer-size graphene layers by atmospheric pressure graphitization of silicon carbide

K. V. Emtsev, Aaron Bostwick, K. Horn, Johannes Jobst, G.L. Kellogg, L. Ley, Jessica L. McChesney, T. Ohta, Sergey A. Reshanov, Jonas Röhrl, Eli Rotenberg, Andreas K. Schmid, Daniel Waldmann, Heiko B. Weber, Thomas Seyller

Fluorouracil, Leucovorin, and Oxaliplatin With and Without Cetuximab in the First-Line Treatment of Metastatic Colorectal Cancer

Purpose This randomized study assessed whether the best overall response rate (ORR) of cetuximab combined with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) was superior to that of FOLFOX-4 alone as first-line treatment for metastatic colorectal...

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.

Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposes unified criteria for the definition of cell death and of its...

Liquidity and Leverage

In anancial system where balance sheets are continuously marked to market, asset price changes show up immediately in changes in net worth, and elicit responses fromnancial intermediaries who adjust the size of their balance sheets. We document evidence...

A Randomized Trial Comparing Conventional and Endovascular Repair of Abdominal Aortic Aneurysms

Background Although the initial results of endovascular repair of abdominal aortic aneurysms were promising, current evidence from controlled studies does not convincingly show a reduction in 30-day mortality relative to that achieved with open repair....

Improved Survival in Patients with Locally Advanced Prostate Cancer Treated with Radiotherapy and Goserelin

Background We conducted a randomized, prospective trial comparing external irradiation with external irradiation plus goserelin (an agonist analogue of gonadotropin-releasing hormone that reduces testosterone secretion) in patients with locally advanced...

A Randomized Trial of a Low-Carbohydrate Diet for Obesity

Background Despite the popularity of the low-carbohydrate, high-protein, high-fat (Atkins) diet, no randomized, controlled trials have evaluated its efficacy. Methods We conducted a one-year, multicenter, controlled trial involving 63 obese men and women...

ORGANIZING ACTION OF PRENATALLY ADMINISTERED TESTOSTERONE PROPIONATE ON THE TISSUES MEDIATING MATING BEHAVIOR IN THE FEMALE GUINEA PIG1

The sexual behavior of male and female guinea pigs from mothers receiving testosterone propionate during most of pregnancy was studied after the attainment of adulthood. As a part of the investigation, the responsiveness of the females to estradiol benzoate...

Regulation and Function of NF-κB Transcription Factors in the Immune System

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from...

Governance Matters VIII: Aggregate and Individual Governance Indicators, 1996-2008

This paper reports on the latest update of the Worldwide Governance Indicators (WGI) research project, covering 212 countries and territories and measuring six dimensions of governance between 1996 and 2007: Voice and Accountability, Political Stability...

Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes

background We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications. methods We randomly assigned women between 24 and 34 weeks’ gestation who had...

Species Distribution Models: Ecological Explanation and Prediction Across Space and Time

Speciesdistributionmodels(SDMs)arenumericaltoolsthatcombineobservations of species occurrence or abundance with environmental estimates. They are used to gain ecological and evolutionary insights and to predict distributions across landscapes, sometimes...

Human Protein Reference Database—2009 update

T. S. Keshava Prasad, Renu Goel, Kumaran Kandasamy, Shivakumar Keerthikumar, Sameer Kumar, Suresh Mathivanan, Deepthi Telikicherla, Rajesh Raju, Beema Shafreen, Abhilash Venugopal, Lavanya Balakrishnan, Arivusudar Marimuthu, Sutopa Banerjee, Devi S. Somanathan, Aimy Sebastian, Sandhya G. Rani, Somak Ray, C. J. Harrys Kishore, Sashi Kanth, Mukhtar Ahmed, Manoj Kumar Kashyap, Riaz Mohmood, Yl Ramachandra, V. Krishna, B Abdul Rahiman, Sujatha Mohan, Prathibha Ranganathan, Subhashri Ramabadran, Raghothama Chaerkady, Akhilesh Pandey

Hospitalized Patients with 2009 H1N1 Influenza in the United States, April–June 2009

Of the 272 patients we studied, 25% were admitted to an intensive care unit and 7% died. Forty-five percent of the patients were children under the age of 18 years, and 5% were 65 years of age or older. Seventy-three percent of the patients had at least...

Silver nanoparticles : Green synthesis and their antimicrobial activities

article i nfo Available online 17 September 2008 This review presents an overview of silver nanoparticles (Ag NPs) preparation by green synthesis approaches that have advantages over conventional methods involving chemical agents associated with environmental...

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Mitchell Guttman, Ido Amit, Manuel Garber, Courtney French, Michael F. Lin, David M. Feldser, Maite Huarte, Or Zuk, Bryce W. Carey, John P. Cassady, Moran N. Cabili, Rudolf Jaenisch, Tarjei S. Mikkelsen, Tyler Jacks, Nir Hacohen, Bradley E. Bernstein, Manolis Kellis, Aviv Regev, John L. Rinn, Eric S. Lander

Obstructive Sleep Apnea

Our understanding of the nature and consequences of upper-airway obstruction in adults during sleep has evolved considerably over the past two decades. Sleep apnea — defined as repeated episodes of obstructive apnea and hypopnea during sleep, together...

The Uppsala Internationalization Process Model Revisited: From Liability of Foreignness to Liability of Outsidership

The Uppsala internationalization process model is revisited in the light of changes in business practices and theoretical advances that have been made since 1977. Now the business environment is viewed as a web of relationships, a network, rather than...

Many roads to maturity: microRNA biogenesis pathways and their regulation

Julia Winter, Stephanie Jung, Sarina Keller, Richard I. Gregory, Sven Diederichs

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women.

Background Long-term estrogen therapy can reduce the risk of osteoporotic fracture and cardiovascular disease in postmenopausal women. At present, however, these beneficial effects are not separable from undesirable stimulation of breast and endometrial...

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

Background Pharmacogenetic determinants of the response of patients to clopidogrel contribute to variability in the biologic antiplatelet activity of the drug. The effect of these determinants on clinical outcomes after an acute myocardial infarction...

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

There are ample genetic and laboratory studies that suggest the PI3K-Akt pathway is vital to the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the clinic at a rapid pace. In this Review, the therapeutic potential...

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

Observations that a pancreatic polypeptide-like substance, possibly neuropeptide Y, is present in hypothalamic areas and may coexist with catecholamines prompted evaluation of its role in controlling feeding behavior. Intracerebroventricular administration...

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

Herein we report that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving short-term therapy in various metastasis assays, including after intravenous injection of tumor...

Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women1

Women with polycystic ovary syndrome (PCOS) are insulin resistant, have insulin secretory defects, and are at high risk for glucose intolerance. We performed this study to determine the prevalence of glucose intolerance and parameters associated with...

Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis

a b s t r a c t The efficacy of the vaccine against severe rotavirus gastroenteritis and against ro- tavirus-associated hospitalization was 85 percent (P<0.001 for the comparison with placebo) and reached 100 percent against more severe...

Gmsh: A 3‐D finite element mesh generator with built‐in pre‐ and post‐processing facilities

SUMMARY Gmsh is an open-source 3-D finite element grid generator with a build-in CAD engine and post-processor. Its design goal is to provide a fast, light and user-friendly meshing tool with parametric input and advanced visualization capabilities. This...

ABySS: A parallel assembler for short read sequence data

Jared T. Simpson, Kim Wong, Shaun D Jackman, Jacqueline E. Schein, Steven J. M. Jones, Inanc Birol

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

Xanthomonas bacteria attack their plant hosts by delivering their own transcription-activator–like (TAL) proteins into the plant cell nucleus and alter the plant's gene regulation (see the Perspective by [ Voytas and Joung ][1] ). Moscou and Bogdanove...

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers The Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.Objective To determine whether selenium, vitamin E, or both...

Treatment of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension, which is characterized by vascular proliferation and remodeling of small pulmonary vessels, leads to a progressive increase in pulmonary vascular resistance and, ultimately, to right ventricular failure and death. Despite...

Quadrivalent Vaccine against Human Papillomavirus to Prevent Anogenital Diseases

Background A phase 3 trial was conducted to evaluate the efficacy of a prophylactic quadrivalent vaccine in preventing anogenital diseases associated with human papillomavirus (HPV) types 6, 11, 16, and 18. Methods In this randomized, placebo-controlled,...

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

Hongyan Zhou, Shili Wu, Jin Young Joo, Saiyong Zhu, Dong Wook Han, Tongxiang Lin, Sunia A. Trauger, Geoffery Bien, Susan Yao, Yong Zhu, Gary Siuzdak, Hans R. Schöler, Lingxun Duan, Sheng Ding

Handbook on Ontologies

An ontology is a formal description of concepts and relationships that can exist for a community of human and/or machine agents. The notion of ontologies is crucial for the purpose of enabling knowledge sharing and reuse. The Handbook on Ontologies provides...

Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly

Background Cigarette smoking and abnormal serum cholesterol concentrations are risk factors for acute coronary syndromes, but the underlying mechanisms are poorly understood. We studied whether cigarette smoking and abnormal cholesterol values may precipitate...

Inhibition of Food Intake in Obese Subjects by Peptide YY3–36

background The gut hormone fragment peptide YY 3–36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food intake by modulating appetite circuits in the hypothalamus....

THE AMPHIBIAN TREE OF LIFE

The evidentiary basis of the currently accepted classification of living amphibians is discussed and shown not to warrant the degree of authority conferred on it by use and tradition. A new taxonomy of living amphibians is proposed to correct the deficiencies...

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts.

NMR chemical shifts in proteins depend strongly on local structure. The program TALOS estab- lishes an empirical relation between 13 C, 15 N and 1 H chemical shifts and backbone torsion angles / and w (Cornilescu et al. J Biomol NMR 13 289-302, 1999)....

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

Background Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis, and antagonism of TNF may reduce the activity of the disease. This study evaluated the safety and efficacy of a novel TNF antagonist...

Cell cycle, CDKs and cancer: a changing paradigm

Marcos Malumbres, Mariano Barbacid

The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

background Benign prostatic hyperplasia is commonly treated with alpha-adrenergic–receptor antagonists (alpha-blockers) or 5 a -reductase inhibitors. The long-term effect of these drugs, singly or combined, on the risk of clinical progression is unknown....

Silent brain infarcts and the risk of dementia and cognitive decline

Background Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia and cognitive decline. Methods We studied the association between silent brain infarcts and the risk...

Transfer of Large-Area Graphene Films for High-Performance Transparent Conductive Electrodes

Graphene, a two-dimensional monolayer of sp2-bonded carbon atoms, has been attracting great interest due to its unique transport properties. One of the promising applications of graphene is as a transparent conductive electrode owing to its high optical...

Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

It is well recognized that different patients respond in different ways to the same medication. These differences are often greater among members of a population than they are within the same person at different times (or between monozygotic twins).1...

Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media

Background Ear infections are a common cause of illness during the first two years of life. New conjugate vaccines may be able to prevent a substantial portion of cases of acute otitis media caused by Streptococcus pneumoniae. Methods We enrolled 1662...

Narrow graphene nanoribbons from carbon nanotubes

Disclosed is a method for making graphene nanoribbons (GNRs) by controlled unzipping of structures such as carbon nanotubes (CNTs) by etching (e.g., argon plasma etching) of nanotubes partly embedded in a polymer film. The GNRs have smooth edges and a...

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid1

The purpose of this study was to determine whether human adipocytes from different depots of obese subjects produce interleukin-6 (IL-6) and whether IL-6 release is regulated by glucocorticoids. Fragments of omental and abdominal sc adipose tissue released...

DIETARY FAT INTAKE AND THE RISK OF CORONARY HEART DISEASE IN WOMEN

Background The relation between dietary intake of specific types of fat, particularly trans unsaturated fat, and the risk of coronary disease remains unclear. We therefore studied this relation in women enrolled in the Nurses' Health Study. Methods We...

Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism

The direct oral thrombin inhibitor dabigatran has a predictable anticoagulant effect and may be an alternative therapy to warfarin for patients who have acute venous thromboembolism.

Gephi: An Open Source Software for Exploring and Manipulating Networks

Gephi is an open source software for graph and network analysis. It uses a 3D render engine to display large networks in real-time and to speed up the exploration. A flexible and multi-task architecture brings new possibilities to work with complex data...

Doxorubicin-Induced Cardiomyopathy

Doxorubicin (Adriamycin) has been used in oncologic practice since the late 1960s. It held promise as a powerful drug in the fight against cancer. The tumors most commonly responding to doxorubicin when it is given as a single agent or in combination...

Antioxidants and Atherosclerotic Heart Disease

Epidemiologic studies have demonstrated an association between increased intake of antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality from coronary artery disease. This association has been explained on the basis...

Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings

The World Health Organization (WHO) announced on 29 April 2009, a level-5 pandemic alert for a strain of H1N1 influenza originating in pigs in Mexico and transmitting from human to human in several countries. Fraser et al. (p. [1557][1], published online...

Efficacy of MRI and Mammography for Breast-Cancer Screening in Women with a Familial or Genetic Predisposition

background The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening...

Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders

SummaryAlcohol consumption has been identified as an important risk factor for chronic disease and injury. In the first paper in this Series, we quantify the burden of mortality and disease attributable to alcohol, both globally and for ten large countries....

Metastasis: from dissemination to organ-specific colonization

Metastasis to distant organs is an ominous feature of most malignant tumours but the natural history of this process varies in different cancers. The cellular origin, intrinsic properties of the tumour, tissue affinities and circulation patterns determine...

Microalgae for oil: strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor.

Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi, Giulia Padovani, Natascia Biondi, Gimena Bonini, Mario R. Tredici

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C

Background Covalent attachment of a 40-kd branched-chain polyethylene glycol moiety to interferon alfa-2a results in a compound (peginterferon alfa-2a) that has sustained absorption, a slower rate of clearance, and a longer half-life than unmodified interferon...

Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease

Background In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between an “off” period (also referred to as “off medication”), when the medication is not working and the motor symptoms of...

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

Techniques for systematically monitoring protein translation have lagged far behind methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome-profiling strategy that is based on the deep sequencing of ribosome-protected mRNA fragments...

Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae.

Highly purified functional cytotrophoblasts have been prepared from human term placentae by adding a Percoll gradient centrifugation step to a standard trypsin-DNase dispersion method. The isolated mononuclear trophoblasts averaged 10 μm in diameter,...

Cuckoo Search via Lévy flights

In this paper, we intend to formulate a new meta-heuristic algorithm, called Cuckoo Search (CS), for solving optimization problems. This algorithm is based on the obligate brood parasitic behaviour of some cuckoo species in combination with the Levy flight...

Missed diagnoses of acute cardiac ischemia in the emergency department.

Background Discharging patients with acute myocardial infarction or unstable angina from the emergency department because of missed diagnoses can have dire consequences. We studied the incidence of, factors related to, and clinical outcomes of failure...

Pathophysiology of Progressive Nephropathies

In patients with renal diseases characterized by proteinuria, the initial insult to the kidney is usually followed by a progressive decline in the glomerular filtration rate. This decline has been thought to be due to changes in renal hemodynamics initiated...

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for replacement therapies. However, the use of viruses encoding the reprogramming factors represents...

Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter

background Despite dramatic declines in children’s blood lead concentrations and a lowering of the Centers for Disease Control and Prevention’s level of concern to 10 µg per deciliter (0.483 µmol per liter), little is known about...

Diagnostic Performance of Coronary Angiography by 64-Row CT

Methods We conducted a multicenter study to examine the accuracy of 64-row, 0.5-mm multidetector CT angiography as compared with conventional coronary angiography in patients with suspected coronary artery disease. Nine centers enrolled...

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Background: The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1(beta) in human pancreatic beta cells, leading...

Planetary Boundaries: Exploring the Safe Operating Space for Humanity

Anthropogenic pressures on the Earth System have reached a scale where abrupt global environmental change can no longer be excluded. We propose a new approach to global sustainability in which we define planetary boundaries within which we expect that...

Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

Background Drugs that inhibit angiotensin-converting enzyme slow the progression of renal insufficiency in patients with diabetic nephropathy. Whether these drugs have a similar action in patients with other renal diseases is not known. We conducted a...

Confronting the challenges of participatory cultures (media education for the 21st century)

Henry Jenkins, Ravi Purushotma, Margaret Weigel, Katie Clinton, Alice Robison

The Political Economy of the World Trading System

The Political Economy of the World Trading System is a comprehensive textbook account of the economics, institutional mechanics and politics of the world trading system. This third edition has been expanded and updated to cover developments in the World...

A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults

background The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella– zoster virus (VZV). We tested the hypothesis that vaccination against...

A Survey of Affect Recognition Methods: Audio, Visual, and Spontaneous Expressions

Automated analysis of human affective behavior has attracted increasing attention from researchers in psychology, computer science, linguistics, neuroscience, and related disciplines. However, the existing methods typically handle only deliberately displayed...

A controlled trial of arthroscopic surgery for osteoarthritis of the knee

Background Many patients report symptomatic relief after undergoing arthroscopy of the knee for osteoarthritis, but it is unclear how the procedure achieves this result. We conducted a randomized, placebo-controlled trial to evaluate the efficacy of arthroscopy...

The Sorghum bicolor genome and the diversification of grasses

Sorghum, an African grass related to sugar cane and maize, is grown for food, feed, fibre and fuel. We present an initial analysis of the 730-megabase Sorghum bicolor (L.) Moench genome, placing 98% of genes in their chromosomal context using whole-genome...

Echocardiographic Assessment of Valve Stenosis: EAE/ASE Recommendations for Clinical Practice

Javier Bermejo, John Chambers, Arturo Evangelista, Brian P. Griffin, Bernard Iung, Patricia A. Pellikka

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

Background Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established. Methods We performed immunohistochemical analysis of 186 frozen specimens from advanced-stage...

Migraine — Current Understanding and Treatment

Migraine is a common and sometimes debilitating disorder. This review describes the epidemiology, pathophysiology, and preventive and symptomatic treatment of migraine, with special attention to drug therapy with the triptans.

Apoptosis in Myocytes in End-Stage Heart Failure

Background Heart failure can result from a variety of causes, including ischemic, hypertensive, toxic, and inflammatory heart disease. However, the cellular mechanisms responsible for the progressive deterioration of myocardial function observed in heart...

Remote sensing of vegetation 3-D structure for biodiversity and habitat: Review and implications for lidar and radar spaceborne missions

Kathleen M. Bergen, Scott J. Goetz, R. Dubayah, Carolyn T. Hunsaker, Marc L. Imhoff, Ross Nelson, Geoffrey G. Parker, Volker C. Radeloff

THE GPR54 GENE AS A REGULATOR OF PUBERTY

Background Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus. We conducted studies in humans...

Artemisinin Resistance in Plasmodium falciparum Malaria

We studied 40 patients in each of the two locations. The overall median parasite clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours (interquartile range, 36 to 66) in Wang Pha (P<0.001). Recrudescence...

A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease

In this randomized-pairs trial, we enrolled 156 patients with advanced Parkinson’s disease and severe motor symptoms. The primary end points were the changes from baseline to six months in the quality of life, as assessed by the Parkinson’s Disease...

Interventions for treating obesity in children

Treating obesity in childrenChildhood obesity affects both the physical and psychosocial health of children and may put them at risk of ill health as adults. More information is needed about the best way to treat obesity in children and adolescents. In...

Energy conservation in wireless sensor networks: A survey

In the last years, wireless sensor networks (WSNs) have gained increasing attention from both the research community and actual users. As sensor nodes are generally battery-powered devices, the critical aspects to face concern how to reduce the energy...

Primary Prevention of Coronary Heart Disease in Women through Diet and Lifestyle

Background Many lifestyle-related risk factors for coronary heart disease have been identified, but little is known about their effect on the risk of disease when they are considered together. Methods We followed 84,129 women participating in the Nurses'...

International Trial of the Edmonton Protocol for Islet Transplantation

Islet transplantation offers the potential to improve glycemic control in a subgroup of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia. We conducted an international, multicenter trial to explore the feasibility and...

Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates.

Summary Background Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and sepsis in children worldwide. However, many countries lack national estimates of disease burden. Eff ective interventions are available, including pneumococcal...

Measurement of Fractional Flow Reserve to Assess the Functional Severity of Coronary-Artery Stenoses

Background The clinical significance of coronary-artery stenoses of moderate severity can be difficult to determine. Myocardial fractional flow reserve (FFR) is a new index of the functional severity of coronary stenoses that is calculated from pressure...

TESTING FOR PHYLOGENETIC SIGNAL IN COMPARATIVE DATA: BEHAVIORAL TRAITS ARE MORE LABILE

The primary rationale for the use of phylogenetically based statistical methods is that phylogenetic signal, the tendency for related species to resemble each other, is ubiquitous. Whether this assertion is true for a given trait in a given lineage is...

Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research

This article is based on a consensus conference, which took place in Certosa di Pontignano, Siena (Italy) on March 7–9, 2008, intended to update the previous safety guidelines for the application of transcranial magnetic stimulation (TMS) in research...

Linking DNA methylation and histone modification: patterns and paradigms

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development. Certain forms of histone methylation cause local formation of heterochromatin, which is readily reversible, whereas DNA methylation...

The enteric nervous system

The enteric nervous system is a collection of neurons in the gastrointestinal tract1 that constitutes the “brain of the gut” and can function independently of the central nervous system.2 This system controls the motility,3,4 exocrine and endocrine...

« Prev. Next »
First ... 1 2 3 4 5 6 7 8 9 10 ... Last

© 2016-2018 CiteWeb.info — WorldWeb citation database

Up ↑