CiteWeb

WorldWeb citation database

Publications in 2009

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Guidelines for the diagnosis and treatment of pulmonary hypertension The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the Inte

Marius M. Hoeper, Marc Humbert, Adam Torbicki, Jean-Luc Vachiery, Paul A. Corris, Sean Gaine, J. Simon R. Gibbs, Miguel Angel Gomez-Sanchez, Guillaume Jondeau, Walter Klepetko, Andrew Peacock, Lewis J. Rubin, Michael J. Zellweger, Gérald Simonneau, Angelo Auricchio, Jeroen J. Bax, Claudio Ceconi, Veronica Dean, Gerasimos Filippatos, Christian Funck-Brentano, Richard Hobbs, Peter Kearney, Theresa McDonagh, Keith McGregor, Bogdan A. Popescu, Zeljko Reiner, Udo Sechtem, Michal Tendera, Panos E. Vardas, Felicita Andreotti, Riccardo Asteggiano, Ray Benza, Rolf M.F. Berger, Damien Bonnet, Marion Delcroix, Luke Howard, Anastasia Kitsiou, Irene Lang, Aldo P. Maggioni, Jens Erik Nielsen-Kudsk, Pasquale Perrone-Filardi, Maria Teresa Subirana Domenech, Anton Vonk-Noordegraaf, Jose Luis Zamorano

Organometal Halide Perovskites as Visible-Light Sensitizers for Photovoltaic Cells

Two organolead halide perovskite nanocrystals, CH3NH3PbBr3 and CH3NH3PbI3, were found to efficiently sensitize TiO2 for visible-light conversion in photoelectrochemical cells. When self-assembled on mesoporous TiO2 films, the nanocrystalline perovskites...

Benefit of Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis

Background Previous studies have shown that carotid endarterectomy in patients with symptomatic severe carotid stenosis (defined as stenosis of 70 to 99 percent of the luminal diameter) is beneficial up to two years after the procedure. In this clinical...

K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer

Background Treatment with cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor, improves overall and progression-free survival and preserves the quality of life in patients with colorectal cancer that has not responded...

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

Most cases of hepatocellular carcinoma occur in the Asia-Pacific region, where chronic hepatitis B infection is an important aetiological factor. Assessing the efficacy and safety of new therapeutic options in an Asia-Pacific population is thus important....

BLAST+: architecture and applications

Sequence similarity searching is a very important bioinformatics task. While Basic Local Alignment Search Tool (BLAST) outperforms exact methods through its use of heuristics, the speed of the current BLAST software is suboptimal for very long queries...

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease ☆

Background Both lipid-modifying therapy and antioxidant vitamins are thought to have benefit in patients with coronary disease. We studied simvastatin–niacin and antioxidant-vitamin therapy, alone and together, for cardiovascular protection in patients...

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

A method is described for measuring glomerular permeability by dextran clearance using Sephadex gel filtration technique. Clearance is shown to be a function of molecular size, decreasing with increasing molecular weight. At a mol. weight higher than...

Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.

We conducted a randomized, double-blind trial comparing salmeterol at a dose of 50 μg plus fluticasone propionate at a dose of 500 μg twice daily (combination regimen), administered with a single inhaler, with placebo, salmeterol alone, or fluticasone...

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

Background Neutralization of tumor necrosis factor α (TNF-α) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are...

Surgeon Volume and Operative Mortality in the United States

Background Although the relation between hospital volume and surgical mortality is well established, for most procedures, the relative importance of the experience of the operating surgeon is uncertain. Methods Using information from the national Medicare...

KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS-LIKE DNA SEQUENCES IN AIDS-RELATED BODY-CAVITY-BASED LYMPHOMAS

Background. DNA fragments that appeared to belong to an unidentified human herpesvirus were re- cently found in more than 90 percent of Kaposi's sarcoma lesions associated with the acquired immunodeficiency syndrome (AIDS). These fragments were also found...

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative...

A Potential Decline in Life Expectancy in the United States in the 21st Century

Forecasts of life expectancy are an important component of public policy that influence age-based entitlement programs such as Social Security and Medicare. Although the Social Security Administration recently raised its estimates of how long Americans...

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Methylation of cytosine bases, 5-methylcytosine (5mC), in DNA plays an important regulatory role in mammalian genomes. Methylation patterns are often inherited across generations, but they can also be dynamic, suggesting that active DNA demethylation...

Beyond Baron and Kenny: Statistical Mediation Analysis in the New Millennium

Understanding communication processes is the goal of most communication researchers. Rarely are we satisfied merely ascertaining whether messages have an effect on some outcome of focus in a specific context. Instead, we seek to understand how such effects...

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

background Selective cyclooxygenase-2 (COX-2) inhibitors have come under scrutiny because of reports suggesting an increased cardiovascular risk associated with their use. Experimental research suggesting that these drugs may contribute to a prothrombotic...

Circulating Angiogenic Factors and the Risk of Preeclampsia

During the last two months of pregnancy in the normotensive controls, the level of sFlt-1 increased and the level of PlGF decreased. These changes occurred earlier and were more pronounced in the women in whom preeclampsia later developed. The sFlt-1...

Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation

Background Continuous infusions of sedative drugs in the intensive care unit may prolong the duration of mechanical ventilation, prolong the length of stay in the intensive care unit and the hospital, impede efforts to perform daily neurologic examinations,...

A COMPARISON OF RATE CONTROL AND RHYTHM CONTROL IN PATIENTS WITH RECURRENT PERSISTENT ATRIAL FIBRILLATION

Background Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm. We hypothesized that ventricular...

Networking named content

Network use has evolved to be dominated by content distribution and retrieval, while networking technology still speaks only of connections between hosts. Accessing content and services requires mapping from the what that users care about to the network's...

Pretreatments to enhance the digestibility of lignocellulosic biomass

Lignocellulosic biomass represents a rather unused source for biogas and ethanol production. Many factors, like lignin content, crystallinity of cellulose, and particle size, limit the digestibility of the hemicellulose and cellulose present in the lignocellulosic...

CoSaMP: Iterative signal recovery from incomplete and inaccurate samples ☆

Compressive sampling offers a new paradigm for acquiring signals that are compressible with respect to an orthonormal basis. The major algorithmic challenge in compressive sampling is to approximate a compressible signal from noisy samples. This paper...

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those caused by gram-negative pathogens. Infections now occur that are resistant to...

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

Background Intensified multifactorial intervention — with tight glucose regulation and the use of renin–angiotensin system blockers, aspirin, and lipid-lowering agents — has been shown to reduce the risk of nonfatal cardiovascular disease among...

Complications of endoscopic biliary sphincterotomy.

Background Endoscopic sphincterotomy is commonly used to remove bile-duct stones and to treat other problems. We prospectively investigated risk factors for complications of this procedure and their outcomes. Methods We studied complications that occurred...

A CONTROLLED TRIAL OF TWO NUCLEOSIDE ANALOGUES PLUS INDINAVIR IN PERSONS WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND CD4 CELL COUNTS OF 200 PER CUBIC MILLIMETER OR LESS

Background The efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear. We compared treatment with the protease inhibitor indinavir in addition to zidovudine...

A Multidisciplinary Intervention to Prevent the Readmission of Elderly Patients with Congestive Heart Failure

Background Congestive heart failure is the most common indication for admission to the hospital among older adults. Behavioral factors, such as poor compliance with treatment, frequently contribute to exacerbations of heart failure, a fact suggesting...

Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.

Background Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons. Methods We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral...

Mortality Results from a Randomized Prostate-Cancer Screening Trial

Background The effect of screening with prostate-specific–antigen (PSA) testing and digital rectal examination on the rate of death from prostate cancer is unknown. This is the first report from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer...

Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America

Peter G. Pappas, Carol A. Kauffman, David R. Andes, D. Benjamin, Thierry Calandra, John E. Edwards, Scott G. Filler, John F. Fisher, Bart-Jan Kullberg, Luis Ostrosky Zeichner, Annette C. Reboli, John H. Rex, Thomas J. Walsh, Jack D. Sobe

Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both

background Angiotensin-converting–enzyme (ACE) inhibitors such as captopril reduce mortality and cardiovascular morbidity among patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. In a double-blind...

Identification and Importance of Brown Adipose Tissue in Adult Humans

Background Obesity results from an imbalance between energy intake and expenditure. In rodents and newborn humans, brown adipose tissue helps regulate energy expenditure by thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown...

Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy

Background The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with other antiretroviral drugs they may be able to cause profound and sustained suppression of HIV replication. Methods In this...

Chronic hepatitis B: Update 2009

Anna S. Lok, Brian J. McMahon

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Background There is evidence that medications or vitamins that increase the levels of brain catecholamines and protect against oxidative damage may reduce the neuronal damage and slow the progression of Alzheimer's disease. Methods We conducted a double-blind,...

A Comparison of Continuous Intravenous Epoprostenol (Prostacyclin) with Conventional Therapy for Primary Pulmonary Hypertension

Background Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospective, randomized trial to improve survival. Methods We conducted a 12-week prospective, randomized, multicenter open trial comparing the...

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.

Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye note that in rats exposed to stressors, the adrenal glands were enlarged, and...

Body weight and mortality among women.

The association between body weight and mortality in the United States is examined using data for 115195 women aged 30-55 who were enrolled in the Nurses Health Study and were followed over a 16-year period. "Body weight and mortality from all causes...

Obstructive Sleep Apnea as a Risk Factor for Stroke and Death

background Previous studies have suggested that the obstructive sleep apnea syndrome may be an important risk factor for stroke. It has not been determined, however, whether the syndrome is independently related to the risk of stroke or death from any...

Long-Term Mortality after Gastric Bypass Surgery

In this retrospective cohort study, we determined the long-term mortality (from 1984 to 2002) among 9949 patients who had undergone gastric bypass surgery and 9628 severely obese persons who applied for driver’s licenses. From these subjects, 7925 surgical...

Learning Deep Architectures for AI

Can machine learning deliver AI? Theoretical results, inspiration from the brain and cognition, as well as machine learning experiments suggest that in order to learn the kind of complicated functions that can represent high-level abstractions (e.g. in...

Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure

Background Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to cardiac transplantation, but their long-term use for the purpose of enhancing survival and the quality of life has not been evaluated....

Human DNA methylomes at base resolution show widespread epigenomic differences

Ryan Lister, Mattia Pelizzola, Robert H. Dowen, R. David Hawkins, Gary C. Hon, Julian Tonti-Filippini, Joseph R. Nery, Leonard Lee, Zhen Ye, Que-Minh Ngo, Lee Edsall, Jessica Antosiewicz-Bourget, Ron Stewart, Victor Ruotti, A. Harvey Millar, James A. Thomson, Bing Ren, Joseph R. Ecker

Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer

Background Adjuvant radiotherapy for rectal cancer has been extensively studied, but no trial has unequivocally demonstrated improved overall survival with radiotherapy, despite a reduction in the rate of local recurrence. Methods Between March 1987 and...

Control of Graphene's Properties by Reversible Hydrogenation: Evidence for Graphane

Although graphite is known as one of the most chemically inert materials, we have found that graphene, a single atomic plane of graphite, can react with atomic hydrogen, which transforms this highly conductive zero-overlap semimetal into an insulator....

A General Framework for Analyzing Sustainability of Social-Ecological Systems

A major problem worldwide is the potential loss of fisheries, forests, and water resources. Understanding of the processes that lead to improvements in or deterioration of natural resources is limited, because scientific disciplines use different concepts...

Biogenesis of small RNAs in animals

V. Narry Kim, Jinju Han, Mikiko C. Siomi

RESTRUCTURING LATTICE THEORY: AN APPROACH BASED ON HIERARCHIES OF CONCEPTS

Lattice theory today reflects the general Status of current mathematics: there is a rich production of theoretical concepts, results, and developments, many of which are reached by elaborate mental gymnastics; on the other hand, the connections of the...

Guías de práctica clínica para el manejo de la candidiasis: actualización del 2009, de la Infectious Diseases Society of America

Peter G. Pappas, Carol A. Kauffman, David R. Andes, D. Benjamin, Thierry Calandra, John E. Edwards, Scott G. Filler, John F. Fisher, Bart-Jan Kullberg, Luis Ostrosky-Zeichner, Annette C. Reboli, John H. Rex, Thomas J. Walsh, Jack D. Sobel

Causes and consequences of microRNA dysregulation in cancer

Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most — if not all — human malignancies. These alterations can be caused by various mechanisms, including...

Influence of the Internal-Mammary-Artery Graft on 10-Year Survival and Other Cardiac Events

We compared patients who received an internal-mammary-artery graft to the anterior descending coronary artery alone or combined with one or more saphenous-vein grafts (n = 2306) with patients who had only saphenous-vein bypass grafts (n = 3625). The 10-year...

Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease

Background Elevated plasma homocysteine levels are a risk factor for coronary heart disease, but the prognostic value of homocysteine levels in patients with established coronary artery disease has not been defined. Methods We prospectively investigated...

Microenvironmental regulation of metastasis.

Johanna A. Joyce, Jeffrey W. Pollard

Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress

background Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown. methods We evaluated 19 patients who presented with left ventricular dysfunction after sudden emotional stress. All...

Methods in Computational Physics

Berni J. Alder, Sidney Fernbach, Manuel Rotenberg

Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis

background Statins reduce the incidence of cardiovascular events in persons with type 2 diabetes mellitus. However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been...

Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis

Background A single infusion of intravenous zoledronic acid decreases bone turnover and improves bone density at 12 months in postmenopausal women with osteoporosis. We assessed the effects of annual infusions of zoledronic acid on fracture risk during...

Statistical methods in education and psychology

Gene V. Glass, Kenneth D. Hopkins

Polymer solar cells with enhanced open-circuit voltage and efficiency

Hsiang-Yu Chen, Jianhui Hou, Shaoqing Zhang, Yongye Liang, Guanwen Yang, Yang Ym, Luping Yu, Yue Wu, Gang Li

An Epidemic, Toxin Gene-Variant Strain of Clostridium difficile

background Recent reports suggest that the rate and severity of Clostridium difficile –associated disease in the United States are increasing and that the increase may be associated with the emergence of a new strain of C. difficile with increased virulence,...

Exact Matrix Completion via Convex Optimization

We consider a problem of considerable practical interest: the recovery of a data matrix from a sampling of its entries. Suppose that we observe m entries selected uniformly at random from a matrix M. Can we complete the matrix and recover the entries...

Immunological and Inflammatory Functions of the Interleukin-1 Family

More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the innate immune response. This linkage became evident upon the discovery that the cytoplasmic domain of the IL-1 receptor type I is highly homologous to the cytoplasmic...

Detecting influenza epidemics using search engine query data

Jeremy Ginsberg, Mohebbi Mh, Rajan S. Patel, Lynnette Brammer, Mark S. Smolinski, Larry Brilliant

Myocardial Reperfusion Injury

Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of the injury, on attempts to protect the heart against it, and on promising...

Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin

Background Heparin-induced thrombocytopenia, defined by the presence of heparin-dependent IgG antibodies, typically occurs five or more days after the start of heparin therapy and can be complicated by thrombotic events. The frequency of heparin-induced...

Matrix Factorization Techniques for Recommender Systems

As the Netflix Prize competition has demonstrated, matrix factorization models are superior to classic nearest neighbor techniques for producing product recommendations, allowing the incorporation of additional information such as implicit feedback, temporal...

Intrauterine Infection and Preterm Delivery

Preterm delivery is the chief problem in obstetrics today, accounting for 70 percent of perinatal mortality and nearly half of long-term neurologic morbidity.1,2 Approximately 10 percent of all births are preterm, but most of the serious illness and death...

Mixed-valence manganites

Mixed-valence manganese oxides (R1-χAχ)MnO3 (R=rare-earth cation, A=alkali or alkaline earth cation), with a structure similar to that of perovskite CaTiO3, exhibit a rich variety of crystallographic, electronic and magnetic phases. Historically they...

2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005

Frederick G. Kushner, Mary M. Hand, Sidney C. Smith, Spencer B. King, Jeffrey L. Anderson, Elliott M. Antman, Steven R. Bailey, Eric R. Bates, James C. Blankenship, Donald E. Casey, Lee A. Green, Judith S. Hochman, Alice K. Jacobs, Harlan M. Krumholz, Douglass A. Morrison, Joseph P. Ornato, David L. Pearle, Eric D. Peterson, Michael A. Sloan, Patrick L. Whitlow, David O. Williams

Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer

Background Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent. Methods We performed a hospital-based, case–control...

Addition of Clopidogrel to Aspirin and Fibrinolytic Therapy for Myocardial Infarction with ST-Segment Elevation

Background A substantial proportion of patients receiving fibrinolytic therapy for myocardial infarction with ST-segment elevation have inadequate reperfusion or reocclusion of the infarct-related artery, leading to an increased risk of complications...

A high-mobility electron-transporting polymer for printed transistors

He Yan, Zhihua Chen, Yan Zheng, Christopher Newman, Jordan R. Quinn, Florian Dötz, Marcel Kastler, Antonio Facchetti

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

We present a new continuum solvation model based on the quantum mechanical charge density of a solute molecule interacting with a continuum description of the solvent. The model is called SMD, where the “D” stands for “density” to denote that...

Cytokine pathways and joint inflammation in rheumatoid arthritis.

Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that cannot be cured and that has substantial personal, social, and economic costs. The long-term prognosis is poor: 80 percent of affected patients are disabled after 20...

A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer

Background Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation. Methods From March...

Apoptosis in the Failing Human Heart

Background Loss of myocytes is an important mechanism in the development of cardiac failure of either ischemic or nonischemic origin. However, whether programmed cell death (apoptosis) is implicated in the terminal stages of heart failure is not known....

Fine Particulate Air Pollution and Mortality in 20 U.S. Cities, 1987–1994

Background Air pollution in cities has been linked to increased rates of mortality and morbidity in developed and developing countries. Although these findings have helped lead to a tightening of air-quality standards, their validity with respect to public...

Lamivudine For Patients With Chronic Hepatitis B And Advanced Liver Disease.

This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work...

Fractional flow reserve versus angiography for guiding percutaneous coronary intervention.

Background In patients with multivessel coronary artery disease who are undergoing percutaneous coronary intervention (PCI), coronary angiography is the standard method for guiding the placement of the stent. It is unclear whether routine measurement...

Computed Tomographic Virtual Colonoscopy to Screen for Colorectal Neoplasia in Asymptomatic Adults

background We evaluated the performance characteristics of computed tomographic (CT) virtual colonoscopy for the detection of colorectal neoplasia in an average-risk screening population. methods A total of 1233 asymptomatic adults (mean age, 57.8 years)...

The Effects of Normal as Compared with Low Hematocrit Values in Patients with Cardiac Disease Who Are Receiving Hemodialysis and Epoetin

Background In patients with end-stage renal disease, anemia develops as a result of erythropoietin deficiency, and recombinant human erythropoietin (epoetin) is prescribed to correct the anemia partially. We examined the risks and benefits of normalizing...

Intracoronary Bone Marrow-Derived Progenitor Cells in Acute Myocardial Infarction

Background Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. Methods In a multicenter trial, we randomly assigned 204 patients with acute...

Enzymatic assembly of DNA molecules up to several hundred kilobases

Daniel G. Gibson, Lei Young, Ray-Yuan Chuang, J. Craig Venter, Clyde A. Hutchison, Hamilton O. Smith

A Comparison of Multimodal Therapy and Surgery for Esophageal Adenocarcinoma

Background Uncontrolled studies suggest that a combination of chemotherapy and radiotherapy improves the survival of patients with esophageal adenocarcinoma. We conducted a prospective, randomized trial comparing surgery alone with combined chemotherapy,...

Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer

background Standard chemotherapy for newly diagnosed ovarian cancer is a platinum–taxane combination. The Gynecologic Oncology Group conducted a randomized, phase 3 trial that compared intravenous paclitaxel plus cisplatin with intravenous paclitaxel...

Safety and Efficacy of Sirolimus- and Paclitaxel-Eluting Coronary Stents

Background The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis, myocardial infarction, and death. Such studies have been inconclusive because of their insufficient size, the use of historical...

High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis

Background Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid...

Location and the Multinational Enterprise: A Neglected Factor?

This article first traces the changing world economic scenario for international business over the past two decades, and then goes on to examine its implications for the location of foreign direct investment and multinational enterprise activity. It suggests...

The Sentinel Node in Breast Cancer — A Multicenter Validation Study

Background Pilot studies indicate that probe-guided resection of radioactive sentinel nodes (the first nodes that receive drainage from tumors) can identify regional metastases in patients with breast cancer. To confirm this finding, we conducted a multicenter...

Cancer of the ovary.

Patients with ovarian cancer usually present with advanced disease, and the disease is generally managed with surgical resection followed by platinum-based chemotherapy. Recent chemotherapeutic advances have led to improved survival, and a better understanding...

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

David E. Harrison, Randy Strong, Zelton Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, J. Erby Wilkinson, Krystyna Frenkel, Christy S. Carter, Marco Pahor, Martin A. Javors, Elizabeth Fernandez, Richard A. Miller

Recent Advances in Sensitized Mesoscopic Solar Cells

Recent Advances in Sensitized Mesoscopic Solar Cells

Hematologic and Cytogenetic Responses to Imatinib Mesylate in Chronic Myelogenous Leukemia

Background Chronic myelogenous leukemia (CML) is caused by the BCR-ABL tyrosine kinase, the product of the Philadelphia chromosome. Imatinib mesylate, formerly STI571, is a selective inhibitor of this kinase. Methods A total of 532 patients with late–chronic-phase...

Circulating Endothelial Progenitor Cells and Cardiovascular Outcomes

Background Endothelial progenitor cells derived from bone marrow are believed to support the integrity of the vascular endothelium. The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic...

Oral Sildenafil in the Treatment of Erectile Dysfunction

Background Sildenafil is a potent inhibitor of cyclic guanosine monophosphate in the corpus cavernosum and therefore increases the penile response to sexual stimulation. We evaluated the efficacy and safety of sildenafil, administered as needed in two...

Hyperinsulinemia as an independent risk factor for ischemic heart disease.

Background Prospective studies suggest that hyperinsulinemia may be an important risk factor for ischemic heart disease. However, it has not been determined whether plasma insulin levels are independently related to ischemic heart disease after adjustment...

Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids

Background In laboratory animals, the consumption of soy protein, rather than animal protein, decreases serum cholesterol concentrations, but studies in humans have been inconclusive. In this meta-analysis of 38 controlled clinical trials, we examined...

IDH1 and IDH2 mutations in gliomas.

Background A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that...

Rates and risk of postpartum depression—a meta-analysis

The average prevalence rate of non-psychotic postpartum depression based on the results of a large number of studies is 13%. Prevalence estimates are affected by the nature of the assessment method (larger estimates in studies using self-report measures)...

Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis.

The prevalence of obesity-induced type 2 diabetes mellitus is increasing worldwide. The objective of this review and meta-analysis is to determine the impact of bariatric surgery on type 2 diabetes in association with the procedure performed and the weight...

Real-Time DNA Sequencing from Single Polymerase Molecules

We present single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs). We detected the temporal...

Gender Differences in Preferences

This paper reviews the literature on gender differences in economic experiments. In the three main sections, we identify robust differences in risk preferences, social (other-regarding) preferences, and competitive preferences. We also speculate on the...

Comparison of Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with the Glycoprotein IIb/IIIa Inhibitor Tirofiban

Background There is continued debate as to whether a routine, early invasive strategy is superior to a conservative strategy for the management of unstable angina and myocardial infarction without ST-segment elevation. Methods We enrolled 2220 patients...

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document.

Giuseppe Mancia, Stéphane Laurent, Enrico Agabiti-Rosei, Ambrosioni E, Michel Burnier, Mark Caulfield, Renata Cifkova, Denis Clement, Anna F. Dominiczak, Serap Erdine, Robert Fagard, Csaba Farsang, Guido Grassi, Hermann Haller, Anthony M. Heagerty, Sverre E. Kjeldsen, Wolfgang Kiowski, Jean Michel Mallion, Athanasios J. Manolis, Krzysztof Narkiewicz, Peter Nilsson, Michael H. Olsen, Rahn Kh, Josep Redon, Rodicio Jl, Luis M. Ruilope, Roland E. Schmieder, Harry Struijker-Boudier, Pieter van Zwieten, Margus Viigimaa, Alberto Zanchetti

Magnetic metal–organic frameworks

The purpose of this critical review is to give a representative and comprehensive overview of the arising developments in the field of magnetic metal–organic frameworks, in particular those containing cobalt(ii). We examine the diversity of magnetic...

Harmonizing the Metabolic Syndrome

A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors include raised blood pressure, dyslipidemia (raised...

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

Background. Cytomegalovirus (CMV) dis- ease in immunocompromised patients correlates with a deficiency of CD8 � cytotoxic T lymphocytes specific for CMV. We evaluated the safety and immunologic effects of immunotherapy with clones of these lymphocytes...

Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events

During a 4.5-year period, we enrolled and followed 1820 patients with ischemic or nonischemic cardiomyopathy, an ejection fraction of 30% or less, a QRS duration of 130 msec or more, and New York Heart Association class I or II symptoms. Patients were...

Classification of Inflammatory Bowel Disease

Infection, ischaemia, physical damage, or specific immunologic sensitivity should be excluded as far as possible before a diagnosis of non-specific inflammatory bowel disease is made. Non-specific inflammations can be subdivided on the basis of macroscopic...

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