CiteWeb

WorldWeb citation database

Publications in 2009

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Helicobacter pylori Infection and the Development of Gastric Cancer

Background Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain. Methods We prospectively studied 1526 Japanese patients who had duodenal...

Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease

We randomly assigned 1800 patients with three-vessel or left main coronary artery disease to undergo CABG or PCI (in a 1:1 ratio). For all these patients, the local cardiac surgeon and interventional cardiologist determined that equivalent anatomical...

Luminescent metal–organic frameworks

Metal–organic frameworks (MOFs) display a wide range of luminescent behaviors resulting from the multifaceted nature of their structure. In this critical review we discuss the origins of MOF luminosity, which include the linker, the coordinated metal...

Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma

Background Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, may benefit patients with this disease. Methods In...

An introduction to latent semantic analysis

Latent Semantic Analysis (LSA) is a theory and method for extracting and representing the contextual‐usage meaning of words by statistical computations applied to a large corpus of text (Landauer & Dumais, 1997). The underlying idea is that the aggregate...

Linked Data - The Story So Far

The term “Linked Data” refers to a set of best practices for publishing and connecting structured data on the Web. These best practices have been adopted by an increasing number of data providers over the last three years, leading to the creation...

Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet

Background The effect of dietary composition on blood pressure is a subject of public health importance. We studied the effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop Hypertension (DASH) diet, which is...

Jalview Version 2 – a multiple sequence alignment editor and analysis workbench

Summary: Jalview Version 2 is a system for interactive WYSIWYG editing, analysis and annotation of multiple sequence alignments. Core features include keyboard and mouse-based editing, multiple views and alignment overviews, and linked structure display...

Hepatitis C Virus Infection

Hepatitis C virus (HCV) infects an estimated 170 million persons worldwide and thus represents a viral pandemic, one that is five times as widespread as infection with the human immunodeficiency virus type 1 (HIV-1). The institution of blood-screening...

Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

Background Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown. Methods We randomly assigned 1637 postmenopausal women...

Asthma and Wheezing in the First Six Years of Life

Background Many young children wheeze during viral respiratory infections, but the pathogenesis of these episodes and their relation to the development of asthma later in life are not well understood. Methods In a prospective study, we investigated the...

2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration Wi

Mariell Jessup, William T. Abraham, Donald E. Casey, Arthur M. Feldman, Gary S. Francis, Theodore G. Ganiats, Marvin A. Konstam, Donna Mancini, Peter S. Rahko, Marc A. Silver, Clyde W. Yancy

Layer Area, Few-Layer Graphene Films on Arbitrary Substrates by Chemical Vapor Deposition

In this work we present a low cost and scalable technique, via ambient pressure chemical vapor deposition (CVD) on polycrystalline Ni films, to fabricate large area (∼cm2) films of single- to few-layer graphene and to transfer the films to nonspecific...

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Lucia A. Hindorff, Praveen Sethupathy, Heather A. Junkins, Erin M. Ramos, Jayashri P. Mehta, Francis S. Collins, Teri A. Manolio

Glucose control and vascular complications in veterans with type 2 diabetes.

William C. Duckworth, Carlos Abraira, Thomas E. Moritz, Domenic J. Reda, Nicholas V. Emanuele, Peter D. Reaven, Franklin Zieve, Jennifer B. Marks, Stephen N. Davis, Hayward Ra, Warren, Steven Goldman, Madeline McCarren, Mary Ellen Vitek, William G. Henderson, Grant D. Huang, Vadt Investigators

IntCal09 and Marine09 radiocarbon age calibration curves, 0-50,000 years cal BP

The IntCal09 and Marine09 radiocarbon calibration curves have been revised utilizing newly available and updated data sets from 14 C measurements on tree rings, plant macrofossils, speleothems, corals, and foraminifera. The calibration curves were derived...

Obesity and the Metabolic Syndrome in Children and Adolescents

background The prevalence and magnitude of childhood obesity are increasing dramatically. We examined the effect of varying degrees of obesity on the prevalence of the metabolic syndrome and its relation to insulin resistance and to C-reactive protein...

IL-17 and Th17 Cells

CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce....

Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay

Background One third of patients with chronic heart failure have electrocardiographic evidence of a major intraventricular conduction delay, which may worsen left ventricular systolic dysfunction through asynchronous ventricular contraction. Uncontrolled...

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris, Ruth Huey, William Lindstrom, Michel F. Sanner, Richard K. Belew, David S. Goodsell, Arthur J. Olson

Rules of the mind

John R. Anderson, Francis S. Bellezza

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.

Background We conducted a multinational, randomized study to compare radiotherapy alone with radiotherapy plus cetuximab, a monoclonal antibody against the epidermal growth factor receptor, in the treatment of locoregionally advanced squamous-cell carcinoma...

Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses

G*Power is a free power analysis program for a variety of statistical tests. We present extensions and improvements of the version introduced by Faul, Erdfelder, Lang, and Buchner (2007) in the domain of correlation and regression analyses. In the new...

Selective gas adsorption and separation in metal–organic frameworks

Adsorptive separation is very important in industry. Generally, the process uses porous solid materials such as zeolites, activated carbons, or silica gels as adsorbents. With an ever increasing need for a more efficient, energy-saving, and environmentally...

Intensive versus Conventional Glucose Control in Critically Ill Patients

This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work...

Hepatitis B virus infection.

The hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people worldwide.1 Hepatitis B is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma, accounting for 1 million deaths annually. Knowledge of the...

Ethical authorship and publishing.

Principles of Ethical Publishing in the International Journal of Cardiology: 1. That the corresponding author has the approval of all other listed authors for the submission and publication of all versions of the manuscript.

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

Acetylcholine is believed to dilate normal blood vessels by promoting the release of a vasorelaxant substance from the endothelium (endothelium-derived relaxing factor). By contrast, if the endothelium is removed experimentally, acetylcholine constricts...

EFFECTS OF A COMBINATION OF BETA CAROTENE AND VITAMIN A ON LUNG CANCER AND CARDIOVASCULAR DISEASE

Background. Lung cancer and cardiovas- cular disease are major causes of death in the United States. It has been proposed that carotenoids and reti- noids are agents that may prevent these disorders. Methods. We conducted a multicenter, randomized, double-blind,...

Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer

vs. 0.0%, P<0.001), proteinuria (3.6% vs. 0.0%, P<0.001), headache (2.2% vs. 0.0%, P = 0.008), and...

Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis

Background Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis. Methods In this randomized, unblinded...

Terrestrial Ecoregions of the World: A New Map of Life on Earth

David M. Olson, Eric Dinerstein, Eric Wikramanayake, Neil D. Burgess, George Powell, Emma C. Underwood, Jennifer A. D'amico, Illanga Itoua, Holly E. Strand, John C. Morrison, Colby Loucks, Thomas F. Allnutt, Taylor H. Ricketts, Yumiko Kura, John F. Lamoreux, Wesley W. Wettengel, Prashant Hedao, Kenneth R. Kassem

Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer

Background We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery. Methods From 1973 to 1980, 701 women with breast cancers measuring no...

A Fast Iterative Shrinkage-Thresholding Algorithm for Linear Inverse Problems

We consider the class of iterative shrinkage-thresholding algorithms (ISTA) for solving linear inverse problems arising in signal/image processing. This class of methods, which can be viewed as an extension of the classical gradient algorithm, is attractive...

Combat Duty in Iraq and Afghanistan, Mental Health Problems, and Barriers to Care

background The current combat operations in Iraq and Afghanistan have involved U.S. military personnel in major ground combat and hazardous security duty. Studies are needed to systematically assess the mental health of members of the armed services who...

Screening and Prostate-Cancer Mortality in a Randomized European Study

In the screening group, 82% of men accepted at least one offer of screening. During a median follow-up of 9 years, the cumulative incidence of prostate cancer was 8.2% in the screening group and 4.8% in the control group. The rate ratio for death from...

EFFECT OF CARVEDILOL ON SURVIVAL IN SEVERE CHRONIC HEART FAILURE

Background Beta-blocking agents reduce the risk of hospitalization and death in patients with mild-to-moderate heart failure, but little is known about their effects in severe heart failure. Methods We evaluated 2289 patients who had symptoms of heart...

Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure

Background B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension. Methods We conducted a prospective study of 1586 patients who came to the emergency department with acute dyspnea and whose B-type natriuretic...

Origins and Mechanisms of miRNAs and siRNAs

Over the last decade, ! 20‐30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs— short interfering RNAs (siRNAs) and microRNAs (miRNAs)—act...

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

Background Bortezomib, a boronic acid dipeptide, is a novel proteasome inhibitor that has been shown in preclinical and phase 1 studies to have antimyeloma activity. Methods In this multicenter, open-label, nonrandomized, phase 2 trial, we enrolled 202...

Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer

Background Lapatinib, a tyrosine kinase inhibitor of human epidermal growth factor receptor type 2 (HER2, also referred to as HER2/neu) and epidermal growth factor receptor (EGFR), is active in combination with capecitabine in women with HER2-positive...

Risk Factors for Hip Fracture in White Women

Background Many risk factors for hip fractures have been suggested but have not been evaluated in a comprehensive prospective study. Methods We assessed potential risk factors, including bone mass, in 9516 white women 65 years of age or older who had...

Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

Approximately 200 studies that examined the relationship between fruit and vegetable intake and cancers of the lung, colon, breast, cervix, esophagus, oral cavity, stomach, bladder, pancreas, and ovary are reviewed. A statistically significant protective...

Trends in prevalence and outcome of heart failure with preserved ejection fraction

Background The prevalence of heart failure with preserved ejection fraction may be changing as a result of changes in population demographics and in the prevalence and treatment of risk factors for heart failure. Changes in the prevalence of heart failure...

Best Practices in Exploratory Factor Analysis: Four Recommendations for Getting the Most from Your Analysis

Exploratory factor analysis (EFA) is a complex, multi-step process. The goal of this paper is to collect, in one article, information that will allow researchers and practitioners to understand the various choices available through popular software packages,...

Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability

Background Functional assessment is an important part of the evaluation of elderly persons. We conducted this study to determine whether objective measures of physical function can predict subsequent disability in older persons. Methods This prospective...

Rehospitalizations among patients in the Medicare fee-for-service program.

Background Reducing rates of rehospitalization has attracted attention from policymakers as a way to improve quality of care and reduce costs. However, we have limited information on the frequency and patterns of rehospitalization in the United States...

CORONARY-ARTERY CALCIFICATION IN YOUNG ADULTS WITH END-STAGE RENAL DISEASE WHO ARE UNDERGOING DIALYSIS

Background Cardiovascular disease is common in older adults with end-stage renal disease who are undergoing regular dialysis, but little is known about the prevalence and extent of cardiovascular disease in children and young adults with end-stage renal...

A RANDOMIZED TRIAL OF THE ANGIOTENSIN-RECEPTOR BLOCKER VALSARTAN IN CHRONIC HEART FAILURE

Background Actions of angiotensin II may contribute to the progression of heart failure despite treatment with currently recommended drugs. We therefore evaluated the long-term effects of the addition of the angiotensin-receptor blocker valsartan to standard...

Exercise Capacity and Mortality among Men Referred for Exercise Testing

Background Exercise capacity is known to be an important prognostic factor in patients with cardiovascular disease, but it is uncertain whether it predicts mortality equally well among healthy persons. There is also uncertainty regarding the predictive...

Early identification of refractory epilepsy.

Background More than 30 percent of patients with epilepsy have inadequate control of seizures with drug therapy, but why this happens and whether it can be predicted are unknown. We studied the response to antiepileptic drugs in patients with newly diagnosed...

An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU

intervention (P≤0.002), and the mean rate per 1000 catheter-days decreased from 7.7 at baseline to 1.4 at 16 to 18 months of follow-up (P<0.002). The regression model showed a significant decrease in infection rates...

IMPROVED SURVIVAL WITH AN IMPLANTED DEFIBRILLATOR IN PATIENTS WITH CORONARY DISEASE AT HIGH RISK FOR VENTRICULAR ARRHYTHMIA

Background Unsustained ventricular tachycardia in patients with previous myocardial infarction and left ventricular dysfunction is associated with a twoyear mortality rate of about 30 percent. We studied whether prophylactic therapy with an implanted...

Structure validation in chemical crystallography

Automated structure validation was introduced in chemical crystallography about 12 years ago as a tool to assist practitioners with the exponential growth in crystal structure analyses. Validation has since evolved into an easy-to-use checkCIF/PLATON...

The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.

Background Recent studies indicate that magnetic resonance imaging (MRI) after the administration of contrast material can be used to distinguish between reversible and irreversible myocardial ischemic injury regardless of the extent of wall motion or...

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

Background BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia (Ph) chromosome. This enzyme is present in virtually all cases of chronic myeloid leukemia (CML) throughout the course of the disease, and in 20 percent...

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Dongliang Ge, Jacques Fellay, Alexander J. Thompson, Jason S. Simon, Kevin V. Shianna, Thomas J. Urban, Erin L. Heinzen, Ping Qiu, Arthur H. Bertelsen, Andrew J. Muir, Mark S. Sulkowski, John G. McHutchison, David B. Goldstein

The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease

background Chronic obstructive pulmonary disease (COPD) is characterized by an incompletely reversible limitation in airflow. A physiological variable — the forced expiratory volume in one second (FEV 1 ) — is often used to grade the severity of COPD....

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

The Carbohydrate-Active Enzyme (CAZy) database is a knowledge-based resource specialized in the enzymes that build and breakdown complex carbohydrates and glycoconjugates. As of September 2008, the database describes the present knowledge on 113 glycoside...

Reciprocal Teaching of Comprehension-Fostering and Comprehension-Monitoring Activities

Two instructional studies directed at the comprehension-fostering and comprehension-monitoring activities of seventh grade poor comprehenders are reported. The four study activities were summarizing (self-review), questioning, clarifying, and predicting....

Chemoradiotherapy after Surgery Compared with Surgery Alone for Adenocarcinoma of the Stomach or Gastroesophageal Junction

Background Surgical resection of adenocarcinoma of the stomach is curative in less than 40 percent of cases. We investigated the effect of surgery plus postoperative (adjuvant) chemoradiotherapy on the survival of patients with resectable adenocarcinoma...

ggplot2: Elegant Graphics for Data Analysis

This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics. With ggplot2, its easy to: produce handsome, publication-quality...

Bulk heterojunction solar cells with internal quantum efficiency approaching 100|[percnt]|

Serge Beaupré, Shinuk Cho, Nelson E. Coates, Ji Sun Moon, D. Moses, Mario Leclerc, Kwanghee Lee, Alan J. Heeger

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

Enhanced surveillance was implemented in the United States for human infection with influenza A viruses that could not be subtyped. Specimens were sent to the Centers for Disease Control and Prevention for real-time reverse-transcriptase–polymerase-chain-reaction...

A core gut microbiome in obese and lean twins.

Peter J. Turnbaugh, Micah Hamady, Tanya Yatsunenko, Brandi L. Cantarel, Alexis E. Duncan, Ruth E. Ley, Mitchell L. Sogin, William J. Jones, Bruce A. Roe, Jason P. Affourtit, Michael Egholm, Bernard Henrissat, Andrew C. Heath, Rob Knight, Jeffrey I. Gordon

Heart Disease and Stroke Statistics—2009 Update

We thank Drs Sean Coady, Eric L. Ding, Brian Eigel, Gregg C. Fonarow, Linda Geiss, Cherie James, Michael Mussolino, and Michael Wolz for their valuable comments and contributions. We acknowledge Tim Anderson and Tom Schneider for their editorial contributions,...

The Seventh Data Release of the Sloan Digital Sky Survey

This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work...

ASSOCIATION BETWEEN MULTIPLE CARDIOVASCULAR RISK FACTORS AND ATHEROSCLEROSIS IN CHILDREN AND YOUNG ADULTS

Background In adults, cardiovascular risk factors reinforce each other in their effect on cardiovascular events. However, information is scant on the relation of multiple risk factors to the extent of asymptomatic atherosclerosis in young people. Methods...

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

Background We investigated the efficacy of cetuximab plus irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment for metastatic colorectal cancer and sought associations between the mutation status of the KRAS gene in tumors and clinical...

How mitochondria produce reactive oxygen species

The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2•−)...

Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction

To define the prevalence of total coronary occlusion in the hours after transmural myocardial infarction, we used coronary arteriography to study the degree of coronary obstruction in 322 patients admitted within 24 hours of infarction. Total coronary...

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

Mutations of the epidermal growth factor receptor (EGFR) gene have been identified in specimens from patients with non–small-cell lung cancer who have a response to anilinoquinazoline EGFR inhibitors. Despite the dramatic responses to such inhibitors,...

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

We are not surprised that GlaxoSmithKline, the manufacturer of rosiglitazone (Avandia), is not happy with the recommendation of the consensus group (1) that rosiglitazone not be used in the treatment of type 2 diabetes (2). Drs. Cobitz and Ambery argue...

Natural history of cervicovaginal papillomavirus infection in young women.

Genital human papillomavirus (HPV) infection is highly prevalent in sexually active young women. However precise risk factors for HPV infection and its incidence and duration are not well known. The authors followed 608 college women at 6-month intervals...

The Influence of Finasteride on the Development of Prostate Cancer

background Androgens are involved in the development of prostate cancer. Finasteride, an inhibitor of 5 a -reductase, inhibits the conversion of testosterone to dihydrotestosterone, the primary androgen in the prostate, and may reduce the risk of prostate...

Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs

Background In the hierarchy of research designs, the results of randomized, controlled trials are considered to be evidence of the highest grade, whereas observational studies are viewed as having less validity because they reportedly overestimate treatment...

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography

Recommendations for the evaluation of left ventricular diastolic function by echocardiography

A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population

The rate of death was 1.5% before the checklist was introduced and declined to 0.8% afterward (P = 0.003). Inpatient complications occurred in 11.0% of patients at baseline and in 7.0%...

Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer

background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the...

CHARMM: The biomolecular simulation program

CHARMM (Chemistry at HARvard Molecular Mechanics) is a highly versatile and widely used molecu- lar simulation program. It has been developed over the last three decades with a primary focus on molecules of bio- logical interest, including proteins, peptides,...

Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer

Background Chemotherapy combinations that include an alkylating agent and a platinum coordination complex have high response rates in women with advanced ovarian cancer. Such combinations provide long-term control of disease in few patients, however....

Physical Activity, All-Cause Mortality, and Longevity of College Alumni

We examined the physical activity and other life-style characteristics of 16,936 Harvard alumni, aged 35 to 74, for relations to rates of mortality from all causes and for influences on length of life. A total of 1413 alumni died during 12 to 16 years...

Protected Carotid-Artery Stenting versus Endarterectomy in High-Risk Patients

background Carotid endarterectomy is more effective than medical management in the prevention of stroke in patients with severe symptomatic or asymptomatic atherosclerotic carotidartery stenosis. Stenting with the use of an emboli-protection device is...

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Background Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2. Methods...

Circos: An information aesthetic for comparative genomics

Martin Krzywinski, Jacqueline E. Schein, Inanc Birol, Joseph M. Connors, Randy D. Gascoyne, Doug Horsman, Steven Jm Jones, Marco A. Marra

The Use of Partial Least Squares Path Modeling in International Marketing

Purpose: This paper discusses partial least squares path modeling (PLS), a powerful structural equation modeling technique for research on international marketing. While a significant body of research provides guidance for the use of covariance-based...

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

In the intention-to-treat analysis involving 16,402 subjects, there was a trend toward the prevention of HIV-1 infection among the vaccine recipients, with a vaccine efficacy of 26.4% (95% confidence interval [CI], −4.0 to 47.9; P =...

To Parcel or Not to Parcel: Exploring the Question, Weighing the Merits

We examine the controversial practice of using parcels of items as manifest variables in structural equation modeling (SEM) procedures. After detailing arguments pro and con, we conclude that the unconsidered use of parcels is never warranted, while,...

Erosional variability along the northwest Himalaya

Rasmus C. Thiede, Todd A. Ehlers, Bodo Bookhagen, Manfred R. Strecker

OLEX2: a complete structure solution, refinement and analysis program

O. Dolomanov, Luc J. Bourhis, Richard J. Gildea, Judith A. K. Howard, Horst Puschmann

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

Background In cross-sectional studies, elevated plasma homocysteine levels have been associated with poor cognition and dementia. Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the...

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

background Selective inhibition of cyclooxygenase-2 (COX-2) may be associated with an increased risk of thrombotic events, but only limited long-term data have been available for analysis. We report on the cardiovascular outcomes associated with the use...

Tensor Decompositions and Applications

This survey provides an overview of higher-order tensor decompositions, their applications, and available software. A tensor is a multidimensional or $N$-way array. Decompositions of higher-order tensors (i.e., $N$-way arrays with $N \geq 3$) have applications...

Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy

Background The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known. Methods We evaluated rosiglitazone, metformin, and glyburide as initial...

Topological insulators in Bi2Se3, Bi2Te3 and Sb2Te3 with a single Dirac cone on the surface

NSF of China; National Basic Research Program of China [2007CB925000]; International Science and Technology Cooperation Program of China [2008DFB00170]; US Department of Energy, Office of Basic Energy Sciences [DE-AC02-76SF00515]

Anomaly detection: A survey

Anomaly detection is an important problem that has been researched within diverse research areas and application domains. Many anomaly detection techniques have been specifically developed for certain application domains, while others are more generic....

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.

background An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind,...

Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer

background We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer. methods In a prospective, multicenter study, we tested 177 patients with measurable metastatic breast cancer for levels of...

Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is characterized by the progressive development of airflow limitation that is not fully reversible.1 The term COPD encompasses chronic obstructive bronchitis, with obstruction of small airways, and emphysema,...

ImageNet: A large-scale hierarchical image database

The explosion of image data on the Internet has the potential to foster more sophisticated and robust models and algorithms to index, retrieve, organize and interact with images and multimedia data. But exactly how such data can be harnessed and organized...

Decline in Invasive Pneumococcal Disease after the Introduction of Protein–Polysaccharide Conjugate Vaccine

background In early 2000, a protein–polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children. methods We examined population-based data from the Active Bacterial Core Surveillance...

The DNA-damage response in human biology and disease

The prime objective for every life-form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has...

Fungi and food spoilage

John I. Pitt, Ailsa D. Hocking

Ranibizumab versus Verteporfin for Neovascular Age-Related Macular Degeneration

Of the 423 patients enrolled, 94.3% of those given 0.3 mg of ranibizumab and 96.4% of those given 0.5 mg lost fewer than 15 letters, as compared with 64.3% of those in the verteporfin group (P<0.001 for...

VIRAL LOAD AND HETEROSEXUAL TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

The authors examined the influence of viral load in relation to other risk factors for the heterosexual transmission of HIV type 1 (HIV-1). In a community-based study of 15127 persons in a rural district of Uganda the authors identified 415 couples in...

Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer

background The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the efficacy of this combination in patients with metastatic colorectal cancer. We evaluated the efficacy of treatment with FL plus oxaliplatin...

Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.

Background Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates in the adaptive response to weight loss, its...

Aging, natural death, and the compression of morbidity.

The average length of life has risen from 47 to 73 years in this century, but the maximum life span has not increased. Therefore, survival curves have assumed an ever more rectangular form. Eighty per cent of the years of life lost to nontraumatic, premature...

Assessment of quality-of-life outcomes

Since 1948, when the World Health Organization defined health as being not only the absence of disease and infirmity but also the presence of physical, mental, and social well-being,1 quality-of-life issues have become steadily more important in health...

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