CiteWeb

WorldWeb citation database

Publications in 2009

Page 1
Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives

This article examines the adequacy of the “rules of thumb” conventional cutoff criteria and several new alternatives for various fit indexes used to evaluate model fit in practice. Using a 2‐index presentation strategy, which includes using the...

Support vector machines

Nello Cristianini, Elisa Ricci

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G. Altman

The electronic properties of graphene

This article reviews the basic theoretical aspects of graphene, a one-atom-thick allotrope of carbon, with unusual two-dimensional Dirac-like electronic excitations. The Dirac electrons can be controlled by application of external electric and magnetic...

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

background Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and clinical activity against metastatic colorectal cancer, particularly in combination with chemotherapy. methods Of 813 patients...

The WEKA data mining software: an update

More than twelve years have elapsed since the first public release of WEKA. In that time, the software has been rewritten entirely from scratch, evolved substantially and now accompanies a text on data mining [35]. These days, WEKA enjoys widespread acceptance...

The "What" and "Why" of Goal Pursuits: Human Needs and the Self-Determination of Behavior

Self-determination theory (SDT) maintains that an understanding of human motivation requires a consideration of innate psychological needs for competence, autonomy, and relatedness. We discuss the SDT concept of needs as it relates to previous need theories,...

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

background Most patients with non–small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical...

Cancer Statistics, 2009†‡

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the...

Cluster Analysis

Cluster analysis comprises a range of methods for classifying multivariate data into subgroups. By organising multivariate data into such subgroups, clustering can help reveal the characteristics of any structure or patterns present. These techniques...

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

Systematic reviews and meta-analyses are essential to summarise evidence relating to efficacy and safety of healthcare interventions accurately and reliably. The clarity and transparency of these reports, however, are not optimal. Poor reporting of systematic...

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

pu o r G g n i h s i l b u P e r u t a N 8 0 0 2 © natureprotocol s / m o c . e r u t a n . w w w / / : p t t h

Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance

Background Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high...

DnaSP v5: a software for comprehensive analysis of DNA polymorphism data

Motivation: DnaSP is a software package for a comprehensive analysis of DNA polymorphism data. Version 5 implements a number of new features and analytical methods allowing extensive DNA polymorphism analyses on large datasets. Among other features, the...

The Sequence Alignment/Map format and SAMtools

Summary: The Sequence Alignment/Map (SAM) format is a generic alignment format for storing read alignments against reference sequences, supporting short and long reads (up to 128 Mbp) produced by different sequencing platforms. It is flexible in style,...

Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins

Background Atrial fibrillation, the most common sustained cardiac arrhythmia and a major cause of stroke, results from simultaneous reentrant wavelets. Its spontaneous initiation has not been studied. Methods We studied 45 patients with frequent episodes...

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

Background In patients with high cholesterol levels, lowering the cholesterol level reduces the risk of coronary events, but the effect of lowering cholesterol levels in the majority of patients with coronary disease, who have average levels, is less...

Heart Disease and Stroke Statistics—2009 Update A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Robert J. Adams, Mercedes R. Carnethon, Giovanni de Simone, T. Bruce Ferguson, Katherine M. Flegal, Earl S. Ford, Karen L. Furie, Alan S. Go, Kurt J. Greenlund, Nancy Haase, Susan M. Hailpern, Michael Ho, Virginia J. Howard, Steven J. Kittner, Daniel T. Lackland, Lynda D. Lisabeth, Ariane J. Marelli, Mary McDermott, James B. Meigs, Dariush Mozaffarian, Graham Nichol, Christopher J. O'Donnell, Véronique L. Roger, Wayne D. Rosamond, Ralph L. Sacco, Paul D. Sorlie, Randall S. Stafford, Julia Steinberger, Thomas Thom, Sylvia Wasserthiel-Smoller, Yuling Hong, Stroke Statistics Subcommittee

CHRONIC KIDNEY DISEASE AND THE RISKS OF DEATH, CARDIOVASCULAR EVENTS, AND HOSPITALIZATION

Background End-stage renal disease substantially increases the risks of death, cardiovascular disease, and use of specialized health care, but the effects of less severe kidney dysfunction on these outcomes are less well defined. Methods We estimated...

An Introduction to MultiAgent Systems

The study of multi-agent systems (MAS) focuses on systems in which many intelligent agents interact with each other. These agents are considered to be autonomous entities such as software programs or robots. Their interactions can either be cooperative...

Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

Recent trends in AIDS-related mortality in the United States are analyzed using data on 1255 patients attending one of nine clinics in various cities between 1994 and 1997. "Mortality among the patients declined from 29.4 per 100 person-years in 1995...

Discrete Choice Methods with Simulation

This book describes the new generation of discrete choice methods, focusing on the many advances that are made possible by simulation. Researchers use these statistical methods to examine the choices that consumers, households, firms, and other agents...

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

Background Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed. Methods We pooled data from 11 case–control studies from nine countries...

Adherence to Medication

The full benefit of many effective medications will be achieved only if patients adhere to prescribed treatment regimens. Unfortunately, applying terms such as “noncompliant” and “nonadherent” to patients who do not consume every pill at the desired...

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.

Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic...

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic...

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P. A. Ioannidis, Mike Clarke, P.J. Devereaux, Jos Kleijnen, David Moher

DnaSP v5

Motivation: DnaSP is a software package for a comprehensive analysis of DNA polymorphism data. Version 5 implements a number of new features and analytical methods allowing extensive DNA polymorphism analyses on large datasets. Among other features, the...

MORTALITY FROM CORONARY HEART DISEASE IN SUBJECTS WITH TYPE 2 DIABETES AND IN NONDIABETIC SUBJECTS WITH AND WITHOUT PRIOR MYOCARDIAL INFARCTION

Background Type 2 (non-insulin-dependent) diabetes is associated with a marked increase in the risk of coronary heart disease. It has been debated whether patients with diabetes who have not had myocardial infarctions should be treated as aggressively...

Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction

Background Patients with reduced left ventricular function after myocardial infarction are at risk for life-threatening ventricular arrhythmias. This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such...

Designing the User Interface: Strategies for Effective Human-Computer Interaction

The much-anticipated fifth edition of Designing the User Interface provides a comprehensive, authoritative introduction to the dynamic field of human-computer interaction (HCI). Students and professionals learn practical principles and guidelines needed...

Amiodarone or an Implantable Cardioverter-Defibrillator for Congestive Heart Failure

background Sudden death from cardiac causes remains a leading cause of death among patients with congestive heart failure (CHF). Treatment with amiodarone or an implantable cardioverter–defibrillator (ICD) has been proposed to improve the prognosis...

Inflammation, Atherosclerosis, and Coronary Artery Disease

ecent research has shown that inflammation plays a key role in coronary artery disease (CAD) and other manifestations of atherosclerosis. Immune cells dominate early atherosclerotic lesions, their effector molecules accelerate progression of the lesions,...

Inflammatory Bowel Disease

Complications Both ulcerative colitis and Crohn's disease are associated with a wide variety of complications, encompassing secondary effects of the inflammatory process in the gastrointestinal tract and associated extraintestinal manifestations.113 114...

Large-scale pattern growth of graphene films for stretchable transparent electrodes

Problems associated with large-scale pattern growth of graphene constituteone of the mainobstacles tousing thismaterial indevice applications 1 . Recently, macroscopic-scale graphene films were prepared by two-dimensional assembly of graphene sheets chemically...

Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer

Background We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer. Methods The National Surgical Adjuvant Breast and Bowel Project...

Automata, Languages and Programming

Susanne Albers, Alberto Marchetti-Spaccamela, Yossi Matias, Sotiris Nikoletseas, Wolfgang Thomas

Mostly harmless econometrics : an empiricist's companion

The core methods in today's econometric toolkit are linear regression for statistical control, instrumental variables methods for the analysis of natural experiments, and differences-in-differences methods that exploit policy changes. In the modern experimentalist...

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.

Background Inflammation may be important in the pathogenesis of atherothrombosis. We studied whether inflammation increases the risk of a first thrombotic event and whether treatment with aspirin decreases the risk. Methods We measured plasma C-reactive...

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

Background Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor. Methods In this noninferiority trial, we randomly assigned...

Efficacy and safety of recombinant human activated protein C for severe sepsis.

Background: Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin alfa activated produced dose-dependent reductions in the levels...

Phenix - a comprehensive python-based system for macromolecular structure solution

Jeffrey J. Headd, Ralf W. Grosse Kunstleve, Nigel W. Moriarty, R.D. Oeffner, Randy J. Read, Jane S. Richardson

Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma

Background We conducted a phase 3, randomized, double-blind, placebo-controlled trial of sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, in patients with advanced clear-cell renal-cell carcinoma. Methods From November...

RENOPROTECTIVE EFFECT OF THE ANGIOTENSIN-RECEPTOR ANTAGONIST IRBESARTAN IN PATIENTS WITH NEPHROPATHY DUE TO TYPE 2 DIABETES

Background It is unknown whether either the angiotensin-II–receptor blocker irbesartan or the calcium-channel blocker amlodipine slows the progression of nephropathy in patients with type 2 diabetes independently of its capacity to lower the systemic...

C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

Background Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events. Methods We conducted a prospective,...

Epithelial-Mesenchymal Transitions in Development and Disease

Most adult tissues and organs arise from a series of conversions of epithelial cells to mesenchymal cells, through the epithelial to mesenchymal transition (EMT) and the reverse process (mesenchymal to epithelial transition [MET]). Epithelial cells establish...

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Sophisticated 21st-century analyses of the signaling pathways that control cell growth have led researchers back to the seminal work of Otto Warburg, who discovered in the 1920s that tumor cells generate their energy in an unusual way—by switching from...

Docetaxel plus Prednisone or Mitoxantrone plus Prednisone for Advanced Prostate Cancer

Background Mitoxantrone plus prednisone reduces pain and improves the quality of life in men with advanced, hormone-refractory prostate cancer, but it does not improve survival. We compared such treatment with docetaxel plus prednisone in men with this...

Intensive Insulin Therapy in Critically Ill Patients

Background Hyperglycemia and insulin resistance are common in critically ill patients, even if they have not previously had diabetes. Whether the normalization of blood glucose levels with insulin therapy improves the prognosis for such patients is not...

COMPARISON OF FOUR CHEMOTHERAPY REGIMENS FOR ADVANCED NON-SMALL-CELL LUNG CANCER

Background We conducted a randomized study to determine whether any of three chemotherapy regimens was superior to cisplatin and paclitaxel in patients with advanced non–small-cell lung cancer. Methods A total of 1207 patients with advanced non–small-cell...

Quantum ESPRESSO: a modular and open-source software project for quantum simulations of materials

QUANTUM ESPRESSO is an integrated suite of computer codes for electronic-structure calculations and materials modeling, based on density-functional theory, plane waves, and pseudopotentials (norm-conserving, ultrasoft, and projector-augmented wave). The...

Computed Tomography — An Increasing Source of Radiation Exposure

The number of computed tomographic (CT) studies performed is increasing rapidly. Because CT scans involve much higher doses of radiation than plain films, we are seeing a marked increase in radiation exposure in the general population. Epidemiologic studies...

Cardiac Resynchronization in Chronic Heart Failure

Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a...

A New Equation to Estimate Glomerular Filtration Rate

Andrew S. Levey, Lesley A. Stevens, Christopher H. Schmid, Yaping Zhang, Alejandro F. Castro, Harold I. Feldman, John W. Kusek, Paul W. Eggers, Frederick Van Lente, Tom Greene, Josef Coresh

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

Background BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine kinase activity is essential to the transforming function of BCR-ABL, an inhibitor of the kinase could be an effective treatment...

Agendas and instability in American politics

Frank R. Baumgartner, Bryan D. Jones

Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension

CREENING studies in the United States, Europe, and Australia have shown that a substantial proportion of the adult population has mild-to-moderate sleep-disordered breathing, a condition characterized by repeated episodes of apnea and hypopnea during...

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

background The influence of excess body weight on the risk of death from cancer has not been fully characterized. methods In a prospectively studied population of more than 900,000 U.S. adults (404,576 men and 495,477 women) who were free of cancer at...

Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery

background Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly reduces the risk of restenosis after percutaneous coronary revascularization. methods We conducted a randomized, double-blind...

Robust Face Recognition via Sparse Representation

We consider the problem of automatically recognizing human faces from frontal views with varying expression and illumination, as well as occlusion and disguise. We cast the recognition problem as one of classifying among multiple linear regression models...

Program MARK : survival estimation from populations of marked animals

Program MARK, a Windows 95 program, provides parameter estimates from marked animals when they are re-encountered at a later time. Re-encounters can be from dead recoveries (e.g., the animal is harvested), live recaptures (e.g. the animal is re-trapped...

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

Patients with stage IIIB or IV non–small-cell lung cancer, with performance status from 0 to 3, were eligible if they had received one or two prior chemotherapy regimens. The patients were stratified according to center, performance...

Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis

Background The role of orthotopic liver transplantation in the treatment of patients with cirrhosis and hepatocellular carcinoma is controversial, and determining which patients are likely to have a good outcome after liver transplantation is difficult....

RNA-Seq: a revolutionary tool for transcriptomics.

RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a far...

The epidemiology of sepsis in the United States from 1979 through 2000.

background Sepsis represents a substantial health care burden, and there is limited epidemiologic information about the demography of sepsis or about the temporal changes in its incidence and outcome. We investigated the epidemiology of sepsis in the...

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

bevacizumab, as compared with 10.3 months in the chemotherapy-alone group (hazard ratio for death, 0.79; P = 0.003). The median progression-free survival in the two groups was 6.2 and 4.5 months, respectively (hazard...

Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities

mothur aims to be a comprehensive software package that allows users to use a single piece of software to analyze community sequence data. It builds upon previous tools to provide a flexible and powerful software package for analyzing sequencing data....

The theory of the growth of the firm

There are not many books that are genuine classics, and only a handful in business and management whose insights and ideas last for 50 years and more. This book is one of the very few 'must reads' for anybody seriously interested in the role of management...

Most mammalian mRNAs are conserved targets of microRNAs

MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7), particularly those in 3 untranslated regions (3UTRs), are preferentially conserved....

Protective and damaging effects of stress mediators

Over 60 years ago, Selye1 recognized the paradox that the physiologic systems activated by stress can not only protect and restore but also damage the body. What links these seemingly contradictory roles? How does stress influence the pathogenesis of...

The Quality of Health Care Delivered to Adults in the United States

background We have little systematic information about the extent to which standard processes involved in health care — a key element of quality — are delivered in the United States. methods We telephoned a random sample of adults living in 12 metropolitan...

A survey of spectrum sensing algorithms for cognitive radio applications

The spectrum sensing problem has gained new aspects with cognitive radio and opportunistic spectrum access concepts. It is one of the most challenging issues in cognitive radio systems. In this paper, a survey of spectrum sensing methodologies for cognitive...

A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

Background The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared...

Adaptive Filtering Prediction and Control

This unified survey focuses on linear discrete-time systems and explores the natural extensions to nonlinear systems. In keeping with the importance of computers to practical applications, the authors emphasize discrete-time systems. Their approach summarizes...

Markov Chains and Stochastic Stability

Meyn & Tweedie is back! The bible on Markov chains in general state spaces has been brought up to date to reflect developments in the field since 1996 - many of them sparked by publication of the first edition. The pursuit of more efficient simulation...

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with elevated high-sensitivity...

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.

background Aldosterone blockade reduces mortality and morbidity among patients with severe heart failure. We conducted a double-blind, placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality...

A physically based, variable contributing area model of basin hydrology / Un modèle à base physique de zone d'appel variable de l'hydrologie du bassin versant

A hydrological forecasting model is presented that attempts to combine the important distributed effects of channel network topology and dynamic contributing areas with the advantages of simple lumped parameter basin models. Quick response flow is predicted...

RANIBIZUMAB FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

Background Ranibizumab — a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A — has been evaluated for the treatment of neovascular age-related macular degeneration. Methods In...

Chemokines — Chemotactic Cytokines That Mediate Inflammation

The attraction of leukocytes to tissues is essential for inflammation and the host response to infection. The process is controlled by chemokines, which are chemotactic cytokines. This review introduces the burgeoning family of cytokines, with special...

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

background Trastuzumab, a recombinant monoclonal antibody against HER2, has clinical activity in advanced breast cancer that overexpresses HER2. We investigated its efficacy and safety after excision of early-stage breast cancer and completion of chemotherapy....

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

background The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly. We compared a first-generation antipsychotic,...

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

background The epidermal growth factor receptor (EGFR), which participates in signaling pathways that are deregulated in cancer cells, commonly appears on colorectal-cancer cells. Cetuximab is a monoclonal antibody that specifically blocks the EGFR. We...

Predicting Obesity in Young Adulthood from Childhood and Parental Obesity

Background Childhood obesity increases the risk of obesity in adulthood, but how parental obesity affects the chances of a child's becoming an obese adult is unknown. We investigated the risk of obesity in young adulthood associated with both obesity...

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

METHODS In this phase 3, open-label study, we randomly assigned previously untreated patients in East Asia who had advanced pulmonary adenocarcinoma and who were nonsmokers or former light smokers to receive gefitinib (250 mg per day) (609 patients) or...

Embedding in Epoxy Resins for Ultrathin Sectioning in Electron Microscopy

Fixed tissue is dehydrated with tertiary butyl alcohol overnight. The following day it is cleared in toluene, infiltrated and embedded in Araldite resin-hardener-accelerator mixture without dibutyl phthalate, and polymerized at 60° C. More rapid than...

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published...

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events

Background Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available. Methods...

Finding the missing heritability of complex diseases

Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture. Most variants identified so far confer relatively small...

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

Background: Currently, a lack of consensus exists on how best to perform and interpret quantitative real-time PCR (qPCR) experiments. The problem is exacerbated by a lack of sufficient experimental detail in many publications, which impedes a reader’s...

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

Background Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel. Methods In this multicenter, double-blind, randomized...

Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internatio

A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors include raised blood pressure, dyslipidemia (raised...

An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG III.

An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG II

This Time Is Different: Eight Centuries of Financial Folly

Throughout history, rich and poor countries alike have been lending, borrowing, crashing--and recovering--their way through an extraordinary range of financial crises. Each time, the experts have chimed, "this time is different"--claiming that the old...

Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes

�Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that had borderline significance. Our study was limited by a lack of access to original...

Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility

With the significant advances in Information and Communications Technology (ICT) over the last half century, there is an increasingly perceived vision that computing will one day be the 5th utility (after water, electricity, gas, and telephony). This...

Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support

Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data capture tools to support clinical and translational research. We present: (1) a brief description...

A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia

Background There is considerable variability in rates of hospitalization of patients with community-acquired pneumonia, in part because of physicians' uncertainty in assessing the severity of illness at presentation. Methods From our analysis of data...

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography

Recommendations for the evaluation of left ventricular diastolic function by echocardiography

Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer

Background In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer. Methods A total of 1851 women for whom follow-up data...

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure

Background It is known that obesity, sodium intake, and alcohol consumption influence blood pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on blood pressure. Methods We enrolled 459...

Power-Law Distributions in Empirical Data

Power-law distributions occur in many situations of scientific interest and have significant consequences for our understanding of natural and man-made phenomena. Unfortunately, the detection and characterization of power laws is complicated by the large...

Evaluating Goodness-of-Fit Indexes for Testing Measurement Invariance.

Measurement invariance is usually tested using Multigroup Confirmatory Factor Analysis, which examines the change in the goodness-of-fit index (GFI) when cross-group constraints are imposed on a measurement model. Although many studies have examined the...

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

Background Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year. Methods Seven consecutive patients with type 1 diabetes...

Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer

background Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent prostate cancer. We compared docetaxel plus estramustine with mitoxantrone plus prednisone in men with metastatic, hormoneindependent...

Adipose Tissue as an Endocrine Organ

Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ. Besides adipocytes, adipose tissue contains connective tissue matrix, nerve tissue, stromovascular cells, and immune cells. Together these components function as...

Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes

The primary efficacy end point occurred in 12.1% of patients receiving clopidogrel and 9.9% of patients receiving prasugrel (hazard ratio for prasugrel vs. clopidogrel, 0.81; 95% confidence interval [CI], 0.73 to 0.90;...

A safe operating space for humanity

The article presents a study that investigates on the importance of identifying and quantifying planetary boundaries to prevent human activities in affecting environmental condition. The author states the industrial revolution and advancement in human...

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

Background Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in chronic heart failure, but the effect of these drugs on survival has not been determined. Methods We enrolled 1094 patients with...

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

Plasma concentrations of adiponectin, a novel adipose-specific protein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity, type 2 diabetes, and cardiovascular disease, conditions...

Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome

PDF ABSTRACT Background In patients with the acute respiratory distress syndrome, massive alveolar collapse and cyclic lung reopening and overdistention during mechanical ventilation may perpetuate alveolar injury. We determined whether a ventilatory...

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

Background Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of gastrointestinal stromal tumors. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical...

Next »
1 2 3 4 5 6 ... Last

© 2016 CiteWeb.info — WorldWeb citation database

Up ↑