CiteWeb

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Publications in 2001

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Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

The two most commonly used methods to analyze data from real-time, quantitative PCR experiments are absolute quantification and relative quantification. Absolute quantification determines the input copy number, usually by relating the PCR signal to a...

Co-integration and error correction: representation, estimation, and testing

The relationship between co-integration and error correction models, first suggested in Granger (1981), is here extended and used to develop estimation procedures, tests, and empirical examples.If each element of a vector of time series xt first achieves...

Random Forests

Random forests are a combination of tree predictors such that each tree depends on the values of a random vector sampled independently and with the same distribution for all trees in the forest. The generalization error for forests converges a.s. to a...

Wireless Communications: Principles and Practice

From the Publisher:The indispensable guide to wireless communications—now fully revised and updated!Wireless Communications: Principles and Practice, Second Edition is the definitive modern text for wireless communications technology and system design....

MRBAYES: Bayesian inference of phylogenetic trees

Summary: The program MRBAYES performs Bayesian inference of phylogeny using a variant of Markov chain Monte Carlo. Availability: MRBAYES, including the source code, documentation, sample data files, and an executable, is available at http://brahms.biology.rochester.edu/softwarel.

Initial sequencing and analysis of the human genome

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome....

The Elements of Statistical Learning

Trevor Hastie, Robert Tibshirani, Jerome H. Friedman

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

Background Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose...

Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond

From the Publisher:In the 1990s, a new type of learning algorithm was developed, based on results from statistical learning theory: the Support Vector Machine (SVM). This gave rise to a new class of theoretically elegant learning machines that use a central...

The Sequence of the Human Genome

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence...

Climate Change 2001: The Scientific Basis

Jennifer Houghton, Y. Ding, David J. Griggs, P. J. Van der Linden, X. Dai, Kathy Maskell, Ca Johnson

Rapid object detection using a boosted cascade of simple features

This paper describes a machine learning approach for visual object detection which is capable of processing images extremely rapidly and achieving high detection rates. This work is distinguished by three key contributions. The first is the introduction...

Chord: A scalable peer-to-peer lookup service for internet applications

A fundamental problem that confronts peer-to-peer applications is to efficiently locate the node that stores a particular data item. This paper presents Chord , a distributed lookup protocol that addresses this problem. Chord provides support for just...

Multi-Objective Optimization Using Evolutionary Algorithms

From the Publisher:Evolutionary algorithms are relatively new, but very powerful techniques used to find solutions to many real-world search and optimization problems. Many of these problems have multiple objectives, which leads to the need to obtain...

Visible-Light Photocatalysis in Nitrogen-Doped Titanium Oxides

To use solar irradiation or interior lighting efficiently, we sought a photocatalyst with high reactivity under visible light. Films and powders of TiO2- x N x have revealed an improvement over titanium dioxide (TiO2) under visible light (wavelength <...

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel, Abdullah Yalcin, Klaus Weber

The elements of statistical learning: data mining, inference, and prediction

During the past decade there has been an explosion in computation and information technology. With it have come vast amounts of data in a variety of fields such as medicine, biology, finance, and marketing. The challenge of understanding these data has...

The Anatomy of the Grid: Enabling Scalable Virtual Organizations

"Grid" computing has emerged as an important new field, distinguished from conventional distributed computing by its focus on large-scale resource sharing, innovative applications, and, in some cases, high performance orientation. In this article, the...

Significance analysis of microarrays applied to the ionizing radiation response

Microarrays can measure the expression of thousands of genes to identify changes in expression between different biological states. Methods are needed to determine the significance of these changes while accounting for the enormous number of genes.We...

Translating the Histone Code

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone...

Pastry: Scalable, Decentralized Object Location, and Routing for Large-Scale Peer-to-Peer Systems

This paper presents the design and evaluation of Pastry, a scalable, distributed object location and routing substrate for wide-area peer-to-peer ap- plications. Pastry performs application-level routing and object location in a po- tentially very large...

A scalable content-addressable network

Hash tables - which map "keys" onto "values" - are an essential building block in modern software systems. We believe a similar functionality would be equally valuable to large distributed systems. In this paper, we introduce the concept of a Content-Addressable...

Modern Control Engineering

From the Publisher:This comprehensive treatment of the analysis and design of continuous-time control systems provides a gradual development of control theory—and shows how to solve all computational problems with MATLAB. It avoids highly mathematical...

PAST: PALEONTOLOGICAL STATISTICAL SOFTWARE PACKAGE FOR EDUCATION AND DATA ANALYSIS

A comprehensive, but simple-to-use software package for executing a range of standard numerical analysis and operations used in quantitative paleontology has been developed. The program, called PAST (PAleontological STatistics), runs on standard Windows...

Room-Temperature Ultraviolet Nanowire Nanolasers

Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated. The self-organized, oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process. These...

Review: Knowledge management and knowledge management systems: conceptual foundations and research issues

Knowledge is a broad and abstract notion that has defined epistemological debate in western philosophy since the classical Greek era. In the past few years, however, there has been a growing interest in treating knowledge as a significant organizational...

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Examination of natures favorite molecules reveals a striking preference for making carbon ‐ heteroatom bonds over carbon ‐ carbon bonds—surely no surprise given that carbon dioxide is natures starting material and that most reactions are performed...

The spatial economy : cities, regions, and international trade

Книга «Пространственная экономика – города, регионы и международная торговля» рассматривает экономику с точки зрения экономической географии...

Atomic Decomposition by Basis Pursuit

The time-frequency and time-scale communities have recently developed a large number of overcomplete waveform dictionaries---stationary wavelets, wavelet packets, cosine packets, chirplets, and warplets, to name a few. Decomposition into overcomplete...

The PHQ-9

Kurt Kroenke, Robert L. Spitzer, Janet B.W. Williams

Stem cells, cancer, and cancer stem cells.

Tannishtha Reya, Sean J. Morrison, Irving L. Weissman

Active contours without edges

We propose a new model for active contours to detect objects in a given image, based on techniques of curve evolution, Mumford-Shah (1989) functional for segmentation and level sets. Our model can detect objects whose boundaries are not necessarily defined...

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

Background: Despite current treatments, patients who have acute coronary syndromes without ST-segment elevation have high rates of major vascular events. We evaluated the efficacy and safety of the antiplatelet agent clopidogrel when given with aspirin...

MEGA2: molecular evolutionary genetics analysis software

Summary: We have developed a new software package, Molecular Evolutionary Genetics Analysis version 2 (MEGA2), for exploring and analyzing aligned DNA or protein sequences from an evolutionary perspective. MEGA2 vastly extends the capabilities of MEGA...

The language of new media

Manovich theorises on the emergence of the computer as a new medium used for web sites, digital imagery and multi-media projects. He draws upon histories of art, photography, video, cinema, telecommunications and design in his analysis of new media and...

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A total of 85 cDNA microarray experiments representing...

Sequential Monte Carlo methods in practice

Monte Carlo methods are revolutionizing the on-line analysis of data in fields as diverse as financial modeling, target tracking and computer vision. These methods, appearing under the names of bootstrap filters, condensation, optimal Monte Carlo filters,...

Recognition of double-stranded RNA and activation of NF-|[kappa]|B by Toll-like receptor 3

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov, Richard A. Flavell

Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

OBJECTIVE —To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WHO).RESEARCH DESIGN AND METHODS —A total of 4,483 subjects aged 35–70...

Experimental verification of a negative index of refraction

We present experimental scattering data at microwave frequencies on a structured metamaterial that exhibits a frequency band where the effective index of refraction (n) is negative. The material consists of a two-dimensional array of repeated unit cells...

Atom Transfer Radical Polymerization

Krzysztof Matyjaszewski, Jianhui Xia

Performance Pay and Top Management Incentives

The authors' estimates of the pay-performance relation (including pay, options, stockholding, and dismissal) for chief executive officers indicate that CEO wealth changes $3.25 for every $1,000 changes in shareholder wealth. Although the incentives generated...

DIGITAL COMMUNICATION OVER FADING CHANNELS

noncoherent communication systems, as well as a large variety of fading channel models typical of communication links often found in the real world, including single- and multichannel reception with a large variety of types. The book gives many numerical...

Neurophysiological investigation of the basis of the fMRI signal

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Identity-Based Encryption from the Weil Pairing

We propose a fully functional identity-based encryption scheme (IBE). The scheme has chosen ciphertext security in the random oracle model assuming an elliptic curve variant of the computational Diffie-Hellman problem. Our system is based on the Weil...

Mechanical alloying and milling

Mechanical alloying (MA) is a solid-state powder processng technique involving repeated welding, fracturing, and rewelding of powder particles in a high-energy ball mill. Originally developed to produce oxide-dispersion strengthened (ODS) nickel- and...

Bone marrow cells regenerate infarcted myocardium

Donald Orlic, Jan Kajstura, Stefano Chimenti, Igor Jakoniuk, Stacie M. Anderson, Baosheng Li, James M. Pickel, Ron McKay, Bernardo Nadal-Ginard, David M. Bodine, Annarosa Leri, Piero Anversa

Nanobelts of Semiconducting Oxides

Ultralong beltlike (or ribbonlike) nanostructures (so-called nanobelts) were successfully synthesized for semiconducting oxides of zinc, tin, indium, cadmium, and gallium by simply evaporating the desired commercial metal oxide powders at high temperatures....

Fast approximate energy minimization via graph cuts

Many tasks in computer vision involve assigning a label (such as disparity) to every pixel. A common constraint is that the labels should vary smoothly almost everywhere while preserving sharp discontinuities that may exist, e.g., at object boundaries....

Gradient-based learning applied to document recognition

Yann LeCun, Léon Bottou, Yoshua Bengio, Patrick Haffner

Prevention of Venous Thromboembolism

William H. Geerts, John A. Heit, G. Patrick Clagett, Graham F. Pineo, Clifford W. Colwell, Frederick A. Anderson, H. Brownell Wheeler

Untangling the ErbB signalling network

Yosef Yarden, Mark X. Sliwkowski

Alzheimer's disease: genes, proteins, and therapy.

Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and association cortices. In turn, new insights into fundamental aspects...

A taxonomy and evaluation of dense two-frame stereo correspondence algorithms

Stereo matching is one of the most active research areas in computer vision. While a large number of algorithms for stereo correspondence have been developed, relatively little work has been done on characterizing their performance. In this paper, we...

Involvement of chemokine receptors in breast cancer metastasis

Anja Müller, Bernhard Homey, Hortensia Soto, Nianfeng Ge, Daniel Catron, Matthew E. Buchanan, Terri McClanahan, Erin Murphy, Wei Yuan, Stephan N. Wagner, Jose Luis Barrera, Alejandro Mohar, Emma Verastegui, Albert Zlotnik

Efficacy of the Theory of Planned Behaviour: A meta‐analytic review

The Theory of Planned Behaviour (TPB) has received considerable attention in the literature. The present study is a quantitative integration and review of that research. From a database of 185 independent studies published up to the end of 1997, the TPB...

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with...

Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species

Boron-doped silicon nanowires (SiNWs) were used to create highly sensitive, real-time electrically based sensors for biological and chemical species. Amineand oxide-functionalized SiNWs exhibit pH-dependent conductance that was linear over a large dynamic...

Item-based collaborative filtering recommendation algorithms

Badrul M. Sarwar, George Karypis, Joseph A. Konstan, John Riedl

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy.

Background Diabetic nephropathy is the leading cause of end-stage renal disease. Interruption of the renin–angiotensin system slows the progression of renal disease in patients with type 1 diabetes, but similar data are not available for patients with...

Trends, Rhythms, and Aberrations in Global Climate 65 Ma to Present

Since 65 million years ago (Ma), Earth's climate has undergone a significant and complex evolution, the finer details of which are now coming to light through investigations of deep-sea sediment cores. This evolution includes gradual trends of warming...

Digital Natives, Digital Immigrants

It is amazing to me how in all the hoopla and debate these days about the decline of education in the US we ignore the most fundamental of its causes. Our students have changed radically. Today’s students are no longer the people our educational system...

Gravity with Gravitas: A Solution to the Border Puzzle

The gravity model has been widely used to infer substantial trade flow effects of institutions such as customs unions and exchange rate mechanisms. McCallum [1995] found that the US-Canada border led to trade between provinces that was a factor 22 (2,200%)...

Bounds testing approaches to the analysis of level relationships

This paper develops a new approach to the problem of testing the existence of a level relationship between a dependent variable and a set of regressors, when it is not known with certainty whether the underlying regressors are trend- or first-difference...

Factor graphs and the sum-product algorithm

Algorithms that must deal with complicated global functions of many variables often exploit the manner in which the given functions factor as a product of "local" functions, each of which depends on a subset of the variables. Such a factorization can...

A voxel-based morphometric study of ageing in 465 normal adult human brains

Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects...

The Emotional Dog and its Rational Tail: A Social Intuitionist Approach to Moral Judgment

Research on moral judgment has been dominated by rationalist models, in which moral judgment is thought to be caused by moral reasoning. The author gives 4 reasons for considering the hypothesis that moral reasoning does not cause moral judgment; rather,...

Large-scale analysis of the yeast proteome by multidimensional protein identification technology.

We describe a largely unbiased method for rapid and large-scale proteome analysis by multidimensional liquid chromatography, tandem mass spectrometry, and database searching by the SEQUEST algorithm, named multidimensional protein identification technology...

Band parameters for III–V compound semiconductors and their alloys

We present a comprehensive, up-to-date compilation of band parameters for the technologically important III–V zinc blende and wurtzite compound semiconductors:GaAs,GaSb,GaP,GaN,AlAs,AlSb,AlP,AlN,InAs,InSb,InP, and InN, along with their ternary and quaternary...

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-α subunits are rapidly destroyed by a mechanism that involves ubiquitylation...

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a “BH3-domain–only” BCL-2 family member, triggers the homooligomerization...

Sparse bayesian learning and the relevance vector machine

This paper introduces a general Bayesian framework for obtaining sparse solutions to regression and classification tasks utilising models linear in the parameters. Although this framework is fully general, we illustrate our approach with a particular...

Understanding and Using Context

Context is a poorly used source of information in our computing environments. As a result, we have an impoverished understanding of what context is and how it can be used. In this paper, we provide an operational definition of context and discuss the...

Interpreting qualitative data : methods for analysing talk, text and interaction

This a much expanded and updated version of David Silvermans best-selling introductory textbook for the beginning qualitative researcher. Features of the New Edition: • Takes account of the flood of qualitative work since the 1990s • All chapters...

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.

Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where the gene encoding adiponectin is located. Here we show that decreased expression...

Chemistry with ADF

G. te Velde, F. Bickelhaupt, E.J. Baerends, C. Fonseca Guerra, S.J.A. van Gisbergen, J.G. Snijders, Tom Ziegler

Role of AMP-activated protein kinase in mechanism of metformin action

Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin’s beneficial effects...

Digital Divide?: Civic Engagement, Information Poverty, and the Internet Worldwide

From the Publisher:Digital Divide examines access and use of the Internet in 179 nations world-wide. A global divide is evident between industrialized and developing societies. A social divide is apparent between rich and poor within each nation. Within...

SPINS: security protocols for sensor networks

As sensor networks edge closer towards wide-spread deployment, security issues become a central concern. So far, much research has focused on making sensor networks feasible and useful, and has not concentrated on security. We present a suite of security...

Historical overfishing and the recent collapse of coastal ecosystems

Ecological extinction caused by overfishing precedes all other pervasive human disturbance to coastal ecosystems, including pollution, degradation of water quality, and anthropogenic climate change. Historical abundances of large consumer species were...

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.

The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite the fact that the impact of these pathways on the pathology of chronic inflammation, heart disease, stroke, the debilitating...

The magical number 4 in short-term memory: A reconsideration of mental storage capacity

Miller (1956) summarized evidence that people can remember about seven chunks in short-term memory (STM) tasks. How- ever, that number was meant more as a rough estimate and a rhetorical device than as a real capacity limit. Others have since suggested...

Information asymmetry, corporate disclosure, and the capital markets: A review of the empirical disclosure literature

Financial reporting and disclosure are potentially important means for management to communicate firm performance and governance to outside investors. We provide a framework for analyzing managers’ reporting and disclosure decisions in a capital markets...

A comprehensive two-hybrid analysis to explore the yeast protein interactome

Protein‐protein interactions play crucial roles in the execution of various biological functions. Accordingly, their comprehensive description would contribute considerably to the functional interpretation of fully sequenced genomes, which are flooded...

Making social science matter: Why social inquiry fails and how it can succeed again

Making Social Science Matter presents an exciting new approach to social science, including theoretical argument, methodological guidelines, and examples of practical application. Why has social science failed in attempts to emulate natural science and...

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection

proper treatment of probe effects is an essential component of any approach to the analysis of such expression array data. Below, we introduce a statistical model for the probe-level data to account for probe-specific effects in the computation of expression...

Conflict monitoring and cognitive control.

Matthew M. Botvinick, Todd S. Braver, Deanna M. Barch, Cameron S. Carter, Jonathan D. Cohen

Particle swarm optimization: developments, applications and resources

This paper focuses on the engineering and computer science aspects of developments, applications, and resources related to particle swarm optimization. Developments in the particle swarm algorithm since its origin in 1995 are reviewed. Included are brief...

Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation.

Context Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions.Objective To assess the predictive value of classification schemes that estimate stroke risk...

Osteoporosis Prevention, Diagnosis, and Therapy

Objectives To clarify the factors associated with prevention, diagnosis, and treatment of osteoporosis, and to present the most recent information available in these areas.Participants From March 27-29, 2000, a nonfederal, nonadvocate, 13-member panel...

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Yasunori Ogura, Denise K. Bonen, Naohiro Inohara, Dan L. Nicolae, Felicia F. Chen, Richard Ramos, Heidi M. Britton, Thomas Moran, Reda Karaliuskas, Richard H. Duerr, Jean-Paul Achkar, Steven R. Brant, Theodore M. Bayless, Barbara S. Kirschner, Stephen B. Hanauer, Gabriel Núñez, Judy H. Cho

Modular Chemistry: Secondary Building Units as a Basis for the Design of Highly Porous and Robust Metal-Organic Carboxylate Frameworks

Secondary building units (SBUs) are molecular complexes and cluster entities in which ligand coordination modes and metal coordination environments can be utilized in the transformation of these fragments into extended porous networks using polytopic...

Do Behavioral Biases Affect Prices

This paper documents strong evidence of behavioral biases among Chicago Board of Trade proprietary traders and investigates the effect these biases have on prices. Our traders appear highly loss-averse. Traders who experience morning losses are about...

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