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Hyperglycemic Crises in Adult Patients With Diabetes

Diabetic ketoacidosis (DKA) and the hyperosmolar hyperglycemic state (HHS) are the two most serious acute metabolic complications of diabetes. DKA is responsible for more than 500,000 hospital days per year (1,2) at an estimated annual direct medical...

Normalization of obesity-associated insulin resistance through immunotherapy.

Shawn Winer, Yin Chan, Geoffrey Paltser, Dorothy Truong, Hubert Tsui, Jasmine Bahrami, Ruslan Dorfman, Yongqian Wang, Julian Zielenski, Fabrizio G. Mastronardi, Yuko Maezawa, Daniel J. Drucker, Edgar G. Engleman, Daniel A. Winer, H.-Michael Dosch

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

Competing Interests: The authors have declared that no competing interests exist.Funding: This work forms part of the first author's PhD, funded by the NICE Liverpool Reviews and Implementation Group. Douglas Altman is supported by Cancer Research UK....

The prevention of overweight and obesity in children and adolescents : a review of interventions and programmes

Summary Overweight and obesity are serious, large-scale, global, public health concerns requiring population-based childhood overweight and obesity prevention. The overall objective of this review is to identify aspects of successful childhood overweight...

Effect of ramipril on the incidence of diabetes.

Background: Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension. METHODS: In a double-blind, randomized clinical trial with a 2-by-2 factorial design,...

Effects of Tolvaptan, a Vasopressin Antagonist, in Patients Hospitalized With Worsening Heart Failure: A Randomized Controlled Trial

Context Nearly 1 million hospitalizations for chronic heart failure occur yearly in the United States, with most related to worsening systemic congestion. Diuretic use, the mainstay therapy for congestion, is associated with electrolyte abnormalities...

Dietary patterns and health outcomes

A systematic review of the literature on dietary patterns (multiple dietary components operationalized as a single exposure) in relation to nutrient adequacy, lifestyle and demographic variables, and health outcome was conducted. Most of the published...

A novel protective effect of erythropoietin in the infarcted heart

Cyrus J. Parsa, Akio Matsumoto, Jihee Kim, Ryan U. Riel, Laura S. Pascal, G. Brant Walton, Richard B. Thompson, Jason A. Petrofski, Brian H. Annex, Jonathan S. Stamler, Walter J. Koch

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Mitchell M. Levy, Mitchell P. Fink, John C. Marshall, Edward Abraham, Derek C. Angus, Deborah Cook, Jonathan Cohen, Steven M. Opal, Jean-Louis Vincent

Helping Patients Follow Prescribed Treatment: Clinical Applications

Low adherence to prescribed medical regimens is a ubiquitous problem. Typical adherence rates are about 50% for medications and are much lower for lifestyle prescriptions and other more behaviorally demanding regimens. In addition, many patients with...

N-Terminal Pro-B–Type Natriuretic Peptide and Long-Term Mortality in Acute Coronary Syndromes

Background—B-type natriuretic peptide (BNP) is a predictor of short- and medium-term prognosis across the spectrum of acute coronary syndromes (ACS). The N-terminal fragment of the BNP prohormone, N-BNP, may be an even stronger prognostic marker. We...

Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: Recommendations for a change in management

Hyperphosphatemia is a predictable consequence of chronic renal failure and is present in most patients on dialysis. Traditionally, the risk associated with elevated serum phosphorus has focused on its impact on renal osteodystrophy. A growing body of...

Associations of General and Abdominal Obesity With Multiple Health Outcomes in Older Women: The Iowa Women's Health Study

Aaron R. Folsom, Lawrence H. Kushi, Kristin E. Anderson, Pamela J. Mink, Janet E. Olson, Ching-Ping Hong, Thomas A. Sellers, DeAnn Lazovich, Ronald J. Prineas

A case for including spirituality in quality of life measurement in oncology

Most of the commonly used quality of life (QOL) instruments in oncology do not include spirituality as a core domain. However, previous research suggests that spirituality might be an important aspect of QOL for cancer patients and that it may, in fact,...

The North American Symptomatic Carotid Endarterectomy Trial Surgical Results in 1415 Patients

Gary G. Ferguson, Michael Eliasziw, Hugh W. K. Barr, G. Patrick Clagett, Robert W. Barnes, M. Christopher Wallace, D. Wayne Taylor, R. Brian Haynes, Jane W. Finan, Vladimir Hachinski, Barnett Hj

Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial

We investigated the effects of different intensities of arm and leg rehabilitation training on the functional recovery of activities of daily living (ADL), walking ability, and dexterity of the paretic arm, in a single-blind randomised controlled trial.

Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma a Multicenter Trial. Discussion

Donald L. Morton, John F. Thompson, T. R. Essner, Robert Elashoff, Sheryl Stern, Omgo E. Nieweg, Daniel F. Roses, Constantine P. Karakousis, Nicola Mozzillo, Douglas S. Reintgen, He-Jing Wang, Edwin C. Glass, Alistair J. Cochran, C. M. Balch

Biliopancreatic Diversion with Duodenal Switch

. In 1990 Scopinaro’s technique of biliopancreatic diversion with distal gastrectomy (DG) and gastroileostomy was modified. A sleeve gastrectomy with duodenal switch (DS) was used instead of the distal gastrectomy; and the length of the common channel...

Coronary artery bypass grafting without cardiopulmonary bypass

Enio Buffolo, José Carlos S Andrade, João Nelson Rodrigues Branco, Carlos Alberto Teles, Luciano de Figueiredo Aguiar, Walter J. Gomes

Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Background Angiotensin-converting enzyme (ACE) inhibitors may exert some of their benefits in the therapy of hypertension, congestive heart failure, and acute myocardial infarction by their improvement of endothelial dysfunction. TREND (Trial on Reversing...

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