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Health consequences of intimate partner violence

Intimate partner violence, which describes physical or sexual assault, or both, of a spouse or sexual Intimate, is a common health-care issue. In this article, I have reviewed research on the mental and physical health sequelae of such violence. Increased...

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi‐Society Task Force on Colorectal Cancer, and the American College of Radiology*

Bernard Levin, David A. Lieberman, Beth McFarland, Durado Brooks, Kimberly S. Andrews, Chiranjeev Dash, Seth Glick, Theodore R. Levin, Perry J. Pickhardt, Douglas K. Rex, Alan G. Thorson, Sidney J. Winawer

A Potential Decline in Life Expectancy in the United States in the 21st Century

Forecasts of life expectancy are an important component of public policy that influence age-based entitlement programs such as Social Security and Medicare. Although the Social Security Administration recently raised its estimates of how long Americans...

Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART)

A randomised controlled trial with a factorial design was done to examine the effects of dietary intervention in the secondary prevention of myocardial infarction (MI). 2033 men who had recovered from MI were allocated to receive or not to receive advice...

European guidelines on cardiovascular disease prevention in clinical practice Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by i

Guidelines aim to present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great...

Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease

Melody A. Cobleigh, Charles L. Vogel, Debu Tripathy, Nicholas J. Robert, Susy Scholl, Louis Fehrenbacher, Janet Wolter, Virginia Paton, Steven Shak, Gracie Lieberman, Dennis J. Slamon

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

background Selective cyclooxygenase-2 (COX-2) inhibitors have come under scrutiny because of reports suggesting an increased cardiovascular risk associated with their use. Experimental research suggesting that these drugs may contribute to a prothrombotic...

Abstracts of Papers

of papers included are: The Infectious Nature of Periodontal Diseases One Century of Controversies; Microbiological Basis for Periodontal and Peri-implant Treatment: What do we need to Know before Starting Therapy?; Systematic Antibiotics in the Treatment...

Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

Context Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER–), luminal A, and luminal B.Objectives To determine population-based...

The Metabolic Syndrome: Time for a Critical Appraisal Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes

Citrome et al. (1) seem to agree with our review (2) of all the shortcomings associated with the metabolic syndrome, yet they claim it is somehow still an aid in identifying risk factors and in the “ongoing education of practitioners,” both of which...

Ventilator-Associated Pneumonia

Ventilator-associated pneumonia (VAP) continues to complicate the course of 8 to 28% of patients receiving mechanical ventilation (MV). In contrast to infections of more frequently involved organs (e.g., urinary tract and skin), for which mortality is...

Difficult tracheal intubation in obstetrics

SummaryDifficult intubation has been classified into four grades, according to the view obtainable at laryngoscopy. Frequency analysis suggests that, in obstetrics, the main cause of trouble is grade 3, in which the epiglottis can be seen, but not the...

Persistent postsurgical pain: risk factors and prevention

Acute postoperative pain is followed by persistent pain in 10–50% of individuals after common operations, such as groin hernia repair, breast and thoracic surgery, leg amputation, and coronary artery bypass surgery. Since chronic pain can be severe...

Circulating Angiogenic Factors and the Risk of Preeclampsia

During the last two months of pregnancy in the normotensive controls, the level of sFlt-1 increased and the level of PlGF decreased. These changes occurred earlier and were more pronounced in the women in whom preeclampsia later developed. The sFlt-1...

Pathological prognostic factors in breast cancer.

C.W. Elston, Ian O. Ellis, S.E. Pinder

Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma

Charles M. Balch, Seng-Jaw Soong, Natale Cascinelli, Daniel G. Coit, Irvin D. Fleming, Jeffrey E. Gershenwald, Alan N. Houghton, John M. Kirkwood, Kelly M. McMasters, Martin Mihm, Donald L. Morton, Douglas S. Reintgen, Merrick I. Ross, Arthur J. Sober, John F. Thompson

Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation

Background Continuous infusions of sedative drugs in the intensive care unit may prolong the duration of mechanical ventilation, prolong the length of stay in the intensive care unit and the hospital, impede efforts to perform daily neurologic examinations,...

Colorectal cancer screening: clinical guidelines and rationale.

Evidence exists that reductions in colorectal cancer (CRC) mortality can be achieved through detection and treatment of early-stage CRCs and the identification and removal of adenomatous polyps, the precursor to these cancers. An expert, multidisciplinary...

Effectiveness and efficiency of guideline dissemination and implementation strategies.

Jeremy Grimshaw, Ruth Thomas, Graeme MacLennan, C Fraser, Ramsay Cr, Luke Vale, Paula Whitty, Martin Eccles, Lloyd K. Matowe, L. Shirran, Michel Wensing, Roald Dijkstra, Cam Donaldson

Multifactorial Index of Cardiac Risk in Noncardiac Surgical Procedures

To determine which preoperative factors might affect the development of cardiac complications after major noncardiac operations, we prospectively studied 1001 patients over 40 years of age. By multivariate discriminant analysis, we identified nine independent...

2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.

OBJECTIVE: The 1987 American College of Rheumatology (ACR; formerly, the American Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticized for their lack of sensitivity in early disease. This work was undertaken...

A COMPARISON OF RATE CONTROL AND RHYTHM CONTROL IN PATIENTS WITH RECURRENT PERSISTENT ATRIAL FIBRILLATION

Background Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm. We hypothesized that ventricular...

Does High Self-Esteem Cause Better Performance, Interpersonal Success, Happiness, or Healthier Lifestyles?

Roy F. Baumeister, Jennifer D. Campbell, Joachim I. Krueger, Kathleen D. Vohs

Contribution of Primary Care to Health Systems and Health

Barbara Starfield, Leiyu Shi, James Macinko

Intra-arterial Prourokinase for Acute Ischemic Stroke: The PROACT II Study: A Randomized Controlled Trial

Context Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed.Objective To determine the clinical...

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

Giulio Marchesini, Elisabetta Bugianesi, Gabriele Forlani, Fernanda Cerrelli, M. Lenzi, Rita Manini, Stefania Natale, E. Vanni, Nicola Villanova, Nazario Melchionda, Mario Rizzetto

HOMOCYSTEINE AND CARDIOVASCULAR DISEASE

▪ Abstract An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial...

Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension

Summary Background Isolated systolic hypertension occurs in about 15% of people aged 60 years or older. In 1989, the European Working Party on High Blood Pressure in the Elderly investigated whether active treatment could reduce cardiovascular complications...

Principles of Neurology

This book covers broad aspects of clinical neurology necessary fro clinical practice. The organization is unique, starting from patient approach, cardinal manifestations of neurological disease, to specific neruological diseases. New developments in neurology,...

Spirometric Reference Values from a Sample of the General U.S. Population

Spirometric reference values for Caucasians, African-Americans, and Mexican-Americans 8 to 80 yr of age were developed from 7,429 asymptomatic, lifelong nonsmoking participants in the third National Health and Nutrition Examination Survey (NHANES III)....

Developing and evaluating complex interventions: the new Medical Research Council guidance

OBJECTIVE: To examine the relation between blood pressure and the development of early retinopathy in adolescents with childhood onset type 1 diabetes. DESIGN: Prospective cohort study. SETTING: Diabetes Complications Assessment Service at the Children's...

Analysis of serial measurements in medical research.

J. N. S. Matthews, Altman Dg, Magda Campbell, Patrick Royston

Excess Deaths Associated With Underweight, Overweight, and Obesity

Results Relative to the normal weight category (BMI 18.5 to 25), obesity (BMI 30) was associated with 111 909 excess deaths (95% confidence interval [CI], 53 754170 064) and underweight with 33 746 excess deaths (95% CI, 15 726-51 766). Overweight was...

1998 clinical practice guidelines for the management of diabetes in Canada. Canadian Diabetes Association.

S. Meltzer, Lawrence A. Leiter, Denis Daneman, H. C. Gerstein, Lau D, S. Ludwig, Jean-François Yale, Zinman B, D. H. Lillie

Diffusion tensor imaging: Concepts and applications

The success of diffusion magnetic resonance imaging (MRI) is deeply rooted in the powerful concept that during their random, diffusion-driven displacements molecules probe tissue structure at a microscopic scale well beyond the usual image resolution....

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

SUMMARY We have examined the incidence and size of infarction after occlusion of different portions of the rat middle cerebral artery (MCA) in order to define the reliability and predictability of this model of brain ischemia. We developed a neurologic...

ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation

Ph. Gabriel Steg, Dan Atar, Carina Blomstrom Lundqvist, Michael A. Borger, Carlo Di Mario, Francisco Fernández-Avilés, Pantaleo Giannuzzi, Sigrun Halvorsen, Kurt Huber, Peter Jüni, Adnan Kastrati, Juhani Knuuti, Mattie J. Lenzen, Kenneth W. Mahaffey, Marco Valgimigli, Arnoud W.J. van't Hof, Doron Zahger, Jeroen J. Bax, Helmut Baumgartner, Claudio Ceconi, Veronica Dean, Christi Deaton, Robert Fagard, Christian Funck-Brentano, David Hasdai, Arno W. Hoes, Paulus Kirchhof, Philippe Kolh, Theresa McDonagh, Cyril Moulin, Bogdan A. Popescu, Željko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Adam Torbicki, Alec Vahanian, Stephan Windecker, Document Reviewers, Felicity Astin, Karin Åström-Olsson, Andrzej Budaj, Peter Clemmensen, Jean-Philippe Collet, Keith Fox, Ahmet Fuat, Olivija Gustiene, Christian W. Hamm, Petr Kala, Patrizio Lancellotti

Natural History of Progression After PSA Elevation Following Radical Prostatectomy

Context In men who develop an elevated serum prostate-specific antigen level (PSA) after having undergone a radical prostatectomy, the natural history of progression to distant metastases and death due to prostate cancer is unknown. Objective To characterize...

A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer

Richard M. Goldberg, Daniel J. Sargent, Roscoe F. Morton, Charles S. Fuchs, Ramesh K. Ramanathan, Stephen K. Williamson, Brian P. Findlay, Henry C. Pitot, Steven R. Alberts

THE QUALITY IN AUSTRALIAN HEALTH CARE STUDY

Ross Wilson, Runciman Wb, Robert Gibberd, Harrison Bt, Laurel M. Newby, John D. Hamilton

The epidemiology of heart failure: The Framingham Study ☆

Congestive heart failure has become an increasingly frequent reason for hospital admission during the last 2 decades and clearly represents a major health problem. Data from the Framingham Heart Study indicate that the incidence of congestive heart failure...

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those caused by gram-negative pathogens. Infections now occur that are resistant to...

Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management

Context Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused.Objective To review the...

THE ADIPOCYTE-SECRETED PROTEIN ACRP30 ENHANCES HEPATIC INSULIN ACTION

Anders H. Berg, Terry P. Combs, Xueliang Du, Michael Brownlee, Philipp E. Scherer

Abiraterone and increased survival in metastatic prostate cancer

Background: Biosynthesis of extragonadal androgen may contribute to the progression of castration-resistant prostate cancer. We evaluated whether abiraterone acetate, an inhibitor of androgen biosynthesis, prolongs overall survival among patients with...

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

Background Intensified multifactorial intervention — with tight glucose regulation and the use of renin–angiotensin system blockers, aspirin, and lipid-lowering agents — has been shown to reduce the risk of nonfatal cardiovascular disease among...

Where and why are 10 million children dying every year

SummaryMore than 10 million children die each year, most from preventable causes and almost all in poor countries. Six countries account for 50% of worldwide deaths in children younger than 5 years, and 42 countries for 90%. The causes of death differ...

Complications of endoscopic biliary sphincterotomy.

Background Endoscopic sphincterotomy is commonly used to remove bile-duct stones and to treat other problems. We prospectively investigated risk factors for complications of this procedure and their outcomes. Methods We studied complications that occurred...

A CONTROLLED TRIAL OF TWO NUCLEOSIDE ANALOGUES PLUS INDINAVIR IN PERSONS WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND CD4 CELL COUNTS OF 200 PER CUBIC MILLIMETER OR LESS

Background The efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear. We compared treatment with the protease inhibitor indinavir in addition to zidovudine...

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Norikazu Maeda, Iichiro Shimomura, Ken Kishida, Hitoshi Nishizawa, Morihiro Matsuda, Hiroyuki Nagaretani, Naoki Furuyama, Hidehiko Kondo, Masahiko Takahashi, Yukio Arita, Ryutaro Komuro, Noriyuki Ouchi, Shinji Kihara, Yoshihiro Tochino, Keiichi Okutomi, Masato Horie, Satoshi Takeda, Toshifumi Aoyama, Tohru Funahashi, Yuji Matsuzawa

Hemorrhagic Colitis Associated with a Rare Escherichia coli Serotype

We investigated two outbreaks of an unusual gastrointestinal illness that affected at least 47 people in Oregon and Michigan in February through March and May through June 1982. The illness was characterized by severe crampy abdominal pain, initially...

Recommendations for Blood Pressure Measurement in Humans and Experimental Animals Part 1: Blood Pressure Measurement in Humans: A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association

Thomas G. Pickering, John E. Hall, Lawrence J. Appel, Bonita Falkner, John W. Graves, Martha N. Hill, Daniel W. Jones, Theodore W. Kurtz, Sheldon G. Sheps, Edward J. Roccella

VITAMIN E CONSUMPTION AND THE RISK OF CORONARY HEART DISEASE IN MEN

Background The oxidative modification of low-density lipoproteins increases their incorporation into the arterial intima, an essential step in atherogenesis. Although dietary antioxidants, such as vitamin C, carotene, and vitamin E, have been hypothesized...

DIET, LIFESTYLE, AND THE RISK OF TYPE 2 DIABETES MELLITUS IN WOMEN

Background Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown. Methods We followed 84,941 female nurses from 1980 to 1996; these women were...

Alterations in Brain and Immune Function Produced by Mindfulness Meditation

Richard J. Davidson, Jon Kabat-Zinn, Jessica R. Schumacher, Melissa A. Rosenkranz, Daniel J. Müller, S. Santorelli, Ferris Urbanowski, Anne Harrington, Katherine Bonus, John F. Sheridan

A Multifactorial Intervention to Reduce the Risk of Falling among Elderly People Living in the Community

Background Since falling is associated with serious morbidity among elderly people, we investigated whether the risk of falling could be reduced by modifying known risk factors. Methods We studied 301 men and women living in the community who were at...

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

d Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine...

The Pathobiology of Diabetic Complications

It’s a great honor to join the exceptional club of Banting Award winners, many of whom were my role models and mentors. In addition, giving the Banting Lecture also has a very personal meaning to me, because without Frederick Banting, I would have died...

A Multidisciplinary Intervention to Prevent the Readmission of Elderly Patients with Congestive Heart Failure

Background Congestive heart failure is the most common indication for admission to the hospital among older adults. Behavioral factors, such as poor compliance with treatment, frequently contribute to exacerbations of heart failure, a fact suggesting...

Recommendations for Blood Pressure Measurement in Humans and Experimental Animals Part 1: Blood Pressure Measurement in Humans: A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association

Accurate measurement of blood pressure is essential to classify individuals, to ascertain blood pressure–related risk, and to guide management. The auscultatory technique with a trained observer and mercury sphygmomanometer continues to be the method...

Response criteria for phase II studies of supratentorial malignant glioma.

We suggest "new" response criteria for phase II studies of supratentorial malignant glioma and favor rigorous criteria similar to those in medical oncology, with important modifications. Four response categories are proposed: complete response (CR), partial...

Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study.

Elevated serum phosphorus is a predictable accompaniment of end-stage renal disease (ESRD) in the absence of dietary phosphate restriction or supplemental phosphate binders. The consequences of hyperphosphatemia include the development and progression...

Global cancer statistics in the year 2000

Estimation of the burden of cancer in terms of incidence, mortality, and prevalence is a first step to appreciating appropriate control measures in a global context. The latest results of such an exercise, based on the most recent available international...

Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.

Background Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons. Methods We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral...

Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America

Peter G. Pappas, Carol A. Kauffman, David R. Andes, D. Benjamin, Thierry Calandra, John E. Edwards, Scott G. Filler, John F. Fisher, Bart-Jan Kullberg, Luis Ostrosky Zeichner, Annette C. Reboli, John H. Rex, Thomas J. Walsh, Jack D. Sobe

Mortality Results from a Randomized Prostate-Cancer Screening Trial

Background The effect of screening with prostate-specific–antigen (PSA) testing and digital rectal examination on the rate of death from prostate cancer is unknown. This is the first report from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer...

Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both

background Angiotensin-converting–enzyme (ACE) inhibitors such as captopril reduce mortality and cardiovascular morbidity among patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. In a double-blind...

Boceprevir for untreated chronic HCV genotype 1 infection

Background Peginterferon–ribavirin therapy is the current standard of care for chronic infection with hepatitis C virus (HCV). The rate of sustained virologic response has been below 50% in cases of HCV genotype 1 infection. Boceprevir, a potent oral...

Pain and Its Treatment in Outpatients with Metastatic Cancer

Background and Methods Pain is often inadequately treated in patients with cancer. A total of 1308 outpatients with metastatic cancer from 54 treatment locations affiliated with the Eastern Cooperative Oncology Group rated the severity of their pain during...

Medical Management of Hyperglycemia in Type 2 Diabetes: a Consensus Algorithm for the Initiation and Adjustment of Therapy

The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors...

Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial

Vascular endothelial growth factor (VEGF) inhibition is a valid therapeutic approach in renal cell carcinoma. Therefore, an investigation of the combination treatment of the humanised anti-VEGF monoclonal antibody bevacizumab with interferon alfa was...

SOME CURRENT DIMENSIONS OF APPLIED BEHAVIOR ANALYSIS1

NOTICE: Optical character-recognition software was used in preparing this document. Please consult the original article before making reference to the material herein.

Neuropathic pain: aetiology, symptoms, mechanisms, and management

We highlight current theories about peripheral neuropathic pain and show that progress in management is contingent on targeting treatment not at the aetiological factors or the symptoms but at the mechanisms that operate to produce the symptoms. This...

Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine

A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient grounds for clinical decision making and stresses the examination of evidence...

Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy

Background The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with other antiretroviral drugs they may be able to cause profound and sustained suppression of HIV replication. Methods In this...

Chronic hepatitis B: Update 2009

Anna S. Lok, Brian J. McMahon

A Comparison of Continuous Intravenous Epoprostenol (Prostacyclin) with Conventional Therapy for Primary Pulmonary Hypertension

Background Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospective, randomized trial to improve survival. Methods We conducted a 12-week prospective, randomized, multicenter open trial comparing the...

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Background There is evidence that medications or vitamins that increase the levels of brain catecholamines and protect against oxidative damage may reduce the neuronal damage and slow the progression of Alzheimer's disease. Methods We conducted a double-blind,...

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.

Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye note that in rats exposed to stressors, the adrenal glands were enlarged, and...

Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness A Systematic Review and Meta-Analysis

Background— Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of...

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease.

Jean Soulier, Laurence Grollet, Eric Oksenhendler, P Cacoub, Dominique Cazals-Hatem, P. Babinet, Mf d'Agay, Clauvel Jp, M Raphael, L. Degos, François Sigaux

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committe

Robert O. Bonow, Blase A. Carabello, Kanu Chatterjee, Antonio C. de Leon, David P. Faxon, Michael D. Freed, William H. Gaasch, Bruce W. Lytle, Rick A. Nishimura, Patrick T. O'Gara, Robert A. O'Rourke, Pravin M. Shah, Jack S. Shanewise

Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults

Vincent J. Felitti, Robert F. Anda, Dale Nordenberg, David F. Williamson, Alison M. Spitz, Valerie J. Edwards, Mary P. Koss, James S. Marks

Recommended standards for reports dealing with lower extremity ischemia: Revised version

Recommended standards for analyzing and reporting on lower extremity ischemia were first published by the Journal of Vascular Surgery in 1986 1 after approval by the Joint Council of The Society for Vascular Surgery and the North American Chapter...

Human brain mechanisms of pain perception and regulation in health and disease

The perception of pain due to an acute injury or in clinical pain states undergoes substantial processing at supraspinal levels. Supraspinal, brain mechanisms are increasingly recognized as playing a major role in the representation and modulation of...

ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-Segment Elevation

ABOARD: Angioplasty to Blunt the Rise of Troponin in Acute Coronary Syndromes Randomized for an Immediate or Delayed InterventionACC: American College of CardiologyACE: angiotensin-converting enzymeACS: acute coronary syndromesACT: activated...

EQ-SD: a measure of health status from the EuroQol Group

Established in 1987, the EuroQol Group initially comprised a network of international, multilingual and multi-disciplinary researchers from seven centres in Finland, the Netherlands, Norway, Sweden and the UK. Nowadays, the Group comprises researchers...

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Anna Leone, Salvador Moncada, Patrick Vallance, Alison Calver, Joe Collier

Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

Deepak L. Bhatt, Keith A.A. Fox, Werner Hacke, Peter B. Berger, Henry R. Black, William E. Boden, Patrice Cacoub, Eric A. Cohen, Mark A. Creager, J. Donald Easton, Marcus Flather, Steven M. Haffner, Christian W. Hamm, Graeme J. Hankey, S. Claiborne Johnston, Koon-Hou Mak, Jean-Louis Mas, Gilles Montalescot, Thomas A. Pearson, P. Gabriel Steg, Steven R. Steinhubl, Michael A. Weber, Danielle M. Brennan, Liz Fabry-Ribaudo, Joan Booth, Eric J. Topol

Obstructive Sleep Apnea as a Risk Factor for Stroke and Death

background Previous studies have suggested that the obstructive sleep apnea syndrome may be an important risk factor for stroke. It has not been determined, however, whether the syndrome is independently related to the risk of stroke or death from any...

Long-Term Mortality after Gastric Bypass Surgery

In this retrospective cohort study, we determined the long-term mortality (from 1984 to 2002) among 9949 patients who had undergone gastric bypass surgery and 9628 severely obese persons who applied for driver’s licenses. From these subjects, 7925 surgical...

Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection

John W. Mellors, Alvaro Muñoz, Janis V. Giorgi, Joseph B. Margolick, Charles J. Tassoni, Phalguni Gupta, Lawrence A. Kingsley, John A. Todd, Alfred J. Saah, Roger Detels, John P. Phair, Charles R. Rinaldo

Coronavirus as a possible cause of severe acute respiratory syndrome

An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients.

The world health organization quality of life assessment (WHOQOL) - position paper from the world health organization

This paper describes the World Health Organization's project to develop a quality of life instrument (the WHOQOL). It outlines the reasons that the project was undertaken, the thinking that underlies the project, the method that has been followed in its...

THE GLOBAL HEALTH BURDEN OF INFECTION-ASSOCIATED CANCERS IN THE YEAR 2002

Several infectious agents are considered to be causes of cancer in humans. The fraction of the different types of cancer, and of all cancers worldwide and in different regions, has been estimated using several methods; primarily by reviewing the evidence...

Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease.

Frick Mh, O. Elo, Kauko Haapa, Olli P. Heinonen, Pertti Heinsalmi, P. Helo, Jussi K. Huttunen, P. Kaitaniemi, Pekka Koskinen, Vesa Manninen, Hanna Mäenpää, Marjatta Mälkönen, Matti Mänttäri, S. Norola, A. Parternack, J Pikkarainen, Matti Romo, Tom Sjöblom, Esko A. Nikkilä

2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Intervention

Glenn N. Levine, Eric R. Bates, James C. Blankenship, Steven R. Bailey, John A. Bittl, Bojan Cercek, Charles E. Chambers, Stephen G. Ellis, Robert A. Guyton, Umesh N. Khot, Richard A. Lange, Laura Mauri, Roxana Mehran, Issam Moussa, Debabrata Mukherjee, Brahmajee K. Nallamothu, Henry H. Ting

Self-rated health: a predictor of mortality among the elderly.

Data from the Manitoba Longitudinal Study on Aging are used to test the hypothesis that self-rated health status is a good predictor of mortality among the elderly. The data are for 3128 elderly noninstitutionalized residents of Manitoba Canada who were...

A textbook of histology

Alexander A. Maximow, William Bloom

Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure

Background Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to cardiac transplantation, but their long-term use for the purpose of enhancing survival and the quality of life has not been evaluated....

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

10 out of 17 (59%) patients with tropical spastic paraparesis (TSP) had antibodies to human T-lymphotropic virus-I (HTLV-I), as did 5 out of 5 TSP patients with systemic symptoms. Only 13 out of 303 (4%) controls, made up of blood donors, medical personnel,...

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