CiteWeb

WorldWeb citation database

Medicine

Page 5
Dating the endometrial biopsy.

It is asserted that examination of the endometrium during the secretory phase yields more information about the time of ovulation degree of progestational change and normality of the endometrium than any other test used in sterility studies. Attention...

Doppler Tissue Imaging: A Noninvasive Technique for Evaluation of Left Ventricular Relaxation and Estimation of Filling Pressures

Objectives. This investigation was designed 1) to assess whether the early diastolic velocity of the mitral annulus (E a) obtained with Doppler tissue imaging (DTI) behaves as a preloadindependent index of left ventricular (LV) relaxation; and 2) to evaluate...

Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer

Background We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery. Methods From 1973 to 1980, 701 women with breast cancers measuring no...

From best evidence to best practice: effective implementation of change in patients' care

Major difficulties arise when introducing evidence and clinical guidelines into routine daily practice. Data show that many patients do not receive appropriate care, or receive unnecessary or harmful care. Many approaches claim to offer solutions to this...

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Chronic kidney disease1 (CKD) is a worldwide public health problem. In the United States, there is a rising incidence and prevalence of kidney failure, with poor outcomes and high cost. The number of individuals with kidney failure treated by dialysis...

Combat Duty in Iraq and Afghanistan, Mental Health Problems, and Barriers to Care

background The current combat operations in Iraq and Afghanistan have involved U.S. military personnel in major ground combat and hazardous security duty. Studies are needed to systematically assess the mental health of members of the armed services who...

Spatial registration and normalization of images

Karl J. Friston, John Ashburner, C. D. Frith, Jean-Baptiste Poline, J. D. Heather, R. S. J. Frackowiak

Users' Guides to the Medical Literature

Medical practice is constantly changing. The rate of change is accelerating, and physicians can be forgiven if they often find it dizzying. How can physicians learn about new information and innovations, and decide how (if at all) they should modify their...

Diffusion of innovations in service organizations: systematic review and recommendations

This article summarizes an extensive literature review addressing the question, How can we spread and sustain innovations in health service delivery and organization? It considers both content (defining and measuring the diffusion of innovation in organizations)...

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012

The originally published version of this paper was incorrect. In the table on page 1816, the Class of recommendation and Level of evidence for ‘The patient is pacemaker dependent as a result of AV …

The Eating Attitudes Test: an index of the symptoms of anorexia nervosa.

The Eating Attitudes Test: an index of the symptoms of anorexia nervosa.

Antiretroviral Treatment of Adult HIV Infection 2012 Recommendations of the International Antiviral Society-USA Panel

Melanie Thompson, Judith A. Aberg, Jennifer Hoy, Amalio Telenti, Constance A. Benson, Pedro Cahn, Joseph J. Eron, Huldrych F. Günthard, Scott M. Hammer, Peter Reiss, Douglas D. Richman, G. Rizzardini, David L. Thomas, Donna M. Jacobsen, Paul A. Volberding

Validating the SF-36 health survey questionnaire: new outcome measure for primary care.

OBJECTIVES--To test the acceptability, validity, and reliability of the short form 36 health survey questionnaire (SF-36) and to compare it with the Nottingham health profile. DESIGN--Postal survey using a questionnaire booklet together with a letter...

Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial

Type 2 diabetes is associated with a substantially increased risk of cardiovascular disease, but the role of lipid-lowering therapy with statins for the primary prevention of cardiovascular disease in diabetes is inadequately defined. We aimed to assess...

Screening and Prostate-Cancer Mortality in a Randomized European Study

In the screening group, 82% of men accepted at least one offer of screening. During a median follow-up of 9 years, the cumulative incidence of prostate cancer was 8.2% in the screening group and 4.8% in the control group. The rate ratio for death from...

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Tyler J Curiel, George Coukos, Linhua Zou, Xavier Alvarez, Peter Mottram, Melina Evdemon-Hogan, Jose R. Conejo-Garcia, Lin Zhang, Matthew E. Burow, Yun Zhu, Ilona Kryczek, Alan Gordon, Leann Myers, Andrew A. Lackner, Keith L. Knutson, Weiping Zou

ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elev

ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation : The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation...

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

David E. Kleiner, Elizabeth M. Brunt, Mark L. Van Natta, Cynthia Behling, Melissa J. Contos, Oscar W. Cummings, Linda D. Ferrell, Yao-Chang Liu, Michael Torbenson, Aynur Unalp-Arida, Matthew M. Yeh, Arthur J. McCullough, Arun J. Sanyal

The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration

Overwhelming evidence now indicates that the quality of reporting of randomized, controlled trials (RCTs) is less than optimal. Recent methodologic analyses indicate that inadequate reporting and design are associated with biased estimates of treatment...

Sick Individuals and Sick Populations

Rose G (Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK). Sick individuals and sick populations. International Journal of Epidemiology 1985;14:32--38. Aetiology confronts two distinct issues:...

EFFECT OF CARVEDILOL ON SURVIVAL IN SEVERE CHRONIC HEART FAILURE

Background Beta-blocking agents reduce the risk of hospitalization and death in patients with mild-to-moderate heart failure, but little is known about their effects in severe heart failure. Methods We evaluated 2289 patients who had symptoms of heart...

Validation of a combined comorbidity index.

Mary E. Charlson, Ted P. Szatrowski, Janey C. Peterson, Jeffrey P. Gold

Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure

Background B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension. Methods We conducted a prospective study of 1586 patients who came to the emergency department with acute dyspnea and whose B-type natriuretic...

Chronic catheterization of the spinal subarachnoid space

To administer drugs into the spinal subarachnoid space of unanesthetized and intact rats and rabbits, a procedure is described whereby a polyethylene catheter (PE-10) may be inserted through a puncture of the atlanto-occipital membrane and secured to...

CLINICAL EPIDEMIOLOGY OF CARDIOVASCULAR DISEASE IN CHRONIC RENAL DISEASE

Robert N. Foley, Patrick S. Parfrey, Mark J. Sarnak

Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention

Objectives. —To assess incidence and preventability of adverse drug events (ADEs) and potential ADEs. To analyze preventable events to develop prevention strategies.Design. —Prospective cohort study.Participants. —All 4031 adult admissions to a...

World cancer report

Bernard W. Stewart, Paul Kleihues, Peter Boyle, Bernard Levin, Christopher P. Wild

The Continuing Epidemics of Obesity and Diabetes in the United States

Context Recent reports show that obesity and diabetes have increased in the United States in the past decade.Objective To estimate the prevalence of obesity, diabetes, and use of weight control strategies among US adults in 2000.Design, Setting, and Participants...

Functional bowel disorders and functional abdominal pain

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic...

An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction

Letters Letters Letters Letters ABSTRACT Background The relative efficacy of streptokinase and tissue plasminogen activator and the roles of intravenous as compared with subcutaneous heparin as adjunctive therapy in acute myocardial infarction are unresolved...

The Natural History of Congestive Heart Failure: The Framingham Study

The natural history of congestive heart failure was studied over a 16-year period in 5192 persons initially free of the disease. Over this period, overt evidence of congestive heart failure developed in 142 persons. In almost every five-year age group,...

Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients

John P. Stein, Lieskovsky G, Richard J. Cote, Susan Groshen, An-Chen Feng, Stuart D. Boyd, Bernard H. Bochner, D. Thangathurai, Derek Raghavan, Donald G. Skinner

Burden of Systolic and Diastolic Ventricular Dysfunction in the Community: Appreciating the Scope of the Heart Failure Epidemic

Context Approximately half of patients with overt congestive heart failure (CHF) have diastolic dysfunction without reduced ejection fraction (EF). Yet, the prevalence of diastolic dysfunction and its relation to systolic dysfunction and CHF in the community...

Childhood obesity: public-health crisis, common sense cure

SummaryDuring the past two decades, the prevalence of obesity in children has risen greatly worldwide. Obesity in childhood causes a wide range of serious complications, and increases the risk of premature illness and death later in life, raising public-health...

The Spread of Obesity in a Large Social Network over 32 Years

Background The prevalence of obesity has increased substantially over the past 30 years. We performed a quantitative analysis of the nature and extent of the person-to-person spread of obesity as a possible factor contributing to the obesity epidemic....

Effect of carvedilol on survival in severe chronic heart failure

Background Beta-blocking agents reduce the risk of hospitalization and death in patients with mild-to-moderate heart failure, but little is known about their effects in severe heart failure. Methods We evaluated 2289 patients who had symptoms of heart...

Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies.

to 25 kg/m 2 in different Asian populations; for high risk it varies from 26 kg/m 2 to 31 kg/m 2 . No attempt was made, therefore, to redefine cut-off points for each population separately. The consultation also agreed that the WHO BMI cut-off points...

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

Background Bortezomib, a boronic acid dipeptide, is a novel proteasome inhibitor that has been shown in preclinical and phase 1 studies to have antimyeloma activity. Methods In this multicenter, open-label, nonrandomized, phase 2 trial, we enrolled 202...

Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data.

Objectives: Implementation of the International Statistical Classification of Disease and Related Health Problems, 10th Revision (ICD-10) coding system presents challenges for using administrative data. Recognizing this, we conducted a multistep process...

Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer

Background Lapatinib, a tyrosine kinase inhibitor of human epidermal growth factor receptor type 2 (HER2, also referred to as HER2/neu) and epidermal growth factor receptor (EGFR), is active in combination with capecitabine in women with HER2-positive...

Antibiotic resistance of bacteria in biofilms

SummaryBacteria that adhere to implanted medical devices or damaged tissue can encase themselves in a hydrated matrix of polysaccharide and protein, and form a slimy layer known as a biofilm. Antibiotic resistance of bacteria in the biofilm mode of growth...

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease

Background C-reactive protein is an inflammatory marker believed to be of value in the prediction of coronary events. We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses,...

Drug and Alcohol Dependence

Objective: Research has shown that safer injection facilities (SIFs) are successful at reducing public nuisance and enhancing public health. Since 2007 support for implementation of a SIF in San Francisco has been building. The objective of this study...

Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

This article discusses the prevention of venous thromboembolism (VTE) and is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practi ...

The functioning and well-being of depressed patients. Results from the Medical Outcomes Study

We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11 242 outpatients in three health care provision systems in three US sites. Patients...

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

Myocardial ischemia has, for many decades, been viewed as an all-or-none process that causes myocardial necrosis when prolonged and severe, but whose effects are transient when it is brief or mild. In view of the evidence that the ischemic process may...

Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease

background Previous trials have demonstrated that lowering low-density lipoprotein (LDL) cholesterol levels below currently recommended levels is beneficial in patients with acute coronary syndromes. We prospectively assessed the efficacy and safety of...

Global data on visual impairment in the year 2002

Donatella Pascolini, Daniel Etya'ale, Ivo Kocur, Ramachandra Pararajasegaram, Gopal P. Pokharel, Silvio P. Mariotti

The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews

In the era of evidence based medicine, with systematic reviews as its cornerstone, adequate quality assessment tools should be available. There is currently a lack of a systematically developed and evaluated tool for the assessment of diagnostic accuracy...

Risk Factors for Hip Fracture in White Women

Background Many risk factors for hip fractures have been suggested but have not been evaluated in a comprehensive prospective study. Methods We assessed potential risk factors, including bone mass, in 9516 white women 65 years of age or older who had...

Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study

F. Javier Nieto, Terry Young, Bonnie K. Lind, Eyal Shahar, Jonathan M. Samet, Susan Redline, Ralph B. D'Agostino, Anne B. Newman, Michael Lebowitz, Thomas G. Pickering

Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

Approximately 200 studies that examined the relationship between fruit and vegetable intake and cancers of the lung, colon, breast, cervix, esophagus, oral cavity, stomach, bladder, pancreas, and ovary are reviewed. A statistically significant protective...

Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene Results From a 3-Year Randomized Clinical Trial

Context Raloxifene hydrochloride, a selective estrogen receptor modulator, prevents bone loss in postmenopausal women, but whether it reduces fracture risk in these women is not known.Objective To determine the effect of raloxifene therapy on risk of...

Overweight and obesity in the United States: prevalence and trends, 1960-1994

Katherine M. Flegal, Margaret D. Carroll, Robert J. Kuczmarski, Clifford L. Johnson

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis The CLASS Study: A Randomized Controlled Trial

Context Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1. Whether COX-2–specific inhibitors are associated...

A model to predict survival in patients with end-stage liver disease

A recent mandate emphasizes severity of liver disease to determine priorities in allocating organs for liver transplantation and necessitates a disease severity index based on generalizable, verifiable, and easily obtained variables. The aim of the study...

Graft-Versus-Leukemia Reactions After Bone Marrow Transplantation

To determine whether graft-versus-leukemia (GVL) reactions are important in preventing leukemia recurrence after bone marrow transplantation, we studied 2,254 persons receiving HLA-identical sibling bone marrow transplants for acute myelogenous leukemia...

Trends in prevalence and outcome of heart failure with preserved ejection fraction

Background The prevalence of heart failure with preserved ejection fraction may be changing as a result of changes in population demographics and in the prevalence and treatment of risk factors for heart failure. Changes in the prevalence of heart failure...

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Pract

Valentin Fuster, Lars Rydén, David S. Cannom, Harry J.G.M. Crijns, Anne B. Curtis, Kenneth A. Ellenbogen, Jonathan L. Halperin, Jean-Yves Le Heuzey, G. Neal Kay, James E. Lowe, S. Bertil Olsson, Eric N. Prystowsky, Juan Tamargo, Samuel Wann, Acc, Aha Task Force Members, Sidney C. Smith, Alice K. Jacobs, Cynthia D. Adams, Jeffery L. Anderson, Elliott M. Antman, Sharon A. Hunt, Rick A. Nishimura, Joseph P. Ornato, Richard L. Page, Barbara Riegel, Silvia G. Priori, Jean-Jacques Blanc, Andrzej Budaj, A. John Camm, Veronica Dean, Jaap W. Deckers, Catherine Despres, John Lekakis, Keith McGregor, Marco Metra, Joao Morais, A. Osterspey, Jose Luis Zamorano

Prevention of Colorectal Cancer by Colonoscopic Polypectomy

Background The current practice of removing adenomatous polyps of the colon and rectum is based on the belief that this will prevent colorectal cancer. To address the hypothesis that colonoscopic polypectomy reduces the incidence of colorectal cancer,...

The Michigan Alcoholism Screening Test: The Quest for a New Diagnostic Instrument

The Michigan Alcoholism Screening Test (MAST), devised to provide a consistent, quantifiable, structured interview instrument to detect alcoholism, consists of 25 questions that can be rapidly administered. Five groups were given the MAST: hospitalized...

Microbial complexes in subgingival plaque.

S. S. Socransky, A. D. Haffajee, Cugini M, C. Smith, R. L. Kent

Air pollution and health

The health effects of air pollution have been subject to intense study in recent years. Exposure to pollutants such as airborne participate matter and ozone has been associated with increases in mortality and hospital admissions due to respiratory and...

Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability

Background Functional assessment is an important part of the evaluation of elderly persons. We conducted this study to determine whether objective measures of physical function can predict subsequent disability in older persons. Methods This prospective...

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to test the hypothesis that for the same blood-pressure control, valsartan would reduce cardiac morbidity and mortality more than amlodipine in hypertensive patients at...

Impact of Psychological Factors on the Pathogenesis of Cardiovascular Disease and Implications for Therapy

Recent studies provide clear and convincing evidence that psychosocial factors contribute significantly to the pathogenesis and expression of coronary artery disease (CAD). This evidence is composed largely of data relating CAD risk to 5 specific psychosocial...

Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative

This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work...

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.

Jeffrey D. Browning, Lidia S. Szczepaniak, Robert L. Dobbins, Pamela Nuremberg, Jay D. Horton, Jonathan C. Cohen, Scott M. Grundy, Helen H. Hobbs

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline

Objective: The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency. Participants: The Task Force was composed of...

Rehospitalizations among patients in the Medicare fee-for-service program.

Background Reducing rates of rehospitalization has attracted attention from policymakers as a way to improve quality of care and reduce costs. However, we have limited information on the frequency and patterns of rehospitalization in the United States...

CORONARY-ARTERY CALCIFICATION IN YOUNG ADULTS WITH END-STAGE RENAL DISEASE WHO ARE UNDERGOING DIALYSIS

Background Cardiovascular disease is common in older adults with end-stage renal disease who are undergoing regular dialysis, but little is known about the prevalence and extent of cardiovascular disease in children and young adults with end-stage renal...

Cancer Statistics, 2002

Every year the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival, using National Cancer Institute...

A RANDOMIZED TRIAL OF THE ANGIOTENSIN-RECEPTOR BLOCKER VALSARTAN IN CHRONIC HEART FAILURE

Background Actions of angiotensin II may contribute to the progression of heart failure despite treatment with currently recommended drugs. We therefore evaluated the long-term effects of the addition of the angiotensin-receptor blocker valsartan to standard...

Physical Activity in the United States Measured by Accelerometer

Purpose: To describe physical activity levels of children (6-11 yr), adolescents (12-19 yr), and adults (20+ yr), using objective data obtained with accelerometers from a representative sample of the U.S. population.Methods: These results were obtained...

Prevalence of Chronic Kidney Disease in the United States

Context The prevalence and incidence of kidney failure treated by dialysis and transplantation in the United States have increased from 1988 to 2004. Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during...

CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials

Overwhelming evidence shows the quality of reporting of randomised controlled trials (RCTs) is not optimal. Without transparent reporting, readers cannot judge the reliability and validity of trial findings nor extract information for systematic reviews....

Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock

Djillali Annane, Claire Charpentier, Pierre-Edouard Bollaert, Korach Jm, G. Capellier, Yves Cohen, Elie Azoulay, Philippe Chaumet-Riffaut, Eric Bellissant

Exercise Capacity and Mortality among Men Referred for Exercise Testing

Background Exercise capacity is known to be an important prognostic factor in patients with cardiovascular disease, but it is uncertain whether it predicts mortality equally well among healthy persons. There is also uncertainty regarding the predictive...

Lymphatic mapping and sentinel lymphadenectomy for breast cancer.

Armando E. Giuliano, Daniel Kirgan, J. M. Guenther, Donald L. Morton

Early identification of refractory epilepsy.

Background More than 30 percent of patients with epilepsy have inadequate control of seizures with drug therapy, but why this happens and whether it can be predicted are unknown. We studied the response to antiepileptic drugs in patients with newly diagnosed...

Measurements of acute cerebral infarction: a clinical examination scale.

Thomas G. Brott, Harold P. Adams, C P Olinger, John R. Marler, William G. Barsan, José Biller, Judith Spilker, Reneé Holleran, R Eberle, V Hertzberg

An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU

intervention (P≤0.002), and the mean rate per 1000 catheter-days decreased from 7.7 at baseline to 1.4 at 16 to 18 months of follow-up (P<0.002). The regression model showed a significant decrease in infection rates...

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

Background Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play a pivotal role in the ability of tumor cells to evade the host's immune system. Blockade of interactions between PD-1 and PD-L1 enhances...

IMPROVED SURVIVAL WITH AN IMPLANTED DEFIBRILLATOR IN PATIENTS WITH CORONARY DISEASE AT HIGH RISK FOR VENTRICULAR ARRHYTHMIA

Background Unsustained ventricular tachycardia in patients with previous myocardial infarction and left ventricular dysfunction is associated with a twoyear mortality rate of about 30 percent. We studied whether prophylactic therapy with an implanted...

Epidemiology and causes of preterm birth

This paper is the first in a three-part series on preterm birth, which is the leading cause of perinatal morbidity and mortality in developed countries. Infants are born preterm at less than 37 weeks' gestational age after: (1) spontaneous labour with...

The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.

Background Recent studies indicate that magnetic resonance imaging (MRI) after the administration of contrast material can be used to distinguish between reversible and irreversible myocardial ischemic injury regardless of the extent of wall motion or...

Flow-mediated endothelial mechanotransduction

Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses...

International Classification of Functioning, Disability and Health (ICF)

As a new member of WHO Family of International Classifications, ICF describes how people live with their health condition. ICF is a classification of health and health related domains that describe body functions and structures, activities and participation....

Epidemiology and outcomes of osteoporotic fractures

The skeleton is essential for terrestrial animal life, and human beings have evolved bone light enough to allow rapid mobility and strong enough to avoid disabling fractures during the reproductive years. However, after the menopause in women and with...

Survival in Patients with Primary Pulmonary Hypertension: Results from a National Prospective Registry

Objective:To characterize mortality in persons diag­ nosed with primary pulmonary hypertension and to investigate factors associated with survival. • Design: Registry with prospective follow-up. • Setting: Thirty-two clinical centers in the United...

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

Aram V. Chobanian, George L. Bakris, Henry R. Black, William C. Cushman, Lee A. Green, Daniel W. Jones, Barry J. Materson

Postoperative pancreatic fistula: An international study group (ISGPF) definition

Claudio Bassi, Christos Dervenis, Giovanni Butturini, Abe Fingerhut, Charles J. Yeo, Jakob R. Izbicki, John P. Neoptolemos, Michael G. Sarr, William Traverso, M.W. Büchler

Efficacy of Gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic Patients with non-small cell lung Cancer a randomized trial

Context More persons in the United States die from non–small cell lung cancer (NSCLC) than from breast, colorectal, and prostate cancer combined. In preclinical testing, oral gefitinib inhibited the growth of NSCLC tumors that express the epidermal...

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction

Summary Background Experimental evidence suggests that autonomic markers such as heart-rate variability and baroreflex sensitivity (BRS) may contribute to postinfarction risk stratification. There are clinical data to support this concept for heart-rate...

Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

THE SECOND report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II, or ATP II) presents the National Cholesterol Education Program's updated recommendations for cholesterol management....

Head and Neck Cancer

Head and neck cancer was last reviewed in the Journal in 19831. At that time, there was promising new information on a possible role for chemotherapy1,2. During the past decade, chemotherapy has undergone further investigation and important clinical advances...

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

Results In 2009-2010 the age-adjusted mean BMI was 28.7 (95% CI, 28.3-29.1) for men and also 28.7 (95% CI, 28.4-29.0) for women. Median BMI was 27.8 (interquartile range [IQR], 24.7-31.7) for men and 27.3 (IQR, 23.3-32.7) for women. The...

Dietary guidelines for Americans, 2005

We are pleased to present the 2005 Dietary Guidelines for Americans. This document is intended to be a primary source of dietary health information for policymakers, nutrition educators, and health providers. Based on the latest scientific evidence, the...

Actual causes of death in the United States

Objective. —To identify and quantify the major external (nongenetic) factors that contribute to death in the United States.Data Sources. —Articles published between 1977 and 1993 were identified through MEDLINE searches, reference citations, and expert...

Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer

Charles L. Vogel, Melody A. Cobleigh, Debu Tripathy, John C. Gutheil, Lyndsay N. Harris, Louis Fehrenbacher, Dennis J. Slamon, M. Murphy, William F. Novotny, Michael Burchmore, Steven Shak, Stanford J. Stewart

The importance of selenium to human health

The essential trace mineral, selenium, is of fundamental importance to human health. As a constituent of selenoproteins, selenium has structural and enzymic roles, in the latter context being best-known as an antioxidant and catalyst for the production...

Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.

Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects...

Sudden Cardiac Death

Sudden cardiac death describes the unexpected natural death from a cardiac cause within a short time period, generally ≤1 hour from the onset of symptoms, in a person without any prior condition that would appear fatal.1 2 Such a rapid death is often...

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II

Reva C. Lawrence, David T. Felson, Charles G. Helmick, Lesley M. Arnold, Hyon K. Choi, Richard A. Deyo, Sherine E. Gabriel, Rosemarie Hirsch, Marc C. Hochberg, Gene G. Hunder, Joanne M. Jordan, Hilal Maradit Kremers, Frederick Wolfe

The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease

background Chronic obstructive pulmonary disease (COPD) is characterized by an incompletely reversible limitation in airflow. A physiological variable — the forced expiratory volume in one second (FEV 1 ) — is often used to grade the severity of COPD....

Maternal and child undernutrition: global and regional exposures and health consequences

SummaryMaternal and child undernutrition is highly prevalent in low-income and middle-income countries, resulting in substantial increases in mortality and overall disease burden. In this paper, we present new analyses to estimate the effects of the risks...

Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study

Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between...

Chemoradiotherapy after Surgery Compared with Surgery Alone for Adenocarcinoma of the Stomach or Gastroesophageal Junction

Background Surgical resection of adenocarcinoma of the stomach is curative in less than 40 percent of cases. We investigated the effect of surgery plus postoperative (adjuvant) chemoradiotherapy on the survival of patients with resectable adenocarcinoma...

« Prev. Next »
First ... 1 2 3 4 5 6 7 8 9 10 ... Last

© 2016-2018 CiteWeb.info — WorldWeb citation database

Up ↑