CiteWeb

WorldWeb citation database

Medicine

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Classification of subtype of acute ischemic stroke : definitions for use in a multicenter clinical trial

Harold P. Adams, B.H. Bendixen, L. J. Kappell, José Biller, Love Bb, David Lee Gordon, E E Marsh

Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies

Objective.— To estimate the incidence of serious and fatal adverse drug reactions (ADR) in hospital patients.Data Sources.— Four electronic databases were searched from 1966 to 1996.Study Selection.— Of 153, we selected 39 prospective studies from...

Histological grading and staging of chronic hepatitis

Kamal G. Ishak, Amélia Baptista, Bianchi L, Francesco Callea, Gudat F, Helmut Denk, Valeer Desmet, Korb G, Roderick N. M. MacSween, M. James Phillips, Bernard Portmann, Hemming Poulsen, Peter J. Scheuer, Schmid M, Heribert Thaler

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

background Trastuzumab, a recombinant monoclonal antibody against HER2, has clinical activity in advanced breast cancer that overexpresses HER2. We investigated its efficacy and safety after excision of early-stage breast cancer and completion of chemotherapy....

EuroQol: the current state of play

The EuroQol Group first met in 1987 to test the feasibility of jointly developing a standardised non-disease-specific instrument for describing and valuing health-related quality of life. From the outset the Group has been multi-country, multi-centre,...

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

background The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly. We compared a first-generation antipsychotic,...

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

background The epidermal growth factor receptor (EGFR), which participates in signaling pathways that are deregulated in cancer cells, commonly appears on colorectal-cancer cells. Cetuximab is a monoclonal antibody that specifically blocks the EGFR. We...

Predicting Obesity in Young Adulthood from Childhood and Parental Obesity

Background Childhood obesity increases the risk of obesity in adulthood, but how parental obesity affects the chances of a child's becoming an obese adult is unknown. We investigated the risk of obesity in young adulthood associated with both obesity...

Why Don't Physicians Follow Clinical Practice Guidelines? A Framework for Improvement

Context Despite wide promulgation, clinical practice guidelines have had limited effect on changing physician behavior. Little is known about the process and factors involved in changing physician practices in response to guidelines.Objective To review...

Radiobiology for the radiologist

Radiobiology for the radiologist

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

ISCHEMIA-induced pathologic processes are responsible for the single greatest cause of death in this country — heart disease; cerebral ischemia also makes a major contribution to our nation's morbidity and mortality. A relatively subtle indicator of...

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the

Elliott M. Antman, Daniel T. Anbe, Paul W. Armstrong, Eric R. Bates, Lee A. Green, Mary M. Hand, Judith S. Hochman, Harlan M. Krumholz, Frederick G. Kushner, Gervasio A. Lamas, Charles J. Mullany, Joseph P. Ornato, David L. Pearle, Michael A. Sloan, Sidney C. Smith, Joseph S. Alpert, Jeffrey L. Anderson, David P. Faxon, Valentin Fuster, Raymond J. Gibbons, Gabriel Gregoratos, Jonathan L. Halperin, Loren F. Hiratzka, Sharon A. Hunt, Alice K. Jacobs

Body-mass index and mortality in a prospective cohort of U.S. adults

Background Body-mass index (the weight in kilograms divided by the square of the height in meters) is known to be associated with overall mortality. We investigated the effects of age, race, sex, smoking status, and history of disease on the relation...

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

METHODS In this phase 3, open-label study, we randomly assigned previously untreated patients in East Asia who had advanced pulmonary adenocarcinoma and who were nonsmokers or former light smokers to receive gefitinib (250 mg per day) (609 patients) or...

THE EFFECT OF SPIRONOLACTONE ON MORBIDITY AND MORTALITY IN PATIENTS WITH SEVERE HEART FAILURE. RANDOMIZED ALDACTONE EVALUATION STUDY INVESTIGATORS

Jolie Palensky, J Wittes, Sergio Pérez, Stephanie R. Cody, Bertram Pitt, Faiez Zannad, Espen W. Remme, José Antonio Pérez-Daga, A Castaigne, B. Pitt

Hay fever, hygiene, and household size.

Hay fever has been described as a "post industrialrevolution epidemic,"' and successive morbiditysurveys from British general practice suggest that itsprevalence has continued to increase over the past 30years.) Other evidence suggests a recent increase...

Vascular dementia Diagnostic criteria for research studies: Report of the NINDS‐AIREN International Workshop*

Román Gc, T. K. Tatemichi, Timo Erkinjuntti, J. L. Cummings, Joseph C. Masdeu, J. H. Garcia, Luigi Amaducci, J.-M. Orgogozo, A. Brun, A. Hofman, D. M. Moody, O'Brien Md, T. Yamaguchi, Jordan Grafman, B. P. Drayer, D. A. Bennett, M. Fisher, Jun Ogata, F. Bermejo, Philip A. Wolf, Gorelick Pb, Katherine L. Bick, Aurora K. Pajeau, M. A. Bell, C.D. DeCarli, A. Culebras, A. D. Korczyn, J. Bogousslavsky, A. Hartmann, Peritz Scheinberg

Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention Trial

OBJECTIVE To assess predictors of CVD mortality among men with and without diabetes and to assess the independent effect of diabetes on the risk of CVD death.RESEARCH DESIGN AND METHODS Participants in this cohort study were screened from 1973 to 1975;...

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the

Kenneth Dickstein, Cohen-Solal A, Gerasimos Filippatos, John J.V. McMurray, Piotr Ponikowski, Philip A. Poole-Wilson, Anna Strömberg, D.J. van Veldhuisen, Dan Atar, A.W. Hoes, Andre Keren, A. Mebazaa, Markku S. Nieminen, Silvia G. Priori, Karl Swedberg, Alec Vahanian, John Camm, R. De Caterina, Veronica Dean, Christian Funck-Brentano, Irene Hellemans, Kristensen Sd, Keith McGregor, Udo Sechtem, Sigmund Silber, Michal Tendera, Petr Widimsky, José Zamorano, Angelo Auricchio, Jeroen J. Bax, Michael Böhm, Ugo Corrà, P. Della Bella, P Elliott, Ferenc Follath, Gheorghiade M, Yonathan Hasin, Hernborg A, Tiny Jaarsma, Michel Komajda, Ran Kornowski, Massimo F. Piepoli, Luigi Tavazzi, Jean-Luc Vachiery, F.W.A. Verheugt, F. Zannad

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Suzanne S. Mirra, Albert Heyman, Daniel W. McKeel, S. M. Sumi, Barbara J. Crain, Linda Brownlee, F. S. Vogel, James P. Hughes, G. van Belle, L. Berg, participating Cerad neuropathologists

Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association

Véronique L. Roger, Alan S. Go, Donald M. Lloyd-Jones, Emelia J. Benjamin, Jarett D. Berry, William B. Borden, Dawn M. Bravata, Shifan Dai, Earl S. Ford, Caroline S. Fox, Heather J. Fullerton, Cathleen Gillespie, Susan M. Hailpern, John A. Heit, Virginia J. Howard, Brett Kissela, Steven J. Kittner, Daniel T. Lackland, Judith H. Lichtman, Lynda D. Lisabeth, Diane M. Makuc, Gregory M. Marcus, Ariane J. Marelli, David B. Matchar, Claudia S. Moy, Dariush Mozaffarian, Michael E. Mussolino, Graham Nichol, Nina P. Paynter, Elsayed Z. Soliman, Paul D. Sorlie, Nona Sotoodehnia, Tanya N. Turan, Salim S. Virani, Nathan D. Wong, Daniel Woo, Melanie B. Turner

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Background Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We assessed the antitumor activity and safety of BMS-936558, an antibody that specifically blocks PD-1. Methods We enrolled...

Sexual Dysfunction in the United States: Prevalence and Predictors

Context While recent pharmacological advances have generated increased public interest and demand for clinical services regarding erectile dysfunction, epidemiologic data on sexual dysfunction are relatively scant for both women and men.Objective To assess...

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

The complexities of the chronic fatigue syndrome and the methodologic problems associated with its study indicate the need for a comprehensive, system­ atic, and integrated approach to the evaluation, classi­ fication, and study of persons with this...

Guidelines for the management of atrial fibrillation The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)

Guidelines for the management of atrial fibrillation : the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)

Youth risk behavior surveillance--United States, 2001.

Problem/Condition: Priority health-risk behaviors, which contribute to the leading causes of mortality and morbidity among youth and adults, often are established during youth, extend into adulthood, are interrelated, and are preventable.

Endarterectomy for Asymptomatic Carotid Artery Stenosis

To the Editor. —The authors of the ACAS1 concluded that patients with asymptomatic carotid artery stenosis of 60% or more and who have an acceptable surgical risk will have a reduced 5-year risk of ipsilateral stroke if carotid endarterectomy is performed...

Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group

There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on...

Global prevalence of dementia: a Delphi consensus study

100 years after the first description, Alzheimer's disease is one of the most disabling and burdensome health conditions worldwide. We used the Delphi consensus method to determine dementia prevalence for each world region.

A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease

Background Coronary-stent placement is a new technique in which a balloon-expandable, stainless-steel, slotted tube is implanted at the site of a coronary stenosis. The purpose of this study was to compare the effects of stent placement and standard balloon...

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

SummaryFlavonoids are polyphenolic antioxidants naturally present in vegetables, fruits, and beverages such astea and wine. In vitro, flavonoids inhibit oxidation of low-density lipoprotein and reduce thrombotic tendency, but their effects on atherosclerotic...

The Cochrane library

Cindy Farquhar, Patrick Vandekerckhove

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials.

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the...

Protecting Adolescents From Harm: Findings From the National Longitudinal Study on Adolescent Health

The main threats to adolescents health are the risk behaviors they choose. Findings are reported from a study conducted to identify risk and protective factors at the family school and individual levels as they relate to emotional health violence substance...

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events

Background Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available. Methods...

The Disease Burden Associated With Overweight and Obesity

Aviva Must, Jennifer L Spadano, Eugenie Coakley, Alison E. Field, Graham A. Colditz, William H. Dietz

TUTORIAL IN BIOSTATISTICS MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS

SUMMARY Multivariable regression models are powerful tools that are used frequently in studies of clinical outcomes. These models can use a mixture of categorical and continuous variables and can handle partially observed (censored) responses. However,...

Functional Bowel Disorders

Employing a consensus approach, our working team critically considered the available evidence and multinational expert criticism, revised the Rome II diagnostic criteria for the functional bowel disorders, and updated diagnosis and treatment recommendations....

EAU Guidelines on Prostate Cancer

To present a summary of the 2007 version of the European Association of Urology (EAU) guidelines on prostate cancer (PCa).

Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes.

David M. Nathan, Patricia A. Cleary, Backlund Jy, John M. Lachin, Trevor J. Orchard, Philip Raskin, Bernard Zinman

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Background Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods In nine countries, we enrolled 1763 couples in which one partner was HIV-1–positive...

Lung volumes and forced ventilatory flows

Quanjer Ph, Tammeling Gj, Cotes Je, Pedersen Of, Peslin R, J C Yernault

Endarterectomy for Asymptomatic Carotid Artery Stenosis-Reply

To the Editor. —The authors of the ACAS1 concluded that patients with asymptomatic carotid artery stenosis of 60% or more and who have an acceptable surgical risk will have a reduced 5-year risk of ipsilateral stroke if carotid endarterectomy is performed...

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

Background Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel. Methods In this multicenter, double-blind, randomized...

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease GOLD Executive Summary

Chronic obstructive pulmonary disease (COPD) is a global health problem, and since 2001, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published its strategy document for the diagnosis and management of COPD. This executive summary...

Compensatory Enlargement of Human Atherosclerotic Coronary Arteries

Whether human coronary arteries undergo compensatory enlargement in the presence of coronary disease has not been clarified. We studied histologic sections of the left main coronary artery in 136 hearts obtained at autopsy to determine whether atherosclerotic...

Evaluating the Quality of Medical Care

This p aper i s a n a ttempt t o d escribe a nd evaluate current methods for assessing the quality of medical care and to suggest some directions for further study. It is concerned with methods rather than findings, and with an evaluation of methodology...

Cancer epidemiology and prevention

David Schottenfeld, Joseph F. Fraumeni

Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000

Context The prevalence of overweight among children in the United States increased between 1976-1980 and 1988-1994, but estimates for the current decade are unknown.Objective To determine the prevalence of overweight in US children using the most recent...

Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomized trials

Summary Background Many trials have been done to compare primary percutaneous transluminal coronary angioplasty (PTCA) with thrombolytic therapy for acute ST-segment elevation myocardial infarction (AMI). Our aim was to look at the combined results of...

Decreased heart rate variability and its association with increased mortality after acute myocardial infarction

A high degree of heart rate (HR) variability is found in compensated hearts with good function, whereas HR variability can be decreased with severe coronary artery disease, congestive heart failure, aging and diabetic neuropathy. To test the hypothesis...

Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults

Background The combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. We studied the associations between the thickness of the carotid-artery intima and media and the incidence of...

Global estimates of the prevalence of diabetes for 2010 and 2030

AimWe estimated the number of people worldwide with diabetes for the years 2010 and 2030.MethodsStudies from 91 countries were used to calculate age- and sex-specific diabetes prevalences, which were applied to national population estimates, to determine...

Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

Background: Many patients with severe aortic stenosis and coexisting conditions are not candidates for surgical replacement of the aortic valve. Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment for...

Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internatio

A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors include raised blood pressure, dyslipidemia (raised...

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

Evidence that the various common types of cancer are largely avoidable diseases is reviewed. Life-style and other environmental factors are divided into a dozen categories and for each category the evidence relating those particular factors to cancer...

Physical Activity and Public Health Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association

This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work...

Mortality by cause for eight regions of the world: Global Burden of Disease Study

The Global Burden of Disease Study used vital registration sample registration and small-scale population study data to develop cause of death estimates for 107 disorders by age sex and world region. Of the estimated 50467000 global deaths in 1990 17.2...

Principles and practice of sleep medicine

Meir H. Kryger, T. J. Roth, William C. Dement

IMPOTENCE AND ITS MEDICAL AND PSYCHOSOCIAL CORRELATES: RESULTS OF THE MASSACHUSETTS MALE AGEING STUDY

H A Felfman, J Goldstein, D. G. Hatzichriston, R J Krane, J U Mckinaly

Technical details of intraoperative lymphatic mapping for early stage melanoma.

Donald L. Morton, Duan-Ren Wen, Jan H. Wong, James S. Economou, F. Kristian Storm, Leland J. Foshag, Alistair J. Cochran

Standards of Medical Care in Diabetes

I write in reference to the recently updated and circulated “Standards of Medical Care in Diabetes,” in particular part II, “Screening for Diabetes,” which were recently updated and published in the American Diabetes Association (ADA) 2006 Clinical...

Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias.

Stephen MacMahon, R Peto, J E Cutler, Rory Collins, P D Sorlie, James D. Neaton, R.P. Abbott, J Godwin, Jeremiah Stamler

Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Margherita Maffei, Jeffrey L. Halaas, E. Ravussin, Richard E. Pratley, G.H. Lee, Yiying Zhang, H. Fei, Song-Chul Kim, Roger L. Lallone, Subramanian Ranganathan, Philip A. Kern, J. Friedman

The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment

Patient AccessPatients and/or caregivers may access this content for use in relation to their own personal healthcare or that of a family member only. Terms and conditions will apply.

Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation.

Context Patients who have atrial fibrillation (AF) have an increased risk of stroke, but their absolute rate of stroke depends on age and comorbid conditions.Objective To assess the predictive value of classification schemes that estimate stroke risk...

Hospital Nurse Staffing and Patient Mortality, Nurse Burnout, and Job Dissatisfaction

Context: Hospitals nationally are experiencing a nursing shortage caused by the declining number of students enrolled in nursing school and the increasing difficulty of retaining nurses. U.S. nurses consistently report that hospital nurse staffing levels...

Guidelines for the management of atrial fibrillation The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)

Guidelines for the management of atrial fibrillation : the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC).

Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes

�Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that had borderline significance. Our study was limited by a lack of access to original...

Cancer Statistics, 2004†

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival rates based on incidence data from...

Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury.

Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical and translational research...

Osteoporosis Prevention, Diagnosis, and Therapy

Objectives To clarify the factors associated with prevention, diagnosis, and treatment of osteoporosis, and to present the most recent information available in these areas.Participants From March 27-29, 2000, a nonfederal, nonadvocate, 13-member panel...

A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia

Background There is considerable variability in rates of hospitalization of patients with community-acquired pneumonia, in part because of physicians' uncertainty in assessing the severity of illness at presentation. Methods From our analysis of data...

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

We did a randomised controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn's disease who respond to a single infusion of infliximab.

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography

Recommendations for the evaluation of left ventricular diastolic function by echocardiography

Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer

Background In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer. Methods A total of 1851 women for whom follow-up data...

High density lipoprotein as a protective factor against coronary heart disease: the Framingham Study.

Starting in 1968 2815 men and women from the Framingham Heart study cohort aged 49-82 years had their lipids and lipoproteins characterized after an overnight fast; measurements included fasting triglycerides and high-density lipoproteins (HDL) low-density...

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure

Background It is known that obesity, sodium intake, and alcohol consumption influence blood pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on blood pressure. Methods We enrolled 459...

Measurement of patient outcome in arthritis

A structure for representation of patient outcome is presented, together with a method for outcome measurement and validation of the technique in rheumatoid arthritis. The paradigm represents outcome by five separate dimensions: death, discomfort, disability,...

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 : The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the...

Tolerance of normal tissue to therapeutic irradiation

The importance of knowledge on tolerance of normal tissue organs to irradiation by radiation oncologists cannot be overemphasized. Unfortunately, current knowledge is less than adequate. With the increasing use of 3-D treatment planning and dose delivery,...

Incidence, Predictors, and Outcome of Thrombosis After Successful Implantation of Drug-Eluting Stents

Context Traditionally, stent thrombosis has been regarded as a complication of percutaneous coronary interventions during the first 30 postprocedural days. However, delayed endothelialization associated with the implantation of drug-eluting stents may...

Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study

Background. Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States. Methods. Data from a nationwide, concurrent surveillance study (Surveillance and Control of Pathogens of Epidemiological Importance...

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

Background Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year. Methods Seven consecutive patients with type 1 diabetes...

Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer

background Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent prostate cancer. We compared docetaxel plus estramustine with mitoxantrone plus prednisone in men with metastatic, hormoneindependent...

Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement

The Quality of Reporting of Meta-analyses (QUOROM) conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs).

NAD(P)H Oxidase Role in Cardiovascular Biology and Disease

Kathy K. Griendling, Dan Sorescu, Masuko Ushio-Fukai

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre ra

The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive...

Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study

Results: More than half of respondents reported at least one, and one-fourth reported $2 categories of childhood exposures. We found a graded relationship between the number of categories of childhood exposure and each of the adult health risk behaviors...

Grading quality of evidence and strength of recommendations.

David Atkins, Dana Best, Peter A. Briss, Martin Eccles, Yngve Falck-Ytter, Signe Flottorp, Gordon H. Guyatt, Robin Harbour, M. Haugh, David Henry, Suzanne Hill, Roman Jaeschke, Gillian Leng, Alessandro Liberati, Nicola Magrini, James Mason, Philippa Middleton, Jacek Mrukowicz, Dianne O'Connell, Andrew D Oxman, Bob Phillips, Holger J. Schünemann, Tessa Tan-Torres Edejer, Helena Varonen, Gunn E Vist, John W. Williams, Stephanie Zaza

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre ra

Summary Background The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease...

Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes

The primary efficacy end point occurred in 12.1% of patients receiving clopidogrel and 9.9% of patients receiving prasugrel (hazard ratio for prasugrel vs. clopidogrel, 0.81; 95% confidence interval [CI], 0.73 to 0.90;...

Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study

Summary Background The effect of obstructive sleep apnoea-hypopnoea as a cardiovascular risk factor and the potential protective effect of its treatment with continuous positive airway pressure (CPAP) is unclear. We did an observational study to compare...

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

Background Controlled clinical trials have shown that beta-blockers can produce hemodynamic and symptomatic improvement in chronic heart failure, but the effect of these drugs on survival has not been determined. Methods We enrolled 1094 patients with...

Human error: models and management

The human error problem can be viewed in two ways: the person approach and the system approach. Each has its model of error causation and each model gives rise to quite different philosophies of error management. Understanding these differences has important...

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

Plasma concentrations of adiponectin, a novel adipose-specific protein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity, type 2 diabetes, and cardiovascular disease, conditions...

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

F. Xavier Bosch, M. Michele Manos, Nubia Muñoz, Angela M. Jansen, Julian Peto, Victor Moreno, Robert J. Kurman, Keerti V. Shan

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Ma

Robert O. Bonow, Blase A. Carabello, Kanu Chatterjee, Antonio C. de Leon, David P. Faxon, Michael D. Freed, William H. Gaasch, Bruce W. Lytle, Rick A. Nishimura, Patrick T. O’Gara, Robert A. O’Rourke, Pravin M. Shah, Jack S. Shanewise

Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome

PDF ABSTRACT Background In patients with the acute respiratory distress syndrome, massive alveolar collapse and cyclic lung reopening and overdistention during mechanical ventilation may perpetuate alveolar injury. We determined whether a ventilatory...

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

Background Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of gastrointestinal stromal tumors. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical...

The Banff 97 working classification of renal allograft pathology

Lorraine C. Racusen, Kim Solez, Robert B. Colvin, Stephen Bonsib, María del Carmen Brito Castro, Tito Cavallo, Byron P. Croker, A Jake Demetris, Cynthia B. Drachenberg, Agnes B. Fogo, Peter N. Furness, Lillian W. Gaber, Ian W. Gibson, Dennis Glotz, Julio Goldberg, Joseph A. Grande, Philip F. Halloran, Hansen He, Barry Hartley, Häyry P, Claire M Hill, Ernesto O Hoffman, Lawrence G. Hunsicker, Anne S. Lindblad, Niels Marcussen, Michael J. Mihatsch, Tibor Nadasdy, Peter W. Nickerson, T. Steen Olsen, John C. Papadimitriou, Parmjeet Randhawa, Rayner Dc, Ian Roberts, Rose Sm, David N. Rush, Luis Salinas-Madrigal, Daniel R. Salomon, Stale Sund, Eero Taskinen, Kiril Trpkov, Yutaka Yamaguchi

Sexually transmitted diseases treatment guidelines, 2010.

The MMWR series of publications is published by the Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333.

Global mortality disability and the contribution of risk factors: Global Burden of Disease Study.

The Global Burden of Disease Study used the disability-adjusted life-year (DALY) to compare death and disability from various disorders in developing and developed countries. In 1990 developing countries carried almost 90% of the global disease burden...

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