CiteWeb id: 20130000040

CiteWeb score: 2643

DOI: 10.1126/science.1232033

Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and plasmid DNA is targeted for cleavage by complementary CRISPR RNAs (crRNAs) bound to a CRISPR-associated endonuclease (see the Perspective by [ van der Oost ][1]). Cong et al. (p. [819][2], published online 3 January) and Mali et al. (p. [823][3], published online 3 January) adapted this defense system to function as a genome editing tool in eukaryotic cells. [1]: /lookup/doi/10.1126/science.1234726 [2]: /lookup/doi/10.1126/science.1231143 [3]: /lookup/doi/10.1126/science.1232033