CiteWeb id: 20120001028

CiteWeb score: 582

DOI: 10.1164/ajrccm.159.2.9803121

The minimal disease severity at which patients with the sleep apnea/hypopnea syndrome (SAHS) gain benefit from treatment is not well characterized, although a pilot study of continuous positive airway pressure (CPAP) therapy showed daytime improvements in patients with 5 to 15 apneas 1 hypopneas per hour slept (AHI). We have thus performed a second, larger, randomized, placebocontrolled study in a prospective series of 34 patients (13 female) with mild SAHS (AHI 5 to 15) and daytime sleepiness. Patients spent 4 wk on CPAP treatment and 4 wk on an oral placebo, with randomization of treatment order, and daytime assessments on the last day of each treatment. Effective CPAP use averaged 2.8 6 2.1 h (mean 6 SD) per night. Compared with placebo, CPAP improved symptom score (p , 0.01), subjective (Epworth; p , 0.01) but not objective (maintenance of wakefulness test; p . 0.2) sleepiness, performances on 2 of 7 cognitive tasks (p , 0.02), depression score (p , 0.01), and five subscales of the SF-36 health/functional status questionnaire (p < 0.03). Fourteen of 34 patients preferred CPAP. In 14 patients with AHI in the range 5 to 10, symptoms, cognitive function, psychological well-being and quality of life were improved. These results confirm benefits for daytime function after CPAP treatment for mild SAHS, but highlight unacceptability of CPAP in many such patients. Engleman HM, Kingshott RN, Wraith PK, Mackay TW, Deary IJ, Douglas NJ. Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome. AM J RESPIR CRIT CARE MED 1999;159:461‐467.

The publication "Randomized Placebo-controlled Crossover Trial of Continuous Positive Airway Pressure for Mild Sleep Apnea/Hypopnea Syndrome" is placed in the Top 10000 in 2012.
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