CiteWeb id: 20101198411

CiteWeb score: 2

Barleria prionitis L. (Family Acanthaceae; commonly known as Vajradanti), is an annual shrub, 1–3 feet high, found throughout tropical Asia and in South Africa. In indigenous system of medicine in India, the aerial parts are used in gastrointestinal disorders. The present study was undertaken in order to evaluate the antidiarrhoeal activity of chromatographic fractions B of butanol extract of leave of B.prionitis using several experimental models in Wistar albino mice/Rats. Leaves of B.prionitis were subjected to fractionate in several non polar solvent in which butnol fraction of B.prionitis Linn. led us to the identification of active fraction (iridoid glycoside). The bio active fraction has been prove that it contain three major iridoid glycosides namely acetyl barlerin (6, 8-di-o-acetylshanzhiside methyl ester), barlein (8-o-acetylshanzhiside methyl ester) and shanshiside methyl ester. These iridoids glycoside was subjected to anti diarrhoeal activity against validated experimental models like Castor oil induced diarrhea, gastrointestinal motility tests & PGE2-induced enteropooling. The extract inhibited castor oil induced diarrhoea and PGE2 induced enteropooling in rats; it also reduced gastrointestinal motility after charcoal meal administration. The obtained data demonstrated the excellent anti-diarrhoeal activity of B.prionitis and thus have great potential as a source for natural health products.

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