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CiteWeb id: 20090000278

CiteWeb score: 2561

DOI: 10.1056/NEJM199505183322008

Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye note that in rats exposed to stressors, the adrenal glands were enlarged, and the thymus and lymph nodes shrunken.1–3 Cortisone, the active principle of the adrenal glands, was isolated by Kendall and Reichstein in the late 1940s and shown to suppress immune organs. These scientists, along with Hench, received the Nobel Prize in Physiology and Medicine, after Hench and colleagues showed that cortisone could ameliorate rheumatoid arthritis.4,5 In recent . . .

The publication "The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation." is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Medicine it is included to the Top 1000. Additionally, the publicaiton "The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation." is placed in the Top 1000 among other scientific works published in 2009.
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