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CiteWeb id: 20090000201

CiteWeb score: 3114

DOI: 10.1056/NEJM199802123380703

Genital human papillomavirus (HPV) infection is highly prevalent in sexually active young women. However precise risk factors for HPV infection and its incidence and duration are not well known. The authors followed 608 college women at 6-month intervals for 3 years. At each visit the authors collected information about lifestyle and sexual behavior and obtained cervicovaginal lavage samples for the detection of HPV deoxyribonucleic acid by polymerase chain reaction and Southern blot hybridization. Papanicolaou-stained cervico-vaginal smears (Pap smear) were obtained annually. The cumulative 36-month incidence of HPV infection was 43% (95% confidence interval [CI] 36-49%). An increased risk of HPV infection was significantly associated with younger age Hispanic ethnicity Black race an increased number of vaginal-sex partners high frequencies of vaginal sex and alcohol consumption anal sex and certain characteristics of partners (regular partners having an increased number of lifetime partners and not being in school). The median duration of new infections was 8 months (95% CI 7-10 months). The persistence of HPV for 6 or more months was related to older age types of HPV associated with cervical cancer and infection with multiple types of HPV but not with smoking. The risk of an abnormal Pap smear increased with persistent HPV infection particularly with high-risk types (relative risk 37.2; 95% CI 14.6-94.8). The incidence of HPV infection in sexually active young college women is high. The short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively. (authors)

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