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CiteWeb id: 20040000235

CiteWeb score: 2756

DOI: 10.1200/JCO.2004.08.163

Purpose To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non‐small-cell lung cancer (NSCLC) previously treated with chemotherapy. Patients and Methods Eligible patients had a performance status 0 to 2, previous treatment with one prior chemotherapy regimen for advanced NSCLC, and adequate organ function. Patients received pemetrexed 500 mg/m 2 intravenously (IV) day 1 with vitamin B12, folic acid, and dexamethasone or docetaxel 75 mg/m 2 IV day 1 with dexamethasone every 21 days. The primary end point was overall survival. Results Five hundred seventy-one patients were randomly assigned. Overall response rates were 9.1% and 8.8% (analysis of variance P .105) for pemetrexed and docetaxel, respectively. Median progressionfree survival was 2.9 months for each arm, and median survival time was 8.3 versus 7.9 months (P not significant) for pemetrexed and docetaxel, respectively. The 1-year survival rate for each arm was 29.7%. Patients receiving docetaxel were more likely to have grade 3 or 4 neutropenia (40.2% v 5.3%; P .001), febrile neutropenia (12.7% v 1.9%; P .001), neutropenia with infections (3.3% v 0.0%; P .004), hospitalizations for neutropenic fever (13.4% v 1.5%; P .001), hospitalizations due to other drug related adverse events (10.5% v 6.4%; P .092), use of granulocyte colony-stimulating factor support (19.2% v 2.6%, P .001) and all grade alopecia (37.7% v 6.4%; P .001) compared with patients receiving pemetrexed. Conclusion Treatment with pemetrexed resulted in clinically equivalent efficacy outcomes, but with significantly fewer side effects compared with docetaxel in the second-line treatment of patients with advanced NSCLC and should be considered a standard treatment option for second-line NSCLC when available. J Clin Oncol 22:1589-1597. © 2004 by American Society of Clinical Oncology

The publication "Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Medicine it is included to the Top 1000. Additionally, the publicaiton "Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy" is placed in the Top 1000 among other scientific works published in 2004.
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