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CiteWeb id: 20040000012

CiteWeb score: 9600

DOI: 10.1126/science.1099314

Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. EGFR mutations were found in additional lung cancer samples from U.S. patients who responded to gefitinib therapy and in a lung adenocarcinoma cell line that was hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell lines. These results suggest that EGFR mutations may predict sensitivity to gefitinib.

The publication "EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy" is placed in the Top 1000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 100. Additionally, the publicaiton "EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy" is placed in the Top 100 among other scientific works published in 2004.
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