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CiteWeb id: 20020000012

CiteWeb score: 11542

DOI: 10.1126/science.1072994

It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance.

The publication "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics" is placed in the Top 1000 of the best publications in CiteWeb. Also in the category Other it is included to the Top 100. Additionally, the publicaiton "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics" is placed in the Top 100 among other scientific works published in 2002.
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