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CiteWeb id: 19990000231

CiteWeb score: 3239

DOI: 10.1016/S0166-2236(99)01401-0

Brain injury following transient or permanent focal cerebral ischaemia (stroke) develops from a complex series of pathophysiological events that evolve in time and space. In this article, the relevance of excitotoxicity, peri-infarct depolarizations, inflammation and apoptosis to delayed mechanisms of damage within the peri-infarct zone or ischaemic penumbra are discussed. While focusing on potentially new avenues of treatment, the issue of why many clinical stroke trials have so far proved disappointing is addressed.This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.

The publication "Pathobiology of ischaemic stroke: an integrated view" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Psychology it is included to the Top 1000. Additionally, the publicaiton "Pathobiology of ischaemic stroke: an integrated view" is placed in the Top 1000 among other scientific works published in 1999.
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