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CiteWeb id: 19990000066

CiteWeb score: 5819

DOI: 10.1016/S0092-8674(00)80595-4

Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. In this study, we demonstrate that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors. In the presence of survival factors, Akt phosphorylates FKHRL1, leading to FKHRL1’s association with 14-3-3 proteins and FKHRL1’s retention in the cytoplasm. Survival factor withdrawal leads to FKHRL1 dephosphorylation, nuclear translocation, and target gene activation. Within the nucleus, FKHRL1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.

The publication "Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 1000. Additionally, the publicaiton "Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor" is placed in the Top 100 among other scientific works published in 1999.
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