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CiteWeb id: 19970000352

CiteWeb score: 2440

DOI: 10.1126/science.277.5328.942

A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2 , a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.

The publication "Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 10000. Additionally, the publicaiton "Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans" is placed in the Top 1000 among other scientific works published in 1997.
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