Autors:

CiteWeb id: 19970000056

CiteWeb score: 6270

DOI: 10.1016/S0092-8674(00)80405-5

Growth factors can promote cell survival by activating the phosphatidylinositide-3′-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3′K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.

The publication "Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 1000. Additionally, the publicaiton "Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery" is placed in the Top 100 among other scientific works published in 1997.
Links to full text of the publication: