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CiteWeb id: 19950000054

CiteWeb score: 6752

DOI: 10.1016/0092-8674(95)90401-8

A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-γ, and the Jak/STAT pathways. The precise role of each of these pathways in cell signaling remains to be resolved, but studies on the differentiation of mammalian PC12 cells in tissue culture and the genetics of cell fate determination in Drosophila and Caenorhabiditis suggest that the extracellular signal-regulated kinase (ERK-regulated) MAPK pathway may be sufficient for these cellular responses. Experiments with PC12 cells also suggest that the duration of ERK activation is critical for cell signaling decisions.

The publication "Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation" is placed in the Top 10000 of the best publications in CiteWeb. Also in the category Biology it is included to the Top 1000. Additionally, the publicaiton "Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation" is placed in the Top 100 among other scientific works published in 1995.
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