CiteWeb id: 19910000021

CiteWeb score: 9447

DOI: 10.1126/science.1957169

Optical coherence tomography (OCT) is a high-speed, three-dimensional optical imaging technique that provides cross-sectional images of tissue microstructure with contrast based on the changes in the optical properties (refractive index) of the tissue. In contrast to conventional microscopy, OCT provides the ability to image tissue with resolution on the order of 10 μm within the first 1–2 mm from the tissue surface to provide nondestructive tissue analysis. The ability to acquire non- and minimally invasive depth-resolved microscopic images at speeds ≥ 100 frames per second has propelled OCT as a viable clinical and research tool for various fields including the assessment of ophthalmic, cardiovascular, gastrointestinal, and pulmonary diseases. In this article, we describe image formation and important considerations required to read and utilize OCT imaging and then review the ability to visualize pathology and pathophysiology within these organ systems in vivo .