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CiteWeb id: 19860000006

CiteWeb score: 18589

DOI: 10.1016/0197-2456(86)90046-2

This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to include relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for char- acterizing the distribution of treatment effects in a series of studies.

The publication "Meta-Analysis in Clinical Trials*" is placed in the Top 1000 of the best publications in CiteWeb. Also in the category Medicine it is included to the Top 100. Additionally, the publicaiton "Meta-Analysis in Clinical Trials*" is placed in the Top 100 among other scientific works published in 1986.
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