CiteWeb id: 19800000106

CiteWeb score: 2878

DOI: 10.1016/0301-0082(80)90018-0

Limbic forebrain structures and the hypothalamus are essential in the initiation of food-seeking, escape from predators and other behaviors essential for adaptation and survival. Neural integrative activities subserving these behaviors initiate motor responses but the neural interface between limbic and motor systems has received relatively little attention. This neglect has been in part because of the emphasis on the motor control of the movements and on the contributions of the cerebral cortex, cerebellum, spinal cord and other components of the motor system, but more importantly, because of a lack of relevant anatomical evidence of connections. Anatomical findings obtained in recent years now make it possible to investigate the neural interface between limbic and motor systems—neural mechanisms by which “motivation” gets translated into “action”. It has been proposed that the nucleus accumbens is a key component of this neural interface since it receives inputs from limbic forebrain structures, either directly or indirectly via the ventral tegmental area of Tsai, and sends signals to the motor system via the globus pallidus.