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CiteWeb id: 19770000044

CiteWeb score: 4524

DOI: 10.1016/0002-9343(77)90874-9

Starting in 1968 2815 men and women from the Framingham Heart study cohort aged 49-82 years had their lipids and lipoproteins characterized after an overnight fast; measurements included fasting triglycerides and high-density lipoproteins (HDL) low-density lipoproteins (LDL) and total cholesterol values. Coronary heart disease (CHD) had developed in 79/1025 men and 63/1445 women in the 4 years studied. In both men and women a clear gradient of CHD risk was HDL level with persons of low HDL cholesterol at higher risk than those with high levels. This inverse relationship of HDL cholesterol with incidence of CHD was significant (P < .001) in either men or women and was equally significant even when other lipids and standard risk factors for CHD were considered. HDL cholesterol levels below 35 mg/dl raised the incidence rate of CHD 8 times that in persons with HDL levels 65 mg/dl or above. A weaker association with CHD incidence (P < .05) was found for LDL cholesterol. Triglycerides were associated with CHD incidence only in women and then only when other lipid levels were not taken into account. At the older ages studied total cholesterol was not associated with CHD risk. HDL cholesterol level seems an important index to the risk of CHD and should be added to the usual risk profile.

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