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From motivation to action: functional interface between the limbic system and the motor system.

Limbic forebrain structures and the hypothalamus are essential in the initiation of food-seeking, escape from predators and other behaviors essential for adaptation and survival. Neural integrative activities subserving these behaviors initiate motor...

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J. Klionsky

The Motivational Effects of Charismatic Leadership: A Self-Concept Based Theory

The empirical literature on charismatic or transformational leadership demonstrates that such leadership has profound effects on followers. However, while several versions of charismatic leadership theory predict such effects, none of them explains the...

The On-Line Encyclopedia of Integer Sequences

The On-Line Encyclopedia of Integer Sequences (or OEIS) is a database of some 130000 number sequences. It is freely available on the Web (http://www.research.att.com/~njas/sequences/) and is widely used.There are several ways in which it benefits research:...

A textbook of histology

Alexander A. Maximow, William Bloom

Elastically deformable models

The theory of elasticity describes deformable materials such as rubber, cloth, paper, and flexible metals. We employ elasticity theory to construct differential equations that model the behavior of non-rigid curves, surfaces, and solids as a function...

Managing Across Borders: The Transnational Solution

The first edition of Managing Across Borders was hailed as a landmark book, widely praised for its pioneering insights into the management of companies operating in an international environment. With the introduction of an entirely new organizational...

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Summary Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-based protocol was used to collect clinical information and biological...

An Overview of CMIP5 and the Experiment Design

The fifth phase of the Coupled Model Intercomparison Project (CMIP5) will produce a state-of-the- art multimodel dataset designed to advance our knowledge of climate variability and climate change. Researchers worldwide are analyzing the model output...

The DNA-damage response in human biology and disease

The prime objective for every life-form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has...

The Nature of Phonological Processing and Its Causal Role in the Acquisition of Reading Skills

Three bodies of research that have developed in relative isolation center on each of three kinds of phonological processing: phonological awareness, awareness of the sound structure of language; phonological receding in lexical access, receding written...

Analyzing the past to prepare for the future: writing a literature review

A review of prior, relevant literature is an essential feature of any academic project. An effective review creates a firm foundation for advancing knowledge. It facilitates theory development, closes areas where a plethora of research exists, and uncovers...

CONSEQUENCES OF INDIVIDUALS' FIT AT WORK: A META-ANALYSIS OF PERSON-JOB, PERSON-ORGANIZATION, PERSON-GROUP, AND PERSON-SUPERVISOR FIT

This meta-analysis investigated the relationships between person‐job (PJ), person‐organization (PO), person‐group, and person‐supervisor fit with preentry (applicant attraction, job acceptance, intent to hire, job offer) and postentry individual-level...

Bigtable: A Distributed Storage System for Structured Data

Bigtable is a distributed storage system for managing structured data that is designed to scale to a very large size: petabytes of data across thousands of commodity servers. Many projects at Google store data in Bigtable, including web indexing, Google...

Testing for nonlinearity in time series: the method of surrogate data

We describe a statistical approach for identifying nonlinearity in time series. The method first specifies some linear process as a null hypothesis, then generates surrogate data sets which are consistent with this null hypothesis, and finally computes...

ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control.

▪ Abstract To cope with environmental fluctuations and to prevent invasion by pathogens, plant metabolism must be flexible and dynamic. Active oxygen species, whose formation is accelerated under stress conditions, must be rapidly processed if oxidative...

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

A method for the analysis of nanogram quantities of glutathione has been developed which is based on the catalytic action of GSH or GSSG in the reduction of Ellman reagent (DTNB) by a mixture of TPNH and yeast glutathione reductase. Unlike previous methods...

Comprehensive molecular portraits of human breast tumours.

Daniel C. Koboldt, Robert S. Fulton, Michael D. McLellan, Heather Schmidt, Joelle Kalicki-Veizer, Joshua F. McMichael, Lucinda Fulton, David J. Dooling, Li Ding, Elaine R. Mardis, Richard K. Wilson, Adrian Ally, Miruna Balasundaram, Yaron S. N. Butterfield, Rebecca Carlsen, Candace D. Carter, Andy Chu, Eric Chuah, Hye-Jung E. Chun, Robin Coope, Noreen Dhalla, Ranabir Guin, Carrie Hirst, Martin Hirst, Robert A. Holt, Darlene Lee, Haiyan I. Li, Michael Mayo, Richard Moore, Andrew J. Mungall, Erin Pleasance, A. Gordon Robertson, Jacqueline E. Schein, Arash Shafiei, Payal Sipahimalani, Jared R. Slobodan, Dominik Stoll, Angela Tam, Nina Thiessen, Richard Varhol, Natasja Wye, Thomas Zeng, Yongjun Zhao, Inanc Birol, Steven J. M. Jones, Marco A. Marra, Andrew D. Cherniack, Gordon Saksena, Robert C. Onofrio, Nam H. Pho

A new force field for molecular mechanical simulation of nucleic acids and proteins

Peter A. Kollman, David A. Case, U. C. Singh, Caterina Ghio, Giuliano Alagona

A Theory of Cerebellar Function

A comprehensive theory of cerebellar function is presented, which ties together the known anatomy and physiology of the cerebellum into a pattern-recognition data processing system. The cerebellum is postulated to be functionally and structurally equivalent...

Prevention of venous thromboembolism : the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

Prevention of venous thromboembolism : the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

Microglia: a sensor for pathological events in the CNS

The most characteristic feature of microglial cells is their rapid activation in response to even minor pathological changes in the CNS. Microglia activation is a key factor in the defence of the neural parenchyma against infectious diseases, inflammation,...

Improved method for the isolation of RNA from plant tissues

Jürgen Logemann, Jeff Schell, Lothar Willmitzer

Epidemiology and causes of preterm birth

This paper is the first in a three-part series on preterm birth, which is the leading cause of perinatal morbidity and mortality in developed countries. Infants are born preterm at less than 37 weeks' gestational age after: (1) spontaneous labour with...

Heterologous protection against influenza by injection of DNA encoding a viral protein.

Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different strains of virus, in contrast to antibodies, which are generally strain-specific. The generation of such CTLs in vivo usually requires endogenous expression...

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

We did a randomised controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn's disease who respond to a single infusion of infliximab.

Teacher Efficacy: Capturing an Elusive Construct.

Teacher efficacy has proved to be powerfully related to many meaningful educational outcomes such as teachers’ persistence, enthusiasm, commitment and instructional behavior, as well as student outcomes such as achievement, motivation, and self-efficacy...

The Universal Protein Resource (UniProt)

The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. Formed by uniting the Swiss-Prot, TrEMBL and PIR protein database activities,...

Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial

There is no standard treatment for unresectable hepatocellular carcinoma. Arterial embolisation is widely used, but evidence of survival benefits is lacking.

Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles

A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported. Introduction of a single-stranded target oligonucleotide (30 bases) into a solution containing the appropriate...

The New Governance: Governing without Government1

The term ’governance‘ is popular but imprecise. It has at least six uses, referring to: the minimal state; corporate governance: the new public management; ‘good governance’: socio-cybernetic systems: and self-organizing networks. I stipulate...

PAHs in the Fraser River basin : a critical appraisal of PAH ratios as indicators of PAH source and composition

Parent and alkyl PAHs (51 compounds and alkyl homologues) have been quantified in suspended particulates and sediments (345 samples) from the Fraser River system, British Columbia, Canada. The best potential to distinguish natural and anthropogenic sources...

Random sets and integral geometry

Random sets and integral geometry

Frontotemporal lobar degeneration A consensus on clinical diagnostic criteria

Article abstract-Objectiue: To improve clinical recognition and provide research diagnostic criteria for three clinical syndromes associated with frontotemporal lobar degeneration. Methods: Consensus criteria for the three prototypic syndromes-frontotemporal...

Powering the planet: Chemical challenges in solar energy utilization

Global energy consumption is projected to increase, even in the face of substantial declines in energy intensity, at least 2-fold by midcentury relative to the present because of population and economic growth. This demand could be met, in principle,...

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. In this study, we...

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

A cell-free system based on cytosols of normally growing cells is established that reproduces aspects of the apoptotic program in vitro. The apoptotic program is initiated by addition of dATP. Fractionation of cytosol yielded a 15 kDa protein that is...

Modelling nonlinear economic relationships

This volume explains recent theoretical developments in the econometric modelling of relationships between different statistical series. The statistical techniques explored analyse relationships between different variables, over time, such as the relationship...

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Werness Ba, Jon M. Huibregtse, Arnold J. Levine, Peter M. Howley

Enhancing thermal conductivity of fluids with nanoparticles

Low thermal conductivity is a primary limitation in the development of energy-efficient heat transfer fluids that are required in many industrial applications. In this paper we propose that an innovative new class of heat transfer fluids can be engineered...

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